The COVID-19 pandemic has changed daily life; with more than 303 million infections contracted globally and over 43.4 Million people infected in India, the pandemic's toll continues to rise. At the end of 2020, the good news was on the horizon that COVID-19 vaccines had been developed. Growing attention has been paid recently all over the countries to control the COVID-19 pandemic. College students are one of the populations for vaccination as they are the pillars of the future. More understanding is needed in the aspects of willingness to take vaccination and factors influencing their vaccination intention, thereby contributing to developing and implementing effective strategies to promote COVID-19 vaccine uptake among this population. Background: All counties were facing an unprecedented public health challenge of the global pandemic The only way to block the spread of the disease is through vaccine administration, like how other vaccine-preventable diseases like smallpox, Poliomyelitis, and measles were controlled or even eradicated. Research also has proven evidence for the safety and scientific validity of COVID 19 vaccines based on trials that presented a promising effective way to control the transmission of the dreadful disease. Although older people are at more significant infection fatality risks for COVID-19, the Younger generation is more vulnerable to COVID-19 infection, and the transmission rate is higher comparatively than the older population, especially those engaged in activities with a higher risk for exposure. College students can be affected by campus outbreaks and the spread of COVID when they return home or go out for social activities. Therefore, students could be an ideal population to investigate their view on COVID-19 since they are well educated and open-minded and supposed to be the active spreader of the current pandemic Methods: An online or web literature review or articles review of 31 articles related to Covid-19 and Vaccination was conducted through Pub Med/Google Scholar and BMJ and NIH databases published during the years from January 2018 to April 2022. Results: The coronavirus pandemic has left a distinctive marking worldwide, and the changes are continuing in all aspects of human life, work, education, and recreational activities. Along with the other preventive strategies, Vaccination uptake is one of the essential preventive strategies to protect people from COVID-19 Infection. This literature review studied attitude and perception related to vaccination uptake, hesitancy, and influential factors related to COVID-19 vaccine administration and the theories related to Vaccination. Most college students intend to accept vaccinations despite differences in attitudes toward vaccination uptake globally. Psychologists believed that motives drove belief in conspiracy theories to understand one's environment, safe environment and maintain a positive self-image and social group. The first two were what people needed during the COVID-19 pandemic. The responsibility lies in government institutions where they should implement strategies to eliminate the concerns about the COVID-19 Vaccines. Conclusion: The article search found that in all the selected literature reviews, a significant proportion of college students have a positive attitude towards vaccine administration to prevent the spread of COVID-19. Correct knowledge of COVID-19, trust, good conceptions and social behaviour were important factors or determinants in students' willingness to vaccinate. The information on social media significantly impacted vaccine acceptance among college students. Government should strengthen creditability and convey trusted communication with the influence of social media, and improvement in vaccination services are critical in provoking college students to be vaccinated at the earliest Keywords: COVID-19 pandemic, Attitude and perception towards Vaccination hesitancy, influencing factors, theories associated with COVID-19 vaccine, college students.