Activity In Albino Rats Research Articles

Effect of adrenal function on changes in serum aminotransferase activity of albino rats with shock produced by crushing the soft tissues

Effect of adrenal function on changes in serum aminotransferase activity of albino rats with shock produced by crushing the soft tissues

EFFECTS OF GLUCURONOLACTONE AND THE OTHER CARBOHYDRATES ON THE BIOCHEMICAL CHANGES PRODUCED IN THE LIVING BODY OF RATS BY HARD EXERCISE

It has been generally recognized that in a living body various biochemical changes were induced as a consequence of hard physical exercise. In the previous paper (1), the authors reported on the metabolism of glucuronic acid in the case of fatigue by physical exercise. This report was summarized as follows: the toxic (amine-like) substance in a living body increased due to physical exercise, and resulted in fatigue. The glucuronic acid content of urine, serum, liver and kidney, and the hepatic glycogen content of a living body decreased. The activity of o-aminophenylglucuronide synthesis of rat's liver was inhibited after hard physical exercise. However, these phenomena were significantly blocked by the administration of glucuronolactone. The arrest of an isolated frog heart due to the accumulation of toxic substance was checked, both prophylactically and therapeutically, by the administration of glucuronolactone. Dutton et al. (2-8) have recently proved that glucuronic acid exerted its effect after it was converted into uridine-diphospho-glucuronic acid. It is therefore apparent that exogenous glucuronic acid cannot exert its effect unless it is changed into uridine-diphospho-glucuronic acid through the Xylulose pathway, or different pathway not yet known. Though the authors have no description of the mechanism of these pathway at present, it is a fact that glucuronolactone can inhibit the toxic substance which stopped the beating of a frog's heart. As well known, uridine-diphospho-glucuronic acid is converted from various kinds of carbohydrate, namely glucose, galactose, glycogen and sodium pyruvate. The authors therefore proceeded to ascertain the effects of these carbohydrates and glucuronolactone upon the swimming-record, o-aminophenylglucuronide synthesis, glucuronic acid content, ascorbic acid content, blood sugar content, hepatic glycogen content, and β-D-glucuronide glucuronohydolase activity in albino rats made to swim hard.

Age-conditioned changes of blood serum insulin activity in albino rats: By I. P. Solenova-Filippova: Institute of Biology, University of Kharkov, pp. 333–336

Age-conditioned changes of blood serum insulin activity in albino rats: By I. P. Solenova-Filippova: Institute of Biology, University of Kharkov, pp. 333–336

Quantitation of oxygen consumption and spontaneous muscular activity of the rat.

Oxygen consumption (Vo2) and spontaneous muscular activity of albino rats, recorded with apparatus previously described and quantitated with a new technique, exhibited highly significant correlations when paired in successive 10-min periods with a 5-min lag of Vo2 ( y) in respect to spontaneous muscular activity ( x). Since fasting and nonfasting male rats of different weights (range: 156—462 g) showed at perfect rest a quite narrow scatter of metabolic rates ( y = yaKgb ± 6% se) and since y was linearly correlated with x (se = 7.1% fasting; 5.5% nonfasting), theoretical Vo2 values could be predicted from y = Kgyb( m + nx) when the appropriate value of b, experimentally found (in this case 0.48), was used. In two-thirds of the observations the lowest 5-min values of Vo2 did not represent the true basal metabolic rate of the animal since they coincided with variable amounts of spontaneous activity. Data show that the basal metabolic rate of the albino rat is more predictable than generally admitted. Submitted on May 26, 1961

Effects of Electro-Convulsive Shocks on Daily Activity of Albino Rats in Revolving Drums

ConclusionElectro-convulsive shocks in 6 female rats greatly reduced the amount of their voluntary activity for a short period of time. The major change appears within the first 24 hours and disappears within 48 hours after the last convulsive shock is administered. Within a 2-week period following their last convulsion the majority of the animals closely approximated their pre-shock levels of daily activity.