Abstract
The aim of the work is to conduct a comprehensive assessment of immunogenetic and biochemical parameters in patients with chronic hepatitis B living in the Odessa region.Material and methods. A total of 41 patients with chronic hepatitis B were examined. The traditional biochemical and immunological parameters, the content of cytokines IL‑4, IL‑10, TNFα and the gene polymorphism of cytokines IL‑4, IL‑10, TNFα were determined.Results. To assess the relationship of non-parametric and parametric indicators (changes in the immunological status, biochemical parameters and cytokine profile), the patients were divided into groups in accordance with the identified polymorphisms of cytokine genes. With the use of the Spearman's rank correlation coefficient, certain relationships have been established. In patients with homozygous SS polymorphism of IL‑4, more pronounced changes in the cytokine profile, immunological status and a higher level ofALA and AsAt activity were noted.Conclusions. The revealed relationship between the AlAt and Asat levels, the immunological status and cytokine profile indicators with certain TNFα and IL‑4 genotypes suggests a genetic predisposition of certain patients with chronic hepatitis B to a more severe course. The information obtained canbe applied as one of the additional criteria for the activity of inflammatory changes in the liver tissue.
Highlights
Цель работы — провести комплексную оценку иммуногенетических и биохимических показателей у больных Хронический вирусный гепатит В (ХГВ), проживающих в Одесском регионе
Hutz The aim of the work is to conduct a comprehensive assessment of immunogenetic and biochemical parameters in patients with chronic hepatitis B living in the Odessa region
To assess the relationship of non-parametric and parametric indicators, the patients were divided into groups in accordance with the identified polymorphisms of cytokine genes
Summary
Цель работы — провести комплексную оценку иммуногенетических и биохимических показателей у больных ХГВ, проживающих в Одесском регионе. Выявленная взаимосвязь уровня АлАт и Асат, показателей иммунологического статуса и цитокинового профиля с определенными генотипами TNFα и ИЛ‐4 позволяет предположить генетическую предрасположенность определенных больных ХГВ к более тяжелому течению. To assess the relationship of non-parametric and parametric indicators (changes in the immunological status, biochemical parameters and cytokine profile), the patients were divided into groups in accordance with the identified polymorphisms of cytokine genes.
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