Joint Activity Research Articles

Predictive factors of methotrexate monotherapy success in patients with rheumatoid arthritis in a national referral center: a cohort study

BackgroundMethotrexate (MTX) remains the recommended first-line treatment for rheumatoid arthritis (RA); however, its response varies and is influenced by various factors. This study aimed to identify predictors of MTX monotherapy treatment success in an Indonesian cohort.MethodsThis retrospective cohort study included newly diagnosed RA patients receiving MTX monotherapy. Treatment success was defined as achieving remission or low disease activity according to Disease Activity Score-28 with erythrocyte sedimentation rate (DAS28-ESR) after 12 months of MTX therapy. The association between demographic, clinical, and laboratory factors and achieving therapy targets was evaluated using multivariate logistic regression analysis.ResultsAmong 254 subjects, 59.4% achieved treatment success with MTX monotherapy, with remission attained in 33% and low disease activity in 26.4%. Most subjects were female (95.7%) with a mean age of 48 ± 11 years. Multivariate analysis revealed that lower disease activity (OR 1.97; 95% CI [1.04–3.72]), normal ESR (OR 2.58; 95% CI [1.05–6.34]), normoweight (OR 2.55, 95% CI [1.45–4.49]), and tender joint count ≤ 5 (OR 2.45, 95% CI [1.31–4.58]) were significant predictors of treatment success.ConclusionThe rate of MTX monotherapy success in our study was 59.4%. Lower disease activity, normal ESR, normoweight, and fewer tender joints at baseline were significant predictors of treatment success.

Creation of multimodal digital twins with reflexive AGI multilogic and multisensory

Reflexive AGI multilogic, multimodality and multisensors are the basis for the multidisciplinary development of intelligent digital twins. Multimodality is implemented in several formats: text, image, speech, formulas, etc. Multilogic is implemented according to several rules or methods or ways of working with knowledge and data, and the criterion for selecting the best result from all implementations. AGI multilogic carries out judgment, understanding, perception, comparison, analysis, choice, etc. Understanding is realized using the technology of unified objectification of the ontology of subject areas for the implementation of specific activities. Multisensor systems are combined groups of electro-optical, spectroscopic and holographic sensors, and combined series of sensors, such as a thermal imager, color camera, low-light camera, laser rangefinder, laser designator, laser, pointer-illuminator and others. Multisensory systems help monitor the psyche and performance of a person at the level of medical indicators of his physical condition in the process of joint activities with digital twins. Multimodal digital twin with AGI multilogic and multisensory is good human assistant in many areas of activity.

Strategies to Increase Social Awareness as a Form of Conflict Resolution in the Kei Islands Community

Social awareness is a very important thing and must be possessed by the community in dealing with conflicts in society. The purpose of this study is to analyze the strategy of analyzing social awareness as a form of conflict resolution in the Kei community. Meanwhile, the method used in this study is qualitative with a phenomenological approach. Data were collected through observation and interviews. The data obtained was analyzed in three stages, namely reduction, data presentation and conclusion drawn. The results of the study show that strategies to increase social awareness as a form of conflict resolution in the Kei community include (a) Education in the family, (b) Promotion of Local Culture, (c) Women’s Empowerment, (d) Joint Activities. The findings can be used as a reference for stakeholders in designing programs and supporting social harmony and emphasizing the values of brotherhood, collective participation and effective communication in society.

Генезис и современное состояние содержания совместной деятельности в условиях образования

<p>In the article we carried out a historical and psychological analysis of psychological and pedagogical research of joint activities (its genesis) from the 60s of the XX century to the present time. Research reference points have been identified/ The first one is the beginning of the 60s of the XX century with a primary study of the genesis of the subject of joint activity in groups of children of preschool and primary school age. The secon is the end of the 80s of the XX, early XXI centuries within the framework of the development of the theory of developmental education (V.V. Davydov, V.V. Rubtsov, D.B. Elkonin, etc.) based on the positions of cultural-historical psychology L.S. Vygotsky, who emphasizes joint activity as the most important sociocultural mechanism of development. The third point takes place in the second decade - the beginning of the third decade of the XXI century, it’s the study of the issues of promoting the ideas of sociogenesis in the traditions of cultural-historical psychology and activity theory, and an attempt to look differently at the key problems of joint activities in a modern school environment. The space of possibilities for modern children is analyzed. Current research shows that educational organizations today form and develop not only the abilities of students, but also their activities (from joint games, educational activities, to role-playing experimentation and project activities).</p>

Control limitations in the null-space of the wrist muscle system

The redundancy present within the musculoskeletal system may offer a non-invasive source of signals for movement augmentation, where the set of muscle activations that do not produce force/torque (muscle-to-force null-space) could be controlled simultaneously to the natural limbs. Here, we investigated the viability of extracting movement augmentation control signals from the muscles of the wrist complex. Our study assessed (i) if controlled variation of the muscle activation patterns in the wrist joint’s null-space is possible; and (ii) whether force and null-space cursor targets could be reached concurrently. During the null-space target reaching condition, participants used muscle-to-force null-space muscle activation to move their cursor towards a displayed target while minimising the exerted force as visualised through the cursor’s size. Initial targets were positioned to require natural co-contraction in the null-space and if participants showed a consistent ability to reach for their current target, they would rotate 5∘\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$^\\circ$$\\end{document} incrementally to generate muscle activation patterns further away from their natural co-contraction. In contrast, during the concurrent target reaching condition participants were required to match a target position and size, where their cursor position was instead controlled by their exerted flexion–extension and radial-ulnar deviation, while its size was changed by their natural co-contraction magnitude. The results collected from 10 participants suggest that while there was variation in each participant’s co-contraction behaviour, most did not possess the ability to control this variation for muscle-to-force null-space virtual reaching. In contrast, participants did show a direction and target size dependent ability to vary isometric force and co-contraction activity concurrently. Our results indicate the limitations of using the muscle-to-force null-space activity of joints with a low level of redundancy as a possible command signal for movement augmentation.

Photocatalytic Methanol Dehydrogenation Promoted Synergistically by Atomically Dispersed Pd and Clustered Pd.

Supported metal in the form of single atoms, clusters, and particles can individually or jointly affect the activity of supported heterogeneous catalysts. While the individual contribution of the supported metal to the overall activity of supported photocatalysts has been identified, the joint activity of mixed metal species is overlooked because of their different photoelectric properties. Here, atomically dispersed Pd (Pd1) and Pd clusters are loaded onto CdS, serving as oxidation and reduction sites for methanol dehydrogenation. The Pd1 substitutes Cd2+, forming hole-trapping states for methanol oxidation and assisting the dispersion of photodeposited Pd clusters. Therefore, methanol dehydrogenation on CdS with supported Pd1 and Pd clusters exhibits the highest turnover frequency of 1.14 s-1 based on the Pd content and affords H2 and HCHO with a similar apparent quantum yield of 87 ± 1% at 452 nm under optimized reaction conditions. This work highlights the synergistic catalysis of supported metal for improved photocatalytic activity.

Role of High-Resolution Grey Scale and Power Doppler Ultrasonography in the Evaluation of Synovial Activity of Wrist and Hand Joints in Rheumatoid Arthritis

Role of High-Resolution Grey Scale and Power Doppler Ultrasonography in the Evaluation of Synovial Activity of Wrist and Hand Joints in Rheumatoid Arthritis

Promotion and Mechanism of Acupotomy on Chondrocyte Autophagy in Knee Osteoarthritis Rabbits.

To explore the effect of acupotomy intervention on autophagy of chondrocytes in rabbits with knee osteoarthritis (KOA), and to determine the possible mechanisms of acupotomy to alleviate cartilage degeneration. The modified Videman method was used to construct a KOA rabbit model. After modeling, 40 rabbits were randomly divided into 4 groups by a random number table: control; KOA (model); KOA + acupotomy (acupotomy), and KOA + sham acupotomy (sham), 10 in each group. After a 3-week treatment course, the knee joint activity was determined by the modified Lequesne MG index. Hematoxylin-eosin staining staining was used to examine the morphological changes of chondrocytes. Autophagy of chondrocytes was observed by transmission electron microscopy. The surface morphology of cartilage tissue was observed by scanning electron microscope. The mRNA and protein levels of AMP kinase/mammalian target of rapamycin/Unc-51 (AMPK/mTOR/ULK1) signal pathway key proteins, autophagy-related factor Beclin-1 and microtubule-associated protein 1A/1B light chain 3 (LC3) in rabbit knee cartilage were assessed by real-time fluorescence quantitative polymerase chain reaction and Western blot, respectively. The modified Lequesne MG score of acupotomy group was significantly lower than that of model group (P<0.05). Pathological results showed that chondrocyte autophagy decreased and cartilage surface was rough in the model group, which recovered after acupotomy treatment. The mRNA expressions of AMPK, ULK1, Beclin-1 and the protein levels of p-AMPK, p-ULK1, Beclin-1, and LC3 II/LC3 I were decreased in the model group, while the mRNA and protein expressions of mTOR were increased (P<0.01). However, acupotomy treatment reversed these abnormal changes (P<0.05). Acupotomy could effectively up-regulate the expressions of AMPK, ULK1 and Beclin1, reduce the expression of mTOR, promote autophagy, and alleviate joint degeneration. Acupotomy is a promising complementary and alternative therapy for KOA.

Dynamic Recrystallization of Olivine During Simple Shear: Evolution of Microstructure and Crystallographic Preferred Orientation From Full‐Field Numerical Simulations

AbstractUpper mantle deformation is mainly controlled by the mechanical behavior of olivine. Crystallographic preferred orientations (CPOs) develop in olivine due to crystal‐plastic deformation during mantle flow, where the a‐axes of olivine polycrystalline aggregates are aligned with the flow direction. Therefore, the observed CPO in olivine‐rich rocks is used as an indicator of the mantle flow direction. Experimental data show that olivine rheology is strongly controlled by the microstructure. While the influence of plastic deformation is in general well characterized, the role of dynamic recrystallization during deformation is not totally understood, limiting our ability to interpret the deformation history of naturally deformed rocks. This contribution presents microdynamic numerical simulations of olivine polycrystalline aggregates with different iron content (i.e., fayalite content) with the aim of exploring the CPO and grain size response to dynamic recrystallization. We use a full‐field approach with an explicit simulation of viscoplastic deformation and dynamic recrystallization processes under simple shear boundary conditions up to high strain. The simulations show that the CPOs are similar and practically reach the same maximum regardless of the iron content. CPOs are characterized by a single cluster of a‐axis and two‐clusters of b‐axis, reveling a joint activity of the easy glide [100](010) and the moderate strength [100](010) slip systems. High‐strain domains of our models are consistent with experimental results, showing an A‐type fabric with double maxima, and where the CPO is aligned with the shear direction. The model provides a deeper understanding of the dynamic recrystallization influence on olivine CPOs resulting from plastic deformation.

Theoretical Aspects of Creating Multimodal Digital Twins with AGI Multilogic and Multisensory

AGI multilogic, multimodality and multisensors are the basis for the multidisciplinary development of intelligent digital twins. Multimodality is implemented in several formats: text, image, speech, formulas, etc. Multilogic is implemented according to several rules or methods or ways of working with knowledge and data, and the criterion for selecting the best result from all implementations. AGI multilogic carries out judgment, understanding, perception, comparison, analysis, choice, etc. Understanding is realized using the technology of unified objectification of the ontology of subject areas for the implementation of specific activities. Multisensor systems are combined groups of electro-optical, spectroscopic and holographic sensors, and combined series of sensors, such as a thermal imager, color camera, low-light camera, laser rangefinder, laser designator, laser, pointer-illuminator and others. Multisensory systems help monitor the psyche and performance of a person at the level of medical indicators of his physical condition in the process of joint activities with digital twins. Multimodal digital twin with AGI multilogic and multisensory is good human assistant in many areas of activity.

EFFECTIVE PEDAGOGICAL APPROACHES TO DEVELOPING SENIOR PRESCHOOLERS’ COMMUNICATIVE ABILITIES

The problem of developing communicative abilities is paramount in the processes of socialization of preschoolers, the formation of interpersonal relationships, orientation in various situations and the search for an appropriate solution. We have analyzed the scientific and theoretical studies of communicative abilities, clarified the purpose, methodology of the problem and identified the problems that were justified by the research work and summarized the results obtained. The article considers communication and joint activity as the most important components of a preschooler’s daily life. It is during communication that the child learns about the world, learns to react to the environment, builds relationships and acquires social experience and abilities. The most important structural element of a child’s activity is the need to communicate with adults and peers. It is scientifically proven that communicative abilities with peers become a guarantee of a child’s social and personal development and determine the success and effectiveness of further development. The desire to cooperate with peers, to become a member of a social group of peers pushes a preschooler to certain actions that, when working together, are compared with the actions of a partner. Comparing classes enriches a child’s social experience. The impact of the pedagogical ways proposed by us, aimed at developing the communicative abilities of older preschool children, will contribute to the social and personal development of the child, the construction of interpersonal relationships. Formation and development of communicative abilities in the senior preschool age is a specially organized pedagogical process. It involves work planning, selection, planning, a sequence of effective means and forms to ensure the continuous development of communication abilities of preschoolers.

High-Performance Flexible Sensor with Sensitive Strain/Magnetic Dual-Mode Sensing Characteristics Based on Sodium Alginate and Carboxymethyl Cellulose.

Flexible sensors can measure various stimuli owing to their exceptional flexibility, stretchability, and electrical properties. However, the integration of multiple stimuli into a single sensor for measurement is challenging. To address this issue, the sensor developed in this study utilizes the natural biopolymers sodium alginate and carboxymethyl cellulose to construct a dual interpenetrating network, This results in a flexible porous sponge that exhibits a dual-modal response to strain and magnetic stimulation. The dual-mode flexible sensor achieved a maximum tensile strength of 429 kPa and elongation at break of 24.7%. It also exhibited rapid response times and reliable stability under both strain and magnetic stimuli. The porous foam sensor is intended for use as a wearable electronic device for monitoring joint movements of the body. It provides a swift and stable sensing response to mechanical stimuli arising from joint activities, such as stretching, compression, and bending. Furthermore, the sensor generates opposing response signals to strain and magnetic stimulation, enabling real-time decoupling of different stimuli. This study employed a simple and environmentally friendly manufacturing method for the dual-modal flexible sensor. Because of its remarkable performance, it has significant potential for application in smart wearable electronics and artificial electroskins.

Peran Mahasiswa dalam Meningkatkan Kualitas Pendidikan Agama Islam di TPA Sulamunajah Kelurahan Tanjung Pinang

Tanjung Pinang is one of the sub-districts in Pahandut District, Palangka Raya City, Central Kalimantan Province, Indonesia. The role of students in community service or what is usually called real work lectures (KKN) increases the value of the quality of Islamic religious education. With the knowledge they have and the presence of KKN students, they have a significant impact in the religious field. The strategy used in implementing this activity is to plan and optimize joint activities to follow up on ideas that arise. From this plan, it will be identified who will coordinate and who should be responsible for each stage of the activity. The role of students in improving the quality of Islamic religious education at TPA Sulamanajah, Tanjung Pinang District. This research aims to analyze the strategy and impact of the student KKN program in improving the quality of Islamic religious education at TPA Sulamanajah. Increasing activities with Islamic religious values ​​for children provides benefits to the surrounding community. Not only as a means to get closer to Allah SWT, but also as a main factor in increasing the potential of Human Resources (HR) who are competent, aspirational and solid and responsible for the Muslim community. This type of research uses qualitative methods, with the aim of describing the phenomena that occur (qualitative descriptive). This type of research is field research, namely research where data collection is carried out in the field. In this case it was carried out in Tanjung Pinang Village. The location of this research was carried out at the location that was the source of the research, namely in Tanjung Pinang Village.

Dinamika Kelompok Usaha Bersama “Mina Jaya” di Desa Puger Kulon, Kecamatan Puger, Kabupaten Jember

A group can be considered to be developing if it is capable to make improvements in responding to changes that occur within the group itself, such as the phenomenon that occurred in Mina Jaya Joint Business Group (KUB) in Puger Kulon Village, Puger Sub-district, Jember Regency. This study aims to analyze the dynamics of the Mina Jaya KUB group. The study used a qualitative approach. Data collection was carried out through in-depth interviews, observations, and documentation. Research informants were selected using the purposive method. The analysis used the Miles &amp; Huberman analysis model. The results of the study indicate that the dynamics of Mina Jaya KUB are considered dynamic based on the elements of group dynamics. The group’s objectives are to serve as a platform for the learning process, a venue for cooperation, an organization for joint activities, and self-reliance. The group members were able to explain and understand the group’s objectives, making the objectives effective. The group’s structure consists of a chairman, secretary, treasurer, supervisor, members, and advisor. Each role has been carried out according to the group’s task functions, including coordination, providing information, taking initiatives, ensuring member satisfaction, explaining, and disseminating information. The group regularly conducts monitoring and evaluation at each meeting and makes efforts to increase participation by fostering communication and providing rewards. Group members do not have specific intentions for their participation in the group.

Ibnu Ashur's Interpretation On Qs. An-Nahl Verse 78 Regarding The Character Building Of Prenatal Children

Prenatal character building reflects the importance of educating children well. Character education can start from the prenatal period in accordance with the Qur'anic verse in QS. Al-A'raf verse 172 which tells the story of fetal interaction with God during the allegiance. Although there is a view that prenatal children cannot be educated on the grounds of the verse QS. An-Nahl verse 78, but learning potential such as hearing and vision can be started early. This research studies the pattern of character building of prenatal children based on the perspective of tafsir at-tahrir wa at-tanwir by Ibn Ashur and its application in society. This research method is a literature study with a descriptive approach of tarbawi interpretation to understand the context of QS. The character building of prenatal children is directed to optimize the potential of as-sam'a, al-abshar, and al-af'idah as mentioned in QS. This involves the coordination of these three potentials to understand the science and nature of things so that children understand the right way to live. Based on the author's analysis, character education methods for prenatal children must pay attention to fundamental values such as al-fitrah, al-samahah, al-musawah, and al-huriyyah by using appropriate methods such as prayer, worship, reading, dhikr, dialogue, joint activities, and naturally conducive methods.

Thinking Together: Advising as Collaborative Deliberation

We spend a good deal of time thinking about how and when to advise others, and how to respond to others advising us. But philosophical discussions of the nature and norms of advising have been scattered and somewhat disconnected. The most focused discussion has come from philosophers of language interested in whether advising is an assertive or directive kind of speech act. This paper argues that the ordinary category of advising is much more heterogenous than has been appreciated: it is possible to advise by asserting relevant facts, by issuing directives, by asking questions, and by other kinds of adviceless advising. The heterogeneity of advising makes speech act-theoretic accounts of advising look like accounts of special cases, which motivates us to look elsewhere for an account of what advising is. I suggest that we think about advising as a distinctive species of joint practical thinking, which I shall call collaborative deliberation, and show how our need for a concept to pick out this kind of joint activity emerges from our practical needs as deliberators. This view helps to illuminate a number of puzzling features of advising, and offers some guidance to be better at advising and at being advised.

Ca2+/ethanol driven in-situ integration of tough, antifreezing and conductive silk fibroin/polyacrylamide hydrogels for wearable sensors and electronic skin

Integrating high strength, flexibility, biocompatibility, adhesion, and freezing resistance into conductive hydrogels for developing wearable electronic devices has consistently posed significant challenges in relevant research fields. Inspired by the silk dissolution behavior, a robust, flexible, antifreezing, and conductive silk fibroin/polyacrylamide (SF/PAM) hydrogel was synthesized in a CaCl2-ethanol–water (Ca2+/E/W) ternary solvent via a one-pot photogelation process. The gelation of SF and AM was enhanced by the ternary solvent, attributed to the inhibitory effects of Ca2+ ions and alcohols on hydrogen bond formation. The SF/PAM hydrogels based on Ca2+/E/W exhibited desirable mechanical properties (stretching: 800 % strain and 120 kPa stress; compression: 80 % strain and 334.0 kPa stress), excellent recoverability after deformation, high ion conductivity (2.4 S·cm−1) and strain sensitivity (gauge factor: ∼2.0), and low-temperature tolerance (−60 °C). These hydrogels were assembled into various wearable electronic devices, such as strain sensors, electronic skin, and electrodes, for detecting multiple physiological parameters, including joint activities, bioelectrical signals, and subtle movements like finger and wrist rotation, heartbeat, and vocal cord vibrations, demonstrating significant potential in flexible electronic applications.

Waterproof strain sensor based on silver/graphene composite film for fine and large strain detection

The development of waterproof sensors with fine and large strain detection capabilities can be better applied to the monitoring of human physiological signals, such as fine physiological signals and joint activities with large amplitude. In this paper, we studied a waterproof sensor by using microstructures to improve the sensitivity of the sensor, and using graphene to bridge microcracks in the silver film, which makes the sensor has low detection limit (as low as 0.2 % strain) and large strain stability detection(up to 50 % strain) with high sensitivity (GF=1814.25, 44 %<ε < 50 %), excellent durability (1,400 dynamic responses), and water resistance(48 h). This makes it suitable for fine and large strain detection, including arterial pulse signals, vibration, and large movements of joint flexion.

Информационная культура педагога как важнейшая компетенция его профессиональной деятельности

The article reveals approaches to defining the concept of “information culture of a teacher”, considers the main components of this component of pedagogical culture. The issues of using innovative teaching aids in the educational process of primary school are touched upon, their role in organizing joint activities of a student and a teacher is characterized.

SCREEN TIME IN PRESCHOOL-AGED CHILDREN

The World Health Organization defines sedentary screen time as the time spent in passive screen-based entertainment (TV, computer, mobile phone), excluding active screen time, specifically time spent playing games requiring physical activity or movement. Researchers agree that preschool-aged children spend longer periods of time in front of screens than recommended for their age, contradicting WHO guidelines on sedentary screen time for children up to 5 years old. The aim of our research was to obtain data on the age at which children are first exposed to screens, determine the duration of screen exposure on a daily basis, the most common type of screen, and the situations in which preschool-aged children use them. The sample consisted of 200 children, aged 48 to 60 months, of both genders. A specially constructed sociodemographic questionnaire was used for the research, which included questions regarding the age at which the child was first exposed to screens, the duration of daily exposure, as well as the most common type of screen and situations in which the child uses them. Informants were the parents of the children included in the study. The research was conducted in preschool institutions in Bosnia and Herzegovina, during February and March 2024. The results of the research show that children are first exposed to screens as early as at the age of 7 to 12 months, and that screen exposure on a daily basis exceeds the recommended time by WHO guidelines for most participants. The most common type of screen to which children are exposed is TV, and the most common situations in which they use them are during meals or while parents perform various household chores. Attention should be directed towards further identifying factors leading to excessive screen usage and providing clear guidelines to parents regarding the timing, content, technology, and joint activities related to screen time for young children in various cultural settings.