This case report explores acute mesenteric ischemia (AMI) in COVID-19 patients, showcasing this as a significant vascular complication from the infection. We discuss two instances of COVID-19-associated AMI, validated through comprehensive imaging and lab tests. The first case is a 54-year-old male with pre-existing hypertension and diabetes who presented with severe abdominal pain and symptoms consistent with COVID-19. The second involves a 65-year-old female with a history of heart disease, similarly, displaying acute abdominal symptoms. Surgical exploration in both cases confirmed mesenteric arterial thrombosis, indicative of a hypercoagulable state induced by COVID-19. These findings emphasize the need for healthcare providers to consider gastrointestinal symptoms as potential indicators of severe COVID-19 complications. Early recognition and appropriate diagnostic imaging are crucial in managing these cases effectively, potentially reducing mortality. The paper highlights the broader systemic effects of COVID-19, stressing the importance of vigilance and rapid response to manage not only the primary respiratory symptoms but also the less common but equally critical vascular complications like AMI. This study contributes to a growing body of evidence that COVID-19 can cause severe systemic complications, necessitating a comprehensive approach to treatment and management.