Abstract Background SCAs (Acute Coronary Syndromes) are one of the most frequent cardiovascular diseases, among which STEMI is certainly the most relevant in terms of short and long–term prognosis. The latest ESC Guidelines about ACS–STEMI indicate some key elements in terms of diagnosis and treatment, from first contact to cardiological rehabilitation. Objective Detect the number of SCA–STEMIs managed in the AST of Ascoli Piceno, along with intra and post–hospital process indicators provided in the PDTA of the “RETE STEMI” issued by the Marche Region specifically in AST of Ascoli Piceno. MATERIALS & METHODS An observational, longitudinal, monocentric, not–for–profit clinical study without diagnostic–therapeutic interventions was designed. The data collection started on 01/11/2022 and ended on 30/06/2023, at “Madonna del Soccorso” Hospital of San Benedetto del Tronto and “Mazzoni” Hospital of Ascoli Piceno in Cardiological Intensive Care Units (UTIC). Useful data for this study were acquired every month, consulting the folders of each patient diagnosed with “SCA–STEMI”, and then, reported in an Excel sheet, they were processed with different mathematical and statistical functions, including frequency, percentage, arithmetic average and standard deviation, and later used to design tables and graphs. All the data have been aggregated in full compliance with current legislation on the protection of patient privacy. Results The most significant results are related to the time between the first medical contact and the’ starting of the PPCI procedure, with an average time detected of 110 minutes. Another very important result is the number of patients sent to a post–acute cardiological rehabilitation program (PCRP): from the present study it appears that only the 1% of the entire sample was sent to a PCRP. Finally, other indicators considered in relation to the PDTA appear to be in line with the current Guidelines. Conclusions The present study highlights the aspects of the STEMI PDTA of the Marche Region which could be improved, namely reducing FCM–Wire crossing time and sending patients to a cardiological rehabilitation program, also by implementing the figure of the nurse specialized in the critical and cardiological area.