Activity In Rat Hippocampus Research Articles

Corticosterone prevents the increase in noradrenaline-stimulated adenyl cyclase activity in rat hippocampus following adrenalectomy or metopirone

Corticosterone modulation of the noradrenaline-responsive cyclic AMP generating system was examined in rat hippocampus. Adrenalectomy was found to produce a small but significant elevation in the rate of cyclic AMP formation in response to noradrenaline. Implantation of corticosterone pellets 5 days prior to sacrifice prevented this adrenalectomy-induced increase. Metopirone, an inhibitor of corticosterone synthesis, was also observed to increase cyclic AMP formation. This elevation was seen 2 h following a 50 mg/kg i.p. injection and was completely prevented by corticosterone pellet implantation. Metopirone had no significant effect on cyclic AMP production after 1 h, while a slight but statistically non-significant elevation remained at 4 h. These observation parallel the inhibitory effect of Metopirone on corticosterone synthesis as determined by serum corticosterone levels.

Correlation of regional brain metabolism with receptor localization during ketamine anesthesia: combined autoradiographic 2-[3H]deoxy-D-glucose receptor binding technique.

LKB film autoradiography of 2-]3H]deoxy-D-glucose uptake shows that ketamine, administered in anesthetic doses, alters the pattern of metabolic activity in rat hippocampus. The labeled metabolic marker can be washed out of the slide-mounted tissue sections by preincubation to permit in vitro autoradiography of drug and neurotransmitter receptors in the same animal. In this way, opiate and phencyclidine receptor distributions may be correlated with patterns of glucose utilization in adjacent sections. If the observed relative enhancement of 2-deoxy-D-glucose uptake in the stratum moleculare of hippocampus reflects elevated metabolism in nerve terminals there, then the binding of ketamine to phencyclidine receptors on neurons in distant afferent sites, such as entorhinal cortex, may initiate the physiologic and metabolic effects.

Neuron activity in rat hippocampus and motor cortex during discrimination reversal

DISTERHOFT, J. F. AND M. SEGAL. Neuron activity in rat hippocampus and motor cortex during discrimination reversal. BRAIN RES. BULL. 3(6) 583–588, 1978.—Chronic unit activity and gross movement were recorded from rats during two discrimination reversals in a classical appetitive conditioning situation. The anticipatory movement decreased in response to the former CS + tone and increased to the previous CS − tone after each reversal. Hippocampus and motor cortex were differently related to these two kinds of behavioral change. Response rates of hippocampal neurons were more closely related to the increased movement response to the former CS − which now signaled food. Motor cortex neuron responses were more closely correlated with the decrease in movement responses to the former CS + which became neutral after the reversal. It appeared that hippocampal neurons could have been involved in one cognitive aspect of the situation, motor cortex neurons in another. The data were related to current functional concepts of these brain regions.

Anatomical and behavioral mapping of rhythmic slow wave activity in rat hippocampus

During learning, rhythmic slow wave activity (RSA) can be recorded from the rat hippocampus. Various theories have been offered as to its functional significance. This confusion may partly reflect unspecified placement of recording electrodes within the hippocampus. The effects of location of recording electrodes within the hippocampus on the properties of RSA, were examined. Recordings were taken before and after learning a temporal discrimination task. The results suggest that there is more than one set of RSA produced by the rat hippocampus. These sets can be identified on the basis of anatomical location and by behavioral and environmental parameters. Type one is associated with movement of the rat which produces a RSA which is widespread within the hippocampus. The properties (e.g. frequency and amplitude) of the RSA correlate with the magnitude of the movement performed by the rat. Type two is associated with environmental stimuli which can produce a RSA whose properties (e.g. appearance and duration) vary according to anatomical location of the recording electrode within the hippocampus.

Behavior of units in hippocampal circuit of the rat during learning.

Behavior of units in hippocampal circuit of the rat during learning.M Segal, and J OldsM Segal, and J OldsPublished Online:01 Sep 1972https://doi.org/10.1152/jn.1972.35.5.680MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByThe Role of the Septo-Hippocampal System and its Noradrenergic Afferents in Behavioural Responses to Non-Reward11 July 2008Long-Term Potentiation/Depotentiation Are Accompanied by Complex Changes in Spontaneous Unit Activity in the HippocampusAkihisa Kimura, and Constantine Pavlides1 October 2000 | Journal of Neurophysiology, Vol. 84, No. 4The Hippocampus, Memory, and Place CellsNeuron, Vol. 23, No. 2The hippocampus: A biological model for studying learning and memoryProgress in Neurobiology, Vol. 44, No. 5The behavioral neurobiology of learning and memory: A conceptual reorientationBrain Research Reviews, Vol. 19, No. 3Responses of hippocampal cells can be conditioned during paradoxical sleepBrain Research, Vol. 581, No. 1Hippocampal responses evoked by tooth pulp and acoustic stimulation: Depth profiles and effect of behaviorBrain Research, Vol. 378, No. 2Low frequency perforant path stimulation as a conditioned stimulus demonstrates correlations between long-term synaptic potentiation and learningPhysiology & Behavior, Vol. 36, No. 5Unit activity of the septo-hippocampal system in classical conditioning with rewarding brain stimulationBrain Research, Vol. 295, No. 1Post-trial reticular facilitation of associative changes in multiunit activity: comparison between dentate gyrus and entorhinal cortexBehavioural Brain Research, Vol. 9, No. 3Characterization and radioautography of [3H] LSD binding by rat brain slices in vitro: The effect of 5-hydroxytryptamineEuropean Journal of Pharmacology, Vol. 67, No. 4Peripheral auditory input to the midbrain limbic area and related structuresBrain Research, Vol. 167, No. 1Unit responses to auditory input in the dorsal and median raphe nuclei of the ratPhysiology & Behavior, Vol. 22, No. 1Neuron activity in rat hippocampus and motor cortex during discrimination reversalBrain Research Bulletin, Vol. 3, No. 6Neuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane response. I. The hippocampusBrain Research, Vol. 145, No. 2Neurohypophyseal principles and memory processesBiochemical Pharmacology, Vol. 27, No. 14Responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathwaysBrain Research, Vol. 123, No. 2Analyse statistique de l'activite des cellules pyramidales de l'hippocampe dorsal du lapinElectroencephalography and Clinical Neurophysiology, Vol. 40, No. 6Dorsal hippocampus: A site of action of neuropeptides on avoidance behavior?Pharmacology Biochemistry and Behavior, Vol. 5The effects of electrical (blocking) stimulation to the dentate of the rat on learning of a simultaneous brighteness discrimination and reversalNeuropsychologia, Vol. 13, No. 4Hippocampal conditioned responses in the absence of entorhinal inputPhysiology & Behavior, Vol. 15, No. 3Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal sliceBrain Research, Vol. 89, No. 1The hippocampus and learningProgress in Neurobiology, Vol. 5Neuroanatomic localization and memory processing in mice: The role of the dentate gyrus of the hippocampusPhysiology & Behavior, Vol. 13, No. 4Model of a plausible learning scheme for CA3 HippocampusKybernetik, Vol. 16, No. 3Dissecting a short-term memory circuit in the rat brain. I. Changes in entorphinal unit activity and responsiveness of hippocampal units in the process of classical conditioningBrain Research, Vol. 64Studies on single neurons in dorsal hippocampal formation and septum in unrestrained ratsExperimental Neurology, Vol. 41, No. 2Short-term changes in the firing pattern of hypothalamic neurons during pavlovian conditioningBrain Research, Vol. 58, No. 1The effect of septal input upon hippocampal unit response in normal conditions in ratsBrain Research, Vol. 58, No. 1 More from this issue > Volume 35Issue 5September 1972Pages 680-90 https://doi.org/10.1152/jn.1972.35.5.680PubMed5054511History Published online 1 September 1972 Published in print 1 September 1972 Metrics

Differential development of conditioned unit changes in thalamus and cortex of rat.

Differential development of conditioned unit changes in thalamus and cortex of rat.J F Disterhoft, and J OldsJ F Disterhoft, and J OldsPublished Online:01 Sep 1972https://doi.org/10.1152/jn.1972.35.5.665MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByLearning-related neuronal activity in the ventral lateral geniculate nucleus during associative cerebellar learningAlireza Kashef, Matthew M. Campolattaro, and John H. Freeman1 November 2014 | Journal of Neurophysiology, Vol. 112, No. 9Neuronal signalling of fear memoryNature Reviews Neuroscience, Vol. 5, No. 11Suppression of cortical representation through backward conditioning21 January 2003 | Proceedings of the National Academy of Sciences, Vol. 100, No. 3Plastic Changes in the Central Auditory System After Hearing Loss, Restoration of Function, and During LearningJosef Syka7 January 2002 | Physiological Reviews, Vol. 82, No. 3Generalization and specialization in artificial neural networksProgress in Neurobiology, Vol. 37, No. 5Neuronal activity in the mediodorsal and intralaminar nuclei of the dorsal thalamus during classical heart rate conditioningBrain Research, Vol. 532, No. 1-2Conditioning-related changes of unit activity in the dorsal lateral geniculate nucleus of urethane-anaesthetized ratsBrain Research Bulletin, Vol. 25, No. 1Physiological plasticity in auditory cortex: Rapid induction by learningProgress in Neurobiology, Vol. 29, No. 1Response plasticity of single neurons in rabbit auditory association cortex during tone-signalled learningBrain Research, Vol. 246, No. 2Peripheral auditory input to the midbrain limbic area and related structuresBrain Research, Vol. 167, No. 1Separation of associative from non-associative short latency changes in medial geniculate and inferior colliculus during differential conditioning and reversal in ratsBrain Research, Vol. 167, No. 1Neuron activity in rat hippocampus and motor cortex during discrimination reversalBrain Research Bulletin, Vol. 3, No. 6Patterns of conditioned unit responses in the auditory system of the ratExperimental Neurology, Vol. 59, No. 2Nictating membrane conditioning to tone in the immobilized albino rabbitBrain Research, Vol. 137, No. 1Differentiated short latency response increases after conditioning in inferior colliculus neurons of alert ratBrain Research, Vol. 130, No. 2Short-term changes in the firing pattern of hypothalamic neurons during pavlovian conditioningBrain Research, Vol. 58, No. 1 More from this issue > Volume 35Issue 5September 1972Pages 665-79 https://doi.org/10.1152/jn.1972.35.5.665PubMed5054510History Published online 1 September 1972 Published in print 1 September 1972 Metrics