Given the growing global computer workforce, concerns exist about the escalation of computer related injury with Carpal tunnel syndrome (CTS) being one of the most reported work-related musculoskeletal disorders (WMSDs) among office workers. The optimal range of keyboard angles for sitting and standing positions based on wrist posture, forearm muscle activities and user preference as well as the keyboard location in relation to user position were analysed. 30 volunteers with an above 40 words per minute typing speed participated in this study. Result show that, although user prefer to use positive keyboard angle, the negatively tilted keyboard is more ergonomically friendly at both sitting and standing workstations, reducing muscle activity and awkward wrist posture while maintaining performance. The findings indicate that negative sloped keyboard might have the possibility to reduce the risk of developing CTS in office workers. Practitioner summary: This study determines the range of optimal slope of keyboard angle in a sit and stand workstation. Our results indicate a trend in the negative slope keyboard as an ergonomically friendly option for the intervention to Carpal tunnel pressure.