<h3>Research Objectives</h3> Present research was aimed to assess motor capabilities according to the Motor Function Measure (MFM) scale and the state of skeletal muscles according to MRI data in patients with DMD. <h3>Design</h3> Movement disorders on the MFM scale and the state of skeletal muscles in both capable and not capable of independent movement patients were assessed and a correlation analysis was performed. <h3>Setting</h3> Subdivisions D1, D2, D3 and the total score on the MFM scale, MRI data of the muscles of the pelvic girdle, hips and legs with further assessment of the severity of fibro-fatty degeneration using the Mercuri scale and STIR images with an assessment of inflammatory activity were estimated. <h3>Participants</h3> 46 boys with genetically confirmed DMD (2.1 to 16.7 years). <h3>Interventions</h3> N/A. <h3>Main Outcome Measures</h3> The pattern of the greatest activity of inflammatory changes in skeletal muscles was determined visually based on the highest signal intensity. Subsequently the sum of points for the muscles and the sum of points for all the studied muscles of the lower extremities were calculated. <h3>Results</h3> In independently moving patients (first group), the D1 abilities were 74.4%, D2 - 97.6%, D3 - 96.2%, total – 87.9 %. In patients without the ability to independently move (second group) D1 – 1.7%, D2 – 47%, D3 – 67.5%, total score – 33.1 %. A high inverse correlation (r = -0.7) of MRI data with tasks D1 and a noticeable inverse correlation with tasks D2 (r = -0.6) in the 1st group of patients were established. In 2nd group, MRI data by a high inverse correlation (r = -0.7) with D3 tasks and a noticeable inverse correlation (r = -0.6) with tasks D1 were characterized. <h3>Conclusions</h3> The MFM scale makes it possible to effectively assess the motor abilities of patients with DMD at different stages of disease. Patients with preserved ability to move showed the greatest involvement of the muscles of the pelvic girdle and hips, represented by both fibro-fatty degeneration and inflammatory activity. <h3>Author(s) Disclosures</h3> The authors declare no conflicts of interest.