Multi-view facial action unit (AU) analysis has been a challenging research topic due to multiple disturbing variables, including subject identity biases, variational facial action unit intensities, facial occlusions and non-frontal head-poses. A deep feature enhancement (DFE) framework is presented to tackle some of these coupled complex disturbing variables for multi-view facial action unit detection. The authors' DFE framework is a novel end-to-end three-stage feature learning model with taking subject identity biases, dynamic facial changes and head-pose into consideration. It contains three feature enhancement modules, including coarse-grained local and holistic spatial feature learning (LHSF), spatio-temporal feature learning (STF) and head-pose feature disentanglement (FD). Experimental results show that the proposed method achieved state-of-the-art recognition performance on the FERA2017 dataset. The code is released at http://aip.seu.edu.cn/cgtang/.