Actionable Outcomes Research Articles

The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.

The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication. To assess the abstract-to-publication proportion of prize-winning ESPR abstracts and prize-winning authors' experience of publishing in Pediatric Radiology, the affiliated journal of the ESPR and other specialist international paediatric radiology societies. PubMed was searched for titles of ESPR prize-winning abstracts from 1977 (the year of first award) up to and including 2021, where the presenter was either first or co-author, and the article was published 2years before or after the presentation year. If not found, a general internet search was performed. Titles of all retrieved articles were evaluated for inclusion. A survey was distributed to all ESPR prizewinners to better understand their experiences around journal submission. Over 44years, 108 prizes were awarded. The prize-winning abstract-to-publication proportion was significantly higher (59.3%, OR=2.10, P=0.012) than the recently published pediatric radiology "abstracttopublication rate" (41.9% from 2013-2016). Moreover, prizewinners were more than twice as likely than to achieve journal publication (OR=2.10), and as first author (OR=1.33). The majority of awardees published their work as first author (52/64, 81.3%): the first-author abstract-to-publication proportion was not significantly higher than the paediatric radiology "abstract-to-publication rate" (48.1%, OR=0.33, P=0.330). Sixty-four survey responses were received (59.3%, out of a total 108 awarded prizes). Just over 20% of prize-winning work was published in Pediatric Radiology, with 41.5% of respondents reporting a good to excellent submission experience. Prize-winning and first-author abstract-to-publication proportions are higher for ESPR-awarded abstracts than the most recently reported paediatric radiology "abstract-to-publication rate", suggesting that prizes are either awarded to work most likely to be published or that being awarded a prize encourages publication. Given that justover 40% of prize-winning abstracts remain unpublished, the ESPR should do more to support and encourage all authors to publish their work.

Liquid Biopsy and Challenge of Assay Heterogeneity for Minimal Residual Disease Assessment in Colon Cancer Treatment.

This review provides a comprehensive overview of the evolving role of minimal residual disease (MRD) for patients with Colon Cancer (CC). Currently, the standard of care for patients with non-metastatic CC is adjuvant chemotherapy (ACT) for all patients with stage III and high-risk stage II CC following surgical intervention. Despite a 5-20% improvement in long-term survival outcomes, this approach also results in a significant proportion of patients receiving ACT without any therapeutic benefit and being unnecessarily exposed to the risks of secondary side effects. This underscores an unmet clinical need for more precise stratification to distinguish patients who necessitate ACT from those who can be treated with surgery alone. By employing liquid biopsy, it is possible to discern MRD enabling the categorization of patients as MRD-positive or MRD-negative, potentially revolutionizing the management of ACT. This review aimed to examine the heterogeneity of methodologies currently available for MRD detection, encompassing the state-of-the-art technologies, their respective advantages, limitations, and the technological challenges and multi-omic approaches that can be utilized to enhance assay performance. Furthermore, a discussion was held regarding the clinical trials that employ an MRD assay focusing on the heterogeneity of the assays used. These differences in methodology, target selection, and performance risk producing inconsistent results that may not solely reflect biological/clinical differences but may be the consequence of the preferential use of particular products in studies conducted in different countries. Standardization and harmonization of MRD assays will be crucial to ensure the liquid revolution delivers reliable and clinically actionable outcomes for patients.

Components of joint health and wellbeing strategies: a pan-London review of all 33 local authorities

BackgroundIn the UK, Health and Wellbeing Strategies (JHWS) were introduced to identify and help address the health needs of local communities. JHWS translate a borough’s Joint Strategic Needs assessment into actionable outcomes and prioritises areas of focus, but the content and approach of JHWS may vary across different local authorities (LAs) due to demographic and priority differences.ObjectiveCharacterise the key health and wellbeing components of existing and emerging health and wellbeing strategies of 33 local authorities in London.DesignScoping review study with content assessment.MethodsAn online search was conducted to identify JHWS documents. This search was supplemented with outreach to health and wellbeing boards to ensure that the latest documents were retrieved. A set of 62 health and wellbeing themes and words to be captured spanning 13 categories was developed by a team of researchers, and data collection was independently carried out by two researchers. Occurrences of words in the strategy documents were recorded, and a configuration matrix was created and used to determine data trends across the local authorities. A broad search of the context in which the search terms appeared was also performed to understand the trends.ResultsThirty-three JHWS were analysed to identify key search term frequencies. The analysis encompassed strategies from 2015 to 2030, ranging from 7 to 94 pages. Mental health and youth terms emerged as the two top priorities across all strategies. Other frequent terms were related to access to healthcare, inequality, employment, smoking, housing, carers, and elderly individuals. Conversely, terms related to dental health, pollution, nutrition, sexual health, green spaces, breastfeeding, and climate were less cited.ConclusionThis analysis provides insights into regional health priorities and a comprehensive overview of health and wellbeing strategies across London's local authorities. Despite certain limitations, the findings offer valuable insights for local authorities' strategic planning and future research.

Strategic Planning in Higher Education Institutions

Strategic planning in higher education has become increasingly essential due to technological advancements, shifting student expectations, and evolving demographic trends. This paper investigates the critical components, processes, and challenges involved in strategic planning, emphasizing its importance for aligning institutional goals with actionable outcomes. The study outlines the key elements of a successful strategic plan, including vision, mission, objectives, and stakeholder involvement. The process of developing, implementing, and monitoring plans is discussed, highlighting data-driven decision-making and adaptability as central themes. Case studies illustrate best practices and the adaptability required to navigate shifting landscapes. Effective planning fosters institutional growth, aligns with societal needs, and ensures accountability while addressing challenges such as resistance to change, resource limitations, and diverse institutional contexts. Keywords: Strategic planning, higher education, institutional growth, stakeholder engagement, vision and mission.

Road Accident Prediction

Road accidents are a global concern, leading to a significant loss of life and property. This paper presents a machine learning-based approach for predicting road accidents by leveraging feature engineering techniques and advanced Ran- dom Forest models. Using enriched datasets with preprocessing methods, the proposed model achieves a predictive accuracy of over 92%. This study also explores key insights from accident data, providing actionable outcomes to improve road safety measures.

Value tensions and actionable knowledge in grassroots innovation: a study of invitational ambiguity and implementation challenges

PurposeThis research paper explores how grassroots innovation initiatives address and resolve the challenges of translating broad and inviting values such as sustainability, inclusiveness and aesthetics into practical and actionable structures. This study examines the tensions and difficulties projects face in operationalizing these values, revealing the gap between idealistic goals and real-world implementation. Moreover, this paper analyzes how role expectations and the concept of invitation ambiguity affect top down and bottom up approaches, offering insights for improving mechanisms to support grassroots innovations.Design/methodology/approachThis study uses an exploratory qualitative methodology with an embedded case study design, focusing on the New European Bauhaus (NEB) and its award-winning projects. Data were collected through online self-assessment surveys, secondary data analysis, and semi-structured interviews with project owners and NEB Unit representatives.FindingsThe findings reveal significant challenges in translating broad and inviting values (sustainability, inclusion and aesthetics) into actionable outcomes for grassroots projects. Key issues include the need for clearer role definitions, tailored support, and adaptability. Conflicts between those values and a mismatch between expectations about stakeholders’ contributions highlight the need for designing more flexible and robust frameworks and robust frameworks.Originality/valueThis research explores the effects of invitational ambiguity within grassroots innovation, revealing how broad values ‐ like sustainability, inclusion and aesthetics ‐ are operationalized in real-world settings. By applying collective action theoretical frameworks to the unique case study of NEB projects, this study provides fresh insights into the dynamics between top-down European policies and bottom-up grassroots practices.

Gender and Development Programs in an Educational Institution: Views of Stakeholders

This phenomenological study understands the views of stakeholders in educational institutions regarding the implementation of the Gender and Development (GAD) program. Using a qualitative approach, six teachers from two public schools in Davao City were interviewed. Participants, selected through purposive sampling, had over five years of teaching experience and were not directly involved in the GAD program. Thematic analysis revealed several key findings. Despite efforts to promote gender equality, stakeholders noted significant challenges in the program's execution, particularly a lack of clarity in its implementation and communication. Teachers expressed concerns over insufficient training and resources, which hindered their ability to fully integrate GAD principles into their classrooms. While the commitment to addressing gender inequality was evident, the study highlighted a need for better coordination and more structured guidance from the program's focal persons. This study emphasises the necessity of enhancing the GAD program to ensure that its objectives align with practical, actionable outcomes within the educational system. By improving the implementation process and providing more precise direction, educational institutions can better contribute to gender inclusivity and equality. These findings contribute to a deeper understanding of how GAD programs are viewed at the school level and offer an understanding of improving gender-related policies in educational settings.

Assessing the Factors for the Effectiveness of the Task Force Staff in Revenue Collection in Tanzania Local Governments Authorities

Recurring challenges in revenue collection and the insufficient revenue collection is pervasive, affecting the financial viability within Tanzania Local Government Authorities (LGAs) prompted this study with a focus on Mpanda Municipal Council. The aim is to assess key factors such as staff training, resource allocation, and community engagement that impact efficiency of task force staff operations. Mpanda Municipal Council was chosen due to its recurring challenges in meeting revenue collection targets and its strategic importance as a rapidly growing municipality with increasing fiscal demands. The study is grounded in both Agency Theory (AT), TAPACO and Resource-Based Theory (RBT). Agency Theory emphasizes the relationship between principals (local governments) and agents (task force staff) in ensuring that revenue collection objectives are aligned, while Resource-Based Theory highlights the importance of internal resources both tangible and intangible in achieving organizational effectiveness. Adopting a pragmatist research philosophy, the study used a convergent mixed-method research design, combining both qualitative and quantitative data to provide a holistic understanding of the research problem. Pragmatism guided the choice of methods, focusing on practical solutions and actionable outcomes. The quantitative data were analyzed using Ordinal Logistic Regression (OLR), which revealed that all independent variables significantly impact revenue collection effectiveness. A population of 75 people with a sample of 63 participants, comprising 46 respondents completed questionnaires while 17 business owners participated in semi-structured interviews. Thematic analysis was used in case of qualitative data. The findings reveal that targeted training programs, adequate resources, and active community engagement significantly enhance the effectiveness of task force staff in revenue collection. The study concludes that improving these areas will result in better revenue generation and financial stability for local governments. It is recommended that local governments increase investment in training, adopt modern technologies, and foster stronger community engagement to reduce reliance on central government funding.

Guidelines for Integrating actionable A-SMART Learning Outcomes into the Backward Design Process.

Learning outcomes are essential in education, guiding both educators and learners towards desired knowledge, skills, and competencies. The backward design process offers a structured approach to curriculum planning, but its integration with actionable, SMART (Specific, Measurable, Achievable, Relevant, Time-bound) learning outcomes needs further exploration. This guide aims to introduce the concept of "A-SMART" learning outcomes and demonstrate their integration into the backward design process, focusing on outcomes that begin with action verbs. The guide outlines a three-stage curriculum planning approach: (i) define desired results, (ii) determine acceptable evidence of learning, and (iii) plan learning activities. It emphasizes the importance of starting with action verbs in formulating learning outcomes, aligning with Stage 1 of backward design and facilitating the transition to Stage 2 (assessment development). By following this guide, educators will acquire tools to develop effective "A-SMART" learning outcomes. This approach immediately advances to Stage 2 of backward design, improving educational practices and ensuring alignment with assessment methods. The guide provides strategies for formulating outcomes that are Action-oriented, Specific, Measurable, Achievable, Relevant, and Time-based. The integration of A-SMART learning outcomes into the backward design process offers a more cohesive and effective educational framework. This approach enhances clarity for learners, provides guidance for instructors, enables more effective assessments, and improves overall learning experiences. The guide also addresses potential challenges in formulating A-SMART outcomes and suggests solutions, including the use of AI tools for inspiration and critical review.

Climate Change Awareness and Policy Implementation in Canberra

Purpose: The aim of the study was to analyze the climate change awareness and policy implementation in Canberra. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The study revealed that while there is a high level of public awareness and concern about climate change among residents, translating this awareness into effective policy action remains a challenge. The local government has implemented various policies aimed at reducing carbon emissions and promoting sustainability, but gaps persist in policy enforcement and public engagement. The findings suggest that stronger collaboration between policymakers, community stakeholders, and educational campaigns is needed to bridge the gap between awareness and actionable outcomes in combating climate change in Canberra. Unique Contribution to Theory, Practice and Policy: Social cognitive theory, framing theory & the theory of planned behavior may be used to anchor future studies on climate change awareness and policy implementation in Canberra. Educational campaigns should incorporate interactive workshops, online resources, and community events that encourage participation and foster a deeper understanding of climate policies. Policymakers should allocate funding for climate education initiatives, ensuring that they are integrated into school curricula and community learning programs, thereby institutionalizing climate education.

Epithelial-Mesenchymal Transition Indexes in Triple-Negative Breast Cancer Progression and Metastases.

Background Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by the lack of expression of estrogen and progesterone receptors and the absence of HER2 protein overexpression or gene amplification. How TNBC becomes so aggressive at the molecular level is not yet fully understood. The epithelial-mesenchymal transition (EMT) has been increasingly recognized as playing a pivotal role in cancer progression and metastasis. This study aimed to elucidate the connection between TNBC progression with EMT-related markers, including vimentin, beta-catenin, and E-cadherin. Methodology Rigorous immunohistochemical analysis was employed to assess the expression of vimentin, beta-catenin, and E-cadherin in primary tumors, tumor buds, and lymph node metastases (LNMs) from 137 cases with an invasive ductal carcinoma triple-negative phenotype diagnosed between 2018 and 2024. The EMT index, which was especially important in our work, is the sum of vimentin and beta-catenin expression divided by that of E-cadherin. Estimated Pearson correlation, multiple linear regression, and Kruskal-Wallis tests were used to determine the relationships of the EMT index with tumor buds and tumor-infiltrating lymphocytes (TILs). Results Vimentin highly correlated within separate regions of interest with Pearson correlation ranging from 0.90 to 0.92 (p < 0.001). Strong negative correlations between E-cadherin and vimentin (r = -0.81 to - 0.89, p < 0.001) showed its role in preserving the epithelial phenotype. The presence of tumor buds, aggregates, or clusters of cancer cells shed from the primary tumor mass invading the connective tissue showed very strong associations with the EMT index (r = 0.91, p < 0.001). Its presence is suggestive of aggressive disease and may identify a high-risk subpopulation that may benefit from more active surveillance or adjuvant treatment. Similarly, TILs correlated inversely with the EMT index (r = -0.90, p < 0.001). The most significant predictor of the EMT index, i.e., vimentin, had a model R-squared value of 1.000 in the regression analysis. Conclusions This study brings to light the importance of EMT-related markers in TNBC progression, with special emphasis on tumor buds as possible prognostic indicators for aggressive disease. The negative correlation of TILs with the EMT index indicates that an effective immune response could antagonize EMT-mediated tumor progression. These results suggest that EMT-based treatments in TNBC should be designed from a multimarker perspective by including interactions among several markers to optimize predictions and therapeutics. The results hold the potential to set future research directions and actionable outcomes that could influence clinical utility in the battle against TNBC.

Decision making for health-related research outcomes that alter diagnosis: A model from paediatric brain tumours.

The question of how to handle clinically actionable outcomes from retrospective research studies is poorly explored. In neuropathology, this problem is exacerbated by ongoing refinement in tumour classification. We sought to establish a disclosure threshold for potential revised diagnoses as determined by the neuro-oncology speciality. As part of a previous research study, the diagnoses of 73 archival paediatric brain tumour samples were reclassified according to the WHO 2016 guidelines. To determine the disclosure threshold and clinical actionability of pathology-related findings, we conducted a result-evaluation approach within the ethical framework of BRAIN UK using a surrogate clinical multidisciplinary team (MDT) of neuro-oncology specialists. The MDT identified key determinants impacting decision-making, including anticipated changes to patient management, time elapsed since initial diagnosis, likelihood of the patient being alive and absence of additional samples since cohort inception. Ultimately, none of our research findings were considered clinically actionable, largely due to the cohort's historic archival and high-risk nature. From this experience, we developed a decision-making framework to determine if research findings indicating a change in diagnosis require reporting to the relevant clinical teams. Ethical issues relating to the use of archival tissue for research and the potential to identify actionable findings must be carefully considered. We have established a structured framework to assess the actionability of research data relating to patient diagnosis. While our specific findings are most applicable to the pathology of poor prognostic brain tumour groups in children, the model can be adapted to a range of disease settings, for example, other diseases where research is dependent on retrospective tissue cohorts, and research findings may have implications for patients and families, such as other tumour types, epilepsy-related pathology, genetic disorders and degenerative diseases.

INTEGRATING FORENSIC MENTAL HEALTH IN LEGAL PROCESSES

The special report titled "Integrating Forensic Mental Health in Legal Processes" focuses on an event held on December 15, 2023, at Sheikh Zayed Medical College in Rahim Yar Khan. This collaborative event, organized by Justice Project Pakistan (JPP), the Pakistan Psychiatric Society (Punjab Chapter), and the departments of Psychiatry and Forensic Medicine, highlighted the crucial intersection of mental health and criminal justice in Pakistan. The report discusses the situation of the death penalty and capital punishment in Pakistan, emphasizing the challenges faced by juvenile prisoners and those with mental health issues. It also features the screening of three documentaries depicting the struggles of individuals affected by the criminal justice system, emphasizing the need for a more compassionate and equitable legal system. The event included an interactive Q&amp;A session with diverse stakeholders and concluded with an acknowledgment of JPP's contributions towards advocating justice reform. The report suggests enhancing the diversity of perspectives, focusing on actionable outcomes, and involving policymakers more directly in future events to strengthen their impact.

Transdisciplinarity: an imperative for information behaviour research

Introduction. Information behaviour research must be methodologically and conceptually sophisticated to generate knowledge reflecting the complexities of information engagement in people’s lives. Information behaviour research can be enriched by the concept of transdisciplinarity — a collaborative approach addressing complex societal problems, with actionable research outcomes. Method. In-depth analysis traces the emergence of transdisciplinary research design. The paper then examines selected information science studies that possess strong transdisciplinary qualities, including those grounded in community-based approaches and centred on people’s experiences who have been marginalised by mainstream research. The paper then discusses opportunities for, and challenges to, increased transdisciplinarity in information behaviour. Results. Information behaviour research is well positioned to embrace transdisciplinarity, although this approach has yet to see widespread uptake. Transdisciplinary approaches present information science, generally, with a timely, multifaceted opportunity to adopt research designs that centre community, government, and/or industry stakeholders, which aligns well with the practice-oriented, interdisciplinary nature of the field. Conclusion. This paper brings a theoretical conceptualisation of transdisciplinarity in relation to information science, focusing primarily on information behaviour research. It expands on the importance of collaboration, innovation, and cross-disciplinarity, and proposes strategies for bridging information science research into more critical investigations of information activities in contemporary society.

The ‘CSR facade’ of the hospitality industry: The importance of social responsibility in fighting sex trafficking and illegal sex purchases in hotels

Hotels are often regarded as (un)wittingly complicit in terms of sex traffickers using their facilities for illegal sex purchases. This article examines chain employees’ experiences of individual social responsibility (ISR) and corporate social responsibility (CSR) in the interaction between hotels and three stakeholder groups (online booking channels; governmental and non-governmental organizations; and nearby hotels) in the fight against sex trafficking and illegal sex purchases. Employee perspectives were gathered through semi-structured interviews in Sweden and the Netherlands, two countries with distinctive prostitution legislation. The findings highlight that the hotel employees found tensions between ISR and CSR and the relationship with the external stakeholders challenging. What became apparent was that CSR is often a facade used to report back positive results to external stakeholders rather than CSR and ISR playing a proactive role in fighting sex trafficking and illegal sexual purchases. We conclude by arguing for the necessity to better understand the relationships between ISR and CSR within the hospitality industry and suggesting that there remains a need for better understandings of how CSR can work across industry stakeholders and within academic research in order to ensure actionable outcomes that make a difference.

Preponderant Relationships: Violent Crime, Premises Security Litigation, and Low-Income Housing

ABSTRACT This paper advances knowledge of the ways in which criminological research can assist the courts in rendering legal decisions. To do so, we examine case examples from premises security litigation involving low-income housing developments. We describe the investigative tasks of a premises security lawsuit, address the challenges of examining and explaining a criminal assault, and show how criminological scholarship can point to the importance of place management in suppressing or facilitating crime in low-income housing developments. We examine three preponderant relationships – offender and victim, security standards and proximate causation, and place management and crime opportunities – to provide insight into the translation of criminological knowledge into actionable legal outcomes. We address the nexus of environmental criminology and premises security litigation to strengthen the scientific foundation of criminological research and improve the quality of forensic social scientific research in the legal system.

Global ranking of the sensitivity of interaction potential contributions within classical molecular dynamics force fields

Uncertainty quantification (UQ) is rapidly becoming a sine qua non for all forms of computational science out of which actionable outcomes are anticipated. Much of the microscopic world of atoms and molecules has remained immune to these developments but due to the fundamental problems of reproducibility and reliability, it is essential that practitioners pay attention to the issues concerned. Here a UQ study is undertaken of classical molecular dynamics with a particular focus on uncertainties in the high-dimensional force-field parameters, which affect key quantities of interest, including material properties and binding free energy predictions in drug discovery and personalized medicine. Using scalable UQ methods based on active subspaces that invoke machine learning and Gaussian processes, the sensitivity of the input parameters is ranked. Our analyses reveal that the prediction uncertainty is dominated by a small number of the hundreds of interaction potential parameters within the force fields employed. This ranking highlights what forms of interaction control the prediction uncertainty and enables systematic improvements to be made in future optimizations of such parameters.

Abstract 6399: Real-world experience of an Asian pan-cancer combined DNA/RNA next generation sequencing (NGS) tissue biopsy assay

Abstract Introduction: Comprehensive molecular profiling with combined DNA-RNA next-generation sequencing (NGS) on tumor tissue is now increasingly being used as standard-of-care for sequence therapy selection to improve cancer survival. Combined DNA-RNA NGS is also considered standard-of-care for central nervous system (CNS) tumor classification. Despite the genetic heterogeneity and diversity of cancers, most commercial combined DNA/RNA NGS assays are validated in Western populations, resulting in knowledge gaps in patient outcomes. We report here for the first time a range of actionable outcomes from a comprehensive DNA/RNA tissue NGS assay designed specifically to probe Asian-prevalent cancers and biomarkers in an international multicenter real-world study in Asia. Methods: 1,002 formalin-fixed paraffin-embedded tissue samples from 995 Asian cancer patients across &amp;gt;70 centers in 7 countries and/or territories underwent real-world DNA/RNA NGS testing in a CAP-accredited CLIA-certified laboratory. Genomic alterations including SNVs, INDELS, gene fusions, CNVs, TMB, and MSI were analyzed using an Asian-centric pan-cancer hybrid-capture NGS panel that comprehensively profiles 572 cancer-related genes and 91 RNA fusion partners (UNITED). Biomarkers were considered actionable if the therapeutic indication in any solid tumor or hematological cancer was FDA-approved, guidelines-recommended, or supported by well-powered phase III clinical trials. Results: 27 cancer types were represented in 1,002 tissue samples, with lung, breast, colorectal, and prostate cancers comprising 45.5% of clinical volume. 79.5% of samples harbored ≥1 actionable biomarker, with the most frequently altered genes being TP53, KRAS, PIK3CA, EGFR, and NF1. Overall, 42.6% of samples had ≥1 biomarker with an indication in the patient’s cancer type, including 81.5% of lung, 59.0% of breast, 61.8% of colorectal, and 42.1% of prostate cancers. Across the pan-cancer cohort, 13.3% was TMB-high and 1.9% was MSI-high. 26.3% of samples were from cancer types outside the original assay design; the top 3 were pancreatic cancer (7.3%), sarcoma (3.3%), and CNS tumor (3.1%). Cancers of unknown primary (CUP) also constituted a significant proportion (3.8%). In CNS tumors, 38.7% harbored an actionable mutation in IDH1, BRAF, or H3-3A. In CUP, 78.8% harbored an actionable mutation; 50% of samples harbored biomarkers that additionally informed potential tumor origin, including mutations in EGFR, MET, ALK, ROS1, and BRCA1. Conclusion: The use of an Asian-focused pan-cancer DNA/RNA NGS panel resulted in detection of actionable biomarkers in 79.5% of clinical cases. These findings support the utility of DNA/RNA NGS assays in informing standard-of-care therapeutic decisions in Asian cancer patients for maximizing cancer survival. Citation Format: Jason Yongsheng Chan, Jing Yi Lee, Zi Yi Wan, Abner Herbert Lim, Tun Kiat Ko, Cedric Chuan-Young Ng, Donald Poon, Jens Samol, Tsz Him So, Su Pin Choo, Ravindran Kanesvaran, Cheng-Vai Hui, Joseph Siu-Kie Au, Aya El Helali, Timothy Yip, Vikneswari Rajasegaran, Sandy Lim, Ruifen Weng, Puay Hoon Tan, Bin Tean Teh, Min-Han Tan, Jonathan Poh. Real-world experience of an Asian pan-cancer combined DNA/RNA next generation sequencing (NGS) tissue biopsy assay [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6399.

Policy pathways to reduce disproportionate burdens in tuna fisheries

AbstractThe United Nations Fish Stocks Agreement requires states to recognise the special requirements of developing countries and to ensure that conservation and management measures do not place a disproportionate burden on developing countries. The aim of this article is to assess what policy arrangements are required to reduce the identified disproportionate burden. We developed a policy pathway that would allow members of tuna regional fisheries management organisations (tRFMOs) to strengthen their efforts to meet their duty to share conservation burdens more equitably. This pathway consists of policy options that were developed by using policy analysis, which is an innovative approach that provides actionable outcomes that can be used by tRFMO member states. Despite the global attention to reducing disproportionate conservation burdens, developing states are still suffering. The results of this article provide novel and timely policy options that have the potential to reduce the conservation burden carried by developing states.

Doing wellbeing policy: A discussion on public policy making for integrative prosperity

AbstractFocusing on holistic wellbeing rather than solely economic prosperity is becoming ever more popular among policy makers, both in Australia and New Zealand, and elsewhere. And yet, turning a complex set of system‐level indicators of wellbeing into actionable policy requires us to rethink how we develop, implement, and evaluate policy. In this article, I review the current trends in wellbeing, including developments in the measurement and tracking of wellbeing, and offer practical steps for integrating actionable wellbeing outcomes into future policymaking processes.Points for practitioners Focusing on wellbeing as part of the policy making process is becoming more popular among governments, including in Australia and New Zealand. The New Zealand Government has been doing wellbeing budgets since 2019 while the Australian Government released a new wellbeing framework in 2023. Wellbeing policy represents an approach to policy making that aims to maximize the general health and happiness of a target population on both subjective and objective measures of wellbeing. This includes both economic and non‐economic measures of prosperity and wellbeing. There are many ways of tracking the wellbeing effect of policy and so choosing the right framework is important for effective wellbeing policy making. This starts with a wellbeing purpose for the policy and a clear and concise definition of wellbeing. Doing wellbeing policy requires a good understanding of what wellbeing represents and how it is measured. You need relevant and measurable indicators of wellbeing, an evaluation strategy, and the ability to reflect and innovate as part of an iterative policy making process.