Actual Activity Research Articles

Delineating urban functional zones using mobile phone data: A case study of cross-boundary integration in Shenzhen-Dongguan-Huizhou area

As cities continuously expand and with the emergence of mega-city regions, the urban functional zones (UFZs) have spread beyond their original administrative boundaries. An accurate and updated delineation of the UFZs is crucial for assessing the functional integration between cities within a mega-city region. Mobility data provides a chance to depict the UFZs from actual human activities at a finer spatial scale. Existing studies mostly adopted network-based approaches relying on the topological relationship but ignoring spatial factors, causing the lack of sensitivity in detecting the cross-cities integration of the functional region. This research proposed a novel regionalisation algorithm that redraws non-overlap boundaries of urban functional zones based on the commuting origin-destination matrix, representing the spatial interactions within cities and cross-cities. In particular, functional zones are drawn by searching for the best partition with the best goodness of fitting in the hierarchical spatial interaction model. The algorithm was applied to a case study of a mega-city region, Shenzhen-Dongguan-Huizhou (SDH) area in China using mobile phone signalling data. By adopting two different settings, this model evaluated the current status and predict the future trend of urban integration respectively. The results show the current boundary of UFZs in the SDH area almost coincides with administrative boundaries. Meanwhile, the results of long-term predictions might be utilised by policymakers to give more attention to the areas near the Dongguan-Huizhou boundary to promote industry cooperation and avoid mismatches between the functional and administrative regions.

Children and neonates anesthesia in magnetic resonance environment in Italy: an active call survey

BackgroundPediatric anesthesia care in the Magnetic Resonance Imaging is a challenge for clinicians. The recent debate about the role of anesthetic agent on neural development, encouraged an evaluation of their actual activity in this environment. In this active call survey, the authors sought to delineate the Italian situation regarding national centers, staff involved, monitoring tools available and sedation techniques.MethodsA complete sample of all national centers performing almost a pediatric discharge in the 2014 was obtained from Health Ministry registers. All Institutions were contacted for a prospective phone investigation and a three-section survey was fill out with the Physician in charge. A descriptive and exploratory analyzes about the organization setting of the Centers were performed.ResultsAmong 876 Institution screened, only 106 (37%) met minimal criteria for inclusion. Children are managed by anesthesiologists in the 95% of cases, while neonates in the 54%. A dedicated nurse is present in 74% of centers. While a pulse oximetry is present in 100% of centers, the rate of prevalence of other monitoring is lower. A specific MRI-compatible ventilator is available in the 95% of Centers, but many tools are not equally homogenously distributed. Pharmacological approach is preferred in pediatric age (98%), but its use for newborns is reduced to 43%.ConclusionsWe found significant heterogeneity in the daily clinical practice of sedation in MRI. Our results could be a starting point to evaluate the further evolution of approach to children and neonates in magnetic resonance setting.Trial registrationClinicalTrials.gov identifier: NCT04775641.

Sustainability of the informal sector space in urban areas in the post-covid-19 pandemic

The informal sector retailers in Indonesia are considered problems in the urban public spaces and a disturbance of comfort, traffics, views, and environmental cleanliness as a concern during the Covid-19 pandemic period. Until now, the government policies toward the retailers are in the form of eviction. In fact, these activities are actual activities that happen around urban areas, so they must be accommodated. Accommodating those activities is reinforced by its advantage that can provide a livelihood for marginalized people who have a problem due to the pandemic critical events. These activities could be sustainable in urban spaces. Their existence problems were found in Salatiga City, so it’s necessary to study the space as a place for their activities there under the pandemic period. This study aims to examine the retailers’ spaces during the pandemic in Pancasila Square Salatiga City. This study applies a quantitative approach using cross-tabulation to understand the relation of the variables between spaces and the activity characteristics of the retailers. Data was collected using observations and questionnaires. The results describe a suitable location, comfortable place, and sustainable spaces for retailers during the pandemic which will have an impact on the sustainability of the informal sector retailers in urban public spaces.

반응표면법에 의한 Lactiplantibacillus plantarum K79를 이용한 ACE(Angiotensin Converting Enzyme) 억제활성 향상을 위한 탈지유 발효조건 최적화

This study was conducted using response surface methodology (RSM) to elucidate fermentation conditions that will optimize ACE inhibitory activity using Lactiplantibacillus plantarum K79. Four independent variables [skim milk (with 1% added glucose) concentration (6%–14%), incubation temperature (32°C–42°C), incubation time (8–24 h), and amount of added starter (0.02%–0.2%)] were evaluated using five-level central composite design and response surface methodology to determine the optimum fermentation condition. The dependent variables were angiotensin converting enzyme (ACE) inhibitory activity (the value obtained from 102 diluted supernatant), and pH. The respective coefficients of determinations (R2) were 0.791 and 0.905 for ACE inhibitory activity and pH. The maximum ACE inhibitory activity was 90% under the following conditions: 10% skim milk (with 1% added glucose) concentration, 37°C incubation temperature, 17.8 h incubation time, and 0.2% added starter. Based on the RSM, using predicted best ACE conditions for fermentation of 13.49% skim milk (with 1% added glucose) with 0.0578% starter at 33.4°C for 21.5 h, the predicted ACE inhibitory activity and pH values were 86.69% and 4.6, respectively. Actual ACE inhibitory activity and pH values were 85.5% and 4.58, respectively.

Transplacental transfer of acetaminophen in pregnant rats

Acetaminophen is among the most widely used analgesics; however, the proportion and mechanism of transplacental transfer of unbound acetaminophen with actual pharmacological activity remain unknown. Our hypothesis is that acetaminophen gradually penetrates the blood-placenta barrier to reach the fetus. A multiple microdialysis coupled to liquid chromatography with photodiode array detection method was developed to monitor acetaminophen levels in the maternal blood, placenta, fetus, and amniotic fluid of a pregnant rat and investigate this hypothesis. The pharmacokinetic data indicates that acetaminophen exhibits a nonlinear behavior in the maternal blood within the dosage regimen of 100 and 300 mg/kg. In addition, acetaminophen penetrates the placenta, fetus, and amniotic fluid during treatment. The transplacental transfer ratio represented by the area under the concentration curve (AUC) ratio for the conceptus (the collective term for the fetus, placenta, and amniotic fluid) and maternal blood (AUCtissue/AUCblood) was approximately 11–23 % after acetaminophen (100 and 300 mg/kg) administration. However, the transporter of multidrug resistance-associated protein (MRP) inhibitor MK-571 did not significantly change the transplacental transfer ratio. This basic study provides constructive information for the clinical application of acetaminophen in pregnant women.

ACL Research Retreat IX Summary Statement: The Pediatric Athlete, March 17-19, 2022; High Point, North Carolina.

ACL Research Retreat IX Summary Statement: The Pediatric Athlete, March 17-19, 2022; High Point, North Carolina.

Study of leisure time physical activity of the Lithuanian adult population

The aim of the study to determine the physical activity of the Lithuanian adult population in their leisure time. The study of leisure-time physical activity of the Lithuanian adult population was the study of the actual diet, nutrition and physical activity habits of the adult and elderly Lithuanian population and the knowledge about nutrition and physical activity, which was conducted in 2019, part; The study was conducted by the Center for Health Education and Disease Prevention in conjunction with municipal public health offices. The survey was conducted at the respondent’s homes with their oral consent. The survey was anonymous, no information had to be written to identify the respondent. Research methods: a survey using the leisure physical activity part of the GPAQ (Global Physical Activity Questionnaire). Sufficiently physically active 31 percent. men and 39 percent. women. The average duration of high-intensity PA was 125 minutes per week for men and 83 minutes per week for women. The duration of moderate-intensity PA was 200 minutes per week for men and 210 minutes per week for women. The older people, the lower the duration of high-intensity PA (both men and women) and the longer the duration of moderate-intensity PA. Primary, secondary education high-intensity PA 122 minutes per week, women – 80 minutes per week.; special higher education – 117 and 77 minutes per week; higher education – 133 and 89 minutes per week. High-intensity PA activities lasted less for women (86 minutes per week in urban areas, 74 minutes per week in rural areas) (130 minutes per week in urban areas and 104 minutes per week in rural areas).

Okadaic acid did not change the nitrate reductase activation state in tomato seedlings

In this study, the total and actual nitrate reductase (NR) activity, and NR activation state, in tomato seedlings (Solanum lycopersicum cvs. Kmicic and Faworyt) treated with okadaic acid (OA) was evaluated. Seedlings were grown in a half-strength Murashige and Skoog (MS) medium in a growth chamber at day/night temperatures of 22/20 °C, a photon flux density of 150 µmol m-2 s-1, and a 16-h photoperiod. After 10 days, plants were transferred into MS medium with 0 (control), 0.01, 0.05, 0.1, 0.5, 1.0 µM OA. It was found that the total and actual NR activity increased in Kmicic leaves treated with 0.1, 0.5, and 1.0 µM OA compared to control. However, the NR activation state did not change in both roots and leaves of OA-treated tomato seedlings.

Features of educational motivation of non-traditional nursing students

The article presents an analysis of the works of Russian and foreign scientists on the motivation of educational activities of adult students depending on the form of study (full-time, part-time). Its features have been studied among students of the specialty ‟Nursing” at a medical college. For the first time in this study, the methodology of structural and psychological analysis was implemented in relation to the problem of motivation of educational activities of female medical students. From the standpoint of this methodology, it is established that during the professional training of future nurses, there are natural – determined by both the learning process and subjective factors – restructurings of the motivational sphere of the personality of women. These transformations characterise their integral structures rather than the dynamics of individual motives. It is found that the dynamics of the motivational sphere is quite deep, leading to structural changes in this sphere; that is, there is a qualitative restructuring of the motivational sphere of the individual. As a consequence of these qualitative transformations, there is also the organisation degree natural dynamics – integration of the motivational sphere of the individual. A decrease in the degree of structuring of the motivational sphere of students by the end of training is revealed; that is, there is a cardinal reorientation to the actual professional activity.

Influence of Management Education on Enterprise Scientific and Technological Innovation Based on K-Means Clustering Algorithm

Scientific and technological innovation is the source of the survival and development of enterprises and the key to the realization of the goal of prosperity. In recent years, more and more companies have begun to focus on technological innovation, but the results are not significant, so companies have begun to explore the factors that affect their technological innovation. The management is the helm of the development of the enterprise, the main body of the company’s actual production activities, and the direct person in charge of the company’s management. Its influence on the innovation of the enterprise is self-evident, and the education level of the management directly determines the manager’s ability and vision. However, the current research on management mainly focuses on the position change of management and the rights of management and does not involve the level of education of management. Based on this, this article started from the management education and subdivided it with the K-means clustering algorithm, so as to explore the impact of management education on the technological innovation of enterprises. The experiment showed that there was a significant positive correlation between the educational level of management and the technological innovation ability of enterprises, and the correlation coefficient was 1.521. It fully shows that the management with a higher education background will promote the enterprise to carry out scientific and technological innovation practice and continuously improve the enterprise’s innovation ability.

Former Nazis in German Intelligence Politics: The Exposure of Moles and Reckless Decision Making, 1959–1962

The early history of the postwar West German foreign intelligence service is replete with accounts of former Nazi security officers who were recruited by the newly founded service thanks to their professional experience, connections, and anti-Soviet credentials, only to later be exposed as Soviet moles. Focusing on the case of Heinz Felfe, this article puts forward the argument that the reaction of a secret service to the impending exposure of moles can be even more harmful than their actual activity. Enemy moles in intelligence organizations are dangerous in more than one way. They cause damage, of course, when they operate in the dark, but also cause just as much, and even more, damage when exposed. The fear of public scandal incentivizes irrational behavior, aggravating rather than decreasing the dangers facing the service.

Investment expectations by vulnerable European firms in times of COVID

The effect of the COVID shock on European economies has been severe and also unequal, with some firms being affected much more strongly than others. To improve the effectiveness of policy interventions, policymakers need to understand which types of vulnerable firms have been suddenly pushed into dire circumstances. We seek to fill this important gap in our knowledge by providing evidence from the European Investment Bank Investment Survey 2016–2020 on how the COVID shock has affected the investment activity and investment-related framework conditions of vulnerable firms. While data on actual investment activity post-COVID is not yet available to us, we focus on investment expectations. We exploit the fact that the same questions relating to investment expectations have been asked in several previous survey waves, which enables a difference-in-differences approach to investigate how investment expectations might have suddenly changed, for vulnerable groups of firms, immediately after the onset of the COVID crisis. We focus on 4 groups of vulnerable firms: High-Growth Enterprises (HGEs), young and small firms, R&D investors and non-subsidiary firms. R&D investors are more likely to be pessimistic about investment plans as a consequence of the COVID shock, and (similarly) HGEs are less likely to be optimistic about investment plans. R&D investors are less likely to be optimistic about the availability of internal finance, while HGEs and R&D investors are more likely to be pessimistic about the availability of external finance. Subsidiary firms, interestingly, are more likely to report a decrease in expected investment, which is not necessarily evidence of financial constraints, because it could instead be part of a conservative group-level strategy and coordinated group-level reduction in investment. Event study graphs generally confirm our regression results.

Quality of Life and Physical Activity in 629 Individuals With Sarcoidosis: Prospective, Cross-sectional Study Using Smartphones (Sarcoidosis App).

BackgroundLarge gaps exist in understanding the symptomatic and functional impact of sarcoidosis, a rare multisystem granulomatous disease affecting fewer than 200,000 individuals in the United States. Smartphones could be used for prospective research, especially for rare diseases where organizing large cohorts can be challenging, given their near ubiquitous ownership and ability to track objective and subjective data with increasingly sophisticated technology.ObjectiveWe aimed to investigate whether smartphones could assess the quality of life (QoL) and physical activity of a large cohort of individuals with sarcoidosis.MethodsWe developed a mobile app (Sarcoidosis App) for a prospective, cross-sectional study on individuals with sarcoidosis. The Sarcoidosis App was made available on both Apple and Android smartphones. Individuals with sarcoidosis were recruited, consented, and enrolled entirely within the app. Surveys on sarcoidosis history, medical history, and medications were administered. Patients completed modules from the Sarcoidosis Assessment Tool, a validated patient-reported outcomes assessment of physical activity, fatigue, pain, skin symptoms, sleep, and lungs symptoms. Physical activity measured by smartphones was tracked as available.ResultsFrom April 2018 to May 2020, the App was downloaded 2558 times, and 629 individuals enrolled (404, 64.2% female; mean age 51 years; 513, 81.6% White; 86, 13.7% Black). Two-thirds of participants had a college or graduate degree, and more than half of them reported an income greater than US $60,000. Both QoL related to physical activity (P<.001, ρ=0.250) and fatigue (P<.01, ρ=–0.203) correlated with actual smartphone-tracked physical activity. Overall, 19.0% (98/517) of participants missed at least 1 week of school or work in an observed month owing to sarcoidosis, and 44.4% (279/629) reported that finances “greatly” or “severely” affected by sarcoidosis. Furthermore, 71.2% (437/614) of participants reported taking medications for sarcoidosis, with the most common being prednisone, methotrexate, hydroxychloroquine, and infliximab. Moreover, 46.4% (244/526) reported medication side effects, most commonly due to prednisone.ConclusionsWe demonstrate that smartphones can prospectively recruit, consent, and study physical activity, QoL, and medication usage in a large sarcoidosis cohort, using both passively collected objective data and qualitative surveys that did not require any in-person encounters. Our study’s limitations include the study population being weighted toward more educated and wealthier individuals, suggesting that recruitment was not representative of the full spectrum of patients with sarcoidosis in the United States. Our study provides a model for future smartphone-enabled clinical research for rare diseases and highlights key technical challenges that future research teams interested in smartphone-based research for rare diseases should anticipate.

Perceived occupational engagement and gaps among community-dwelling older adults in Malaysia

Introduction: Engagement in occupations is an essential aspect of daily life among older people. Changes in age are often associated with changes in the pattern of engagement in occupations. However, the relationship between the actual and desired activities pattern of occupational engagement remains unclear among community-dwelling older adults in Malaysia. This study aimed to determine occupational engagement for each activity and occupational gaps related to domains among the older adults. Method A cross-sectional study was conducted among 335 community-dwelling older people, using the Malay version of the Occupational Gaps Questionnaire (OGQ-M). Findings: The findings indicate that there are significant differences in occupational engagement across domains: leisure ( p &lt; 0.001), social ( p = 0.04) and total occupational domains ( p &lt; 0.001). There is a significant difference between actual and desired performed activities in doing laundry ( p = 0.031), outdoor activities ( p &lt; 0.001), listening to the radio and watching television/video ( p = 0.003), helping and supporting others ( p = 0.019), travelling for pleasure ( p &lt; 0.001) and performing voluntary work ( p = 0.025). Conclusion: In conclusion, OGQ is a useful tool in screening the occupational gaps among community-dwelling older adults. Age, health and continuity of roles and responsibility as caretakers of the family are several factors that lead to higher occupational gaps among the older people in the community. With the emergence of occupational engagement and gaps, advancements in health care delivery are necessary for retirement planning among community-dwelling older adults in enhancing active participation towards better retirement life.

In Silico Phytochemical Screening for Dengue Virus

&#x0D; &#x0D; By and by, the world is fighting with dengue for long decades. However, the pathogenesis of dengue has not yet been fully elucidated. Dengue fever is a virus infection that is spread by the Aedes aegypti mosquito and can cause severe disease especially in children. Dengue fever is a major problem throughout the world especially tropical and sub-tropical regions of the world.The disease is still tearing down the world. Millions of researchers are still continuing for the potential medication up-and-comer that could help the medical care framework to keep world health. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Gingerol, Honokiol, Thiosulfinate, Saponin, Coumarin, Apigenin, Limonin, Baicalin, Quercetin, Tannin amine, Ajoene, Curcumin, with proteins with PDB id’s 4OIG, 6VSO could display antiviral activity against destructive dengue virus. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against Dengue virus.&#x0D; &#x0D;

Forensic Data Analysis Using the Case Studies on Anti Forensic Devices

Individuals' interactions with machines would change. The technology which started with using buttons have developed to the touchpad screen, which allows people to control devices. merely conversing with them Intelligent house assistants (IHAs), which allow customers to manage their smart devices, read their mail, and occasionally place orders, are becoming increasingly popular. As a result, it’s possible that they'll be discovered at a crime scene shortly for this reason. and are capable of carrying the weight of digital evidence. This research looked into the most famous Alexa Echo and Google Home devices. Documentation was uncovered when this came to forensic research and evidence that made up metadata. Then, by fabricating operations, Changing the device's name, establishing a bogus routine, and so on talent improvement on an individual basis. As a result of the research, cyber defence experts and professors working in this field were given information on the several sorts the digital evidence that can be found in home automation system acts. Anti-forensic was also used to elicit the distinction between actual and false activities

New approach of bioprocessing towards lignin biodegradation

Bio-utilization of lignocellulosic biomass is of huge significance as it can directly replace petroleum resources by producing liquid fuels and organic chemical products in a more sustainable way. However, studies on developing lignin-degrading microbial resources are still very few, which affects on establishing a consolidated bioprocessing of lignocellulosic resource. The main aim of this work is to discover thermostable laccases for lignin thermo-biodegradation by metagenome-mining and biochemical characterization. Results indicate that 124 putative thermostable laccase genes were identified from generated metagenomes. Significantly, 3 rationally selected proteins showed actual activity and structural stability at temperatures up to 60 °C and pH values as low as 4.87. These active recombinant enzymes verify a practical advance in the functional prediction of target proteins, and simultaneous sequence-to-function relationships in this metagenome. In short, the identified thermostable laccase genes in this work could expand range of lignin biocatalysts and contribute to build an efficient lignin biorefinery.

Rancangan Produk Rekreasi Wisata Memancing Sungai Bogowonto, Kabupaten Purworejo

The distribution of tourism potential in Purworejo Regency has been well mapped and must be supported by suitable approach, one of which is the development of river tourism. The actual river tourism activities that have been developed on the Bogowonto River are adventure tourism activities, namely white water rafting. However, the potential of river tourism on Bogowonto River is not only limited for rafting. The development of recreational fishing products on the Bogowonto River can be an opportunity for tourism development in Purworejo Regency. Recreational fishing regarded as a form of tourism activity in accordance with sustainable tourism (Hall, 2019; UNWTO, 2021). This can be seen from the pattern of recreational fishing that does not focus on the number of fish caught, the arrangement of the tools used, as well as the positive impact given to the community on the economic side. The study (Butler et al., 2020) shows that there is a positive contribution of fishing tourism to ecological preservation. From the business side, the Government of Indonesia has regulated fishing tourism businesses (Regulation of the Minister of Tourism of the Republic of Indonesia No. 19 of 2015 concerning Standards for Fishing Tourism Business, 2015), including business arrangements for providing places and facilities for fishing activities using special equipment and safety equipment including the provision of guide services. This study will identify and analyze recreational fishing tourism products based on packages, fishing equipment, fishing tour guides and supporting facilities in the Bogowonto River Area, Purworejo Regency. The long-term goal of this research is to contribute to the design of recreational fishing products for the development of tourist destinations in Purworejo Regency as a guide for stakeholders regarding the utilization of the Bogowonto River

The importance of analyzing the serum C3-epimer level for evaluating vitamin D storage in some special populations.

The serum 25-hydroxyvitamin D [25(OH)D] is recommended by various management agencies for evaluating the nutritional status of vitamin D (VitD). However, 25(OH)D cannot reflect the actual composition and activity of VitD in vivo. This study used UPLC-MS/MS to detect the levels of serum VitD metabolites in some special populations, so as to clarify its importance in accurately evaluating VitD storage in vivo. A total of 2029 subjects were enrolled, including 1204 cases in minor health (MH), 467 in the minor disease (MD), 119 in the adult health (AH) and 239 in adult disease (AD). Serum VitD2 and VitD3 levels were measured by UPLC-MS/MS. Serum C3-epi concentrations were also measured in 144 subjects by a spot check method. There were significant differences in the levels of VitD2, VitD3 and 25(OH)D among groups (all p <0.001). According to serum level of 25(OH)D, percentage of subjects with sufficient VitD in the MH, MD, AH and AD group were 65.4%, 52.7%, 29.4% and 20.9%, respectively. After converting VitD2 activity to AVitD3, subjects with sufficient VitD in MH, MD, AH and AD group accounted for 53.2%, 40.9%, 17.7% and 11.3%, respectively. C3-epi levels in the MH (z = 7.49, p <0.001), MD (z = 7.03, p <0.001) and AD group (z = 4.68, p <0.001) were higher than that in the AH group. Not only the serum 25(OH)D level, but also the simultaneous detection of VitD2 and VitD3 levels will overestimate the VitD storage in some subjects. Accurate evaluation of VitD storage in these individuals also requires detection of C3-epi levels.

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