The incorporation of interdisciplinary connections is a key element of contemporary education and plays a crucial role in the development of secondary school students. The purpose of the study is to analyze the features of the introduction and influence of interdisciplinary education on the study of physics, chemistry, and biology in the secondary school. To achieve research goals, various works of authors were used, who studied the issues of interdisciplinary connections of natural sciences, as well as such methods: generalization, survey, and axiomatic. The results of the work determined that interdisciplinary education of schoolchildren in Kazakhstan plays an important role in the development of complex and critical thinking, as well as the ability to apply knowledge in various contexts. This approach to learning integrates physics, chemistry, and biology to help students see the connections between them and apply what they have learned to real situations. As a result of the analysis, it was found that the implementation of interdisciplinary connections had a positive effect on about 90% of schoolchildren who, within the framework of this educational paradigm, learned to develop integrative abilities, the ability to see the relationship between subjects, apply analytical and creative skills, and work in a team. Moreover, the study highlighted that interdisciplinary education fostered greater student motivation and enthusiasm for learning, as it provided a more comprehensive understanding of how their subjects could be applied in practice. However, the research also identified several challenges, with the most significant being the insufficient preparation and readiness of teachers to engage in collaborative and integrated teaching activities.