Antiinflammatory activity of leaf extracts ofKalanchoe crenataAndr

Abstract

<b>Objective:</b> To evaluate the acute and chronic antiinflammatory properties of leaf extracts of <i> Kalanchoe crenata</i> in rats.<br><b> Material and methods:</b> The methylene chloride/methanol extract of <i> K. crenata</i> was extracted by using hexane, methylene chloride, ethyl acetate, and n-butanol. The antiinflammatory profile of these extracts was investigated on the basis of paw edema induced by carrageenan. The n-butanol fraction (most potent) was further assessed through acute inflammatory models induced by histamine, serotonin, and formalin. The chronic antiinflammatory and the ulcerogenic activities of the n-butanol fraction were also examined. <br><b> Results:</b> The oral administration of n-butanol fraction (600 mg/kg) caused a maximum inhibition of about 45% in paw edema induced by carrageenan. The n-butanol fraction also exhibited acute antiinflammatory activity on paw edema induced by histamine (47.51%), serotonin (54.71%), and formalin-(40.00%) . In the chronic inflammation model, this extract showed maximum inhibition of 61.26% on the ninth day of treatment. The ulcerogenic assessment showed that ulcer indices after oral treatment with n-butanol fraction were zero and 0.4±0.2, for the 300 and 600 mg/kg doses, respectively. <br><b> Conclusion:</b> On the basis of these findings, it may be inferred that <i> K. crenata </i> is an antiinflammatory and antiarthritic agent that blocks histamine and serotonin pathways. The results are in agreement with the traditional use of the plant in inflammatory conditions.