In acute care settings, subcutaneous insulin administration is usually prepared by nurses with vial and syringe. Certain drawbacks with this method have been demonstrated in the research literature, namely preparation time and safety. Insulin pen technology (IPT) has emerged over the past 2 decades as an alternative. A project introducing the IPT was conducted in 3 inpatients units for a 3-month period in the summer of 2012. The purpose of this quality-assurance pilot project was to evaluate the advantages and disadvantages of using IPT to administer insulin to patients hospitalized in acute care setting. Using a combined qualitative and quantitative approach, the nurses’ perspective with this practice change was explored. A questionnaire and exploratory qualitative interviews were administered 1-month post-pilot, comparing both methods according to specific indicators, such as time motion, adverse events related to medication administration practice, needle prick/injury, nurses’ satisfaction and cost comparisons. Overall the nurses (n=47) expressed satisfaction in using the IPT in a proportion of 94%. The most important features contributing to enhancing their practice related to safety (80%), time of preparation (95%) and comfort for patients (76%). The nurses expressed high satisfaction levels using the IPT. Although the cost of using this method can be more expensive than using a syringe, when looking at gained efficiencies related to inpatient care, discharge planning processes and reductions in health and occupational safety hazards, the introduction of IPT seems promising in the context of acute care settings.