Acute Closure Glaucoma Research Articles

Evaluation of the pattern of contrast sensitivity in glaucoma patients

This prospective cross-sectional study was conducted to measure the contrast sensitivity in different types of glaucoma patients. The patients for this study were identified using a non-probability convenient sampling method from 01st February 2020 to 30th August 2020. The diagnosis and sensitivity were tested using lea contrast sensitivity, Snellen visual acuity charts, trial box, and occluder. The data were analyzed using Statistical Package for Social Sciences (SPSS version 20.0). Out of 60 patients, including 37 males and 23 females, between 16-80 years of age. 33 (55 %) patients were diagnosed with Primary Open Angle Glaucoma(POAG), 17 (28.3 %) patients with Primary Close Angle Glaucoma, 7 (11.7%) patients with Acute Closure Glaucoma(PCAG), and 3 (5%) patients with Secondary Glaucoma. Similarly, with glasses, 46 (76.7 %) patients had visual acuity 6/6 to 6/12, 11 (81.3%) patients had 6/18 to 6/36 and 3 (5 %) patients had 6/60. According to contrast sensitivity 30 (50%) patients had 1.25% (80%), 21 had 2.50% (40%) and 9 had 5% (20%). 15 subjects had 1.25% (80%), 13 subjects had 2.5 %( 40%) and 5 subjects had 5% contrast sensitivity in POAG. Around 11 subjects had 1.25% (80%), 4 subjects had 2.5 % (40) and 2 subjects had 5% contrast sensitivity in PCAG, 3 subjects had 1.25% (80%), 3 subjects had 2.5 % (40) and 2 subjects had 5% contrast sensitivity in PCAG. There was a reduction in contrast visual acuity with and without refraction. Most of the patients had variation at the level of Contrast Visual Acuity in POAG.

Application of triamcinolone acetonide in combined surgery of glaucoma and cataract

Objective To observe the efficacy of intravitreal triamcinolone acetonide (TA) injection in combined surgery of acute angle-closure glaucoma and cataract. Methods A prospective control study. Fifty-two eyes of 52 patients of acute angle closure glaucoma combined with cataract from Jan. 2017 to Mar. 2018 were randomly divided into two groups, 26 eyes in each group. All patients underwent phacoemulsification combined with trabeculectomy. In TA group, intravitreal injection of TA was proformed during operation. The follow-up time was 1 month. Results The visual acuity of TA group after operation was better than that of the control group (t=-2.614, P=0.018). At 1 and 10 days after operation, the control of anterior chamber inflammation in TA group was better than that of the control group (P=0.005, 0.004). The difference was not significant in intraocular pressure between the two groups at each time points after operation (P>0.05). Conclusion Intravitreal injection of TA can effectively control the inflammatory reaction after the combined operation of glaucoma and cataract, can get better visual acuity. Key words: Glaucoma, cataract; Phacoemulsification; Trabeculectomy; Triamcinolone acetonide, intravitreal injection

Observation on the efficacy of combined operation for the treatment of acute angle-closure glaucoma with cataract

Objective To observe the efficacy of phacoemulsification combined with goniosychialysis for the treatment of acute angle closure glaucoma with cataract. Methods The data of 92 eyes of 75 patients with acute primary closure angle glaucoma with cataract from Nov. 2015 to 2017 Feb. were collected. All patients were divided into two groups randomly.The control group, 44 eyes of 37 cases received phacoemulsification and IOL implantation and the clinical trial group, 48 eyes of 38 cases underwent phacoemulsification and IOL implantation combined with goniosychialysis.The followed-up time was 6 months. Results The intraocular pressure, anterior chamber depth, visual acuity and visual field of the two groups were significantly better than those before operation. The changes of the above indexes at the same time after operation in the clinical trial group were significantly better than those in the control group (all P<0.05). Postoperative anterior chamber angle grade of the two groups was significantly better than that before operation. The improvement of angle grade in the clinical trial group was better than that in the control group (P<0.05). Conclusion Phacoemulsification and IOL implantation combined with goniosynechialysis for the treatment of acute primary closure angle glaucoma with cataract is effective and safe. Key words: Cataract; Glaucoma, primary, angle closure, acute; Phacoemulsification; Goniosychialysis

Comparison on the efficacy of two kinds of suturing of scleral flap in trabeculectomy

Objective To compare the efficacy of two kinds of suturing of triangular scleral flap in trabeculectomy. Methods The data of 82 eyes of 67 cases with acute angle closure glaucoma were collected and all cases were divided into 2 groups. Group A, 41 eyes of 33 cases received 3 stitches of scleral flap and group B, 41 eyes of 34 cases received 2 stitches of scleral flap. The follow-up period was 12 months, and the deep of anterior chamber and intraocular pressure were compared between the two groups. Results At 1 week after operation, the shallow anterior chamber occurred in 1 eye in group A and 10 eyes in group B, and the difference was statistically significant (P=0.002). The mean intraocular pressure in group A was(12.53+ 0.50) mmHg and (10.41+ 1.08) mmHg in group B (1 mmHg=0.133 kPa) at 3 weeks after operation. The difference was statistically significant (P=0.000). Conclusion Trabeculectomy with 3 stitches of triangular scleral flap is easy to form anterior chamber and stabilize intraocular pressure. Key words: Trabeculectomy; Scleral flap, triangle, 3 stitches, 2 stitches; Anterior chamber; Intraocular pressure

The auxiliary effect of suramin application in acute angle closure glaucoma surgery patients

Objective To investigate the effects of suramin application in acute angle closure glaucoma surgery patients. Methods A prospective study method was used. From February 2012 to January 2016, 178 acute angle closure glaucoma surgeries in our hospital for treatment were selected, and were equally divided into observation and control groups (89 cases in each group) according to the order of admission, and two groups were given filtration surgery. The observation group was treated with suramin adjuvant therapy after surgery. The duration were 1~14 d after operation. The prognosis of two groups was observed. Results All patients were successfully completed surgery. The intraoperative and postoperative complications were no seriously occurred; the postoperative intraocular pressure in the observation group and the control group were (11.52±3.24) mmHg and (16.98±5.33) mmHg that compared preoperative [(31.98±5.22) mmHg, (31.87±5.11) mmHg] with significantly different (P<0.05), while the observation group was significantly lower than that of the control group (P<0.05). The postoperative peak systolic velocity (PSV) and end diastolic velocity (EDV) values of the central retinal artery of the observation group and the control group were significantly higher than that of preoperation (P<0.05), and the postoperative PSV and EDV values of the central retinal artery of the observation group were significantly higher than that in the control group (P<0.05). The postoperative ratios of functional filtering bleb in the observation group and control group were 80.9% and 60.7%, respectively. The observation group was significantly higher than that of the control group (P<0.05). Conclusions The application of suramin in acute close angle glaucoma filtration surgery can promote the function of filtering bleb and intraocular pressure reduction, and improve the ocular blood flow speed that has good application effects. Key words: Suramin/TU; Glaucoma, angle-closure/TH; Filtering surgery

Clinical characteristics of 679 cases from an Ophthalmologic Emergency Department at night

Objective To investigate the clinical characteristics of patients in the Ophthalmologic Emergency Department (OED) at night. Methods The records of 679 patients attending to the OED of the First Affiliated Hospital of Zhengzhou University at night (from 5: 30 p. m. to 8: 00 a. m. of the next morning) were collected from Aug. 2012 to Jul.2013. The gender, age, career, visiting time, initial diagnosis, emergency treatment and visual outcome were analyzed. Results In this study, for the patients younger than 60 years old, there were more male patients than female. For the patients more than 60 years old, there were more female patients than the male. Peasants(33.3%) and workers(29.9%) accounted for the majority proportion of the patients, followed by preschool children(17.5%) and students(15.0%). The most common diseases in OED were ocular trauma(83.9%), ocular surface inflammation(13.4%) and acute primary angle closure glaucoma(PACG, 2.2%). There was significant difference between male and female(χ2=41.943, P=0.000) in those three types of diseases. The proportion of patient admitted to the OED were 54.8%, 36.1%, 9.1% in the period of 22: 00-03: 00 o'clock, 17: 30-22: 00 o'clock and 03: 00-08: 00 o'clock, respectively. Among the 679 cases, 563 cases(82.9%) required hospital admission, 508 eyes of 487 cases (63.6%) underwent emergent operations, in which 41 eyes of 33 cases (5.1%) were treated by multiple combined operations. The final best corrected visual acuity (BCVA) of less than 0.05 occurred in 38 eyes (6.0%), 0.05~0.25 in 176 eyes (27.6%), and ≥0.3 in 423 eyes (66.4%). Conclusion Ocular trauma, ocular surface inflammation, and acute PACG are the three main diseases in OED from 17: 30 to 08: 00 of the next day. The largest number of patients visiting OED was in the period of 22: 00~03: 00 o'clock. Most of the patients need emergent surgeries. Key words: Ophthalmologic emergency, night; Characteristics, clinical; Trauma, ocular

Glaucoma—early diagnosis could prevent vision loss

Sight, one of the special senses, is often taken for granted—until it is impaired or lost. The number of people losing their vision is growing, yet much of this vision loss could be prevented. Many conditions can cause visual impairment and glaucoma is one of them. To understand how best to care for people with glaucoma, the healthcare assistant and assistant practitioner (HCA and AP) must have an understanding of this special sense. This article discusses acute closure glaucoma and primary open angle glaucoma. This article provides an overview of the anatomy and physiology of the eye, the risk factors associated with glaucoma and the signs and symptoms people experience. There is a discussion concerning the various investigations required to make a diagnosis and the treatment and care required. Finally, a glossary of terms is provided.

Curative effect observation on 90 cases of acute angle closure glaucoma combined with cataract by phacoemulsification combined with goniosynechialysis

Objective To investigate the clinical effect of phacoemulsification combined with goniosynechialysis in treatment for acute angle closure glaucoma combined with cataract.Methods In our hospital 180 cases of acute angle closure glaucoma with cataract were divided into experimental group and control group,experimental group was treated by phacoemulsification combined with goniosynechialysis treatment,the control group used glaucoma combined with cataract surgery,two groups were observed before and after treatment in intraocular pressure,visual acuity,central anterior chamber depth and complications.Results After treatment,the intraocular pressure of experimental group patients (14.3 ± 2.7) mmHg was significantly lower than that of the control group (19.1 ± 3.4) mmHg,and the central anterior chamber depth (3.31 ± 0.15) mm was significantly higher than that in the control group (3.01 ± 0.11) mm,and the incidence of anterior chamber inflammation and ciliochoroidal detachment in experimental group patients was significantly lower than that in the control group patients,the difference was statistically significant (P ＜ 0.05).Conclusion Phacoemulsification combined with goniosynechialysis for acute angle closure glaucoma with cataract has better clinical effect,can reduce the occurrence of complications. Key words: Phacoemulsification; Goniosynechialysis; Acute angle closure glaucoma; Cataract

Clinical application of Pentacam anterior segment system

Objective To investigate the application of Pentacam anterior segment system in the early screening of angel-closure glaucoma and the quantitative evaluation of combined glaucoma and cataract surgery.Methods The Pentacam anterior segment analysis system was applied in 25 senile volunteers (25 eyes),25 acute angle closure glaucoma and cataract patients(25 eyes),and 25 chronic angle closure glaucoma and cataract patients (25 eyes).The morphological parameters of anterior chamber,including anterior chamber depth (ACD),anterior chamber volume (ACV) and anterior chamber angle (ACA),were measured.They were compared with the paramenters 1 d,7 d,30 d after combined glaucoma and cataract surgery respectively.Results The three parameters were significantly higher in senile volunteers than that of patients in the two glaucoma groups,the differences had statistical significance.There were no significant differences in three parameters between the two glaucoma groups.The three parameters significantly increased after combined glaucoma and cataract surgery compared with that of preoperation in two glancoma groups.Conclusion The Pentacam anterior segment analysis system can quantitatively evaluate the changes of morphological parameters of ocular anterior segment after combined cataract and glaucoma surgery,providing reference for the evaluation of prognosis. Key words: System, analysis,Pentacam, three-dimensional,anterior segment; Surgery, combined,glaucoma, cataract; Depth, chamber, anterior; Volume, chamber, anterior; Angle, chamber, anterior

The analysis of corneal endothelium of patients with cataract

Objective To investigate the corneal endothelial in cataract patients combined with different diseases and evaluate the endurance of cornea in cataract surgery.Methods 277 eyes of 198 patients were divided into seven groups based on accompanied eye disease.The corneal endothelial cell density (CD),average cell area (AVE) and percentage of hexagonal cell density(HEXA)were detected in each eye.The data were analyzed by one-way analysis of variance with SPSS 16.0.Results There were 7 groups:group A (senile cataract),group B1 (cataract combined with acute primary angle closure glaucoma),group B2(cataract combined with chronic primary angle closure glaucoma),group C1 (cataract combined with non-proliferative diabetic retinopathy),group C2 (cataract combined with proliferative diabetic retinopathy),group D (cataract combined with uveitis),group E (cataract combined with high myopia).Compared with group A,CD was lower and AVE was higher in group B1 and C2 significantly (P ＜ 0.05).HEXA was lower in group C2 than group A.Compared with group A,there were no significant differences in CD,AVE and HEXA in group B2,C1,D and E (P ＞ 0.05).Conclusion Acute primary angle closure glaucoma and proliferative diabetic retinopathy have influence on corneal endothelia; chronic primary angle closure glaucoma,non-proliferative diabetic retinopathy,uveitis and high myopia have no obvious influence on corneal endothelia. Key words: Endothelia, corneal ; Glaucoma ; Diabetes ; Uveitis ; Myopia, high

Clinical efficacy of peripheral iridectomy through scleral tunnel incision

Objective To evaluate the clinical efficacy of peripheral iridectomy through scleral tunnel incision for glaucoma.Methods The peripheral iridectomy through scleral tunnel incision had been performed on 108 eyes of 68 cases diagnosed as remission phase of acute angle closure glaucoma,narrow angle and shallow anterior chamber or early stage of chronic angle closure glaucoma.The perioperative and postoperative complications and surgical effect were observed.Results The visual acuities of 108 eyes of 68 cases had no significant differences before and after surgeries.The intraocular pressure had been controlled satisfactorily during 3 ～ 5 years follow-up.Conclusion The peripheral iridectomy through scleral tunnel incision is safe,effective and easy to operate with little damage,light postoperative reactions and few surgical complications. Key words: Glaucoma, angle closure; Incision,tunnel,scleral; Iridectomy,peripheral

A study on abnomality of anatomic structures of primary acute angle closure glaucoma

Objective To explore the differences in anatomic structures of primary acute angle closure glaucoma (PAACG).Methods sixty eyes of 30 cases of PAACG and 60 eyes of 30 cases of normal eyes were enrolled in the study.For PAACG patients,anatomical structural data were obtained before and after trabeculectomy surgery.Then the results were compared with the data of normal eyes.Observational items included anterior chamber depth,lens thickness,vitreous cavity length,axial length and corneal diameter.The relative location of lens was calculated by the formula (anterior chamber depth + 1/2 lens thickness) over axial length.The coefficient of lens thickness over axial length was calculated and analyzed.Results Compared with normal eyes,PAACG patients had shallower anterior chamber,thicker lens,shorter axial length,forward shifting of lens position,smaller corneal diameter and larger coefficient of lens thickness/axial length.The differences were statistically significant (P ＜ 0.05).Conclusion PAACG patients have shallower anterior Chamber,thicker lens,shorter axial length and smaller corneal diameter.The relative location of lens and coefficient of lens thickness/axial length are the early indicators for PAACG. Key words: Glaucoma, angle closure, acute; Structure, anatomic ; Ultrasonography; Trabeculectomy

The causes and preventive measures of misdiagnosis on primary acute angle closure glaucoma

Objective To explore the causes and preventive measures for misdiagnosed primary acute angle closure glaucoma(PAACG).Methods In this retrospective analyses,the causes of 38 cases of misdiagnosed PAACG were analyzed who first visited other departments and were diagnosed as other diseases.The preventive measures of misdiagnosis were concluded.Results Of 38 cases,misdiagnoses included hypertensive encephalopathy in 13 cases,lacunar infarction in 11 cases,migraine in 5 cases,nerveous headache in 7 cases and gastrointestinal diseases in 2 cases.All cases were transferred to ophthalmology department after consultation and underwent antiglaucoma surgeries.After treatment,the patients' visual acuities were at non-light perception in 4 eyes,light perception in 3 eyes,counting fingers in 7 eyes,O.05 ～0.08 in 8 eyes,0.1 ～ 0.2 in 11 eyes and 0.3 ～ 0.5 in 5 eyes.The longer misdiagnoses lasted,the severer visual impairment became.Conclusion PAACG without systemic symptoms and first visit other department except ophthalmology department will easily to be misdiagnosed.To avoid misdiagnosis,it is glaucoma specialist' s responsibility to promote PAACG education for doctors and patients. Key words: Glaucoma, primary, angle closure, acute; Misdiagnosis

Clinical significance of Laser iridoplasty on acute attack of glaucoma

Objective To observe the efficacy and safety of laser iridoplasty for sustained high intraocular pressure in acute angle closure glaucoma before surgery.Methods 23 eyes in 23 patients during acute attack of acute angle closure glaucoma were analyzed retrospectively.All the patients had sustained high intraocular pressure (IOP) more than 48 hours after the medical treatment of maximal dose.They underwent laser iridoplasty first and after the IOP and inflanmation were effectively controlled,20 patients underwent trabeculectomy with adjustable suture and Mitomycin C during the surgery.Three patients underwent phacoemulsification and intraocular lens (IOL) implantation.Results IOP before laser iridoplasty were 43-82 mm Hg,average (66.23 ±:10.40) mm Hg.IOP after laser iridoplasty were 12 -28 nn Hg,average (19.59 ± 3.89) mm Hg(t =21.503,P =0.000 ).After 3 months of operation,IOP in 19 eyes were 8- 20 mm Hg,average ( 15.24 ±2.76) nun Hg,cure rate was 82.6％,IOP in 4 eyes were 21 -27 nn Hg,effeetive rate was 17.39％.Visual acuity increased to varying degrees in all patients.Conclusion Laser iridoplasty can reduce IOP and inhibit inflammation in acute angle closure glaucoma with sustained high IOP,transform the high risk surgery into the conventional surgery.Glaucoma filtration and phacoemulsification in the second stage had higher success rate and less complications. Key words: Glaucoma,angle closure; Iridoplasty,laser; Intraoculax pressure

Comparison of anterior segment changes before and after laser peripheral iridectomy by anterior segment optical coherence tomography in eyes with primary acute angle closure glaucoma

To evaluate the changes of anterior segment configuration after surgical peripheral iridectomy (SPI) in patients with primary acute angle closure glaucoma (PAACG) by using anterior segment optical coherence tomography (AS-OCT). This retrospective self control study consisted of thirty-seven eyes of 37 patients with PAACG who were consecutively recruited in Zhongshan Ophthalmic Center. The peripheral anterior synechiae (PAS) of these patients was less than 5 clock time point. Central anterior chamber depth (ACD), angle opening distance (AOD), trabecular iris area (TISA), angle recess area (ARA), anterior chamber width (ACW), anterior chamber volume (ACV), and crystalline lens rise (CLR) were measured using AS-OCT before and one month after SPI. After SPI, AOD (0.125 ± 0.072) µm, TISA (0.091 ± 0.041) mm(2), ARA (0.095 ± 0.042) mm(2), ACA (14.230 ± 2.000) mm(2) and ACV (90.074 ± 16.796) mm(3) were significantly increased compared with before SPI AOD (0.088 ± 0.078) µm, TISA (0.050 ± 0.048) mm(2), ARA (0.059 ± 0.057) mm(2), ACA (12.332 ± 2.457) mm(2), ACV (73.131 ± 16.976) mm(3) (t = -8.015 to 1.066, P = 0.001 to 0.044), respectively. There were no significantly changes in ACD, ACW and CLR (t = -1.505 to 0.516, P = 0.102 to 0.609). PAACG can be controlled by SPI resulting in an increase of AOD, TISA, ARA, ACA and ACV, but not ACD or CLR.

Novel exploration of emergency treatment for ueitic acute angle closure glacuma

To explore the effects of anterior chamber paracentesis plus pupillary block relief under slit-lamp microscope for the emergency treatment of uveitic acute angle closure glaucoma (ACG). In early stage, 14 uveitc acute ACG patients received anterior chamber paracentesis plus pupillary block relief while another 10 uveitc acute ACG patients underwent laser peripheral iridectomy (LPI). The intraocular pressure (IOP), degree of Tyndall, degree of pupillary block and severe adverse events were recorded at each observation timepoint. The IOP values for the paracentesis plus pupillary block relief group were (9.2 ± 2.1) mm Hg, (12.4 ± 3.7) mm Hg and (14.1 ± 2.6) mm Hg at 1, 48 h and 10 d vs (24.5 ± 7.1) mm Hg, (22.2 ± 8.6) mm Hg and (19.3 ± 9.3) mm Hg respectively for the LPI group. The inflammatory reaction of anterior chamber was more relieved in the paracentesis plus pupillary block relief group at Day 10. Pupillary block was observed in 1(1/14) patient from the paracentesis plus pupillary block relief group and 6 (6/10) patients from the LPI group at Day 10. Mild hemorrhage at pupillary margin was observed in 2 cases from the paracentesis plus pupillary block relief group. Both were self-absorbed within 10 days. Anterior chamber paracentesis plus pupillary block relief under slit-lamp microscope is the safe and effective emergency treatment for uveitic acute ACG. And it may offer a basis for further therapy.

Clinical study on the therapeutic alliance of acute angle-closure glaucoma with cataract

Objective To investigate the clinical significance of phacoemulsification combining initial iridoplasty by krypton and iridectomy by Nd:YAG laser treatment for cataract with acute angle closure glaucoma. Methods twenty-five eyes of 25 cases with first attack of acute angle-closure glaucoma with cataract were treated by initial laser iridoplasty and iridectomy after intraocular pressure controlled equability,followed by phacoemulsification and intraocular lens implantation after 3-14 days. The intraocular pressure,anterior chamber depth, visual acuity were observed, and the appearance of anterior chamber angle were found by Stratus OCT. Results From initial condition to after-operation, Intraocular pressure was decreased obviously from 62.17 ± 14. 12 mmHg to 14.32 ± 3. 17 mmHg. Anterior chamber depth changed from 1.67 ± 0.32 mm to 2.86 ± 0.40 mm, and the anterior chamber angle open widely. All patients had improved visual acuity. Conclusions To attack of acute angle-closure glaucoma combined with cataract, laser iridoplasty and iridectomy with followed phacoemulsification can effectively control the intraocular pressure,open the angle of anterior chamber, and improve visual acuity. It can reduce complications of glaucoma filtrating surgery, reduce the probability of trauma, improve vision, and improve quality of life. Key words: cataracts; glaucoma; surgery

Phacoemulsification and lens implantation for primary acute closure glaucoma

目的 探讨晶状体超声乳化吸出联合人工晶状体植入治疗急性闭角型青光眼合并白内障的疗效.方法 回顾分析我院2005年2月～2008年3月收治的合并白内障的急性闭角型青光眼46例(48眼),行超声乳化白内障吸出联合囊袋内人工晶状体植入术,术后随访3月～3年.观察术前术后视力、眼压、前房深度及前房角的变化.结果 45眼眼压控制正常,3眼需滴降眼压药物.视力均有不同程度提高.结论 晶状体超声乳化吸出联合人工晶状体植入能有效治疗合并白内障的急性闭角型青光眼。

Phacoemulsification and lens implantation for primary acute closure glaucoma

目的 探讨晶状体超声乳化吸出并人工晶状体植入治疗原发性急性闭角型青光眼合并白内障的疗效.方法原发性急性闭角型青光眼12例(14眼),视力＜0.4,晶状体不同程度浑浊,行晶状体超声乳化联合人工晶状体植入术,随访3月～3年.观察术前、术后视力、眼压、前房深度及前房角的变化.结果12眼(房角关闭＜1/2周)术后眼压控制正常;2眼(房角关闭＞3/4周)需滴降眼压滴眼液.其中1眼在1月后再次眼压急性升高,经YAG激光虹膜造孔后好转.视力均有不同程度提高.结论晶状体超声乳化并人工晶状体植入术治疗急性闭角型青光眼合并白内障,房角关闭小于1/2周者手术有效;房角关闭大于3/4周的病例需进一步随访观察。

Trabeculectomy for acute primary angle closure glaucoma

目的 对比观察小梁切除术联合丝裂霉素C(mitomycin-C,MMC)和单纯小梁切除术治疗急性原发性闭角型青光眼的结果.方法 67例(67眼)分为两组,分别采用小梁切除术联合MMC和单纯小梁切除术治疗.结果术后随访时间6～18月,平均(11.12±3.57)月.小梁切除术联合MMC组(35眼),眼压控制绝对成功率为82.86%(29眼),相对成功率为94.29%(33眼);单纯小梁切除术组(32眼),眼压控制绝对成功率为59.38%(19眼),相对成功率为75.00%(24眼);两组在眼压控制方面的差异具有显著意义(P＜0.05).术后主要并发症是前葡萄膜炎和虹膜后粘连.结论小梁切除术联合MMC是药物治疗无反应的急性原发性闭角型青光眼治疗可供选择的手术方法。