Activity In Diabetic Patients Research Articles

Effect of physical activity on risk reduction of infective endocarditis among patients with diabetes: a nationwide cohort study.

Patients with diabetes mellitus (DM) are at a higher risk of infectious diseases, and exercise is an important treatment modality for DM. Despite their susceptibility to infection in diabetic patients, the association between the amount of physical activity and the incidence of infective endocarditis (IE) is unclear. We attempted to demonstrate risk reduction by physical activity in diabetic patients with IE. From the National Health Insurance database, patients with DM were verified, and the incidence of IE was investigated. The level of physical activity was categorized into < 500, 500-999, 1,000-1,499, and ≥ 1,500 metabolic equivalent task (METs) minutes/week. Cox proportional hazard models were used to analyze the relationship between incident IE and physical activity. A total of 2,603,012 patients were included in this study. The incidence rate of IE was 10.06, 9.45, 7.78, and 8.84 in < 500, 500-999, 1,000-1,499, and ≥ 1,500 METs-minutes/week groups, respectively (100,000 person/year). A significant risk reduction of incident IE was observed in the 1,000-1499 and ≥ 1,500 METs-min/week groups compared to the < 500 METs-min/week group (Hazard ratio = 0.82, 95% confidence interval [0.690-0.976], HR = 0.831, 95% CI [0.704-0.981]). An analysis of a large national cohort database demonstrated that physical exercise reduced the risk of IE in patients with DM.

Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality.

Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and retinopathy. Our previous research identified CTSL as a pivotal protease promoting SARS-CoV-2 infection. Here, we demonstrate elevated blood CTSL levels in individuals with diabetes, facilitating SARS-CoV-2 infection. Chronic hyperglycemia correlates positively with CTSL concentration and activity in diabetic patients, while acute hyperglycemia augments CTSL activity in healthy individuals. In vitro studies reveal high glucose, but not insulin, promotes SARS-CoV-2 infection in wild-type cells, with CTSL knockout cells displaying reduced susceptibility. Utilizing lung tissue samples from diabetic and non-diabetic patients, alongside Leprdb/dbmice and Leprdb/+mice, we illustrate increased CTSL activity in both humans and mice under diabetic conditions. Mechanistically, high glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum (ER) to the lysosome via the ER-Golgi-lysosome axis. Our findings underscore the pivotal role of hyperglycemia-induced CTSL maturation in diabetic comorbidities and complications.

Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and retinopathy. Our previous research identified CTSL as a pivotal protease promoting SARS-CoV-2 infection. Here, we demonstrate elevated blood CTSL levels in individuals with diabetes, facilitating SARS-CoV-2 infection. Chronic hyperglycemia correlates positively with CTSL concentration and activity in diabetic patients, while acute hyperglycemia augments CTSL activity in healthy individuals. In vitro studies reveal high glucose, but not insulin, promotes SARS-CoV-2 infection in wild-type cells, with CTSL knockout cells displaying reduced susceptibility. Utilizing lung tissue samples from diabetic and non-diabetic patients, alongside Leprdb/dbmice and Leprdb/+mice, we illustrate increased CTSL activity in both humans and mice under diabetic conditions. Mechanistically, high glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum (ER) to the lysosome via the ER-Golgi-lysosome axis. Our findings underscore the pivotal role of hyperglycemia-induced CTSL maturation in diabetic comorbidities and complications.

Nurse-led follow-up care versus routine health education and follow-up in diabetes patients: An effectiveness analysis.

Patients with diabetes have physical and psychological issues due to chronic illness. According to the guidelines of the Chinese Diabetes Society, after the diagnosis of patients with diabetes, they should receive routine health education, but this is the passive installation method of education. Nurses have made important contributions to the follow-up, education, and support of patients with diabetes and their families. The objective of this study was to evaluate the effectiveness of nurse-led follow-up care in routine health education and follow-up for patients with diabetes. Medical records of 721 patients with type 1 and type 2 diabetes were reviewed. Patients received nurse-led follow-up care including educational programs + Tai Chi exercises (patients received nurse-led follow-up care including educational programs for 6 months, n = 108), routine health education and follow-up + Tai Chi exercises (patients received routine health education and follow-up for 6 months, n = 205), or Tai Chi exercises only, but did not receive nurse-led follow-up care or routine health education and follow-up (patients received Tai Chi exercises only for 6 months, n = 408) for 6-months. The Zung Self-Rating Depression and Anxiety Scale and Summary of Diabetes Self-Care Activities were used to evaluate anxiety, depression, and self-care activities, respectively. Before the start of follow-up care (BFC), knowledge regarding diabetes and its threat was ≤1.75, anxiety and depression scores were ≥52 each, and self-care activities were ≤37. After 6 months of follow-up care, patients in the patients received nurse-led follow-up care including educational programs for 6 months improved their knowledge regarding diabetes and its threat, anxiety, depression, and self-care activities as compared to their before the start of follow-up care conditions and patients in the RF and patients received Tai Chi exercises only for 6 months at after 6 months of follow-up care conditions (P < .001 for all). Chinese type 1 or 2 diabetes patients had worse physical and psychological conditions and less knowledge regarding diabetes and its threat. Nurse-led aftercare, including educational programs with Tai Chi exercises for 6 months, decreased anxiety and depression and improved knowledge regarding diabetes and its threat and self-care activities in diabetic patients (Level of Evidence: IV; Technical Efficacy: Stage 5).

ACMSD mediated de novo NAD+ biosynthetic impairment in cardiac endothelial cells as a potential therapeutic target for diabetic cardiomyopathy

Object: The highly conserved α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) is the key enzyme that regulates the de novo NAD+ synthesis from tryptophan. NAD+ metabolism in diabetic cardiomyopathy (DCM) was not elucidated yet. MethodsMice were assigned to non-diabetic (NDM) group, streptozocin (STZ)-induced diabetic (DM) group, and nicotinamide (NAM) treated (DM+NAM) group. ACMSD mediated NAD+ metabolism were studied both in mice and patients with diabetes. ResultsNAD+ level was significantly lower in the heart of DM mice than that of the NDM group. Supplementation with NAM could partially increased myocardial capillary density and ameliorated myocardial fibrosis by increasing NAD+ level through salvage pathway. Compared with NDM mice, the expression of ACMSD in myocardial endothelial cells of DM mice was significantly increased. It was further confirmed that in endothelial cells, high glucose promoted the expression of ACMSD. Inhibition of ACMSD could increase de novo NAD+ synthesis and improve endothelial cell function by increasing Sirt1 activity. Targeted mass spectrometry analysis indicated increased ACMSD enzyme activity in diabetic patients, higher ACMSD activity increased risk of heart diastolic dysfunction. ConclusionIn summary, increased expression of ACMSD lead to impaired de novo NAD+ synthesis in diabetic heart. Inhibition of ACMSD could potentially improve DCM.

Altered brain activity in diabetic patients with erectile dysfunction revealed by fractional amplitude of low-frequency fluctuation: A resting-state fMRI study.

Diabetes mellitus is one of the major chronic diseases, which enhances the risk of erectile dysfunction. However, the central pathological mechanisms of erectile dysfunction in diabetes mellitus patients are still unclear. Resting-state functional magnetic resonance imaging data were acquired in 30 type-2 diabetes mellitus, 31 type-2 diabetes mellitus with erectile dysfunction patients, and 31 healthy controls. The measure of fractional amplitude of low-frequency fluctuation was calculated and compared among groups. Differences of fractional amplitude of low-frequency fluctuation values were found in the left superior frontal gyrus (medial) and middle temporal gyrus among three groups. Compared with healthy controls group, type-2 diabetes mellitus group exhibited lower fractional amplitude of low-frequency fluctuation values in the left superior frontal gyrus (dorsolateral), anterior cingulate gyrus, calcarine fissure, and increased fractional amplitude of low-frequency fluctuation values in the left post-central gyrus. Compared with healthy controls group, erectile dysfunction with type-2 diabetes mellitus group exhibited lower fractional amplitude of low-frequency fluctuation values in the left superior frontal gyrus (medial), middle temporal gyrus, temporal middle (pole), and increased fractional amplitude of low-frequency fluctuation values in the right post-central gyrus. Compared with type-2 diabetes mellitus group, erectile dysfunction with type-2 diabetes mellitus group exhibited increased fractional amplitude of low-frequency fluctuation values in the right median cingulum gyrus and left calcarine fissure. Erectile dysfunction with type-2 diabetes mellitus patients showed functional changes in brain regions that were closely correlated with sexual dysfunction, which suggested that altered regional brain activity might be related to the pathophysiology of erectile dysfunction with type-2 diabetes mellitus.

Determinatin of Aldose Reductase (AR) activity in Diabetic Patients

The current study included estimation of Aldose reductase (AR) activity in serum of diabetic patients. The study included (47) samples of seram from diabetic patients serum (both types I and II), the patients age ranged from (9-80) years old, and (36) samples of seram from healthy people (control group) aged between (12-80) years old. The results showed significant elevation (P &lt;0.05) in the AR activity in diabetic patients for both types compared with control group. The AR activity was (38.65 ±9.60) IU/ L in the serum of type II diabetes patients and (29.52 ± 5.75) IU/ L in patients with type I diabetes, compared to (11.01 ± 2.19) IU/ L in the serum of healthy people

The Relationship of Self-Care Activities with Blood Pressure of Diabetes Mellitus Type II Patients

Diabetes mellitus (DM) and hypertension are diseases that often appear together. DM patients with hypertension are at risk for microvascular and macrovascular complications. Self-care activities that are carried out regularly will improve the health condition of DM patients, thereby reducing the risk of complications. This study aims to determine the relationship between self-care activities and blood pressure in type II DM patients at the BPJS Kesehatan Palangka Raya Prolanis Club. The research design uses correlation analysis with a cross-sectional approach; the research population is all members of the Prolanis Club BPJS Kesehatan Palangka Raya. The number of samples was as many as 35 people with the purposive sampling technique. The research instrument used a questionnaire, The Summary of Diabetes Self-Care Activities Measure (SDSCA); the collected data was analyzed using the chi-square test. The results showed that as many as (51.4%) of diabetic patients had good self-care activity status, totaling 18 respondents. As many as 51.4% of respondents have normal blood pressure status. The statistical results of this study obtained p value = 0.028 (p &lt;0.05), and r = 6.240, meaning that there is a relationship between self-care activities and blood pressure in type II DM patients. It means that the higher the self-care activity in diabetic patients, the blood pressure tends to be normal. Recommendations for further research are identifying the inhibiting factors in self-care activities for type II DM patients.

Association between physical exercise and all-cause and CVD mortality in patients with diabetes: an updated systematic review and meta-analysis.

Physical activity is recommended in guidelines for treatment for diabetes, but the association between physical activity and mortality among diabetic patients has not been extensively studied. Databases were searched from inception to July 10, 2020. Prospective studies were selected to evaluate the association between physical activity and risk for total and cardiovascular diseases (CVD) mortality among diabetic patients. Data were pooled using random-effect model to calculate the relative risks (RRs) with 95% confidence intervals (CIs). We included 16 eligible studies involving with 155,203 diabetic participants and 13,821 cases of death. Our study suggested that physical activity in diabetic patients may decrease risk for all-cause (RR 0.57, 95% CI 0.49-0.67) and CVD mortality (RR 0.55, 95% CI 0.34-0.68). The summary RR for CVD events was 0.65 (95% CI 0.41-1.03). Furthermore, the reductions in all-cause mortality were more significant in diabetic patients with old age (> 60 years) (RR 0.46, 95% CI 0.29 -0.75), higher body mass index (BMI ≥ 28) (RR 0.53, 95% CI 0.42-0.69) and shorter duration of diabetes (RR 0.45, 95% CI 0.24-0.84). Physical activity reduced the risk of total and CVD mortality among patients with diabetes, in particular in diabetic patients with old age (> 60 years), obesity and shorter duration of diabetes.

Approach of Physical Activity in Type 1 Diabetic Patients

Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease caused by an absolute deficiency of insulin because of the destruction of β cells islet of the pancreas. Aerobic exercise and diet are the two main points of diabetes treatment. Methods: The data for this study comes from un online survey of 50 people with health diseases, conducted between June 8 and July 12, 2021. More precisely, the data of our study are un mail-only data, with people selected randomly from a database maintained by B-Sport Plus Project. The database contains questions about physical activities in diabetic patients. Results: Among the 50 interviewers with type 1 diabetes, the largest age group covers those younger than 18 years old. 31% of the patients answered that health conditions limit their daily activity. 47% of them spent 1-2 h on sport and recreational activity per day. 47% of the patients reported they do multiple sport activities, the others do leisurely walking (walking their dog), bicycling, skating, swimming and curling, gardening and light housework, dancing or other moderate exercise classes, weight training and running, brisk walk. 62% of them reported that they are willing to exercise 1-2 hours per day. 33% of the patients reported they do not participate in sport and recreational activities from lack of time, the others from financial constraints, family and friends influence, lack of self-confidence, illness/injury, problems with transportation. Conclusion Aerobic exercise can improve the sensitivity of Insulin, blood glucose and lipid metabolism, thereby reducing insulin dosage and improving glycemic control. WHO recommends at least 150 minutes of moderate physical activity per week. T1DM patients, physiotherapists or fitness trainers, kinesiologists and endocrinologists need to fully understand how physical activity effect metabolism and implement individualized aerobic exercise programs.

Estimating The Efficiency Of Phagocytic Neutrophil Cells And Studying Its Risk Factors Among Diabetic Foot Ulcers

There are several factors that affect the efficiency of phagocytic activity in diabetic patients. In this study, a significant difference of phagocytosis efficiency showed in diabetic patients and controls (non-diabetic). The means of phagocytic activity were 43.05%, 52.70% and 71.35% for diabetic foot ulcer, diabetes mellitus patients and controls respectively. Age groups, mean blood glucose levels and controlling fasting blood glucose were significant factors effects on phagocytic activity (P-value = 0.022, 0.013 and 0.045) respectively. There was reverse significant correlation between the mean blood glucose and phagocytic activity (P-value = 0.049; r =-0.314). Wagner grade ulcers classified I and II were the most prevalent 30% for both in diabetic foot ulcer patients. And we found that there is a weak negative correlation between the phagocytic activity efficiency and the grades of the classified ulcers (r =-0.323). In this study, we revealed that the efficiency of phagocytic activity was affected by many factors. Level of blood glucose control was the most important factor.

Self-management activities and diabetes control of diabetic patients in Muang district, Nan province

Objectives To evaluate the prevalence of uncontrolled diabetes and diabetic self-care activities in type 2 diabetic patients in Muang District, Nan Province and to explore the association between self-care activities and glycemic control. Methods Participants were interviewed for general information, self-care activities and self-efficacy. Self-care activities in diabetic patients were assessed using the Summary Diabetes Self-Care Activities (SDSCA) questionnaire. Hemoglobin A1c (HbA1c) was collected to evaluate glycemic control. The data was analyzed using logistic regression analysis. Results Of 222 patients, more than half (56.76%) had poor glycemic control. Using multivariate regression analysis, lower SDSCA scores in diet and foot care activities were found to be associated with poor glycemic control (adjusted odds ratio = 2.29, p &lt; 0.001 and adjusted odds ratio = 1.52, respectively; p-value 0.022). Conclusion The majority of the diabetic patients had poor glycemic control. Healthy diet is an important factor in good glycemic control. The association between foot care activity and glycemic control may not be straight forward; however, good foot care may represent adherence to prescribed diabetes treatment and appropriate life-style modification.

Beneficial Effects of Physical Activity in Diabetic Patients.

One of the main goals of diabetic therapy is to achieve the best metabolic control to prevent the development and progression of potential complications. A multidisciplinary approach characterized by the combination of diet, physical activity (PA) and drug therapy with oral and injectable (non-insulin) pharmacological agents, is desirable to optimize metabolic control. The aim of this review is to explain the contribution of PA and its beneficial effects on patients affected by type 1 (T1D) and type 2 diabetes (T2D). We provide an overview of evidence on the effects of PA for the main two types of diabetes mellitus (DM) to identify the right level of PA to be recommended. We discuss the physiological and clinical role of PA in people with DM. It can be concluded that the objective of antidiabetic therapy should be the achievement and optimization of metabolic control through a multidisciplinary approach involving non-pharmacological therapy such as diet and PA, which has a crucial role.

Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-β1/Smad signaling activity in diabetic patients complicated with pulmonary infection.

ObjectiveTo investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-β1/Smad signaling activity in diabetic patients with pulmonary infection.MethodsEighty-two type 2 diabetic patients with pulmonary infection were included in the observation group and 75 patients with simple type 2 diabetes were recruited into the control group. The fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and PLR in the two groups were compared. Complement-C1q/tumor necrosis factor related protein 3 (CTRP-3), complement-C1q/tumor necrosis factor related protein 9 (CTRP-9), leptin, adiponectin, and TGF-β1/Smad signaling pathway activity in peripheral blood mononuclear cells (PBMCs) was detected.ResultsCompared with patients in the control group, patients in the observation group presented with increased levels of FGB, HbA1c, and leptin, an increase in the PLR, and decreased serum CTRP-3, CTRP-9, and adiponectin levels. TGF-β1, p-Smad2, and p-Smad3 protein expression levels were up-regulated in PBMCs from patients in the observation group compared with the control group.ConclusionsThese results show that in type 2 diabetic patients with pulmonary infection, adipocytokine expression is altered, PLR is disturbed, and the TGF-β1/Smad signaling pathways in PBMCs are significantly activated.

2142-PUB: Major Limb Amputation Decreased Plasma DPP-1 Activity in Diabetes Patients

Metabolic syndrome and diabetes mellitus (DM) are associated with increasing DPP-4 level. In recent researches, DPP-4 inhibitor, besides from glycemic control, was found to have benefit in inflammation and cardiovascular disease. The changes of DPP-4 level in metabolic syndrome or DM patients with peripheral arterial occlusive disease (PAOD) have not been clarified. We collected 30 patients with metabolic syndrome and 30 patients without metabolic syndrome, who were scheduled to receive operation. The patients in acute disease status, in pregnancy or breast-feeding, with coagulopathy were excluded. Smoking, BMI (body mass index), underlying disease were extracted from medical record. The blood sample and the fat tissue near the surgical wound were collected. Serum DPP-4, GLP-1, HbA1c, TG, LDL level, and cytokines in fat tissue (TNF-⍺, IL-1β, IL6) were examined. This research has been approved by IRB of VGHKS. The serum DPP-4 level was significantly higher in overweight (BMI≧24) patients, and slightly higher in patient with metabolic syndrome, DM or PAOD. Among patients with metabolic syndrome, the DPP-4 level was significant lower in patients who received amputation for DM foot and/PAOD. However, this condition was not observed in traumatic amputation patients. The DPP-4 inhibitor only lower serum DPP-4 level in patients with metabolic syndrome. Serum DPP-4 level decreased after amputation for severe infection with poor peripheral perfusion, but not in traumatic amputation. This finding supports that DPP-4 was associated with inflammation and vascular disease. Disclosure L. Chen: None.

A Novel Role for Piezo1 in Diabetes-Associated Thrombosis

Thrombosis, as the underlying mechanism of coronary heart disease, stroke, and venous thromboembolism, is the leading cause of death. The risk of thrombosis is drastically increased in diabetes. As thrombosis occurs in the blood flow, cells involved undergo dynamic mechanical triggers that can result in downstream cellular responses. One key player of mechano-sensing in blood cells is the Piezo1 channel, which transduces physical stretch to Ca2+ influx in cells. We investigated in the role of Piezo1 in thrombosis and how it is dysregulated in diabetes. We developed a high-throughput imaging-based platform to test Piezo1's function in erythrocytes, leukocytes and platelets from patients’ peripheral blood. The assay utilizes Ca2+ imaging, Piezo1 modulators, and machine-learning-based imaging analysis. To test force-induced Ca2+ entry in vitro, we incorporated microfluidic devices that mimic vessel constrictions. Finally, we used Zebrafish as animal model to assess Piezo1's role in thrombosis in vivo. We found that acute hyperglycemia attenuated Piezo1 activator Yoda1-mediated Ca2+ elevation in erythrocytes by 13.0±3.0% (40 patients, p=0.004). Consistently, we observed in microfluidic devices that hyperglycemia reduced pressure-induced Ca2+ increase in erythrocytes. Conversely, Piezo1-mediated Ca2+ entry in varies blood cells increased in diabetic patients compared to healthy group, suggesting an adaptive regulation of Piezo1 expression in diabetes. To test whether the elevated Piezo1 activity contributes to the prothrombotic state, we tested in WT and Piezo1 knock-down Zebrafish. In vivo clot formation after FeCl3 injury was suppressed in Piezo1 morphants (time to occlusion WT: 64.3±3.5s, Piezo1 morphant: 92.5±4.9s, p=0.0002), suggesting that Piezo1 promotes thrombosis. Overall, we demonstrated that Piezo1's activities in blood cells are modulated in hyperglycemia and diabetes. The upregulated Piezo1 activity in diabetic patients is potentially one of the underlying mechanisms for their increased thrombosis risk, which makes Piezo1 an important diagnostic and therapeutic target.

Comparative assessment of the lifestyle and medical activity of diabetic patients with higher and secondary specialized education

The article presents the results of a sociological study, the purpose of which was to conduct a comparative analysis of the subjective opinion of the lifestyle and medical activity of patients with diabetes mellitus with higher and secondary specialized education. The data was collected using a specially designed questionnaire consisting of 36 questions. The study was conducted in 2019 at the city hospital in Khabarovsk. The study involved 90 people. The research results are analyzed using relative and average values. There were no statistically significant differences in the answers of the respondents between the groups.

Evaluation of serum gamma glutamyl transferase activity among type-2 diabetic patients in Erbil

Methods: A cross-sectional study was carried out from January to June 2016 in collaboration between the Clinical Biochemistry Department at the College of Medicine, Hawler Medical University and the Chemistry Department at the Faculty of Science and Health of Koya University. The study included 50 type 2 diabetic patients (group 1), and 50 healthy individuals (group 2). Results: The mean value of serum gamma glutamyl transferase activity was significantly higher in type 2 diabetic patients (group 1) than that of healthy individuals (group 2) (P &lt;0.001). The mean value of serum gamma glutamyl transferase activity in men diabetic patients was non significantly lower than women diabetic patients. The mean value of serum gamma glutamyl transferase activity in diabetic patients whose age was ≥50 years was non significantly higher than diabetic patients whose age was &lt;50 years. Conclusion: Based on the findings of the present study, it can be concluded that high serum gamma glutamyl transferase activity is an independent factor and has considerable potential in diagnosing and monitoring for type 2 diabetic patients.

Effects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes

ABSTRACTWe investigated the effects of Nigella sativa oil on ovary volume, nuclear factor-kappaB (NF-κB), X-linked inhibitor of apoptosis protein (XIAP) expression, and serum malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS) levels in diabetic rats. We divided 21 adult female rats into three groups: controls, diabetics and diabetics + N. sativa oil. The diabetics + N. sativa oil group was given 0.2 mg/kg/day N. sativa oil 6 days/week for 4 weeks. NF-κB and XIAP expression was assessed in ovarian sections using immunohistochemistry. The right and left ovary volumes were calculated using stereology. We also measured serum MDA, SOD, TAS and TOS levels. We found that N. sativa oil reduced hyperglycemia, but not to control levels. N. sativa oil also exhibited antioxidant properties as demonstrated by reduced serum TOS and MDA levels, and increased SOD and TAS levels compared to controls. We found no significant difference in total ovarian volume, XIAP or NF-κB expression among the groups, which may be due to the short study period. Our findings suggest that N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.

Relationship between range of motion of foot joints and amount of physical activity in middle-aged male diabetic patients.

[Purpose] This study aimed to verify the relationship between foot range of motion and the amount of physical activity in diabetic patients. [Participants and Methods] There were twenty-eight male patients with diabetes (age ranged from 50 to 69 years old) and 10 healthy, non-diabetic male individuals within the same age range in the diabetes group and control group, respectively. The passive ranges of motion of the following joints were measured in the right foot of each participant: the ankle joint, the first metatarsophalangeal joint, and the subtalar joint. The amount of daily physical activity was estimated using the short Japanese version of the International Physical Activity Questionnaire. [Results] The mean range of motion of the ankle joints in the diabetic and control groups was 55.4 ± 8.4° and 69.1 ± 9.2°, respectively, whereas the mean range of motion of the first metatarsophalangeal joints in the diabetic and control groups was 82.9 ± 9.6° and 96.3 ± 8.9°, respectively. The diabetic group showed a significantly higher restriction in joint range of motion than did the control group. The amount of physical activity was a contributing factor toward the ankle range of motion according to multiple regression analysis. [Conclusion] We determined that the range of motion in the ankle joints of diabetic patients was affected by their level of physical activity.