Active Woman Research Articles

Qualidade muscular, mas não espessura, é reduzida em diferentes grupos etários em idosas ativas

The aim of this study was to compare the muscle thickness (MT), muscle quality (MQ), and functionality of two different age groups of active elderly women. Twenty seven older women (between 60 and 80 years old), physically active was dividing in two age groups: old 60-66 years (Old) and old 73-80 years (Older) volunteered for the present study. Knee extension isometric peak torque (PT) was obtained during a muscle isometric voluntary contraction (MIVC), and the value was normalized by MT. The Quadriceps Echo Intensity (QEI) was defined as the mean Echo Intensity (EI) value founded in all quadriceps muscle portions in ultrasound imaging. Was found MIVC increased (p=0.024) in the O1 (120.26±24.77 N/m) group when compared with the O2 (99.25±20.95 N/m) group, but when the MIVC was normalized the difference did not exist between groups (p≥0.05). The QEI was found increased in the Older group (97.10±17.35 a.u.) when compared with the Old group (80.18±14.95 a.u.) (p<0.05). Contrary to that, the QMT did not differ significantly between the groups (p≥0.05). The Old group presented a significant higher number of repetitions in the 30SS (14.13±2.29 repetitions) when compared to Older group (11.25±1.95 repetitions) (p<0.05). We observed that even without significantly greater muscle size, the Old group presented the results of 30SS significantly greater when compared with the older group. Besides that, the QEI was found increased in the older group and suggests that EI may be the best predictor of functional capacity than muscle quantity in active older woman.

'Cupid and Psyche': a novel technique for robotic hysterosacropexy in the treatment of pelvic organ prolapse.

The purpose of any surgical repair of pelvic organ prolapse (POP) is to restore pelvic anatomy, preserving urinary, intestinal and sexual functions while avoiding complications. We present a novel robotic approach to hysterosacropexy (HSP) in the treatment of POP. In our technique (named 'Cupid and Psyche', recalling as it does the famous sculpture by Canova), the two branches of the MESH encircle the uterus from behind, lifting and supporting it.The aim of this technique is to resolve POP, minimizing the risk of vaginal erosion: the posterior 'embrace' of the uterus limits the direct contact of the mesh with the vagina, thus reducing any risk of erosion/extrusion at this level. We performed 10 cases of robotic HSP. All procedures are completed robotically. Median operative time (skin-to-skin) is 125 min [interquartile range (IQR) 85-145], including port placement, robot docking and console time. We have never had any cases of intraoperative or postoperative complications.With regard to short-term follow-up, analysis of outcomes is limited; in any case, we have never had any cases of MESH erosion or other complications, and no sexually active woman complained of dyspareunia. Maintaining sufficient motility of the vagina is another advantage of 'Cupid and Psyche', avoiding as it does any negative effects on patients' later sexual activity, granting more natural motility of both uterus and vagina but resolving the prolapse.Further prospective studies comparing the long-term functional outcomes of the various HSP techniques are needed to confirm these findings.

Ida McKinley: The Turn-of-the-Century First Lady through War, Assassination, and Secret Disability by Carl Sferrazza Anthony (review)

Reviewed by: Ida McKinley: The Turn-of-the-Century First Lady through War, Assassination, and Secret Disability by Carl Sferrazza Anthony Nicole Marino Ida McKinley: The Turn-of-the-Century First Lady through War, Assassination, and Secret Disability. By Carl Sferrazza Anthony (Kent, Ohio: Kent State Univ. Press, published in cooperation with the National First Ladies’ Library, 2013. 358pp. Cloth $45, isbn 978-1-60635-152-9.) Ida McKinley was destined for great things even before she met “the Major.” Highly educated, to a degree that many prominent men could not achieve, Ida Saxton was a bright and active young woman. She worked in her father’s bank in several capacities, eventually as manager, more as a testimony to her merit than to nepotism. Her success in the workplace, which was highly unusual for the late nineteenth century, was an indication of her mental acuity. In his biography of Ida McKinley, Carl Sferrazza Anthony gives insight into her character beyond being an ornament and political tool to William McKinley. Portrayed as not only extraordinarily bright in her youth, but also physically fit, she favored hiking and physical exercise in stark contrast to her later public image as an invalid. The ebb and flow of Ida’s health is instrumental in Anthony’s storytelling. Her varying health frequently corresponded with her husband’s political events and activity. Based in tragic truth, Ida’s epilepsy, or “infirmity” as they would call it, was not the only physical ailment she would contend with. Her illness was genuine but politically manipulated to portray her loving and doting husband as a gentle caregiver. Anthony supports this as reality by citing examples in every [End Page 102] chapter. As together they faced several tragedies—including the deaths of both of their daughters, a spinal injury to Ida, her ongoing seizures, and a financial near-catastrophe along with the struggles of public life and political jockeying—the McKinleys valued one another in a loving and supportive partnership. This devotion did not end with her husband’s untimely demise; Anthony spends a full chapter on the newly widowed Ida’s visitations to “the vault” and her mourning process. Eventually she overcame her grief, like her other obstacles, through family support and her own strength of character. Because her physical ailments are such an important component of her story, many readers would benefit from a better contextualization of the social view of epilepsy during the nineteenth century. Anthony makes reference to how it may have been viewed, but does not detail it for those without an existing understanding of the depth and pervasive stigma assigned to the affliction, which was tantamount to lunacy at the time. His attention and description of the possibilities of her spinal or nerve damage was appropriate and very helpful. Carl Sferrazza Anthony enjoys a prolific career with a dozen books published. His storytelling style makes his work accessible and enjoyable to a wide audience. Anthony is very skilled at weaving the personal story with the political and making the reader feel intimate with the subjects through his narrative style. His use of “the Major,” Ida’s pet name for W. M., throughout is an effective example. Although at times the pendulum swings toward the political over the personal, it always returns to Ida, while providing context. The introduction to this book reflects his screenwriting abilities. Some sections border on historical fiction as Anthony skillfully recreated an episode with Ida, visitors, and her husband, including complete dialogue that was presumably gleaned from clues found in a personal letter. (He includes a footnote about the letter from the girl who is the other participant in this scene, but it is unclear how much of this is directly sourced and how much is conjecture.) One minor detraction to this work, which may be nothing more than a personal preference of this reviewer, is the use of endnotes and their structure. Although a useful key is provided for the abbreviations used in the endnotes, the indicators themselves are unnecessarily convoluted. A single endnote may cover a page or more, and several different direct quotations within the text requires the reader to hunt through the notation to discover the...

Spontaneous Osteonecrosis as a Cause of Knee Pain in an Older Active Woman

The patient was a 63 year old woman with a chief complaint of worsening right knee pain, which began 6 weeks prior while walking down a steep incline. Prior to symptom onset, the patient ran 6.5 km daily. The patient’s symptoms initially presented as tightness in the posterior aspect of the knee, but changed to a constant varying ache along the medial aspect of the knee with occasional sharp pain during ambulation. The patient also reported night pain and as well as morning stiffness. Radiographic findings were significant for mild degenerative changes with minimal medial joint space narrowing for the right knee (Figure 1). The patient was treated with a corticosteroid injection, which only provided temporary minimal relief. Magnetic resonance imaging was subsequently ordered and revealed findings consistent with spontaneous osteonecrosis of the medial femoral condyle (Figure 2), which is a distinct form of osteonecrosis and usually demonstrates a subchondral fracture identifiable on magnetic resonance imaging. This can affect males or females but it more commonly affects older women and is typically characterized by the sudden onset of knee pain [1]. In general, the lesion is more commonly located in a femoral condyle and it is not usually associated with systemic disorders or previous corticosteroid therapy [1]. The patient attempted a course of conservative treatment including protected weightbearing with hyaluronic acid, and physical therapy. However, the patient did not respond to conservative management and is awaiting unicompartmental knee arthroplasty. Note: The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the US Air Force or Department of Defense.

Making waves: Giacomo Balla and Emilio Pucci

Emilio Pucci emerged as an international fashion force in the 1960s with his bold and brilliant, streamlined outfits for the active woman. Delving into Pucci's first career as a bomber pilot and Fascist aviation hero, this article demonstrates his unacknowledged debt to the fashion theories and textile designs of the Futurist Giacomo Balla. Pucci was linked to Futurist aeropittura of the 1930s by the common culture of Fascism, aviation, and the cult of speed. Though Futurism was tainted by its affiliation with Fascism, in the post-war years, the works of Balla and others were kept in the public eye through exhibitions and their influence on a younger generation of modernist artists. In the same period, Pucci began to produce his vibrant eye-popping textile designs, which elaborated the proto-psychedelic imagery of wave-like swells, spinning vortexes, and exuberant floral arabesques developed by Balla between the World Wars.

한국 중년 여성의 패션이미지 유형에 따른 디자인 요소와 특성

This purpose of this study is to analyze the pursuit of current fashion trends and fashion image types of middle-aged women in Korea. This study attempted to investigate the standards and properties of these different types of fashion images. The overall characteristics of middle-aged women and the concepts of personal image and fashion image were investigated through literature research. Survey and analysis based on Q methodology was conducted. Factors of personal image, fashion image and components of fashion image were analyzed by collecting information from in-depth workshops and focus group interview of an expert group. The results of this study are as follows: 1) The main factors influencing the current fashion image of women in their forties and fifties in Korea are classified into six types. 2) The elements of fashion image that Korean women in their 40s and 50s pursue are divide into four types. 3) Each type can be recognized by specific fashion image components and colors. 4) This shows that middle-aged Korean women are highly conscious of how others perceive them and have a desire to not stand out from others. It also shows that they are very active in pursuing fashion and following trends, which is the image of an active and dignified woman. This study provides the framework that enables sorting of the fashion images types that middle-aged Korean women want to pursue. The results from analyzing the factors can be used to recognize specific fashion images, and can be used in the planning and designing of fashion items for middle-aged Korean women.

Vaginal Trachelectomy Following Laparoscopic Supracervical Hysterectomy and Sacrocervicopexy

Current evidence supports cervical preservation at the time of abdominal prolapse repair using synthetic mesh to minimize vaginal mesh extrusion. This report aims to describe management of benign cervical disease following laparoscopic sacrocervicopexy including successful trachelectomy performed vaginally. A 70-year-old sexually active woman presented with symptomatic pelvic organ prolapse and stress urinary incontinence. Her Papanicolaou smears over several years were unremarkable, and she had a benign endocervical polyp removed in the office 3 months before surgery. She underwent an uncomplicated robotic-assisted laparoscopic supracervical hysterectomy and sacrocervicopexy. She presented 8 months after surgery with persistent vaginal spotting after intercourse and was found to have a recurrent endocervical polyp. Ultimately, she underwent uncomplicated trachelectomy performed vaginally with resolution of her symptoms. Retention of the cervix at the time of mesh-augmented abdominal prolapse repairs introduces a unique set of evaluation and management considerations for benign cervical disease. Trachelectomy performed vaginally was successful and uncomplicated in this case.

Civil education in the theory and practice of Women’s Civil Work Association in the Second Polish Republic

One of the main aims of Women’s Civil Work Association (Związek Pracy Obywatelskiej Kobiet) (1928-1939): the largest and the most influential women’s organisation of the Sanation political camp in Poland in the interwar period, was the creation of a new model of a woman citizen and forming and educating women, in concordance with ideological and political ideas of the Sanation (the state-forming idea of J. Piłsudski), to be “a new type of citizens”, aware of their rights and duties, who take an interest in the affairs of the state and who take an active stance towards the strengthening of the new independent state. The Association tried to achieve this aim by organising various forms and methods of civil education, setting up and running various educational, supportive, an economic institutions, which made it possible for the Association to bring into effect its ideas, including the main goal, that is, the creation of a modern, active, and responsible woman citizen.

Mesenteric Venous Thrombosis After Laparoscopic Sleeve Gastrectomy: Pathophysiology and Literature Review

In the last 10 years, laparoscopic sleeve gastrectomy has become an increasingly popular surgical option for morbidly obese patients. Mesenteric venous thrombosis, as a complication of laparoscopic sleeve gastrectomy, has been rarely reported. We report two cases of thrombosis of the superior mesenteric vein after sleeve gastrectomy. It is confirmed by CT scan. Treatment is primarily medical. Three months later, the patients were asymptomatic still under antivitamin K. Thrombosis of the superior mesenteric vein after bariatric surgery is a diagnosis that one should know how to raise in front of any postoperative abdominal pain. The laparoscopic abdominal pressure ( &gt; 14 mm Hg), associated with a marked position in bariatric surgery, reduces the venous flow by 50% which may increase the risk of thrombosis. In addition, soft tissue trauma during surgery (manipulation of the small intestine during short gastric bypass or duodenal switch) releases tissue factors that could cause a mesenteric venous thrombosis in patients with a previously undiagnosed hypercoagulable state. The clinical signs of mesenteric venous ischemia are variable and nonspecific. The etiology of portal thrombosis must be done before the introduction of heparin therapy which is not always possible in emergency. An obese patient with a history of thrombosis should receive a complete etiology of these thromboses before bariatric surgery. Abnormal blood dirt, an active smoking fat woman having oral contraceptive, or a patient with a history of recurrent venous thrombosis may be a relative contraindication against a complex bariatric surgery with digestive bypass. J Curr Surg. 2014;4(3):101-104 doi: http://dx.doi.org/10.14740/jcs229w

Surgery or chemoradiation for stage IB cervical cancer? How cost effectiveness impacts a complex decision

Surgery or chemoradiation for stage IB cervical cancer? How cost effectiveness impacts a complex decision

Being a Cancer Caregiver for an Older, Active, and Able Woman

P health care experiences often propel individuals to pursue careers in health care. For me, it was the experience of caring for my father who had early-onset neurodegenerative dementia that set the stage for my current work. Now, with an advanced degree in health policy with a focus on caregiving policy and research, I am part of a research team studying the information needs of cancer caregivers. Interest in family caregiving in the cancer context has grown over the past several years and is driven largely by the bubbling volcano that is older population growth in the United States. Due to a projected increase in the U.S. older adult population, a corresponding increase in cancer diagnoses is anticipated. A 67% increase in cancer diagnoses among adults 65 and older is anticipated between 2010 and 2030 (Smith, Smith, Hurria, Hortobagyi, & Buchholz, 2009). Meanwhile, a variety of factors contribute to the burden of care being shifted onto family caregivers, including a move toward more outpatient cancer care, advances in home-care technologies, and financial constraints (e.g., the cost of financing home aides or nurses). Caregiving research is vital as it is the scientific story of many caregivers. Yet, the story of one still holds value. The following is my commentary on being a cancer caregiver for an 87-year-old woman. This woman is a nonbiological “grandmother” to me. She was never married and never had children. Thus, I formally fit within the family caregiver spectrum as a “friend.” My official tenure as a cancer caregiver began when my pseudo-grandmother, Betty, noticed a large lump on her left breast. She immediately called her gynecologist and scheduled a mammogram. A mammogram was a test she had not had in years, which, unfortunately, is not uncommon of someone of her age and background. The mammogram verified what she knew—an abnormal growth. She moved on in the assembly line of good care and was scheduled for a biopsy. I, along with others, urged her to have patience and wait for the laboratory result. “It may be cancer, but it also may not be,” I offered in an attempt to be calm but not overly optimistic. The biopsy result indicated cancer, a diagnosis that numerous other older women likely received that same day. Despite sharing a similar diagnosis with many other older women, Betty is no typical 87-year-old. Most notable is her number of prescription medications compared to the average adult 60 or older. A 2008 report indicated that nearly 9 of 10 adults 60 or older were taking at least one prescription medication, whereas nearly 4 of 10 were taking five or more (Gu, Dillon, & Burt, 2010). Betty’s number of prescription medications was zero. Her prescription card showed only a daily multivitamin and garlic pill. My pseudo-grandmother also owns her own car and, importantly, is exceptional at driving. On several occasions, she has driven my kindergarten daughter from school to home. Among her friends at the long-term care facility where she has an apartment, she is the designated driver (not that kind!) of many

Chemotherapy-Induced Pseudobulbar Affect: A Novel Case

Chemotherapy-Induced Pseudobulbar Affect: A Novel Case

Profil épidémiologique de 290 cas d’échinococcose kystique humaine diagnostiqués au CHU Mustapha d’Alger (2006 à 2011)

The aim of the studyThis study reports a series of 290 cases of hydatidosis confirmed by the surgery and/or the imagery with a positive immuno-diagnosis collected between 1st January 2006 and 31 March 2011 at parasitology-mycology laboratory of hospital university center of Mustapha of Algiers. Our aim is to specify, through the listed cases, the epidemiological aspects of this affection and compared with those obtained in two previous Algerian epidemiological investigations carried out, between 1963–1964 and 1966–1975. Patients and methodsIt is a retrospective (2006–2008) and prospective (2008–2011) study. The parasitological diagnosis was carried out by the direct macroscopic and/or microscopic identification of the parasite and indirect diagnosis based on four techniques: passive hemagglutination, Elisa IgG “Echinococcus granulosus”, Western Blot IgG “Echinococcus” and electrophoresis. ResultsThe study shows that this affection is still prerogative of the young adult. It bring out also in this study that the child of school age (ten years), in particular the boy, pays a heavy tribute. At the child, the preferential pulmonary seat of the hydatic disease is not devoid of risk. At adult, this parasitic disease mainly affect the active woman. ConclusionGenerally, the epidemiological and clinical characteristics join the endemic countries data and confirmed the row of our country among them. The transmission seems as strong as in the past, in spite of a much better social educational level.

Intertrochanteric fracture under an arthrodesed hip

Patient:Female, 30Primary Diagnosis:Intertrochanteric fracture under an arthrodesed hipCo-existing Diseases:Developmental dysplasia of the hipMedication:Pain • inability to walkClinical Procedure:Open reduction and internal fixationSpecialty:Orthopedics and traumatologyObjective:Rare disease, Unusual setting of medical careBackground:An intertrochanteric fracture among elderly people is common, but it is rare to see such a fracture under a longstanding hip arthrodesis. Its surgical management represents a real challenge to orthopedic surgeons.Case Report:A 30-year-old female teacher with long-standing hip arthrodesis was involved in a traffic accident. Clinical and radiological examination revealed the presence of a displaced intertrochanteric fracture under an arthrodesed hip and high neck shaft angle.Before embarking on surgery, we have to consider many factors such as patient personality (a young active and ambitious woman) and the mature of the fracture (a displaced fracture, coxa valga, and atrophied muscles). After a deep discussion and evaluation of the available devices, we selected a heavy duty locked plate and cannulated screws to fix the fracture.Conclusions:Because of the rarity of intertrochanteric fracture under an arthrodesis hip, the proper surgical treatment is controversial. Nevertheless, we were fortunate in successfully treating this unusual fracture using a locked plate and cannulated screws, which are implants that can be useful in treatment of such fractures.

Marija Pavelić: The invisible Female Leader of the Independent State of Croatia (1941-1945)

The Independent State of Croatia was established in 1941 with the help of Nazi Germany and fascist Italy after the Kingdom of Yugoslavia was destroyed and divided by the Axis powers. As an anti-Yugoslavian, anti-Communist and anti-Semitic organisation, the ustasha displayed very strong tendencies towards National Socialist and fascist ideology, incorporated it and implemented it as legislation. The dispossession and annihilation of Serbs, Jews, Roma and resistance fighters were the consequences of the totalitarian state that was headed by the ustasha cult figure Dr. Ante Pavelic. Also women played an important role in the creation of the new state, even if the ustasha in their propaganda practiced the centuries-old, conservative-Catholic patriarchy in a form that resembled Fascism in many aspects. This article aims to analyze the role of one of the most powerful women in the Independent State of Croatia: Marija Pavelic, the wife of the ustasha-leader. Although Pavelic’s wife Marija gave birth to three children and rarely appeared in public, she was already a politically active woman in the Italian exile (1929-1941) and attempted to support the power of her husband from the beginning of his political occupation. DOI: 10.5901/mjss.2013.v4n2p205

Changed for Good: A Feminist History of the Broadway Musical (review)

STAGE AND SCREEN Changed for Good: Feminist History of the Broadway Musical. By Stacy Wolf. Oxford: Oxford University Press, 2011. [306 p. ISBN 9780195378238 (hardcover), $99; ISBN 9780195378245 (paperback), $24.95.] Photographs, bibliography, index. As academics, we occasionally have those precious moments when we encounter scholarly works inspire us toward new thoughts and research directions. We experience an Aha! moment as we read a book or article brings to light observations we ourselves have sensed, yet never fully formulated, ideas resonate with the impulses and motivations rooted in our minds. As a young graduate student drawn to intersections between queer histories and musical theater studies, one of those rare instances occurred when I first picked up Stacy Wolf's Problem Like Maria: Gender and Sexuality in the American Musical (Ann Arbor: University of Michigan Press, 2002). Problem Like Maria presents multi-layered interpretations of iconic female performers and characters from American musicals, interpretations demonstrate how these performances subvert conventional gender roles and thus reach queer audiences. With her newest publication, Changed for Good, Wolf continues this project begun in Problem Like Maria, in which she traces female characters' and performers' importance in musical theater. Wolf's history is impressively broad in scope; it chronicles roughly sixty years of American musical theater history (from the 1950s to today), and discusses about twenty shows in depth. Each chapter focuses on theatrical or musical conventions (e.g., female duets, the eleven o'clock number), that bubbled to the surface at [a specific moment in] time (p. 19). Detailed readings of shows elucidate the convention and its significance to American musical theater history. Additionally, Wolf grounds chapters in historical moments by considering cultural issues relevant to each period (such as the backlash to feminism in the 1980s). Through this combination of feminist American and musical theater histories, Wolf demonstrates how in the genre of the musical are intertwined with changes in women's roles and activities in U.S. culture (p. 19). In other words, we can read the Broadway musical as a cultural product directly influenced by the historical trajectory of American women. Wolf's chronicle begins with the 1950s, thus opening this feminist history in an era distinctly lacking in organized feminist movements. Within 1950s musicals such as Wonderful Town and Guys and Dolls, she categorizes the female duet as either collaborative or pedagogical. She elaborates how these duets effectively disrupt the musicals' project, which prizes heterosexual relationships/unions in their narrative and structure (p. 27). Her reading of West Side Story and Anita and Maria's duet A Boy Like That / I Have a Love illustrates the transformative, homosocial power of the female duet. Following this reinterpretation of 1950s musicals, Wolf launches into the 1960s, focusing on mid-decade musicals like Mame and Cabaret. Wolf explains these musicals' protagonists can be seen as variations on the 1960s single girl, an employed, independent, sexually active woman who- despite her current single-hood-looks towards an ultimate marriage (p. 59). This section of Changed for Good stands out in musical theater scholarship for its blend of evidence. Wolf merges musical and dramatic readings with accounts of characters' physicality to demonstrate how these musicals, which, though they may narratively punish women, still present female characters whom audiences may view as powerful through the performances of the character/ actor (a duality she parses well). For example, while the title character of Sweet Charity is quite literally thrown into a lake (twice!) by men, her character nonetheless emerges as powerful through the actor's impressive singing and dancing throughout the show. …

Innovative Mobility Strategies for the Patient With Intensive Care Unit–Acquired Weakness: A Case Report

Although the benefits of early mobilization in the intensive care unit (ICU) have been well documented in recent years, the decision-making process and customization of treatment strategies for patients with ICU-acquired weakness have not been well defined in the literature. This case report will describe a patient with ICU-acquired weakness in the long-term acute care hospital (LTACH) setting and mobilization strategies that include novel devices for therapeutic exercise and gait training. A 73-year-old, active woman underwent a routine cardioversion for atrial fibrillation but developed multiple complications, including sepsis and respiratory failure. The patient spent 3 weeks of limited activity in the ICU and was transferred to our LTACH for continued medical intervention and rehabilitation. A 4-phase graded mobilization program was initiated in the LTACH ICU. Within that program, the physical therapy interventions included partial weight-bearing antigravity strength training with a mobile leg press and gait training with a hydraulic-assist platform walker. Before interventions, the patient had severe weakness (Medical Research Council [MRC] sum score of 18/60) and displayed complete dependence for all functioning. She progressed to being able to ambulate 150 ft (1 ft=0.3048 m) using a rolling walker with accompanying strength increases to an MRC sum score of 52/60. This case report describes novel mobility strategies for managing a patient with ICU-acquired weakness. The application of a graded mobilization program using a mobile leg press and a hydraulic-assist platform walker was safe and feasible, and appeared to expedite the patient's recovery process while decreasing the amount of manual lifting for the therapists.

Aprosodic Speech and Insular Lesions as Main Features of a Massive Tauopathy in Frontotemporal Dementia (P07.188)

Objective: To describe a patient with a massive and widespread tauopathy who presented with an atypical speech disturbance and MRI findings along 6 years of follow-up. Background The spectrum of frontotemporal dementia is characterized by distinct behavioural changes and aphasia, either non-fluent/agrammatic, semantic, or logopenic together with neuroimaging evidence of different patterns of atrophy related to the underlying pathology. Design/Methods: A 46-year-old woman presented with a 2-year history of progressive personality change. Having been an active, cheerful and empathic woman she started having problems with work colleagues and turned apathetic. Her speech became slow and aprosodic, somehow robotic (see video), without aphasic features. She had a healthy twin sister and another older sister diagnosed of schizophrenia. She progressively worsened, showing a childish and disinhibited behaviour. She never suffered hallucinations, autonomic dysfunction or parkinsonism. She died by accident 6 years after disease onset. Results: She did not developed any of the typical patterns of aphasia described in frontotemporal dementia . Brain MRI showed subcortical hyperintensities involving both insulae, that later spread into both frontal cortices. No gross atrophy was detected. Tests for progranulin, prion protein, CADASIL, sequentiation of the MAPT gene and presenilin-1 were negative. The neuropathological study showed a massive neuronal loss in the frontal cortex with deposits of 4R-Tau in the frontal and insular cortex, striatum, amygdala, hippocampus, entorhinal cortex, hypothalamus, thalamus, locus coeruleus and cerebellum. Deposits were predominantly intracytoplasmatic. There was some scattered deposition of TDP-43 and complete lack of amyloid and alpha-synuclein. Conclusions: Aprosodic speech without aphasia and insular hyperintensities add to the unusual manifestations of frontotemporal dementia. This histologically proven case adds to our knowledge of frontotemporal dementia and also reinforces the crucial role of the insula for the development of the behavioural and speech symptoms in frontotemporal dementia. Disclosure: Dr. Gomez Beldarrain has nothing to disclose. Dr. Ruiz Ojeda has nothing to disclose. Dr. Ferrer Abizanda has nothing to disclose. Dr. Cabrera has nothing to disclose. Dr. Garcia Monco has nothing to disclose.

Physical activity in the life of a woman with cerebral palsy: physiotherapy, social exclusion, competence, and intimacy

Although physical activity can have substantial mental and physical health benefits, people with cerebral palsy usually lead sedentary lives. To understand, at an individual level, this inactivity, we interviewed a 29-year-old minimally active woman with cerebral palsy (Alana) about the meanings and experiences of physical activity throughout her life. Using a case-study approach, we found that Alana had adverse childhood experiences with physical activity, including: having to perform difficult, and sometimes painful, physiotherapy; wearing callipers to assist her walking; demonstrating limited competence at physical activity; being excluded from physical education and other organised physical activity at school; and feeling socially isolated from her classmates. These experiences seemed to contribute to feelings of difference/inferiority and the subsequent avoidance of physical activity, which, in turn, might have contributed to premature functional decline. Physical activity levels in people with cerebral palsy might be increased through focusing on enhancing childhood experiences.

A Healthy Newborn Delivered From an Active Acromegalic Woman Receiving High-dose Long-acting Octreotide During her Entire Pregnancy

Pregnancy rarely occurs during the course of acromegaly, and if present it is associated with comorbidities. The data about medical therapy with somatostatin analogs during pregnancy are limited. Although discontinuation of somatostatin analogs is recommended in the event of pregnancy, there are reported cases of pregnant acromegaly treated generally with a short-acting formulation of octreotide. We report herein a case of acromegaly in whom the entire pregnancy course was uneventful with 40 mg of long-acting octreotide use, resulting in a healthy infant birth. To our knowledge, this is the highest dose to be used during pregnancy, which has not been reported previously. The natural course and management of acromegaly during pregnancy are discussed.