Competitive Activity Research Articles

Evaluation of the Homogenous Mobility Shift Assay for Infliximab and Adalimumab Anti-drug Antibody Detection in the Clinical Laboratory.

Detecting antidrug antibodies (ADAs) against infliximab or adalimumab is useful for therapeutic drug monitoring. Various ADA detection methods exist, and antibody titer is an output in some algorithms. Homogenous mobility shift assay (HMSA) measures relative ADA concentration and determines drug-ADA complex size in vitro. However, the relevance of complex size determination in drug monitoring remains unclear. Hence, the association between complex size, ADA concentration, and sample detectable neutralizing activity was evaluated. Sera from infliximab-treated and adalimumab-treated patients who tested positive for ADA in the National Screening Service were analyzed using 3 ADA assays. HMSA determined the relative ADA concentrations and complex sizes, competitive ligand-binding assay evaluated the sample neutralizing capacity, and enzyme-linked immunosorbent assay detected immunoglobulin (Ig)G4 ADA. Most ADA-positive samples (>80%) formed drug-ADA dimer complexes, whereas 17% had dimer and multimer complexes, and 3% had multimeric complexes. Multimer presence had 100% positive predictive value for detectable neutralizing activity. ADA concentration and detectable neutralizing activity were moderately correlated (r = 0.65) in adalimumab-treated patients and strongly correlated (r = 0.81) in infliximab-treated patients. In adalimumab-treated patients, multimer presence was a stronger predictor of neutralizing activity than ADA concentration was, but not in infliximab-treated patients. However, in infliximab-treated patient samples, multimer presence revealed a distinct subset with high ADA concentrations, neutralizing activity, and IgG4 ADA. Multimers detected using HMSA had a strong positive predictive value for competitive ligand-binding assay detectable neutralizing activity. Multimeric IgG4-containing ADA-drug complexes revealed a distinct subset of infliximab-treated patient samples, whose clinical relevance merits further investigation.

Abstract LB199: Condensate modulator sequesters beta-catenin into depot condensates and demonstrates competitive anti-tumor activity in animal models ofcolorectal cancer

Abstract Constitutive activation of beta-catenin is a well-known driver of malignancy. However, traditional drug discovery approaches have proven challenging and largely unsuccessful in identifying therapeutic agents to modulate the function of beta-catenin. Biomolecular condensates have recently been demonstrated to play key roles in regulating most cellular processes and biological pathways by compartmentalizing biomolecules in membranelles organelles, thus lending novel opportunities to drug previously “undruggable” targets. Here, we leverage condensate biology to discover small molecules that reverse the hyperactive function of beta-catenin in colorectal cancer by entrapping it into depot condensates. We developed a high-throughput phenotypic assay that identifies beta-catenin condensate-modifying compounds (c-mods). Through condensate screening and functional secondary assays, we have identified c-mods that sequester beta-catenin into depots, induce selective cancer cell killing, and reverse oncogenic beta-catenin specific gene expression programs. C-mods identified in our screen are effective in genetically diverse colorectal cancers and a range of Wnt-associated cancers, providing the opportunity to treat a broad patient population. Furthermore, oral dosing of lead c-mod demonstrates competitive tumor growth inhibition as a single agent in xenograft and PDX models of colorectal cancer. Taken together, these results highlight the promise of condensate biology in drugging previously intractable high-value targets in oncology and developing novel treatments for patients suffering from diseases of high unmet need. Citation Format: Costa Salojin, Douglas Baumann, Adam Talbot, Kip West, Thomas Durand-Reville, Isaac Klein, Ann Boija. Condensate modulator sequesters beta-catenin into depot condensates and demonstrates competitive anti-tumor activity in animal models ofcolorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB199.

Abstract LB428: Discovery of KY-001:A Direct Inhibitor of TEAD-YAP Protein-Protein Interaction for the Treatment of Advanced Solid Tumors with Abnormal Hippo Signaling Pathway

Abstract Background:The Hippo signaling is an important pathway that plays a crucial role in the regulation of numerous biological processes. The binding of YAP/TAZ transcriptional coactivators to TEAD proteins is the core of Hippo signaling in regulating the expression of a variety of genes that mediate many cellular functions. Abnormalities of Hippo signaling including mutation deficiency, fusion and YAP/TAZ overexpression are often found in solid tumors associated with excessive proliferation, drug resistance, or tumor immune evasion. Blocking the Hippo transcription activation, particularly the TAP/TAZ and TEAD interaction, therefore is an attractive therapeutic strategy for the treatment of advanced solid tumors associated with Hippo dysregulation. Results:We have developed a small molecule inhibitor, KY-001, that can bind to TEAD protein and directly disrupt its interaction with YAP/TAZ, thereby blocking Hippo signaling pathway. KY-001 can bind to TEAD (1-4) proteins with strong YAP/TAZ competitive activities in biochemical assays and can inhibit TEAD-YAP mediated transcriptional signals in cell. KY-001 selectively and potently inhibits the proliferation of cancer cells harboring Hippo deficient mutations, such as mesothelioma, lung cancer and other cell lines. Importantly, KY-001 directly affects the expression of some target genes downstream of YAP/TAZ-TEAD transcription activation in cell. KY-001 can strongly inhibit tumor growth in a dose dependent manner against Hippo mutation mesothelioma cancers in two different xenograft mouse tumor models. In addition, KY-001 shows remarkable synergistic effects with EGFR or KRAS G12C inhibitors in mouse non-small lung cancer models, suggesting it may be a promise therapy for treating targeted therapy induced resistant tumors with Hippo dysregulation. Pre-clinical studies shows that KY-001 has good overall druggable profiles with good safety windows in several animal species. Collectively, KY-001 shows high potency and selectivity in vitro and strong anti-tumor activities against Hippo mutation deficient cancers in pre-clinical models. Conclusions:KY-001 is a small molecule drug candidate which directly inhibits the interactions between TEAD and YAP1/TAZ proteins, thereby blocking the transcriptional activation of downstream Hippo signaling. In various tumor models, KY-001 monotherapy shows good efficacy for Hippo mutation deficient tumors. KY-001 also synergizes with other targeted therapy such as EGFR or KRAS G12C inhibitors for treating non-small lung cancers. KY-001 is expected to enter clinical studies in H2, 2024 for the treatment of Hippo dysregulated solid tumors. Citation Format: Kehao Zhao, Yong Zhag, Yufang Shi, Jian Chen. Discovery of KY-001:A Direct Inhibitor of TEAD-YAP Protein-Protein Interaction for the Treatment of Advanced Solid Tumors with Abnormal Hippo Signaling Pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB428.

A study on Overseas Chinese bank in Indonesia - Focusing on Bank Central Asia

This study seeks to comprehensively analyze the historical development and current status of the Indonesian banking industry. Furthermore, it aims to delve into the origins, developmental trajectory, and current standing of Overseas Chinese Bank Central Asia, a pivotal player in the Indonesian banking landscape, while evaluating its competitive edge. Drawing from this examination, practical implications and strategic developmental approaches will be proposed. Through an extensive review of literature, we will scrutinize the evolution and present state of Indonesia's banking sector, along with the establishment, growth history, and current position of Bank Central Asia. Utilizing Porter's Five Forces analysis model, we will assess the competitive dynamics of Bank Central Asia, complemented by a SWOT analysis to scrutinize its internal and external environments. Despite its inception by overseas Chinese, Bank Central Asia has emerged as a frontrunner in Indonesia's financial realm. While it exhibits deficiencies in digital transformation, product innovation, customer experience, risk management, and collaborative innovation, it boasts strengths in network expansion, talent cultivation, and system enhancement for promotion and development. Leveraging these competitive advantages, Bank Central Asia has sustained its leading position within the Indonesian financial landscape. To maintain this competitive edge, Bank Central Asia must astutely navigate market trends, competitor actions, and regulatory shifts, making informed decisions and flexibly adjusting strategies as needed. Leveraging its external networks and internal strengths, Bank Central Asia has upheld a sterling reputation and achieved sustainable growth. The exploration of these Overseas Chinese banks not only sheds light on the intricacies of the Southeast Asian economies but also offers valuable insights into the dynamics of global banking and finance.

Multilevel Synergy of Information Technology for Operational Integration: Competition Networks and Operating Performance

Firms’ multilevel access to information plays a significant role in improving operating performance. Increasingly, firms are enhancing their operational integration through information technology (IT) as they grapple with intense competition. Competition networks are an essential but often overlooked source of information that, if leveraged correctly, can provide firms with significant competitive and operational advantages. In this study, we develop a multilevel research model of operating performance (firm level) that simultaneously considers the effects of IT for operational integration (ITOI, firm level) and competitive brokerage (competition network level). We explicate how ITOI and competitive brokerage afford firms’ synergy through complementarities and relatedness of competitive actions, information, and resources to improve their operating performance. We assess the model using a 7-year longitudinal secondary data set that includes firms from multiple industries and find support for our thesis that ITOI and competitive brokerage have a synergistic effect on operating performance. Our exploratory analysis uncovers innovation efficiency as a theoretical mechanism underlying the relationships between ITOI, competitive brokerage, and operating performance. Further exploratory analyses with disaggregated measures of ITOI highlight that synergies arise from IT-enabled coordination and integration across the supply chain and within functional areas of an organization. These findings are robust to concerns of endogeneity and alternative model specifications. We make three critical contributions to our collective understanding of the relationship between IT and operating performance—synergy as a means through which operating performance is realized, a multilevel model of relationships, and a nuanced understanding of the relationships between ITOI, competitive brokerage, and operating performance. Overall, we provide a summative view of the multilevel effects of IT on operating performance.

Obsessive-compulsive symptoms in professional tennis players

IntroductionEngaging in moderate physical activity holds a vital role in our daily lives, serving as both a means of social recreation and a fundamental contributor to physical and mental wellbeing. It is also worth noting that such activity can potentially produce mood-enhancing effects by promoting neurogenesis and neuronal adaptability. Intriguingly, certain individual psychological traits such as rituals, compulsions, obsessional thinking, and superstitious beliefs, as well as inflexibility in daily routines, appear to serve a purpose in competitive athletic endeavors.ObjectivesThe aim of our study was to investigate the possible presence of obsessive-compulsive symptoms or disorders, as well as of superstitions or magical thinking, in a group of professional tennis players, by means of standardized assessment scales, as compared with healthy subjects who did not professionally perform any kind of sport activity.MethodsTwenty-five current or former professional tennis were recruited within the Italian Tennis Federation during an international competition and during a master meeting of coaches. All of them underwent a psychiatric interview with a structured scale and a psychopathological assessment carried out with the Mini-International Neuropsychiatric Interview (MINI) and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Data were analyzed and compared.analysis was performed by means of contingency tables, χ² tests, group statistics, paired, independent and Mann Whitney’s tests.ResultsThe Y-BOCS total score was significantly higher in both current and retired athletes than control subjects (5.96 ± 5.76 versus 1.24 ± 2.65, p = 0.001, t = 3.72). Current athletes showed more frequently current aggressive obsessions (χ2 = 0.041, r = 5.24) and current miscellaneous compulsions (χ2 = 0.030, r = 5.94) than past athletes. The Y-BOCS (t = 3.4, p = 0.002) obsessions (t = 3.48, p = 0.002), and compulsions subscale (t = 3.11, p = 0.005) scores were higher in current players than in the other group.ConclusionsOur results support the hypothesis that high-level competitive sports activities, which suppose compliance with strict daily routines and extensive training, could constitute a risk factor for the onset of full-blown obsessive-compulsive disorder in more vulnerable subjects. Similarly, there is a growing demand for sport psychological support experts in order to prevent high stress in training and competitions.Disclosure of InterestNone Declared

Indicators of Spectacle in Wrestling at the 2021 Olympic Games

Background and Study: Spectacle plays a key role in sports wrestling in attracting viewers' attention, creating emotional involvement, and making the sport an integral part of culture. Aim: To identify the most significant indicators of wrestlers' competitive activity based on the analysis of the 2021 Olympic Games, which influence the spectacle in sports wrestling. Material and Methods: The study involved 289 wrestlers. An analysis of protocols and video recordings of 340 matches at the 2021 Olympic Games in three types of sports wrestling was conducted: in women's wrestling – 113 matches (n=96 female wrestlers), in Greco-Roman wrestling – 113 matches (n=97 wrestlers), and in freestyle wrestling – 114 matches (n=96 wrestlers). Expert assessment method was used to evaluate the indicators of competitive activity. Statistical analysis of the data was conducted using licensed Excel spreadsheet packages. Results: For Greco-Roman wrestling and women's wrestling, the ratio of actions performed in par terre and standing is about 70 to 30. Whereas, for freestyle wrestlers, almost 80% of actions are performed in standing. The efficiency coefficient of wrestling in standing for Greco-Roman style wrestlers averaged 1.43 points per action; for freestyle wrestlers, it was 1.78 points per action, and for female wrestlers – 2.01 points per action. The highest number of one-point actions was performed in Greco-Roman wrestling, which significantly and statistically significantly (p<0.05) exceeds the indicators in freestyle and women's wrestling. Meanwhile, female wrestlers and freestyle wrestlers statistically significantly (p<0.05) executed more two-point actions. The average number of actions per match does not significantly differ (p>0.05): 4.23 actions for Greco-Roman wrestling; 4.47 actions for freestyle wrestling, and 4.08 actions for women's wrestling. However, when considering the average number of points scored per match, statistically significant differences were found. Thus, Greco-Roman style wrestlers score an average of 6.95 points, this indicator is statistically significantly lower (p<0.05) than in freestyle (8.12 points) and in women's wrestling (8.07 points). Conclusions: The analysis of matches at the 2021 Olympic Games made it possible to identify competitive activity indicators that influence the spectacle in sports wrestling. Positive indicators include: a large number of technical-tactical actions performed in standing; execution of throws in par terre by Greco-Roman style wrestlers; a high percentage of early victories in matches. Negative indicators: execution of simple one-point and two-point technical-tactical actions; in Greco-Roman wrestling, a large number of matches that ended with a score of 1:1; interruptions in matches (Challenge, Negative Wrestling, Caution), lack of dynamism in the match, and the inability to score too many points. The obtained results will help provide recommendations for changing competition rules and enhancing the spectacle of sports wrestling.

The importance of the health motive in undertaking sports and recreational activities by Austrian school students compared to other motives

Sports and recreational activity is an important element of an effective use of their free time by children and school youth. In contrast to competitive sports, which focus on achieving maximum sports results through intense competition, sports and recreational activity should be assessed mainly in terms of its health benefits. Sports and recreational behaviour can be analysed in the context of psychophysical development, personality development, regeneration of vital forces, contact with nature, active rest and relaxation. The literature on the subject distinguishes various motives for undertaking sports and recreational activity, the most important of which include: pleasure, relaxation, health, aesthetic values, physical fitness and social aspects. This work aims to examine what motives guide Austrian school youth when undertaking sports and recreational activity, with particular emphasis on the health motive. The analysis also includes the differences related to gender and environmental conditions. The study included 391 students of general secondary schools in Austria, aged 18. The study group consisted of 96 boys and 103 girls from a large city and 94 boys and 98 girls from a small town. The Sports Activity Motives Questionnaire was used for the analysis. The study results emphasize the significant role played by the health motive in undertaking sports and recreational activities, especially among girls. The social aspect and relaxation also turned out to be important motives for both sexes. Statistical analysis showed significant differences in motives such as physical fitness and risk, which were more important for boys, while aesthetics was much more important for girls. The study did not find any statistically significant differences in the motives for undertaking sports and recreational activities between young people from large and small towns.

Digital Transformation of the Resource Potential of Accounting and Analytical Workers in the Preparation of Competitive Actors of the Service Sector

The article is devoted to a comprehensive study of the digital transformation of the resource potential of accounting and analytical workers in the preparation of competitive actors in the service sector. The purpose is to consider the competencies of accounting and analytical workers as an integral part of the resource potential in the context of digital economy transformation. The low level of digital competencies causes the lack of new skills as components of resource potential in terms of economic growth. In this regard, the topic of the study is relevant. The scientific novelty of the research consists in development of universal model of digital competences for workers of registration and analytical positions as a derivative of resource potential. It was concluded that the digital transformation of the resource potential of accounting and analytical specialists consists in the acquisition of digital competencies, which contributes to economic growth and the development of competition, favorably affecting the improvement of the service sector in the country, thought indirectly. The research method was not based on individual methods, but on their combination. Working on the article the author used cognitive and systemic approaches.

A study and an analysis of the competitiveness of the enterprise: the case of Utum +

This article contains research materials on the analysis of the competitiveness of the construction company Utum-Stroy OOO, which is a structural component of Utum+ Group of Companies. This organization is one of the largest representatives of the industry, operating on the market for more than 20 years. The paper presents the characteristics of the activities of this organization, identifies the main competitors, evaluates the level of competitiveness of the organization and develops recommendations for improving its activities. The paper considers the current state of the industry in the city of Yakutsk, as well as internal and external factors affecting the competitiveness of this organization. In addition, analytical calculations are presented to assess the level of competitiveness of Utum-Stroy OOO and an analysis of the activities of the main competitors of this organization is carried out. The presented calculations were carried out for the previous year, which contributes to obtaining the most up-to-date data. The analysis of the competitiveness of Utum-Stroy OOO was carried out in accordance with generally accepted scientific methods, including the express analysis using the Porter method and the PEST analysis of the competitive environment of the organization. Based on the results of the calculations, an assessment of the level of competitiveness of the organization is presented, a list of problems that exist in the organization is determined. Based on the results of the analytical work, the authors developed a list of recommendations, the application of which can increase the competitiveness of the analyzed organization and the effectiveness of the organization’s activities. The content of the recommendations is aimed at improving the management and analytical activities, marketing strategy of the organization’s development. According to the findings, the relevance of the study was confirmed and the need for additional research was noted in order to develop a comprehensive development plan for Utum-Stroy OOO.

Intensifying the Supported Ruthenium Metallic Bond to Boost the Interfacial Hydrogen Spillover Toward pH‐Universal Hydrogen Evolution Catalysis

AbstractThe effectuation of pH‐universal electrocatalysis is highly attractive but still challenging for the hydrogen evolution reaction (HER). It appeals for not only the facilitated electron transport but also the kinetical proton mass transfer. In this study, a via‐hole Ru/MoO2 confined heterostructure is profiled as a metal‐support platform for the electron/mass transfer‐boosted pH‐universal HER studies. It is indicated that the as‐formed Ru─O─Mo bridge can modulate the electronic transport at the interface, and the proton adsorption and transfer are kinetically derived by the intensified metallic Ru─Ru bond. Resultantly, the Ru/MoO2 heterostructure stably attains the Pt‐beyond HER activity with an ultralow overpotential of 9.2 mV at 10 mA cm−2 in 1 m KOH, and also achieves the competitive HER activity and stability in the acidic/neutral electrolytes. Both the experimental and computational results reveal the accelerated HER kinetics is attributable to the intensive mass transfer through the interfacial Ru→MoO2 hydrogen spillover effect. This work opens up the opportunities to rationalize the advanced metal‐support HER electrocatalysts through the interfacial hydrogen spillover effect and metallic bond engineering.

Sudden cardiac death in young athletes: exome sequencing results

BACKGROUND: Ranking risks and prevention of sudden cardiac death in professional young athletes is a crucial unresolved problem in sports medicine. Intense physical exertion can lead to adaptive changes in the cardiovascular system, which can mask inherited diseases with predominant myocardial involvement, such as hypertrophic cardiomyopathy. Undiagnosed cases of such diseases can be a risk factor for fatal outcomes associated with training and competitive activities, making this problem extremely relevant.
 AIM: To conduct a diagnostic search for possible molecular causes of cardiovascular diseases associated with a high risk of sudden death in young athletes.
 MATERIALS AND METHODS: Whole-exome sequencing of DNA extracted from two groups of biomaterials was performed: nine autopsy samples of heart tissues from young athletes who died during intense physical exertion and three venous blood samples from active athletes of the Russian national team. Obtained data were subjected to bioinformatic analysis and clinical interpretation.
 RESULTS: In total, 12 DNA samples were analyzed using a panel of 277 genes associated with the development of cardiovascular diseases with a high risk of sudden death. In 4 of 12 samples (33.3%), variants possibly related to the phenotype were found upon clinical interpretation of the sequencing results. A pathogenic variant was found in the MYBPC3 gene, leading to the development of hypertrophic cardiomyopathy (OMIM: 115197), and a potential pathogenic variant was found in the TRPM4 gene, associated with progressive familial heart block type IB (OMIM: 618531). Moreover, two variants with uncertain clinical significance were found in CAV3 and SCN1B.
 CONCLUSION: Currently, data from high-throughput sequencing are collected to identify the molecular basis of cardiovascular diseases with a high risk of sudden cardiac death. Identifying young athletes who are carriers of pathogenic and possibly pathogenic gene variants is beneficial for preventing fatal outcomes and personalizing medical support for professional athletes.

Дослідження впливу показників із веслування на ергометрах для прогнозування змагальної діяльності

The problem of training high-class athletes in Ukraine is reflected in the Strategy for the Development of Physical Culture and Sports for the period until 2028. In recent years, as a result of the pandemic and military operations, the Concept-2 simulator has been used in the training of rowing athletes, competitions for election into national teams are held, and control standards are met. Objective: Study the factors, particularly ergometric indicators on a rowing ergometer, influencing competitive results in completing a 2000 m rowing distance. Material & Methods: The protocols for the 2023 Ukrainian Championship on rowing ergometers from a distance of 2000 m and 6000 m were analyzed. 26 athletes of the Ukrainian rowing team (men) took part in the competition. Data processing was carried out on the results from control tests over 6000 m at a set pace of 26 strokes per minute for 24 male adult rowers, conducted across various regions of Ukraine. Correlation analysis was used. Conclusions: It was revealed that there are close relationships between the time of covering the distance of 2000 m and the distance of 6000 m in male athletes (r = 0.70). A regression equation formula has been established that allows one to predict the result at a distance of 2000 m (y): y=0.26x+52.58), x is the result (in seconds) of completing a distance of 6000 m. The influence of average time indicators on segments of 500 m on the time of covering a distance of 6000 m was established (r = 0.99). A close relationship was established between the time to complete a 6000 m distance (in seconds) and the average stroke power (in Watts) at a set pace. It has been established that the results of testing a distance of 6000 m with a given pace of 26 strokes per minute are associated with the results of the Ukrainian Championship from a distance of 6000 m (rxy= 0.98). A relationship has been established between the weight of athletes and stroke power (rxy=0.93). Thus, pretesting at a given pace will predict performance in ergometer rowing competitions. Results: As a result of the analysis of documents, scientific sources, analysis of protocols of indoor rowing competitions, indicators were determined that are measured when rowing on an ergometer and correlate with the competitive result. The scientific work of scientists to study the influence of factors on the completion of distances of 500 m, 2000 m, 6000 m makes it possible to predict competitive results using shorter distances (or using a 60-s test), which does not require expensive equipment and a long testing duration.

Ефективність методики навчання спортивному орієнтуванню курсантів спеціальності артилерійська розвідка з урахуванням змагальної діяльності спортсменів-орієнтувальників

Success in a modern fast-paced and maneuverable battle requires the use of high-precision weapons, the effectiveness of which is possible with the use of satellite navigation systems, unmanned aerial vehicles, etc. At the same time, the experience of combat operations on the territory of Ukraine has shown that even if they cannot be used, and sometimes even in their absence, the ability to navigate with a conventional map is an important condition for the successful completion of a combat mission. The purpose of the study is to experimentally investigate the effectiveness of the methodology for teaching orienteering to cadets majoring in artillery intelligence, taking into account the requirements of competitive activity in the conditions of real training and competitive process of orienteering athletes. Material and methods of the research. To solve the tasks, we organized and conducted a pedagogical observation to determine the arsenal of means and methods of physical training of orienteering cadets in the process of studying at a military university and a pedagogical experiment to test the effectiveness of the physical training program for cadets majoring in artillery intelligence. There were 20 respondents, including 10 men of the artillery intelligence specialty with a minimum level of orienteering training (EO) and 10 male athletes who have been involved in orienteering for 2–3 years. The respondents are 18-25 years old (average age – 20.8±0.2). Results. It has been established that during the experiment there was a significant increase in the cadets’ fitness indicators compared to the beginning of the study. At the end of the study, the level of training of artillery cadets differs from athletes of the KMU and MSU level at a distance (sprint in the city by 28.9 %; sprint in the park by 37.7 %; extended distance in the forest by 26.4 %). Conclusions. The conducted research and analysis of the results showed that the level of preparedness of cadets specializing in artillery reconnaissance was significantly reduced compared to the beginning of the training process. At the end of the experiment, the training process was aimed more at developing endurance than at developing speed, which is important for performing tasks in real combat operations, and the cadets’ technical skills in map reading, which is necessary for their specialty of artillery reconnaissance, increased.

Idiopathic Premature Ventricular Contraction Catheter Ablation, Sedentary Population vs. Athlete's Populations: Outcomes and Resumption of Sports Activity.

There are no investigations about the outcomes of idiopathic PVC catheter ablation (CA) in athletes compared to the sedentary population. We conducted a prospective single-centre observational study. The primary and secondary procedural outcomes were the post-ablation reduction of premature ventricular contractions (PVCs) in an athletes vs. non-athletes group and in agonist vs. leisure-time athletes. The third was the evaluation of the resumption of physical activity and the improvement of symptoms in agonist and leisure-time athletes. From January 2020 to October 2022 we enrolled 79 patients with RVOT/LVOT/fascicular PVC presumed origin. The median percentage of decrease between the pre-procedure and post-procedure Holter monitoring in the non-athletes group was 96 (IQR 68-98) and 98 in the athletes group (IQR 92-99) (p = 0.08). Considering the athletes, the median percentage of decrease in the number of PVCs was 98 (IQR 93-99) and 98 (IQR 87-99), respectively, in leisure-time and agonistic athletes (p = 0.42). Sixteen (70%) leisure time and seventeen (90%) agonist athletes (p = 0.24) have resumed physical activity 3 months after PVC CA; among agonistic athletes, 59% have resumed competitive physical activity. Many leisure-time (88%) and agonist (70%) athletes experienced an improvement in symptoms after ablation. PVC CA was effective and safe in both groups, reducing symptoms and allowing a quick and safe return to sports activities in athletes.

Features of the influence of special strength training on performance in competitive activities in Mixed Martial Arts (example of horting)

The article is devoted to the study of the problem of the specific influence of strength training in horting on the effectiveness of the implementation of the functional adaptation potential of the athletes' body and their level of technical and tactical skill in the process of competitive activity. In the process of the research, a comparative analysis of the results of the matches between the athletes of all three experimental groups identified at the stage of selection for the championship of Ukraine was carried out after three months of using experimental models of strength training classes and during the competition for the selection for the Cup of Ukraine. The results of the study showed that the number of victories of athletes of the second group at this stage of the study during qualifying matches decreased by 41.7% compared to the previous results. At that time, on the contrary, among the athletes of the third group, we observe an increase in the effectiveness of competitive activity by 62.5% compared to the number of victories recorded during qualifying matches for the championship of Ukraine before the use of the experimental model of strength training classes. In the process of analyzing the results of competitive activity recorded in at the end of the study, during qualifying matches for the Cup of Ukraine, it was found that among the athletes of the second group, compared to the magnificent indicators of the previous control, we observed the largest decrease in the number of victories by 4 times due to technical knockout. At the same time, among the athletes of this group, the indicator of the number of victories obtained due to knockout decreased by 50.0% compared to the results that were revealed during the qualifying competitions before the start of the application of the proposed experimental model of training sessions. The corresponding negative dynamics to a 3-fold decrease in the number of victories obtained in matches with athletes of the third group in the conditions of the use of suffocating techniques, we record in the participants of the second group at this stage of the study compared to the results found in previous competitions.

Features of the applicatuion of mareyting audit in the developmenr of a fitness club strategy

The article presents the results of the conducted research on the peculiarities of the application of marketing audit in the development of the marketing strategy of a fitness club. The main reasons why it is necessary to conduct a systematic marketing audit of the activity of a fitness club are given. It was determined that focus groups are the most common qualitative method of marketing audit of fitness clubs - 82.3%. The peculiarities of the use of marketing audit in the activity of a fitness club were characterized, namely, it was established that it was most often used to study trends in the development of the fitness club market (83.40%), and least often - to analyze the activities of competitors (34.50%). The main indicators that must be used when conducting a marketing audit of a fitness club have been formed: performance indicators of tactical and long-term measures; indicators characterizing the degree of influence of environmental factors; indicators reflecting the use of human resources; indicators characterizing the organization of marketing activities; indicators characterizing the achievement of goals and the implementation of the strategy of the fit ness club.

Model characteristics of technical and tactical activity of basketball players at the stage of preparation for higher achievements

The article examines the features of the competitive activity of basketball players who are at the stage of preparation for higher achievements. Presented are model characteristics of implementation of technical and tactical actions by basketball players aged 18-20, taking into account their role in the game. The need to take playing time into account when building model characteristics of technical and tactical actions is well-founded. The players of the youth national teams (U 20) show a tendency to increase the quality of the implementation of various shots in the match (two-point, three-point, free throw) in comparison with the players of the youth national teams (U 18). Significant differences (p<0.05) in terms of these indicators were observed in basketball players playing the central player position (49,91±17,06 vs. 55,06±12,47).
 According to such technical and tactical actions as block shots and steals of the ball, the basketball players of the youth national teams (U 18) were reliably ahead of the players of the youth national teams (U 20) (0,18±0,30 vs. 0,10±0.21, 2,19±1, 24 vs. 1,87±1,07, respectively). Considered possible directions of using the developed models during the training of basketball players of youth teams and prospective methodical provisions for creating reference models of technical and tactical activity for the best basketball players within the framework of a specific game role.

More or complex actions? Effects of supply networks on firms' competitive aggressiveness

PurposeThis study investigates the extent to which a firm’s centrality and autonomy in its supply network are associated with the intensity and complexity of its competitive actions.Design/methodology/approachUtilizing social network analysis and dynamic panel data models, this study analyzes a comprehensive panel dataset with 10,802 firm-year observations across various industries between 2011 and 2018 to test the hypotheses.FindingsOur findings show that a firm’s level of centrality in its supply network has an inverted U-shaped relationship with both competitive intensity and competitive complexity. In addition, the turning points of these two inverted U-shaped relationships differ in that firms with a lower level of centrality tend to compete aggressively by launching more actions within fewer categories, while firms with a higher level of centrality tend to compete aggressively by launching fewer actions that cover a larger range of categories. Finally, we find that a firm’s structural autonomy has a positive relationship with competitive complexity.Originality/valueThis study bridges the gap between the supply chain management literature and strategic management literature and investigates how supply networks shape competitive aggressiveness. In particular, this research investigates how a firm’s structural position in its supply network affects its competitive actions, an important intermediate mechanism for competitive advantage that has been overlooked in the supply chain management literature.

Improvement of the special running training of the highly qualified triathlete

Abstract. Introduction. The problem of improving the preparedness of highly qualified athletes requires solving questions about the individualization of the training process based on taking into account the sports form of the athlete, the specific conditions of the competitive distance, as well as substantiating the intensity and volume of various types of training and their importance depending on the period of training. The purpose of the study is to develop an individual running training program for triathlon and experimentally check its effectiveness. Methodology. The experiment was conducted as part of the preparations for the Ukrainian triathlon championship. A student of the Cherkasy National University named after Bohd Khmelnytsky, who is a master of sports of Ukraine, took part in the study. The formative part of the experiment involved the development of an individual running training program, its implementation in the training process and analysis of its effectiveness. The following research methods were used in the study: analysis of scientific and methodical literature, pedagogical testing, pedagogical experiment. The main characteristics of special running fitness were measured using GPS speedometer. Results. The effectiveness of the individual running training program for the Ukrainian Winter Aquathlon Championship was developed and experimentally verified, which was based on information about the current state of the athlete's sports form, the priorities of different types of training were determined depending on the training period and the justification of individual intensity, pace, volume and combination of different types of training. The content, forms, methods and means of preparation for the final competitions of the season have been improved. Provisions on the methodology of managing the training process and competitive activity in triathlon have gained further development. Conclusion. The effectiveness of the presented individual running training program has been experimentally proven.