Facing the increasingly serious issues of energy crisis and environmental pollution, it is vital to develop efficient and durable photocatalysis systems for hydrogen (H2) production from water splitting. However, for the famous CdS-based systems, the bottleneck of poor efficiency and low stability arisen from photocorrosion has not been broken through yet. In this study, a ternary composite of CdS, MoS2 and Ti3C2 MXene with intimately contact interfaces was successfully constructed via an in situ growth method, which exhibited reinforced photocatalytic H2-production activity and increased photocorrosion resistant capability. Both of experimental characterizations and density functional theory (DFT) calculations well proved that the photogenerated holes and electrons of CdS timely migrated to Ti3C2 and MoS2, respectively. As a consequence, the optimal sample displayed a high H2 production rate of 14.88 mmol·h−1·g−1 with a lifetime of up to 78 h, and the component and structure of the composite were kept intact during the photocatalysis reaction. This work highlights the synergistic effect of the Ti3C2 MXene and MoS2 as redox dual cocatalysts on the promoted photocatalytic performance and durability of CdS, which can be anticipated to significantly enhance the commercial availability of CdS and even boost its incorporation into industrial applications.