Nonlinear vibration analysis of thin circular pre-stressed functionally graded (FG) plate integrated with two uniformly distributed piezoelectric actuator layers with an initial nonlinear large deformation are presented in this paper. Nonlinear governing equations of motion are derived based on classical plate theory (CPT) with von-Karman type geometrical large nonlinear deformations. A nonlinear static problem is solved first to determine the initial stress state and pre-vibration deformations of the plate that is subjected to in-plane forces and applied actuator voltage. By adding an incremental dynamic state to the pre-vibration state, the differential equations that govern the nonlinear vibration behavior of pre-stressed piezoelectrically actuated circular FG plate are derived. An exact series expansion method is used to model the nonlinear electro-mechanical vibration behavior of the structure. Control of the FG plate’s nonlinear deflections and natural frequencies using high control voltages are studied and their nonlinear effects are evaluated. In a parametric study the emphasis is placed on investigating the effect of varying the applied actuator voltage as well as gradient index of FG plate on the dynamic characteristics of the structure.