Activity Behavior Research Articles

Targeting fear memories: Examining pharmacological disruption in a generalized fear framework

Labilization-reconsolidation, which relies on retrieval, has been considered an opportunity to attenuate the negative aspects of traumatic memories. A therapeutic strategy based on reconsolidation blockade is deemed more effective than current therapies relying on memory extinction. Nevertheless, extremely stressful memories frequently prove resistant to this process. Here, after inducing robust fear memory in mice through strong fear conditioning, we examined the possibility of rendering it susceptible to pharmacological modulation based on the degree of generalized fear (GF). To achieve this, we established an ordered gradient of GF, determined by the perceptual similarity between the associated context (CA) and non-associated contexts (CB, CC, CD, and CE) to the aversive event. We observed that as the exposure context became less similar to CA, the defensive pattern shifted from passive to active behaviors in both male and female mice. Subsequently, in conditioned animals, we administered propranolol after exposure to the different contexts (CA, CB, CC, CD or CE). In males, propranolol treatment resulted in reduced freezing time and enhanced risk assessment behaviors when administered following exposure to CA or CB, but not after CC, CD, or CE, compared to the control group. In females, a similar change in behavioral pattern was observed with propranolol administered after exposure to CC, but not after the other contexts. These results highlight the possibility of indirectly manipulating a robust contextual fear memory by controlling the level of generalization during recall. Additionally, it was demonstrated that the effect of propranolol on reconsolidation would not lead to a reduction in fear memory per se, but rather to its reorganization resulting in greater behavioral flexibility (from passive to active behaviors). Finally, from a clinical viewpoint, this would be of considerable relevance since following this strategy could make the treatment of psychiatric disorders associated with traumatic memory formation more effective and less stressful.

Influence of a Modified Drinking System and Barn Climate on the Behavior of Fattening Turkeys (Meleagris gallopavo)

Agonistic behavior is a problem of animal welfare in commercial turkey fattening. In this study, possible influences of the barn layout and the climate of the barn on the behavior of fattening turkeys on a commercial farm were investigated. The study was conducted on a turkey farm with two comparable barns. A modified ventilation system was installed in the trial barn to improve the removal of NH3 and CO2. The drinkers were rearranged to increase the animals’ free floor area. In each barn, 3600 male turkeys (B.U.T. 6) were housed. Videos were recorded continuously from housing until removal for three consecutive fattening periods. NH3 and CO2 values were recorded. Turkeys showed increased activity (p < 0.001) and comfort behavior in the trial barn during late fattening (p = 0.002). Agonistic behavior increased during late fattening, particularly around the drinkers (p < 0.001). NH3 levels differed at the beginning of fattening. The study shows that extending the resting area contributes to increased activity and comfort behavior. The rearrangement of drinkers showed no positive effects on agonistic behavior, as the distance between individual drinkers was too small. Due to behavioral differences being most evident in late fattening, no conclusions can be drawn concerning the influence of CO2 and NH3.

Effects of Universal School-Based Parental Support for Children's Healthy Diet and Physical Activity-the Healthy School Start Plus Cluster-Randomised Controlled Trial.

Health promotion from an early age is key to preventing unhealthy weight development in childhood, and parental involvement is essential. The school-based Healthy School Start intervention aims to promote healthy dietary and activity habits in the home environment and prevent child obesity through parental support. This study evaluated the effectiveness of the third iteration of the programme on children's dietary and activity behaviours, and body composition through a cluster-randomised controlled trial. The trial included 17 schools (8 intervention) in disadvantaged areas in mid-Sweden with 353 families with 5- to 7-year-old children. The primary outcomes were intake of selected healthy and unhealthy foods and beverages measured using photography. Secondary outcomes were physical activity and sedentary time measured by accelerometry, and measured weight and height. All outcomes were assessed at baseline and post-intervention (8months). Linear multi-level regression showed significant favourable effects of the intervention for intake of sweet beverages (b = - 0.17, p = 0.04), intake of healthy foods (b = 0.11, p = 0.04), and more time in moderate to vigorous physical activity during weekdays (b = 5.68, p = 0.02). An unfavourable sub-group effect of the intervention was found for children from families with low education regarding sedentary time on weekends (b = 23.04, p = 0.05). The results align with the previous two trials of the programme, indicating that school-based parental support is a useful approach for health promotion in young children in disadvantaged areas. Trial registration: ClinicalTrials.gov: No. NCT03390725, retrospectively registered on January 4, 2018, https://clinicaltrials.gov/ct2/show/NCT03390725 .

Physical activity and sedentary behavior perceptions in overweight and obese adults: A systematic review of qualitative study

Background One of the largest hazards to human health is obesity, which is intimately related to sedentarism and physical inactivity. Understanding the perspectives and attitudes of adults with overweight or obesity towards their lifestyle choices related to sedentary behavior and physical activity is essential for mitigating associated health risks. Objective This systematic review aims to collate the extent of qualitative research on the perception of sedentary behavior and physical activity among adults with overweight and obesity. Methods A comprehensive search of Scopus, PubMed, CINAHL, and Web of Science, databases was conducted, which yielded 2,881 articles. A total of 2591 abstracts were screened, and 45 full-text articles were examined. A total of nine qualitative studies involving adults with overweight or obesity (BMI > 25 kg/m2) were included in this systematic review. Data extraction utilized Rayyan.qcri.org software, and studies were critically appraised using Joanna Briggs’s Institute checklist for qualitative research. Results The included studies revealed a diverse array of themes, wherein a few perceived factors reported towards sedentary behavior were lack of awareness about the hazards, mode of relaxation, family commitment, technology use, motivation deficits, and fatigue. Barriers to physical activity encompassed social, cultural, and environmental factors. In contrast, peer support, fitness facility access, accountability, mental health awareness, well-being, and weight management facilitate physical activity involvement. Conclusion Perceptions in overweight and obese adults on sedentary living and exercise are intricate and multifaceted. This review provides valuable insights that can inform clinicians and researchers in promoting regular physical activity for adults with overweight and obesity.

Effectiveness of behavioural interventions with motivational interviewing on physical activity outcomes in adults: systematic review and meta-analysis

ObjectiveTo evaluate the effectiveness of behavioural interventions that include motivational interviewing on physical activity outcomes in adults.DesignSystematic review and meta-analysis.Study selectionA search of seven databases for randomised controlled trials published...

Structurally-constrained encoding framework using a multi-voxel reduced-rank latent model for human natural vision.

Voxel-wise visual encoding models based on convolutional neural networks (CNNs) have emerged as one of the prominent predictive tools of human brain activity via functional magnetic resonance imaging (fMRI) signals. While CNN-based models imitate the hierarchical structure of the human visual cortex to generate explainable features in response to natural visual stimuli, there is still a need for a brain-inspired model to predict brain responses accurately based on biomedical data. To bridge this gap, we propose a response prediction module called the Structurally Constrained Multi-Output (SCMO) module to include homologous correlations that arise between a group of voxels in a cortical region and predict more accurate responses. This module employs all the responses across a visual area to predict individual voxel-wise BOLD responses and therefore accounts for the population activity and collective behavior of voxels. Such a module can determine the relationships within each visual region by creating a structure matrix that represents the underlying voxel-to-voxel interactions. Moreover, since each response module in visual encoding tasks relies on the image features, we conducted experiments using two different feature extraction modules to assess the predictive performance of our proposed module. Specifically, we employed a recurrent CNN that integrates both feedforward and recurrent interactions, as well as the popular AlexNet model that utilizes feedforward connections. In the end, we demonstrate that the proposed framework provides a reliable predictive ability to generate brain responses across multiple areas, outperforming benchmark models in terms of stability and coherency of features.

Community-Based Participatory Obesity Prevention Interventions in Rural Communities: A Scoping Review

Child obesity is a worldwide public health concern. In America, children from rural areas have greater odds of obesity in comparison to those from urban areas. Community-engaged research is important for all communities, particularly under-represented communities. This paper reports the results of a scoping review investigating community-engaged research in obesity prevention programs tested with school-aged children in rural America. A literature search of Medline Ovid was conducted to identify interventions reporting the results of obesity prevention interventions that promoted a healthy diet or physical activity (PA) behaviors to school-age children in rural communities of the United States (US). After title and abstract review, potentially relevant citations were further examined by assessing the full text. Each stage of review was conducted by two independent reviewers. Twelve studies met the inclusionary criteria and are included in this review. Most of the studies focused on elementary school participants (n = 7) and improving both diet and PA (n = 9). Out of the twelve studies, only five included the target audience in intervention development or implementation. The most popular type of community engagement was community participation (n = 4). This review revealed that community-engaged research is under-utilized in obesity prevention interventions tested with school-aged children in rural US communities.

Effectiveness of behavioural interventions with motivational interviewing on physical activity outcomes in adults: systematic review and meta-analysis

ObjectiveTo evaluate the effectiveness of behavioural interventions that include motivational interviewing on physical activity outcomes in adults.DesignSystematic review and meta-analysis.Study selectionA search of seven databases for randomised controlled trials published...

The Effect of Omega-3 Fatty Acid Supplementation and Exercise on Locomotor Activity, Exploratory Activity, and Anxiety-Like Behavior in Adult and Aged Rats.

Aging is an inevitable and complex biological process that is associated with a gradual decline in physiological functions and a higher disease susceptibility. Omega-3 fatty acids, particularly docosahexaenoic acid, play a crucial role in maintaining brain health and their deficiency is linked to age-related cognitive decline. Combining omega-3-rich diets with exercise may enhance cognitive function more effectively, as both share overlapping neurobiological and physiological effects. This study aimed to evaluate the effect of exercise and omega-3 fatty acid (FA) supplementation in two different doses (160 mg/kg and 320 mg/kg) on anxiety-like behavior and cognitive abilities in both adult and aged rats. Male Wistar rats (4-5- and 23-24-month-old) were randomly divided into seven groups: 3-week control supplemented with placebo without exercise, low-dose omega-3 FAs, high-dose omega-3 FAs, 7-week control supplemented with placebo without exercise, exercise-only, low-dose omega-3 FAs with exercise, and high-dose omega-3 FAs with exercise. The administered oil contained omega-3 FAs with DHA:EPA in a ratio of 1.5:1. Our results indicate that aging negatively impacts the locomotor and exploratory activity of rats. In adult rats, a low dose of omega-3 FAs reduces locomotor activity when combined with exercise while high dose of omega-3 FAs reduces anxiety-like behavior and improves recognition memory when combined with exercise. The combination of omega-3 FAs and exercise had varying impacts on behavior, suggesting a need for further research in this area to fully understand their therapeutic efficacy in the context of cognitive changes associated with aging.

Physical Activity Behaviors of Female Adolescents in Saudi Arabia.

Saudi Arabia has one of the highest childhood obesity rates worldwide. The primary factor associated with the high prevalence of obesity among adolescents is a lack of physical activity (PA). Compared to male adolescents, very few Saudi female adolescents meet the World Health Organization recommendation of achieving 60 min of moderate to vigorous PA per day, putting them at a higher risk of overweight and obesity. This cross-sectional study aimed to examine the relationship between the theory of planned behavior and psychosocial factors, including attitude toward PA, subjective norms, perceived behavioral control (PBC), PA intention, and self-reported PA among Saudi female adolescents. A convenience sample of 329 Saudi female adolescents was recruited from all-female public intermediate and high schools in the Eastern Region of Saudi Arabia. Data were collected using online self-administered questionnaires. The theoretical model was examined using structural equation modeling. The findings revealed a higher prevalence of overweight compared to obesity among participants. About half the participants were from families with a medium monthly income. The mean PA score indicated a low level of PA. The model demonstrated significant explanatory power for both PA intention and PA behavior, respectively. The strongest predictor of adolescents' intention was attitude, followed PBC.Moreover, the female adolescents' attitudes and PBC had significant indirect effects on self-reported PA through intention, while intention had a direct effect on PA. The model did not support a direct or indirect relationship between subjective norms and PA. The findings provide essential support for targeting attitude and perceived behavior control of female adolescents in order to enhance their PA intention. This theoretical understanding can help design effective theory-based interventions that promote PA among Saudi female adolescents.

The relationship between physical activity and procrastination behavior among Chinese university students: a chain mediated effect of body self-esteem and overall self-esteem.

This study aimed to explore the relationship between physical activity and procrastination behavior among college students and the serial mediating roles of body self-esteem and overall self-esteem. A cross-sectional survey was conducted involving 1,018 college students. The Physical Activity Rating Scale, the College Students' Physical Self-perception Profile, the Self-Esteem Scale, and the Chinese Procrastination Scale were utilized. Serial mediating effect analysis and Bootstrap analysis were applied to the data. (1) Individuals engaging in high levels of physical activity demonstrated significantly lower levels of procrastination behavior compared to those with moderate or low levels of physical activity (Partial η2 = 0.01, F = 2.762, p < 0.01). (2) Physical activity was positively correlated with body self-esteem (r = 0.37, p < 0.01) and overall self-esteem (r = 0.29, p < 0.01), and negatively correlated with procrastination behavior (r = -0.14, p < 0.01). body self-esteem was positively correlated with overall self-esteem (r = 0.11, p < 0.01) and negatively correlated with procrastination behavior (r = -0.13, p < 0.01). Overall self-esteem also showed a significant negative correlation with procrastination behavior (r = -0.26, p < 0.01). (3) Mediation effect analysis indicated that body self-esteem and overall self-esteem played partial mediating roles in the relationship between physical activity and procrastination behavior among college students. The mediating effects were composed of three pathways: "Physical Activity → body self-esteem → Procrastination Behavior," "Physical Activity → Overall Self-Esteem → Procrastination Behavior," and "Physical Activity → body self-esteem → Overall Self-Esteem → Procrastination Behavior," with the effect sizes accounting for 27.70, 12.26, and 7.28% of the total effect, respectively. The findings of this study lead to several key conclusions regarding the relationship between physical activity, self-esteem, and procrastination behavior among college students. Firstly, engagement in moderate levels of physical activity is more effective in reducing procrastination behavior among college students. Secondly, participation in high volumes of physical activity is associated with increased levels of both body self-esteem and overall self-esteem. Lastly, physical activity not only directly impacts procrastination behavior but also indirectly influences it by enhancing body self-esteem and overall self-esteem, thereby further reducing the individual's level of procrastination. These conclusions suggest that physical activity plays a multifaceted role in mitigating procrastination behavior in college students. By promoting self-esteem, physical activity can foster a positive psychological state that is conducive to proactive behavior and academic success. The study's findings underscore the importance of integrating physical activity into college students' daily routines as a strategy to combat procrastination and enhance self-esteem.

The relationship between physical activity and procrastination behavior among Chinese university students: a chain mediated effect of body self-esteem and overall self-esteem

ObjectiveThis study aimed to explore the relationship between physical activity and procrastination behavior among college students and the serial mediating roles of body self-esteem and overall self-esteem.MethodsA cross-sectional survey was conducted involving 1,018 college students. The Physical Activity Rating Scale, the College Students’ Physical Self-perception Profile, the Self-Esteem Scale, and the Chinese Procrastination Scale were utilized. Serial mediating effect analysis and Bootstrap analysis were applied to the data.Results(1) Individuals engaging in high levels of physical activity demonstrated significantly lower levels of procrastination behavior compared to those with moderate or low levels of physical activity (Partial η2 = 0.01, F = 2.762, p &amp;lt; 0.01). (2) Physical activity was positively correlated with body self-esteem (r = 0.37, p &amp;lt; 0.01) and overall self-esteem (r = 0.29, p &amp;lt; 0.01), and negatively correlated with procrastination behavior (r = −0.14, p &amp;lt; 0.01). body self-esteem was positively correlated with overall self-esteem (r = 0.11, p &amp;lt; 0.01) and negatively correlated with procrastination behavior (r = −0.13, p &amp;lt; 0.01). Overall self-esteem also showed a significant negative correlation with procrastination behavior (r = −0.26, p &amp;lt; 0.01). (3) Mediation effect analysis indicated that body self-esteem and overall self-esteem played partial mediating roles in the relationship between physical activity and procrastination behavior among college students. The mediating effects were composed of three pathways: “Physical Activity → body self-esteem → Procrastination Behavior,” “Physical Activity → Overall Self-Esteem → Procrastination Behavior,” and “Physical Activity → body self-esteem → Overall Self-Esteem → Procrastination Behavior,” with the effect sizes accounting for 27.70, 12.26, and 7.28% of the total effect, respectively.ConclusionThe findings of this study lead to several key conclusions regarding the relationship between physical activity, self-esteem, and procrastination behavior among college students. Firstly, engagement in moderate levels of physical activity is more effective in reducing procrastination behavior among college students. Secondly, participation in high volumes of physical activity is associated with increased levels of both body self-esteem and overall self-esteem. Lastly, physical activity not only directly impacts procrastination behavior but also indirectly influences it by enhancing body self-esteem and overall self-esteem, thereby further reducing the individual’s level of procrastination. These conclusions suggest that physical activity plays a multifaceted role in mitigating procrastination behavior in college students. By promoting self-esteem, physical activity can foster a positive psychological state that is conducive to proactive behavior and academic success. The study’s findings underscore the importance of integrating physical activity into college students’ daily routines as a strategy to combat procrastination and enhance self-esteem.

Role of ten different exogenous plant growth promoters in regulating cytotoxic and genotoxic processes in barley exposed to high temperature stress

Agricultural crop affected preliminary and the most prominent by the adverse effects of global climate change have to adapt to various abiotic factors that will occur as a result of climate fluctuations in the near-future and struggle to survive. Among abiotic factors, the one of the greatest impact on plant stress is high temperature. Therefore, the most important step to take action against the global threat is the development of new temperature tolerant varieties. Barley, which is the fourth most important cereal in the world after wheat, maize, and rice are affected by high ambient temperatures. In this work, the effects of their alone and in double, triple combinations of ten various plant growth regulators (PGRs) on mitotic activity and chromosome behaviors in root meristems of barley exposed to high temperature (30°C) were investigated. In the experiments, Hordeum vulgare L. cv. Bülbül 89 variety and GA3, KIN, BA, E, EBR, TRIA and PAs (Spm, Spd, Put, Cad) as growth regulators were used. The results obtained were compared with each other and with those of the seeds germinated at optimum temperature (20°C). Consequently; it has been determined that most of the PGRs studied, especially the GA3 and their combinations with GA3, exhibit a very successful performance on mitotic activity and cytogenetic aberrations in barley seeds germinated under high temperature stress- HTS conditions. The effects of these PGRs (except for EBR) and their combinations on mitotic activity and chromosome behaviors under HTS have been presented in this study for the first time.

Adult neurogenesis is necessary for functional regeneration of a forebrain neural circuit

In adult songbirds, new neurons are born in large numbers in the proliferative ventricular zone in the telencephalon and migrate to the adjacent song control region HVC (acronym used as proper name) [A. Reiner et al., J. Comp. Neurol. 473, 377-414 (2004)]. Many of these new neurons send long axonal projections to the robust nucleus of the arcopallium (RA). The HVC-RA circuit is essential for producing stereotyped learned song. The function of adult neurogenesis in this circuit has not been clear. A previous study suggested that it is important for the production of well-structured songs [R. E. Cohen, M. Macedo-Lima, K. E. Miller, E. A. Brenowitz, J. Neurosci. 36, 8947-8956 (2016)]. We tested this hypothesis by infusing the neuroblast migration inhibitor cyclopamine into HVC of male Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii) to block seasonal regeneration of the HVC-RA circuit. Decreasing the number of new neurons in HVC prevented both the increase in spontaneous electrical activity of RA neurons and the improved structure of songs that would normally occur as sparrows enter breeding condition. These results show that the incorporation of new neurons into the adult HVC is necessary for the recovery of both electrical activity and song behavior in breeding birds and demonstrate the value of the bird song system as a model for investigating adult neurogenesis at the level of long projection neural circuits.

Evidence of acrylamide-induced behavioral deficit, mitochondrial dysfunction and cell death in Drosophila melanogaster

Acrylamide (ACR), a ubiquitous compound with diverse route of exposure, has been demonstrated to have detrimental effects on human and animal health. The mechanisms underlying its toxicity is multifaceted and not fully elucidated. This study aims to provide further insight into novel pathways underlying ACR toxicity by leveraging on Drosophila melanogaster as a model organism. The concentrations of acrylamide (25, 50 and 100 mg/kg) and period of exposure (7-days) used in this study was established through a concentration response curve. ACR exposure demonstrably reduced organismal viability, evidenced by decline in survival rate, offspring emergence and deficits in activity, sleep and locomotory behaviors. Using a high-resolution respirometry assay, the role of mitochondria respiratory system in ACR-mediated toxicity in the flies was investigated. Acrylamide caused dysregulation in mitochondrial bioenergetics and respiratory capacity leading to an impaired OXPHOS activity and electron transport, ultimately contributing to the pathological process of ACR-toxicity. Furthermore, ACR exacerbated apoptosis and induced oxidative stress in D. melanogaster. The up-regulation of mRNA transcription of Reaper, Debcl and Dark genes and down-regulation of DIAP1, an ubiquitylation catalyzing enzyme, suggests that ACR promotes apoptosis through disruption of caspase and pro-apoptotic protein ubiquitination and a mitochondria-dependent pathway in Drosophila melanogaster. Conclusively, this study provides valuable insights into the cellular mechanism underlying ACR-mediated toxicity. Additionally, our study reinforces the utility of D. melanogaster as a translational tool for elucidating the complex mechanisms of ACR toxicity.

The relationship between mentally active sedentary behavior and cognitive function across different educational levels.

How education affects the relationship between sedentary behavior and cognitive function remains unclear. The aim of this study was to investigate the relationship between mentally active sedentary behavior and cognitive function in rural older Chinese across different levels of education. Data from 517 participants aged 60 years and older in rural China at baseline, 4 weeks, 8 weeks, 6 months, 12 months, and 24 months were analyzed. Univariate analysis was carried out using descriptive statistical techniques and bivariate analysis was performed using Linear mixed effects models. Total mentally active sedentary behavior time and playing cards/mahjong time were significantly associated with global cognition (0.27 points (95% CI, 0.15 to 0.39), P＜0.001; 0.30 points (95% CI, 0.18 to 0.41), P＜0.001, respectively), the attention dimension (0.08 points (95% CI, 0.02 to 0.14), P = 0.005; 0.10 points (95% CI, 0.04 to 0.16), P = 0.001, respectively), and the memory dimension (0.18 points (95% CI, 0.05 to 0.31), P &lt; 0.001; 0.19 points (95% CI, 0.13 to 0.25), P＜0.001, respectively). Such associations were more pronounced in illiterate participants. Our study suggested a positive association between mentally active sedentary behavior and cognitive function, with the association being more pronounced among illiterate older adults compared to the relatively well-educated. Future cognitive interventions should focus more on mentally active behavior. In addition, education-specific intervention strategy may be considered in cognitive interventions.

Phonon-mediated spin transport in quantum paraelectric metals

The concept of ferroelectricity is now often extended to include continuous inversion symmetry-breaking transitions in various metals and doped semiconductors. Paraelectric metals near ferroelectric quantum criticality, which we term ‘quantum paraelectric metals,’ possess soft transverse optical phonons which can have Rashba-type coupling to itinerant electrons in the presence of spin-orbit coupling. We find through the Kubo formula calculation that such Rashba electron-phonon coupling has a profound impact on electron spin transport. While the spin Hall effect arising from non-trivial electronic band structures has been studied extensively, we find here the presence of the Rashba electron-phonon coupling can give rise to spin current, including spin Hall current, in response to an inhomogeneous electric field even with a completely trivial band structure. Furthermore, this spin conductivity displays unconventional characteristics, such as quadrupolar symmetry associated with the wave vector of the electric field and a thermal activation behavior characterized by scaling laws dependent on the phonon frequency to temperature ratio. These findings shed light on exotic electronic transport phenomena originating from ferroelectric quantum criticality, highlighting the intricate interplay of charge and spin degrees of freedom.

From anticipation to action: A RCT on mental imagery exercises in daily life as a motivational amplifier for individuals with depressive symptoms.

Encouraging engagement in rewarding or pleasant activities is one of the most important treatment goals for depression. Mental imagery exercises have been shown to increase the motivation for planned behaviour in the lab but it is unclear whether this is also the case in daily life. Therefore, we aimed to investigate the effect of mental imagery exercises on motivation and behaviour in daily life. Participants with depressive symptoms (N = 59) were randomly assigned to a group receiving mental imagery (MI) exercises or a control group receiving relaxation (RE) exercises via study phones. We employed an experience sampling design with 10 assessments per day for 10days (three days baseline, four days with two exercises per day and three days post-intervention). Data was analysed using t-tests and multilevel linear regression analyses. As predicted, MI exercises enhanced motivation and reward anticipation during the intervention phase compared to RE. However, MI did not enhance active behaviour or strengthen the temporal association from reward anticipation (t-1) to active behaviour (t). Mental imagery exercises can act as a motivational amplifier but its effects on behaviour and real-life reward processes remain to be elucidated.

Associations of activity, sedentary and sleep behaviors with prevalent steatotic liver disease in middle-aged and older adults: the ELSA-Brasil study

BackgroundSteatotic liver disease (SLD) is a prevalent metabolic disease. While single component movement behaviors have been related to its development, comprehensive assessments of their joint associations are scarce.ObjectiveTo investigate the single-component and multi-component associations of moderate and vigorous physical activity (MVPA), light physical activity (LPA), sedentary behavior (SB), and sleep with prevalent SLD in Brazilian adults.MethodsA cross-sectional analysis using data from the third wave of the ELSA-Brasil cohort (2017–2019). Participants wore an ActiGraph wGT3X-BT in the waist for seven days and completed a sleep diary. SLD was defined by a Fatty Liver Index ≥ 60. To investigate single-component and multi-component associations, we used three exposure modeling approaches based on Poisson models: multivariable-adjusted regression, restricted cubic splines, and compositional data analysis.ResultsAmong 8569 participants (55.7% women, mean age 59.2 ± 8.60), 43.9% had SLD. Total activity volume adjusted for covariates was inversely associated with prevalent SLD. Every 1 mg/day increase in total activity volume was associated with a PR of 0.95 in individuals sleeping < 7 h/day (95% CI 0.94–0.97) and 0.95 (95% CI 0.93–0.96) in those sleeping ≥ 7 h/day. Increasing 30 min/day of MVPA was associated with decreasing prevalence of SLD (sleep ≥ 7 h/day [PR 0.83; 95% CI 0.77–0.89]; sleep ≥ 7 h/day [PR 0.78; 95% CI 0.74–0.83]). Sleep, SB, and LPA were not associated with SLD. Associations of total activity volume and MVPA were more pronounced among females. Adjustment with adiposity markers attenuated the associations.ConclusionsIn adults, total activity volume and MVPA were inversely associated with SLD in a dose–response fashion. Substituting lower-intensity behaviors with MVPA was associated with a lower prevalence of SLD independent of sleep duration, sex, and age.

Five-year follow-up of the OptiTrain trial on concurrent resistance and high-intensity interval training during chemotherapy for patients with breast cancer

The protocol predefined aim of this study is to assess sustained effects of the OptiTrain trial on several health outcomes, 5 years after the baseline assessment. The OptiTrain study was a prospective, randomised controlled trial with 240 patients with breast cancer undergoing adjuvant chemotherapy that compared the effects of 16 weeks of two exercise programs, RT-HIIT and AT-HIIT, with usual care (UC). After a 5-year follow-up, eligible participants were evaluated for the primary outcome of cancer-related fatigue (CRF) and secondary outcomes including quality of life, symptoms, muscle strength, cardiorespiratory fitness, body mass, physical activity, and sedentary behavior. Statistical analysis was conducted using linear mixed models adjusted for baseline values. Tumour profile and menopausal status were additionally adjusted for CRF. Mean differences (MD), 95% confidence intervals (CIs), and standardized effect sizes (ES) were reported. At the 5-year follow-up, there were no statistically significant differences in total CRF between the intervention groups and the UC group. RT-HIIT reported significantly reduced pain sensitivity at the gluteus MD = 79.00 (95% CI 10.17, 147.83, ES = 0.55) compared to UC. Clinically meaningful differences for an increase in cognitive CRF and cardiorespiratory fitness were observed for the AT-HIIT versus UC group, and for lower limb strength for the RT-HIIT versus UC group, albeit without statistical significance. Engaging in targeted exercise during adjuvant chemotherapy for breast cancer provides short-term benefits in reducing fatigue and maintaining physical function. However, our 5-year follow-up indicates that these effects are limited in the long term. This underscores the need to support breast cancer survivors maintain their PA levels throughout their survivorship journey.