Introduction: The COVID-19 pandemic has necessitated a transition from face-to-face to e-learning, which caught many medical educators unaware. However, it is imperative to develop skills as an e-educator through the application of active learning (AL) principles based on Bloom’s taxonomy. This study highlights the effect of using AL principles on the perception of students toward an e-learning environment using Dundee ready education environment measure (DREEM) questionnaire. The aims of this study were as follows: (1) to introduce the AL principles during online teaching learning sessions. (2) To assess the feedback on the module among the students. (3) To evaluate the change of perception of students toward the e-learning environment through the DREEM questionnaire. Materials and Methods: An educational interventional study was carried out among (76) undergraduate students of a medical institution in coastal Andhra Pradesh. Perception toward the e-learning environment was collected through the DREEM questionnaire online before and after the intervention (application of AL principles as per the Bloom’s taxonomy during online T/L sessions). Statistical analysis: The data thus collected were analyzed using IBM SPSS version 20 statistical software, descriptive and inferential statistics for quantitative data and thematic analysis for qualitative data. Results: The Global DREEM score was 122 which was 62 before the intervention. Similarly, 68% reported positive perception which was only 37% initially. Students’ social self-perception scored lowest initially, but scores were improved to 2nd highest after the intervention. For a few items such as teacher-centered, nonstimulating teaching, not being able to memorize, lack of motivating environment, feedback, feeling lonely, bored, and not having a good support system, the individual scores were negative, i.e., <2 which became positive, i.e., >3.5 after. Conclusion: There was a significant change perceived by the students toward the e-learning environment with increased DREEM scores. Thus, this study concludes use of AL principles in online platforms is effective in improving students’ perception of the e-learning environment. The following core competencies are addressed in this article: Practice-based learning and improvement, Medical knowledge, Interpersonal and communication skills.