Activity Of Reproductive System Research Articles

Effect of Some Psychotic Drug Quetiapine on Reproductive System Activity in Male Rats

Aim of study: To investigate the effects of antipsychotic medications utilized to treat schizophrenic patients and its effects on the reproductive system. Introduction: Antipsychotics, anticonvulsants, and other all psychotropic drugs have negative effects on the quality of sperm and sexual activity. These negative side effects differ amongst males and its less severe for some drugs, enabling some degree of control over their effects. Sperm can suffer oxidative damage from spending too much time in the male reproductive system. One of the antipsychotics most frequently administered to treat schizophrenia in adults is quetiapine. In this work, the effects of repeated rats’ healthy production of sperm in response to therapeutic doses of quetiapine was studied. Rats were also used to assess quetiapine’s effects on hormonal balance and oxidative state. Methodology: The experiment employed male wistar rats weighing 300 to 350 g at 10 to 12 weeks of age. The experiment employed male wistar rats weighing 300 to 350 g at 10 to 12 weeks of age. Rats received oral dosages of quetiapine for 30 days. At this time’s conclusion, the body’s weights and the organs were analyzed, additionally to sperm concentration, motility, shape, and degree of sperm damage. The levels of testosterone, LH, and other male hormones related to reproduction were measured in the serum. Malondialdehyde and glutathione levels were measured to assess the oxidative state of testicular tissues. Results: The results of this investigation demonstrated that in rats receiving quetiapine, aberrant sperm morphology increased while relative epididymis weights and sperm concentration dropped. Rats receiving quetiapine experienced a drop in serum LH and testosterone levels. Rats receiving quetiapine also had lower amounts of malondialdehyde, which was assessed. Conclusion: Quetiapine therapy this negative effect may be attributed to lower sperm quality, changed hormone levels, and enhanced oxidative stress.

The toxic effect of nickel chloride (II) and potassium dichromate (VI) on the activity of reproductive system in male mice

Increase distribution of heavy metal and its compound in the environment, especially through anthropogenic and natural activity, raises increasing concern for toxicological effects. The present study was based on the fact that Ni and Cr elements are important as the environmental factor produce the male genital system abnormalities. 35 male mice (10 weeks old) were randomly divided into seven groups 5 animals for each group, group 1 served as control received tap water, group 2,3 and 4 received (20, 40, and 60 mg/kg of Nicl2 respectively), while group 5,6 and 7 received (20, 60, and 100 mg/kg of K2Cr2O7 respectively). The results showed a high significant decrease (P≤0.0001) in the sperm count of male mice for intermediate and high dose treated with Nicl2 (II) as compared with control group, while no any significant differences between the lowest doses as compared with control group. The result showed a high significant difference (P≤0.0001) in the percentage of sperm abnormalities for intermediate and high dose treated with Nicl2 (II) as compared with control group. Also the result showed a high significant difference (P≤0.0001) in the sperm count for all groups treated with different doses of K2Cr2O7 (VI) as compared with control group. About percentage of sperm abnormalities the result showed a high significant difference (P≤0.0001) in the percentage of sperm abnormalities for intermediate and high dose treated as compared with control group.

Seasonal changes in activity of males’ reproductive system in Eurasian lynx

Eurasian lynx is strongly seasonal in its reproduction. This seasonality in reproduction becomes apparent in spatial population structure and behavior of lynx males during the year. However it was not clear how are these changes correlated with physiological changes at the individual level. In this article we studied the changes in sperm quality and testosterone level in Eurasian lynx males over the year. It was shown that activity of reproductive system in Eurasian lynx males changed seasonally as well. Testosterone level increased in advance of the mating season and spermatogenesis normalized at the same period.

Seasonal and age-related changes in blood parasite prevalence in Dark-eyed Juncos (Junco hyemalis, Aves, Passeriformes).

We determined seasonal changes in blood parasite infections in a free-living population of Dark-eyed Juncos (Junco hyemalis) breeding in interior Alaska (65 degrees N; 148 degrees W). The common parasites found in blood smears were Leucocytozoon fringillinarum (56%), Trypanosoma avium (33%), and Haemoproteus fringillae (9%). In males, parasite prevalences were relatively high at arrival on breeding grounds and increased during the breeding season. Intensity of infection with Leucocytozoon also increased between spring and summer, and then decreased at the time of migration (September). This decrease did not occur in adult females. Elevated prevalences during the breeding season probably reflected the addition of new cases via vector activity to positive status resulting from spring relapse. We observed neither an association between parasite species nor a consistent relationship between parasite intensity and body condition. To further study relationships between reproductive system activity and parasite infections, we compared prevalences in adult males that were undergoing their first cycle of gonadal development and regression (males in their second calendar year, or SY) with those of older males (males in their third or more calendar year, i.e., after-second-year males or ASY). Circulating testosterone concentrations declined in both groups between arrival on breeding grounds (end of April-early May) and the end of the reproductive period (July), and they were higher in May in ASY than in SY males. At the peak of the breeding season (June), ASY males also had a higher parasite prevalence than SY males. This difference may have resulted from immunosuppressive effects of gonadal hormones and/or from behavioral differences between SY and ASY males such that older males were exposed to more insect vectors than younger males. .