The aqueous (Adb) and methanol (Mdb) extracts of the dry bulbils of Dioscorea bulbifera were evaluated against pain induced by acetic acid, formalin or pressure and for anti-inflammatory properties in carrageenan-, histamine-, serotonin- and formalin- animal models. Oral administration of these extracts at the doses of 150, 300 and 600mg/kg induced a dose dependant inhibition of pain and inflammation. At the dose of 600mg/kg, Adb produced a maximum effect of 56.38%, 73.06% and 42.79%, respectively on pain induced by acetic acid, formalin and pressure while Mdb produced an inhibition of 62.70% on acetic acid induced-pain, 84.54% on formalin induced-pain and 47.70% on pain induced by pressure. The oral administration of Adb and Mdb (600mg/kg) caused a maximum inhibition of 60.63% and 80.00%, respectively, in paw oedema induced by carrageenan. Adb (600mg/kg) also exhibited acute anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin, inhibiting this by 42.37%, 42.04% and 45.02%, respectively. A respective inhibition of 34.39, 46.92% and 32.06%, was observed after administration of Mdb at the dose of 600mg/kg. In the chronic inflammation model, the extracts showed maximum inhibition of 50.43% (Adb) and 40.84% (Mdb), respectively on the 3rd and 5th days of treatment.