Abstract
The objective of this study is to investigate the impact of control of blood glucose level during treatment of sudden deafness. A retrospective study was performed involving 197 patients from January, 2011 to September, 2015. All patients were administrated prednisolone (Pharmaprednisolone tab®, 5 mg/T; KoreaPharma) p.o under the following regimen: 60 mg/day for 4 days, 40 mg/day for 2 days, 30 mg/day for 1 day, 20 mg/day for 1 day, and 10 mg/day for 2 days. During treatment, pure tone audiometry and blood glucose level were investigated for each patient and the results were statistically analyzed. Mean hearing improvement was 19.2 dB for the non-diabetes group and 24.8 dB for the diabetes group. The greater improvement for diabetics was not statistically significant (p = 0.146). Hearing improvement was 25.1 dB for subjects with mean blood glucose <200 mg/dl and 24.6 dB for subjects with mean blood glucose >200 mg/dl; the difference was not statistically significant (p = 0.267). Mean blood glucose level was 200.8 mg/dl for subjects with hearing improvement >20 dB and 181.8 mg/dl for subjects with hearing improvement <20 dB; the difference was not statistically significant (p = 0.286). Control of blood glucose level during treatment of sudden deafness does not have a direct effect on prognosis.
Highlights
Sudden deafness is defined as the sudden development of unilateral or bilateral sensorineural hearing loss
The objective of this study is to investigate the impact of control of blood glucose level during treatment of sudden deafness
Studies have investigated the prognosis of sudden deafness with diabetes as a factor [1, 2], but prognosis according to hyperglycemia during steroid treatment has not yet been studied
Summary
Sudden deafness is defined as the sudden development of unilateral or bilateral sensorineural hearing loss. Mechanisms involved in the induction of hearing loss by different viruses vary greatly, raging from damage to direct inner ear structures, to induction of host immune-mediated damage. Steroid use is an effective treatment in treating patients with sudden deafness [2]. Hyperglycemia in patients with diabetes remains as an obstacle in treating sudden deafness. Studies have investigated the prognosis of sudden deafness with diabetes as a factor [1, 2], but prognosis according to hyperglycemia during steroid treatment has not yet been studied. The purpose of our study was to suggest mechanism that blood glucose level during steroid treatment could affect improvement in sudden deafness patients
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