Tele-rehabilitation refers to the use of information and communication technologies to more efficiently provide rehabilitation services to people remotely in their homes or other community-based settings. The goal is to improve patient access to care by receiving therapy beyond the physical walls of a traditional healthcare facility as well as to increase self-practice thus expanding the continuity of rehabilitation care. The recent developments of advanced sensors, graphic and remote monitoring technologies have enabled development of an increasing number of Virtual Reality (VR)-based tele-rehabilitation applications. The inclusion of VR into tele-neurorehabilitation aims, similar to regular rehabilitation, to increase the physical fidelity of the treatment to enable better generalization to real life activities and to increase engagement and motivation by providing the “right” challenge to users by “immersing” them into the therapeutic task. In addition, it allows implementation of principles to increase neural plasticity by providing opportunities for intensive and goal oriented practice. When delivered remotely, this form of VR intervention is challenging, for example, due to the need of the user to learn complex activities without a therapist physically present. An additional challenge is the need to develop applications that will achieve a balance between physical fidelity, level of challenge to the user and immersion, to assure quality of movements when the therapist is not present. The purpose of this presentation is to show evidence-based examples gleaned from our database of more than 200 users (and 5000 on-line sessions) who have used the CogniMotion VR tele-neurorehabilitation services over the past four years. A discussion will focus on the lessons learned while providing this form of intervention remotely. NA. NA. NA.