Estimating The Efficiency Of Phagocytic Neutrophil Cells And Studying Its Risk Factors Among Diabetic Foot Ulcers

Abstract

There are several factors that affect the efficiency of phagocytic activity in diabetic patients. In this study, a significant difference of phagocytosis efficiency showed in diabetic patients and controls (non-diabetic). The means of phagocytic activity were 43.05%, 52.70% and 71.35% for diabetic foot ulcer, diabetes mellitus patients and controls respectively. Age groups, mean blood glucose levels and controlling fasting blood glucose were significant factors effects on phagocytic activity (P-value = 0.022, 0.013 and 0.045) respectively. There was reverse significant correlation between the mean blood glucose and phagocytic activity (P-value = 0.049; r =-0.314). Wagner grade ulcers classified I and II were the most prevalent 30% for both in diabetic foot ulcer patients. And we found that there is a weak negative correlation between the phagocytic activity efficiency and the grades of the classified ulcers (r =-0.323). In this study, we revealed that the efficiency of phagocytic activity was affected by many factors. Level of blood glucose control was the most important factor.