Objectives: The study presented an empirical analysis of the impact of US foreign policy toward Iran on Iran’s foreign policy toward Saudi Arabia during the Obama and Trump presidencies. It argues that Iran’s foreign policy toward Saudi Arabia is one way of getting back at the US, considering it a key ally. Method: It adopted an action-reaction model to test various hypotheses on the proposed relationships, using American and Iranian presidential remarks utilizing stimulus-response theory to test the relationships. Results: The study showed a set of correlations between certain US behavior toward Iran and Iran’s foreign policy toward Saudi Arabia, based on the monthly and annual data. Conclusion: It concluded that Iran’s action toward Saudi Arabia appeared to be a reaction to the US strategies toward Iran.