Pressure drop oscillation (PDO) is one of the most common flow instabilities occurred in microchannel cooling systems, which could result in partial dry-out, heat transfer deterioration, and temperature fluctuation. In this study, the effects of three oscillatory electronic valve settings (square, sinusoidal, and sawtooth) on mass flow rate and PDO characteristics are examined numerically and experimentally. A one-dimensional lumped model is developed for the microchannel cooling system, which indicates that a specific range of valve oscillation amplitude and frequency can reduce PDO amplitude significantly. The PDO amplitude can be reduced by 85 % when the valve amplitude is 30 % and the frequency is 0.1 Hz. A smaller valve oscillation amplitude shows a weaker effect on the suppression of PDO. The square function has a better PDO suppression than the sinusoidal and sawtooth functions under the same pulsating valve amplitude and frequency. Experimental results demonstrate a similar effect of valve setting on PDO, for instance, a valve setting oscillates from 20 % to 80 % and a fixed frequency of 0.05 Hz can reduce pressured drop amplitude from 3 kPa to 0.5 kPa, and reduce the mass flow rate oscillation amplitude from 60 ml/min to 10 ml/min. The overly large oscillation amplitude of the valve setting could increase the oscillation amplitude of the mass flow rate and the overall pressure drop significantly. Thus, both the pressure drop through the microchannel evaporator and the valve should be considered in the selection of the oscillatory valve parameters. Based on the analysis of this study, an active control strategy could be developed to suppress flow oscillation and optimize the overall cooling performance using the oscillatory valve setting.