Pneumatic actuator is one of the key technologies in the field of active suspension due to its low cost, cleanliness, and high power-to-weight ratio characteristics. However, the dynamic models and control strategies of the pneumatic suspension have not been well demonstrated because they are nonlinear systems. Besides, the vertical displacement stability of sprung mass is very important for ensuring ride comfort, but accurate control is still a challenging problem in the presence of parametric uncertainties. In this study, an adaptive neural networks backstepping scheme is designed for the stability control of the pneumatic suspension. Firstly, a mathematical model of the pneumatic system is studied to investigate the dynamic system behavior and to obtain the control algorithm. Secondly, an extended state observer is applied to estimate uncertain parameters, unmodeled dynamics, and external disturbances. Thirdly, unknown masses of various load passengers are approximated by using radial basis function neural networks (RBFNNs). To enhance the system stability, a proposed control with a prescribed performance function (PPF) is designed to guarantee the vertical displacement of the chassis. Adaptive backstepping control with PPF is developed to stabilize the perturbed system and guarantee tracking performance. Finally, the simulation examples for the pneumatic suspension are employed to investigate the effectiveness of the proposed method.