Activation In Superior Temporal Gyrus Research Articles

Sex Differences in Neural Responses to the Perception of Social Interactions.

Social interaction is critical to emotional well-being. Previous studies have suggested sex differences in the perception of social interaction. However, the findings depend on the nature of interactions and whether it involves facial emotions. Here, we explored sex differences in neural responses to the perception of social interaction using the Human Connectome Project data. Participants (n = 969, 505 women) were engaged in a social cognition task with geometric objects moving and colliding to simulate social interaction. Behaviorally, men relative to women demonstrated higher accuracy in perceiving social vs. random interactions. Men vs. women showed higher activation in the right superior temporal gyrus, bilateral occipital and posterior cingulate cortex and precuneus, and women vs. men showed higher activation in the right inferior frontal cortex, during exposure to social vs. random interactions. In whole-brain regressions, the differences in accuracy rate in identifying social vs. random interactions (ARSOC – ARRAN) were associated with higher activation in the paracentral lobule (PCL) and lower activation in bilateral anterior insula (AI), pre-supplementary motor area (preSMA), and left middle frontal gyrus (MFG) in men and women combined, lower activation in bilateral AI, preSMA and left MFG in men alone, and higher activation in the PCL and the medial orbitofrontal cortex in women alone. The latter sex differences were confirmed by slope tests. Further, the PCL activity mediated the correlation between an internalizing syndromal score, as assessed by the Achenbach Self-Report, and (ARSOC – ARRAN) across all subjects. These findings highlighted sex differences in the behavioral and neural processes underlying the perception of social interaction, as well as the influence of internalizing traits on these processes.

Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder

ObjectiveStudies on alterations in the regional neural activity in the brain of patients with bipolar disorder (BD) have provided conflicting results because of different medications used and study designs. A low bone mineral density (BMD) is also observed in patients with BD. This study aimed to further explore regional neural activities in unmedicated patients with BD and their association with BMD.MethodsIn this study, 40 patients with BD and 42 healthy controls were scanned through resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo) and pattern classification. Pearson’s correlation analyses were performed to explore the correlations between abnormal ReHo and BMD.ResultsA significant increase in ReHo values in the left inferior frontal gyrus (IFG)/temporal pole, left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem, and right superior temporal gyrus (STG) and a decrease in ReHo in the occipital gyrus (OG; left middle OG/superior OG/bilateral cuneus) were found in the patients with BD (p < 0.05) compared with those in the healthy controls. No significant correlation was observed between the abnormal ReHo values in any of the brain regions of the patients with BMD.Support vector machine (SVM) analyses revealed that the ReHo values in the right STG for distinguishing patients from healthy controls showed an accuracy of 91.89%, a sensitivity of 75.68%, and a specificity of 83.78%. The ReHo values in the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem indicated an accuracy of 78.38%, a sensitivity of 75.68%, and a specificity of 81.08%.ConclusionThis study further confirms the abnormal brain activities in extensive regions, and these brain regions are primarily located in the fronto–temporal–occipital circuit and the cerebellum vermis of patients with BD. The regional neural activity in the right STG and the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem may serve as potential imaging markers to distinguish patients with BD from healthy controls.

The role of left vs. right superior temporal gyrus in speech perception: An fMRI-guided TMS study

Debate continues regarding the necessary role of right superior temporal gyrus (STG) regions in sublexical speech perception given the bilateral STG activation often observed in fMRI studies. To evaluate the causal roles, TMS pulses were delivered to inhibit and disrupt neuronal activity at the left and right STG regions during a nonword discrimination task based on peak activations from a blocked fMRI paradigm assessing speech vs. nonspeech perception (N = 20). Relative to a control region located in the posterior occipital lobe, TMS to the left anterior STG (laSTG) led to significantly worse accuracy, whereas TMS to the left posterior STG (lpSTG) and right anterior STG (raSTG) did not. Although the disruption from TMS was significantly greater for the laSTG than for raSTG, the difference in accuracy between the laSTG and lpSTG did not reach significance. The results argue for a causal role of the laSTG but not raSTG in speech perception. Further research is needed to establish the source of the differences between the laSTG and lpSTG.

State-dependent perception and perceptual reversals during intermittent binocular rivalry: An electrical neuroimaging study

The object-context relationship and valence are two important stimulus attributes that affect visual perception. Although previous studies reveal how these two factors affect visual perception individually, the interplay between valence with congruent or incongruent object-context associations during visual perception is explored scarcely. Further, what is perceived, is affected by the intrinsic state of the brain at the moment of appearance of the stimulus which could be assessed by EEG microstates. Hence, the current study was designed to explore how the pre-stimulus EEG microstate influences the perception of emotional congruent and incongruent stimuli as well as perceptual reversals and stability during an intermittent binocular rivalry. Results revealed the association of specific pre-stimulus microstates with the perception of neutral and negative congruent stimuli as well as perceptual reversals and stability. Electrical neuroimaging of these microstates showed higher activation in the precuneus and middle occipital gyrus preceding the perception of neutral congruent stimuli and lingual gyrus preceding the perception of negative congruent stimuli. Increased source activity in superior temporal gyrus and superior frontal gyrus was found preceding stability and lower activation in parahippocampal gyrus was observed preceding reversals. Together these results suggest that the pre-stimulus activation of areas involved in visual priming, retrieval, and semantics leads to congruent perception. Pre-stimulus DMN suppression was required for perceptual reversals whereas stability was accompanied by pre-stimulus activation of areas related to the specific nature of the stimulus. Therefore, we propose that in addition to stimulus attributes, the pre-stimulus intrinsic brain activity could be an important determinant of the performance.

Recursive music elucidates neural mechanisms supporting the generation and detection of melodic hierarchies

The ability to generate complex hierarchical structures is a crucial component of human cognition which can be expressed in the musical domain in the form of hierarchical melodic relations. The neural underpinnings of this ability have been investigated by comparing the perception of well-formed melodies with unexpected sequences of tones. However, these contrasts do not target specifically the representation of rules generating hierarchical structure. Here, we present a novel paradigm in which identical melodic sequences are generated in four steps, according to three different rules: The Recursive rule, generating new hierarchical levels at each step; The Iterative rule, adding tones within a fixed hierarchical level without generating new levels; and a control rule that simply repeats the third step. Using fMRI, we compared brain activity across these rules when participants are imagining the fourth step after listening to the third (generation phase), and when participants listened to a fourth step (test sound phase), either well-formed or a violation. We found that, in comparison with Repetition and Iteration, imagining the fourth step using the Recursive rule activated the superior temporal gyrus (STG). During the test sound phase, we found fronto-temporo-parietal activity and hippocampal de-activation when processing violations, but no differences between rules. STG activation during the generation phase suggests that generating new hierarchical levels from previous steps might rely on retrieving appropriate melodic hierarchy schemas. Previous findings highlighting the role of hippocampus and inferior frontal gyrus may reflect processing of unexpected melodic sequences, rather than hierarchy generation per se.

Cortical activity during social acceptance and rejection task in social anxiety disorder: A controlled functional near infrared spectroscopy study

BackgroundThe cognitive and emotional vulnerability of individuals with social anxiety disorder (SAD) and their response to repeated experiences of social rejection and social acceptance are important factors for the emergence and maintenance of symptoms of the disorder. Functional neuroimaging studies of SAD reveal hyperactivity in regions involved in the fear circuit such as amygdala, insula, anterior cingulate, and prefrontal cortices (PFC) in response to human faces with negative emotions. Observation of brain activity, however, involving studies of responses to standardized human interaction of social acceptance and social rejection have been lacking. MethodsWe compared a group of index subjects with SAD (N = 22, mean age:26.3 ± 5.4, female/male: 7/15) (SADG) with a group of healthy controls (CG) (N = 21, mean age:28.7 ± 4.5, female/male: 14/7) in measures of cortical activity during standardized experiences of human interaction involving social acceptance (SA) and social rejection (SR) video-simulated handshaking tasks performed by real actors. In a third, control condition (CC), the subjects were expected to press a switch button in an equivalent space. Subjects with a concurrent mood episode were excluded and the severity of subclinical depressive symptoms was controlled. 52-channel functional near-infrared spectroscopy (fNIRS) was used to measure cortical activity. ResultsActivity was higher in the SAD subjects compared to healthy controls, in particular in channels that project to middle and superior temporal gyri (STG), frontal eye fields (FEF) and dorsolateral prefrontal cortex (DLPFC) in terms of both SA and SR conditions. Cortical activity during the CC was not different between the groups. Only in the SAD-group, activity in the pre-motor and supplementary motor cortices, inferior and middle temporal gyri and fronto-polar area was higher during the rejection condition than the other two conditions. Anxiety scores were correlated with activity in STG, DLPFC, FEF and premotor cortex, while avoidance scores were correlated with activity in STG and FEF. ConclusionsSA and SR are represented differently in terms of cortical activity in SAD subjects compared to healthy controls. Higher activity in both social conditions in SAD subjects compared to controls may imply biological sensitivity to these experiences and may underscore the importance of increased cortical activity during social interaction experiences as a putative mediator of vulnerability to SAD. Higher cortical activity in the SADG may possibly indicate stronger need for inhibitory control mechanisms and higher recruitment of theory of mind functions during social stress. Higher activity during the SR compared to the SA condition in the SAD subjects may also suggest distinct processing of social cues, whether they involve acceptance or rejection.

Musicians use speech-specific areas when processing tones: The key to their superior linguistic competence?

It is known that musicians compared to non-musicians have some superior speech and language competence, yet the mechanisms how musical training leads to this advantage are not well specified.This event-related fMRI study confirmed that musicians outperformed non-musicians in processing not only of musical tones but also syllables and identified a network differentiating musicians from non-musicians during processing of linguistic sounds.Within this network, the activation of bilateral superior temporal gyrus was shared with all subjects during processing of the acoustically well-matched musical and linguistic sounds, and with the activation distinguishing tones with a complex harmonic spectrum (bowed tone) from a simpler one (plucked tone). These results confirm that better speech processing in musicians relies on improved cross-domain spectral analysis.Activation of left posterior superior temporal sulcus (pSTS), premotor cortex, inferior frontal and fusiform gyrus (FG) also distinguishing musicians from non-musicians during syllable processing overlapped with the activation segregating linguistic from musical sounds in all subjects. Since these brain-regions were not involved during tone processing in non-musicians, they could code for functions which are specialized for speech. Musicians recruited pSTS and FG during tone processing, thus these speech-specialized brain-areas processed musical sounds in the presence of musical training.This study shows that the linguistic advantage of musicians is linked not only to improved cross-domain spectral analysis, but also to the functional adaptation of brain resources that are specialized for speech, but accessible to the domain of music in the presence of musical training.

O4.4. REAL TIME FMRI NEUROFEEDBACK TARGETING STG AND DMN REDUCES AUDITORY HALLUCINATIONS

BackgroundAuditory hallucinations (AH) are one of the core symptoms of schizophrenia (SZ) and constitute a significant source of suffering and disability. One third of SZ patients experience pharmacology-resistant AH, so an alternative/complementary treatment strategy is needed to alleviate this debilitating condition. In this study, real-time functional Magnetic Resonance Imaging neurofeedback (rt-fMRI NFB), a non-invasive technique, was used to help 10 SZ patients modulate their brain activity in key brain regions belonging to the network involved in the experience of auditory hallucinations. In two experiments we selected two different brain targets. 1. the superior temporal gyrus (STG) and 2. default mode network (DMN)-central executive network (CEN) connectivity. STG is a key area in the neurophysiology of AH. Hyperactivation of the default mode network (DMN) and of the superior temporal gyrus (STG) in SZ has been shown in imaging studies. Furthermore, several studies point to reduced anticorrelation between the DMN and the central executive network (CEN). Finally, DMN hyperconnectivity has been associated with positive symptoms such as AHs while reduced DMN anticorrelations have been associated with cognitive impairment.MethodsIn the STG-focused NFB experiment, subjects were trained to upregulate the STG activity while listening to their own voice recording and downregulate it while ignoring a stranger’s voice recording in the course of 21 min NFB session. Visual feedback was provided to subjects at the end of each run from their own STG activity in the form of a thermometer. AH were assessed with auditory hallucination scale pre-NFB and within a week after the NFB session.The DMN-CEN focused NFB experiment was conducted about 1 month later to minimize the carry over effects from the STG-focused NFB and was designed to help SZ patients modulate their DMN and CEN networks. DMN and CEN networks were defined individually for each subject. The goal of the task was to increase CEN-DMN anti-correlations. To achieve that patients were provided with meditation strategies to guide their performance. Feedback was provided in the form of a ball that traveled up if the modulation of DMN-CEN connectivity was successful and traveled down if it was not successful. AH measures were taken before the NFB session and within a week after the session.ResultsIn the STG-focused NFB task, significant STG activation reduction was found in the comparison of pre- relative to post-NFB in the condition of ignoring another person’s voice (p<0.05), FWE-TFCE corrected. AH were also significantly reduced (p<0.01). Importantly, significant correlation was found between reductions in the STG activation and AH reductions (r=.83).In the DMN-CEN focused NFB task, significant increase in the anti-correlations between medial prefrontal cortex (mPFC) and dorsolateral prefrontal cortex (DLPFC) (p<0.05) was observed as well as significant reduction in the mPFC-PCC connectivity (p <0.05), in the pre-post NFB comparisons. AH were significantly reduced in post- relative to pre-NFB comparison (p<0.02). Finally, there was a significant correlation between individual scores in mPFC-STG connectivity and AH reductions.DiscussionThese the two experiments suggest that targeting both the STG BOLD activation and DMN-CEN connectivity in NFB tasks aimed at AH reduction result both in brain changes and in AH reductions. Together, these results provide strong preliminary support for the NFB use as a means to impact brain function leading to reductions in AH in SZ. Importantly, these results suggest that AH result from brain abnormalities in a network of brain regions and that targeting a brain region belonging to this network will lead to AH symptom reduction.

Modulation of Brain Activity by Selective Attention to Audiovisual Dialogues.

In real-life noisy situations, we can selectively attend to conversations in the presence of irrelevant voices, but neurocognitive mechanisms in such natural listening situations remain largely unexplored. Previous research has shown distributed activity in the mid superior temporal gyrus (STG) and sulcus (STS) while listening to speech and human voices, in the posterior STS and fusiform gyrus when combining auditory, visual and linguistic information, as well as in left-hemisphere temporal and frontal cortical areas during comprehension. In the present functional magnetic resonance imaging (fMRI) study, we investigated how selective attention modulates neural responses to naturalistic audiovisual dialogues. Our healthy adult participants (N = 15) selectively attended to video-taped dialogues between a man and woman in the presence of irrelevant continuous speech in the background. We modulated the auditory quality of dialogues with noise vocoding and their visual quality by masking speech-related facial movements. Both increased auditory quality and increased visual quality were associated with bilateral activity enhancements in the STG/STS. In addition, decreased audiovisual stimulus quality elicited enhanced fronto-parietal activity, presumably reflecting increased attentional demands. Finally, attention to the dialogues, in relation to a control task where a fixation cross was attended and the dialogue ignored, yielded enhanced activity in the left planum polare, angular gyrus, the right temporal pole, as well as in the orbitofrontal/ventromedial prefrontal cortex and posterior cingulate gyrus. Our findings suggest that naturalistic conversations effectively engage participants and reveal brain networks related to social perception in addition to speech and semantic processing networks.

Enhanced Gray Matter Volume Compensates for Decreased Brain Activity in the Ocular Motor Area in Children with Anisometropic Amblyopia

PurposeAnisometropic amblyopia usually occurs during early childhood and results in monocular visual deficit. Recent neuroimaging studies have demonstrated structural and functional alterations in pediatric anisometropic amblyopia (PAA) patients. However, the relationship between structural and functional alterations remains largely unknown. The aim of this study was to investigate the relationship between structural and functional alterations in PAA patients. Materials and Methods Eighteen PAA patients and 14 healthy children underwent a multimodal MRI scanning including T1WI and functional MRI (fMRI). Voxel-based morphometry was used to assess structural alterations between PAA patients and healthy children. Regional homogeneity (ReHo) was used to investigate changes in local spontaneous brain activity in the enrolled subjects. Correlations between structural, functional alterations, and clinical information were analyzed in the PAA group. Results Compared with healthy children, PAA patients exhibited significantly reduced ReHo of spontaneous brain activity in the right superior temporal gyrus (STG) and right middle frontal gyrus (MFG) and increased gray matter volume in the right lobules 4 and 5 of the cerebellum. The gray matter volume of the right lobules 4 and 5 of the cerebellum was negatively correlated with the ReHo values of the right MFG. Conclusions Our findings may suggest that PAA patients experience structural and functional abnormalities in brain regions related to oculomotor and visual-spatial information. In addition, the increased gray matter volume may compensate the decreased brain activity in the oculomotor regions, which reflects compensatory or neural plasticity in PAA patients.

Exploring Frequency-Dependent Brain Networks from Ongoing EEG Using Spatial ICA During Music Listening

Recently, exploring brain activity based on functional networks during naturalistic stimuli especially music and video represents an attractive challenge because of the low signal-to-noise ratio in collected brain data. Although most efforts focusing on exploring the listening brain have been made through functional magnetic resonance imaging (fMRI), sensor-level electro- or magnetoencephalography (EEG/MEG) technique, little is known about how neural rhythms are involved in the brain network activity under naturalistic stimuli. This study exploited cortical oscillations through analysis of ongoing EEG and musical feature during freely listening to music. We used a data-driven method that combined music information retrieval with spatial Fourier Independent Components Analysis (spatial Fourier–ICA) to probe the interplay between the spatial profiles and the spectral patterns of the brain network emerging from music listening. Correlation analysis was performed between time courses of brain networks extracted from EEG data and musical feature time series extracted from music stimuli to derive the musical feature related oscillatory patterns in the listening brain. We found brain networks of musical feature processing were frequency-dependent. Musical feature time series, especially fluctuation centroid and key feature, were associated with an increased beta activation in the bilateral superior temporal gyrus. An increased alpha oscillation in the bilateral occipital cortex emerged during music listening, which was consistent with alpha functional suppression hypothesis in task-irrelevant regions. We also observed an increased delta–beta oscillatory activity in the prefrontal cortex associated with musical feature processing. In addition to these findings, the proposed method seems valuable for characterizing the large-scale frequency-dependent brain activity engaged in musical feature processing.

The relationship between frontotemporal effective connectivity and performance during auditory working memory task in noise

The present study examined the relationship between effective connectivity among frontotemporal brain regions and auditory working memory (AWM) performance. Twenty healthy participants performed a word-based backward recall task in four signal-to-noise ratio (SNR) conditions during functional magnetic resonance imaging scans. Functional data were pre-processed and analyzed using Statistical Parametric Mapping. Optimum connectivity model and strength of effective connectivity were analyzed using Dynamic Causal Modelling. Group results indicated significant brain activation in left superior temporal gyrus (STG) and left inferior frontal gyrus (IFG). Behavioral results showed that performance was enhanced in good SNR but worsened in low SNR. Bayesian model selection showed strong evidence of a bidirectional connection between left STG and left IFG. Correlation analyses showed a moderate positive linear relationship between effective connectivity from left STG to left IFG and behavioral performance. These findings suggest that the strength of effective connectivity from left STG and left IFG may underpin successful AWM performance.

Real-time fMRI feedback impacts brain activation, results in auditory hallucinations reduction: Part 1: Superior temporal gyrus -Preliminary evidence-

Auditory hallucinations (AH) are one of the core symptoms of schizophrenia (SZ) and constitute a significant source of suffering and disability. One third of SZ patients experience pharmacology-resistant AH, so an alternative/complementary treatment strategy is needed to alleviate this debilitating condition. In this study, real-time functional Magnetic Resonance Imaging neurofeedback (rt-fMRI NFB), a non-invasive technique, was used to teach 10 SZ patients with pharmacology-resistant AH to modulate their brain activity in the superior temporal gyrus (STG), a key area in the neurophysiology of AH. A functional task was designed in order to provide patients with a specific strategy to help them modify their brain activity in the desired direction. Specifically, they received neurofeedback from their own STG and were trained to upregulate it while listening to their own voice recording and downregulate it while ignoring a stranger's voice recording. This guided performance neurofeedback training resulted in a) a significant reduction in STG activation while ignoring a stranger's voice, and b) reductions in AH scores after the neurofeedback session. A single, 21-minute session of rt-fMRI NFB was enough to produce these effects, suggesting that this approach may be an efficient and clinically viable alternative for the treatment of pharmacology-resistant AH.

Perturbing the activity of the superior temporal gyrus during pain encoding prevents the exaggeration of pain memories: A virtual lesion study using single-pulse transcranial magnetic stimulation.

Past studies have shown that pain memories are often inaccurate, a phenomenon known as mnemonic pain bias. Pain memories are thought to play an important role on how future pain is felt. Recent evidence from our laboratory suggests that individuals who exaggerate past pain display increased superior temporal gyrus (STG) activity during the encoding of experimental painful stimulations, suggesting that this brain structure plays an important role in pain memories. /hypothesis. To determine whether a virtual lesion paradigm, targeting the STG during pain encoding, can affect long-lasting pain memories. We hypothesized that interfering with the activity of the STG would attenuate mnemonic bias. Randomized double-blind study with two parallel groups. Participants received either sham (n = 21) or real (n = 21) transcranial magnetic stimulation (TMS - virtual lesion paradigm) over the STG during pain encoding (milliseconds after the administration of a painful stimuli). Pain intensity and unpleasantness were evaluated using a visual analog scale (VAS; 0 to 10) immediately after the painful event, and at recall, 2 months later. The mnemonic pain bias (calculated by subtracting the pain scores obtained at recall from the pain score obtained during encoding) was compared between the two groups for both pain intensity and unpleasantness. Participants in both groups did not differ in terms of age and gender (real TMS = 27 years ± 9, 43% female; sham TMS = 25 years ± 4, 49% female; p > 0.64). The mnemonic bias related to pain intensity was similar in both groups (p = 0.83). However, the mnemonic bias related to pain unpleasantness was lower in the real TMS group (p = 0.04). Our results provide the first evidence that the STG, is causally involved in the formation of biased memories of pain unpleasantness.

Exposure to linguistic labels during childhood modulates the neural architecture of race categorical perception

Perceptually categorizing a face to its racial belonging may have important consequences on interacting with people. However, race categorical perception (CP) has been scarcely investigated nor its developmental pathway. In this study, we tested the neurolinguistics rewiring hypothesis, stating that language acquisition modulates the brain processing of social perceptual categories. Accordingly, we investigated the electrophysiological correlates of race CP in a group of adults and children between 3 and 5 years of age. For both groups we found a greater modulation of the N400 connected with the processing of between category boundaries (i.e., faces belonging to different race groups) than within-category boundaries (i.e., different faces belonging to the same race group). This effect was the same in both adults and children, as shown by the comparable between-group amplitude of the differential wave (DW) elicited by the between-category faces. Remarkably, this effect was positively correlated with racial-labels acquisition, but not with age, in children. Finally, brain source analysis revealed the activation of a more modularized cortical network in adults than in children, with unique activation of the left superior temporal gyrus (STG) and the inferior frontal gyrus (IFG), which are areas connected to language processing. These are the first results accounting for an effect of language in rewiring brain connectedness when processing racial categories.

Neural representations of phonology in temporal cortex scaffold longitudinal reading gains in 5- to 7-year-old children

The objective of this study was to investigate whether phonological processes measured through brain activation are crucial for the development of reading skill (i.e. scaffolding hypothesis) and/or whether learning to read words fine-tunes phonology in the brain (i.e. refinement hypothesis). We specifically looked at how different grain sizes in two brain regions implicated in phonological processing played a role in this bidirectional relation. According to the dual-stream model of speech processing and previous empirical studies, the posterior superior temporal gyrus (STG) appears to be a perceptual region associated with phonological representations, whereas the dorsal inferior frontal gyrus (IFG) appears to be an articulatory region that accesses phonological representations in STG during more difficult tasks. 36 children completed a reading test outside the scanner and an auditory phonological task which included both small (i.e. onset) and large (i.e. rhyme) grain size conditions inside the scanner when they were 5.5–6.5 years old (Time 1) and once again approximately 1.5 years later (Time 2). To study the scaffolding hypothesis, a regression analysis was carried out by entering brain activation in either STG or IFG for either small (onset > perceptual) or large (rhyme > perceptual) grain size phonological processing at T1 as the predictors and reading skill at T2 as the dependent measure, with several covariates of no interest included. To study the refinement hypothesis, the regression analysis included reading skill at T1 as the predictor and brain activation in either STG or IFG for either small or large grain size phonological processing at T2 as the dependent measures, with several covariates of no interest included. We found that only posterior STG, regardless of grain size, was predictive of reading gains. Parallel models with only behavioral accuracy were not significant. Taken together, our results suggest that the representational quality of phonology in temporal cortex is crucial for reading development. Moreover, our study provides neural evidence supporting the scaffolding hypothesis, suggesting that brain measures of phonology could be helpful in early identification of reading difficulties.

Neural tracking of subjective value under riskand ambiguity in adolescence

Although many neuroimaging studies on adolescent risk taking have focused on brain activation during outcome valuation, less attention has been paid to the neural correlates of choice valuation. Subjective choice valuation may be particularly influenced by whether a choice presents risk (known probabilities) or ambiguity (unknown probabilities), which has rarely been studied in developmental samples. Therefore, we examined the neural tracking of subjective value during choice under risk and ambiguity in a large sample of adolescents (N = 188, 12–22 years). Specifically, we investigated which brain regions tracked subjective value coding under risk and ambiguity. A model-based approach to estimate individuals’ risk and ambiguity attitudes showed prominent variation in individuals’ aversions to risk and ambiguity. Furthermore, participants subjectively experienced the ambiguous options as being riskier than the risky options. Subjective value tracking under risk was coded by activation in ventral striatum and superior parietal cortex. Subjective value tracking under ambiguity was coded by dorsolateral prefrontal cortex (PFC) and superior temporal gyrus activation. Finally, overlapping activation in the dorsomedial PFC was observed for subjective value under both conditions. Overall, this is the first study to chart brain activation patterns for subjective choice valuation under risk and ambiguity in an adolescent sample, which shows that the building blocks for risk and ambiguity processing are already present in early adolescence. Finally, we highlight the potential of combining behavioral modeling with fMRI for investigating choice valuation in adolescence, which may ultimately aid in understanding who takes risks and why.

Memory response and neuroimaging correlates of a novel cognitive rehabilitation program for memory problems in epilepsy: A pilot study.

Memory deficits are very common in epilepsy, but no standard of care exists to effectively manage them. We assessed effectiveness of cognitive rehabilitation (CR) on memory and neural plasticity in people with epilepsy (PWE) reporting memory impairments. Nine PWE completed 6 weekly sessions adapted from 2 generic CR programs enriched with information regarding epilepsy. Participants completed neuropsychological, mood, and quality of life (QOLIE-31) measures prior and after completion of CR; 5/9 participants also completed pre- and post-CR fMRI while performing a verbal paired associates learning task. FMRI data were analyzed using group spatial independent components analysis methods; paired t-tests compared spatial activations for pre-/post-CR. Improvements were seen in immediate recall in Rey Auditory Verbal Learning Task, QOLIE-31, and read word recognition in paired associates task (all p's≤0.05). FMRI changes comparing pre-to-post CR were noted through increased activation in the left inferior frontal gyrus (IFG) and anterior cingulate and decreased activation in the left superior temporal gyrus; also noted were decreased activations in the default mode network (DMN), right cingulate, right middle temporal gyrus, right supramarginal gyrus, and increased DMN activation in the left cuneus. This study demonstrates feasibility of conducting CR program in PWE with fMRI as a mechanistic biomarker. Improvements in cognition and cortical plasticity await confirmation in larger samples.

A causal role of superior temporal gyrus in auditory-motor control of vocal production

Accumulating evidence has shown that the superior temporal gyrus (STG) plays an important role in auditory feedback control of vocal production. The precise role of this region in auditory-vocal integration, however, remains unclear. The present event-related potential study applied a transcranial magnetic stimulation (TMS) protocol, continuous theta-burst stimulation (c-TBS), to depress activity in the left STG as young adults produced sustained vowels while their voice was unexpectedly pitch-shifted downwards by 50 or 200 cents. The behavioral results showed significantly larger vocal compensations for pitch perturbations in the c-TBS condition as compared to the sham condition. At the cortical level, c-TBS over left STG led to significantly smaller cortical P2 responses than the sham condition. These findings provide the first causal evidence for linking the STG to auditory feedback control of vocal production. Enhanced vocal compensations for pitch perturbations as a result of disrupting the STG activity lend support to the idea that the STG may be critically involved in top-down inhibitory mechanisms of speech motor control, through which vocal motor behaviors can be appropriately regulated without being excessively influenced by auditory feedback.Accumulating evidence has shown that the superior temporal gyrus (STG) plays an important role in auditory feedback control of vocal production. The precise role of this region in auditory-vocal integration, however, remains unclear. The present event-related potential study applied a transcranial magnetic stimulation (TMS) protocol, continuous theta-burst stimulation (c-TBS), to depress activity in the left STG as young adults produced sustained vowels while their voice was unexpectedly pitch-shifted downwards by 50 or 200 cents. The behavioral results showed significantly larger vocal compensations for pitch perturbations in the c-TBS condition as compared to the sham condition. At the cortical level, c-TBS over left STG led to significantly smaller cortical P2 responses than the sham condition. These findings provide the first causal evidence for linking the STG to auditory feedback control of vocal production. Enhanced vocal compensations for pitch perturbations as a result of disrupting the STG activ...

Neural processing of infant and adult face emotion and maternal exposure to childhood maltreatment.

Face processing in mothers is linked to mother–infant social communication, which is critical for parenting and in turn for child development. Neuroimaging studies of child maltreatment-exposed (CME) mothers are sparse compared to studies of mothers with postpartum depression, which have suggested blunted amygdala reactivity to infant stimuli. We expected to see a similar pattern in CME mothers. Based on broader studies in trauma-exposed populations, we anticipated increased amygdala reactivity to negative adult face stimuli in a comparison task in CME mothers given heightened evaluation of potential threat. We examined Neuroimaging studies of mothers with childhood maltreatment exposure (CME) (18–37 years old), who performed infant (N = 45) and/or adult (N = 46) face processing tasks. CME mothers exhibited blunted bilateral amygdala reactivity to infant faces. There was no between-group difference in amygdala reactivity to adult faces. In infant and adult face processing tasks regardless of CME, superior temporal gyrus activation was increased for negative-valence stimuli. Our preliminary findings suggest that childhood maltreatment alters maternal processing of infant social cues, a critical skill impacting infant socioemotional development.