Combined Action Research Articles

Oxygen-Carbon and Strontium Isotope Composition in Primary Carbonatites of the World: The Data Summary and Linear Trends

A statistical regression analysis was performed of a summary of borrowed literary isotopic data on 176 carbonatite occurrences worldwide (a total of 1829 paired δ18О-δ13С values in primary carbonatites). For most of the occurrences, distinct linear trends in δ18О-δ13С values were revealed, approximated in diagrams by vectors using the regression formula y = kx + b. Trends in three directions are distinguished. The dominating trend possesses the angular coefficient k in the range of 0.0÷+0.6, averaging at + 0.31 (direct correlation δ18О-δ13С). In the literature, it is associated with the Rayleigh high-temperature fractionation of carbonatite melts or with their sedimentary crustal contamination. The second trend with k from 0.0 to -0.7 (inverse correlation δ18О-δ13С) is associated with CO2 degassing from the melts. The third trend with k from +0.6 to +1.5 is rare. In other carbonatite occurrences, no linear trends in δ18О-δ13С values are detected. This may be a consequence of a combined action of the multidirectional linear trends. In this regard, the initial point of the trend vectors is accepted as a universal isotope indicator for all the carbonatite occurrences. In the δ18О-δ13С diagram, the box PC-90 is outlined in the field of the initial points, including 90 % of the primary carbonatite occurrences. The coordinates of the corner points of the box in δ18О-δ13С ‰ are (+5÷-8), (+5÷-5), (+5.5÷-2.5), (+12÷-2.5), (+12÷-7), (+9÷-8.5). The box PC-90 is subdivided into two parts by the carbon isotope composition, using the value δ13C = -5.2 ‰. This suggests that the deep sources differ in carbon isotope composition. No correlation is found in the oxygen-carbon and strontium isotope compositions in the carbonatites, which suggests that the deep sources are also heterogeneous in the strontium isotope composition.

Relationship between Vitality and Characteristics of Coping Strategies in Deviant Adolescents

Adolescence is important in the development and formation of a personality, and the family radically influences the development of a teenager; under the family influence, foundations of intentional behavior, ways of responding to stress, level of vitality and defense mechanisms are laid, and a general direction in the formation of moral concepts and relationships emerges. And all this happens against the background of contradictions in physiological and mental development, spiritual formation. The reasons for the use of psychoactive drugs are varied, and most often chemical dependence is determined by the combined action of various factors and conditions. The purpose of the research work was to study the relationship between family structure and characteristics of the adolescents’ response to stress in undergoing inpatient treatment due to the use of psychoactive substances. The study was conducted on the basis of the Novosibirsk Regional Clinical Narcological Dispensary (teenage department). The main group included 18 young men, age: from 15 to 18 years, with experience of using psychoactive substances from one year to three or more years - “teenage addicts”. The control group, “conditionally healthy”, denying the use of psychoactive substances, was represented by high school students of one of the gymnasiums, 15 young men of the same age group. The following methods were used: the Family Adaptation and Cohesion Scale (FACES-3) questionnaire; Plutchik, Kellerman, Conte questionnaire - Life Style Index (LSI) methodology; questionnaire “Methods of coping behavior” by R. Lazarus and S. Folkman and test of vitality (S. Muddy) adapted by D.A. Leontyev. Results. It was revealed that adolescent addicts differ from adolescents without addictive behavior in the following parameters: low level of family adaptation and family cohesion; Adolescents with addictive behavior differ in their style of responding to difficult life situations: they more often use defenses and coping, which serve the function of regulating negative emotional states associated with unmet needs for communication, self-affirmation, etc., while adolescents without addictive behavior use coping and defense, which main function is to resolve the situation; Adolescents with addictive behavior have a lower level of resilience than relatively healthy adolescents. The possibilities of psychotherapeutic influences are discussed.

A chitosan macroporous hydrogel integrating enrichment, adsorption and delivery of blood clotting components for rapid hemostasis

Traditional hemostatic hydrogels face considerable limitations in achieving rapid control of severe bleedings, a crucial factor in reducing casualties in both military and civilian settings. This study presents a chitosan-based hemostatic hydrogel with interconnected secondary macropores designed to enhance interactions with blood clotting components by reducing diffusion resistance and increasing contact area. The macropores were created using a straightforward process involving NaOH-mediated SiO2 template dissolution and NH3 generation. The resulting macroporous structure increased the hydrogel's overall porosity without compromising its viscoelasticity. Functional studies demonstrated that the macroporous hydrogel effectively concentrated and adsorbed blood clotting components, while also facilitating the delivery of artificially embedded clotting factor to further expedite clot formation. These combined actions resulted in improve hemostatic efficacy, reducing whole blood clotting time by over 94 % in vitro. Furthermore, in vivo studies using rat tail amputation and liver injury models showed a reduction in blood loss by over 65 % and a decrease in bleeding time by over 70 %. Additionally, the porous chitosan hydrogel exhibited minimal biotoxicity and promoted biodegradability in vivo. In conclusion, this work introduces a macroporous chitosan-based hemostatic hydrogel with great potential for rapid hemorrhage control.

Mechanisms of calcium-mediated As(V) immobilization by undissolved and dissolved biochar in saline-alkali environments

The environmental impact of arsenic (As) pollution has been a focal point within environmental science. In arsenic-polluted saline-alkali environment, the addition of exogenous biochar can affect the morphological transformation of As both through direct and indirect mechanisms, with calcium ions (Ca(II)) playing a crucial role. This study investigates the immobilization mechanisms of undissolved biochar (UOB) and dissolved biochar (DOB) on As(V) in the absence and presence of Ca(II) under alkaline conditions and aerobic atmosphere. While UOB and DOB alone are insufficient for As(V) immobilization, their combined action in the presence of Ca(II) achieves remarkable immobilization rates of 91.9% and 98.1%, respectively. Precipitation of calcium arsenate is identified as the primary immobilization pathway in both the UOB-Ca(II)-As(V) and DOB-Ca(II)-As(V) systems. Furthermore, Ca(II) acts as a mediator for As(V) immobilization through the formation of ternary UOB/DOB-Ca-As complexes, which are corroborated by Density Functional Theory (DFT) analysis from a microscopic perspective. Notably, the synergistic immobilization of As by DOB and newly generated CaCO3 in DOB-Ca(II)-As(V) system is highlighted. Additionally, the increase in Ca(II) concentration (0–100 mM) and solution pH (9.0–12.0) both significantly enhance the immobilization of As(V). An increase in the dosage of UOB (0.4–4 g/L) reduces the immobilization of As(V), while effect of the DOB concentration is insignificant. This study provides new insights into how the release of two biochar fractions into a typical Ca(II)-rich saline-alkali environment may alter the fate and transport of As species.

Native tree promotes invasion when native grasses are absent

Despite the expected co‐occurrence of effects from resident species, the environment, and disturbance on non‐natives, these factors have largely been treated as acting separately. Co‐occurring factors may, however, act in combination to result in a powerful, yet little explored, mechanism of invasion. Here, we addressed three hypotheses to explain the localized invasion of the non‐native Chenopodium album (Chenopodium) under the canopy of the dominant native tree Neltuma caldenia (Neltuma) in central Argentina. First, we evaluated that Neltuma favors Chenopodium by modifying environmental conditions, and specifically assessed the importance of soil versus that of the microclimate created by Neltuma shade. Second, we tested that Neltuma benefits Chenopodium by promoting under its canopy (calden microsite) the dominance of a grass species, Nassella tenuissima (Nassella), that exerts weaker competitive effects on Chenopodium than those exerted by the dominant grass, Piptochaetium napostaense (Piptochaetium), in adjacent communities free of the tree (open microsite). Lastly, we explored that the invasion of Chenopodium is mediated by disturbance. Chenopodium displayed increased biomass and fecundity (performance) in soil from calden relative to that from open microsites, whereas it exhibited no response to shade treatments. Also, Chenopodium performance in pots with Nassella was similar to that in pots with Piptochaetium. Finally, Chenopodium performance was much greater in pots with no initial plants than in those with grasses. Importantly, in pots without plants, Chenopodium performed much better in calden than open microsites, but in pots with grasses, Chenopodium performance exhibited no differences between microsites. These findings suggest that disturbance mediates Chenopodium invasion in calden microsites. Specifically, disturbance may weaken strong competitive effects from native grasses on Chenopodium, allowing this non‐native herb to benefit from favorable soil conditions under Neltuma. The combined action of natives enhancing resource levels and disturbance providing access to them could be a general mechanism of invasion.

Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages for refractory colorectal cancer treatment

BackgroundArginase is abundantly expressed in colorectal cancer and disrupts arginine metabolism, promoting the formation of an immunosuppressive tumor microenvironment. This significant factor contributes to the insensitivity of colorectal cancer to immunotherapy. Tumor-associated macrophages (TAMs) are major immune cells in this environment, and aberrant arginine metabolism in tumor tissues induces TAM polarization toward M2-like macrophages. The natural compound piceatannol 3ʹ-O-glucoside inhibits arginase activity and activates nitric oxide synthase, thereby reducing M2-like macrophages while promoting M1-like macrophage polarization.MethodsThe natural compounds piceatannol 3ʹ-O-glucoside and indocyanine green were encapsulated within microparticles derived from tumor cells, termed PG/ICG@MPs. The enhanced cancer therapeutic effect of PG/ICG@MP was assessed both in vitro and in vivo.ResultsPG/ICG@MP precisely targets the tumor site, with piceatannol 3ʹ-O-glucoside concurrently inhibiting arginase activity and activating nitric oxide synthase. This process promotes increased endogenous nitric oxide production through arginine metabolism. The combined actions of nitric oxide and piceatannol 3ʹ-O-glucoside facilitate the repolarization of tumor-associated macrophages toward the M1 phenotype. Furthermore, the increase in endogenous nitric oxide levels, in conjunction with the photodynamic effect induced by indocyanine green, increases the quantity of reactive oxygen species. This dual effect not only enhances tumor immunity but also exerts remarkable inhibitory effects on tumors.ConclusionOur research results demonstrate the excellent tumor-targeting effect of PG/ICG@MPs. By modulating arginine metabolism to improve the tumor immune microenvironment, we provide an effective approach with clinical translational significance for combined cancer therapy.

Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression.

Prostate cancer, the most common malignancy in men, has a relatively favourable prognosis. However, when it spreads to the bone, the survival rate drops dramatically. The development of bone metastases leaves patients with aggressive prostate cancer, the leading cause of death in men. Moreover, bone metastases are incurable and very painful. Hepatocyte growth factor receptor (MET) and fusion of genes encoding E26 transformation-specific (ETS) transcription factors are both involved in the progression of the disease. ETS gene fusions, in particular, have the ability to induce the migratory and invasive properties of prostate cancer cells, whereas MET receptor, through its signalling cascades, is able to activate transcription factor expression. MET signalling and ETS gene fusions are intimately linked to high-grade prostate cancer. However, the collaboration of these factors in prostate cancer progression has not yet been investigated. Here, we show, using cell models of advanced prostate cancer, that ETS translocation variant 1 (ETV1) and transcriptional regulator ERG (ERG) transcription factors (members of the ETS family) promote tumour properties, and that activation of MET signalling enhances these effects. By using a specific MET tyrosine kinase inhibitor in a humanised hepatocyte growth factor (HGF) mouse model, we also establish that MET activity is required for ETV1/ERG-mediated tumour growth. Finally, by performing a comparative transcriptomic analysis, we identify target genes that could play a relevant role in these cellular processes. Thus, our results demonstrate for the first time in prostate cancer models a functional interaction between ETS transcription factors (ETV1 and ERG) and MET signalling that confers more aggressive properties and highlight a molecular signature characteristic of this combined action.

Breast Cancer Bone Metastasis Therapy and Tumor‐Associated Bone Destruction Repair by Versatile Semiconducting Nanointegrators with X‐Ray Adjuvant

AbstractTumor progress and tumor‐associated osteolysis are two key issues of breast cancer bone metastasis, which makes it challenging for bone metastasis treatment. To settle these two issues concurrently, a versatile semiconducting nanointegrator (termed as SPNCpG/Ca) containing semiconducting polymer nanoparticle (SPN), Ca2+ and cytosine‐phosphate‐guanine (CpG) oligonucleotides conjugated on the surface via a singlet oxygen (1O2)‐responsive linker, is designed. The antitumor effect can be triggered with X‐ray irradiation as an adjuvant, in which SPN works as a radiosensitizer to produce 1O2 for radiotherapy and controlled release of CpG via disrupting 1O2‐responsive linkers. The Ca2+ accumulation via SPNCpG/Ca delivering causes tumor cell death and the released CpG activates immune response to realize immunotherapy. The combinational action of radiotherapy, Ca2+ overloading, and immunotherapy results in complete clearance of metastatic tumor cells in 4T1 breast cancer‐based bone metastasis mouse models. Furthermore, Ca2+ can accelerate osteogenesis of bone marrow mesenchymal stem cells while CpG inhibits osteoclast differentiation in the bone metastasis microenvironment to alleviate osteolysis, which synergistically contributes to repair of tumor‐associated bone destruction. SPNCpG/Ca represents a versatile therapeutic nanosystem with the abilities to treat bone metastasis and repair tumor‐associated bone destruction, providing a new tactic for bone metastasis therapy.

Dynamic analysis of whipping behavior induced by the circumferential fracture of high energy pipes considering fluid-structure interaction effect

To analyze the dynamic characteristics of whipping behavior induced by the circumferential fracture of high energy pipes, a numerical model of the piping system was presented based on the bidirectional fluid-structure interaction method. The reliability of this model was validated against experimental results. Furthermore, the dynamic characteristics of whipping behavior were studied, as well as the effects of some main parameters. The numerical results suggest that the entire whipping behavior can be divided into four stages: free-whipping stage Ⅰ, free-whipping stage Ⅱ, collision stage and periodic stage. The dynamic response of whipping behavior is different in the four stages and is dominated by a single mode with a frequency of 29.35 Hz under the combined action of the thrust force and U-bolt restraints. The increase of inlet flow rate causes the enhancement of thrust force and thus makes its dynamic response more complicated. The parameter analysis shows that the whipping behavior can be suppressed by choosing the small initial clearance, setting the suitable gap and increasing the straight segment length of U-bolt restraints. The above results are helpful to understand the dynamic characteristics of whipping behavior and provide valuable suggestions for the optimization of the protection measures.

Gender Stereotyping and Social Norms: Exploring Theoretical Perspectives and Educational Implications

This review is a theoretical paper which examined gender stereotyping and social norms. The review was supported by feminist theory, critical theory and social psychology theory. The review utilizes a comprehensive strategy to investigate the theoretical lenses and consequences of gender stereotyping and social norms. The approach comprised of a few key stages. A survey incorporating gender stereotyping, social norms, feminist theory, critical theory and social psychology to assemble an all encompassing comprehension of the review was done. The review of gender stereotyping and social norms through critical assessment of key idea and viewpoints from feminist theory, critical theory and social psychology. The structure for revealing perplexing social peculiarities is given by the integration of feminist theory, critical theory and social psychology theory. This enlightened the basic component of inequality and injustice by considering the joint impact of gender, power and social setting. The review revealed the pervasive nature of gender stereotyping and social norms, their effect on causing inequality and injustice and the significance of promoting gender equality and social equity. In this way, the significance of interdisciplinary collaborative effort and combined actions in addressing the issue of gender stereotyping and social norms within educational setting and more extensive cultural setting. It emphasized the need for holistic approaches that will consider the broad intersection of power, ideology, and social issue in order to create gender equality and social justice both in the social and educational domain.

Integrated induction of silver resistance determinants and production of extracellular polymeric substances in Cupriavidus metallidurans BS1 in response to silver ions and silver nanoparticles

Although the antimicrobial mechanisms of nanomaterials have been extensively investigated, bacterial defense mechanisms associated with AgNPs have not been fully elucidated. We here report that dissolved Ag+ (>0.05 μg mL−1) displayed higher toxicity on cell growth of strain Cupriavidus metallidurans BS1 (GCA_003260185.2) in comparison to 2 and 20 nm AgNPs. The genes necessary for synthesis of distinct abundance and composition of extracellular polymeric substances (EPS) were induced in strain BS1 exposed to Ag stress. This resulted in 20.1% (Ag(I)-EPS) and 24.2% (2 nm AgNPs-EPS) of the CO band integrated intensities being converted into C-OH/C-O-C group vibrations and the Ag-O bond was formed between EPS and 20 nm AgNPs. Meanwhile, the expression of primary resistance genes of the cus, sil and cup operon encoding HME-RND-driven efflux systems as well as a PIB1-type ATPase (CupA) were significantly induced after exposure to Ag(I), 2 and 20 nm AgNPs, respectively. Furthermore, distinct genes involved in biosynthesis pathways responsible for production of EPS were induced to relieve the toxicity of Ag(I), 2 nm and 20 nm AgNPs. This combined action is one potential reason why strain BS1 displayed distinct resistances in response to Ag(I) compared to 2 and 20 nm AgNPs. This work will help in understanding processes important in bacterial defensive mechanisms to AgNPs.

Research on mechanical properties and microscopic mechanism of multi-based geopolymer concrete under combined action of pre-curing and nano-silica

In order to study the combined action of curing conditions and nano-silica (NS) on geopolymer concrete (GPC), the multi-based geopolymer concrete (FSSGC) was prepared with fly ash (FA), slag (SG) and steel fiber (SF), the experiments were carried out in three stages. Firstly, the mechanical properties of FSSGC was tested by monofactor analysis, with pre-curing temperature (20, 40, 60, 80, and 100 °C) and pre-curing time (6, 12, 18, 24, 30, and 36 h) as parameters. The compressive strength and splitting tensile strength initially increased and then decreased with the increase of parameters, and there was an optimal value for subsequent experimental research (80 °C and 18 h). Secondly, the effects of NS content (0, 0.5, 1.0, 1.5, and 2.0 wt%) on the mechanical properties of FSSGC under different curing conditions were analyzed. The results indicated that the mechanical properties of the FSSGC exhibited a trend of initially increasing and then decreasing with the increase of NS content, with the optimal mechanical performance observed under the combined action of high-temperature pre-curing conditions and the incorporation of NS (1.0 wt%). Thirdly, X-ray diffraction, scanning electron microscopy, image analysis, and microhardness tests had been conducted, and the results were consistent with the mechanical properties. The pre-curing temperature affected the rate of geopolymerization, while the pre-curing time influenced the degree of geopolymerization by maintaining this rate. The small particle size and high Young's modulus of the NS effectively filled pores and inhibited the propagation of microcracks. High-temperature pre-curing enhanced the nucleation effect and pozzolanic effect of NS, resulting in a combined action that formed a denser microstructure in the matrix and interfacial transition zone (ITZ).

Numerical study of vehicle motion during water exit under combined lifting force and wave action

During the retrieval process of the deep-sea mining vehicle (DSMV), the stability of the retrieval system is strongly influenced by the interaction between the vehicle body and the surrounding seawater due to the vehicle's complex shape and wave motion. Naturally, the negative side effects of significant changes in the vehicle's attitude and the water exit position can only increase retrieval's challenge. To investigate the characteristic of the flow field of the DSMV, this study employs the computational fluid dynamics method based on the Reynolds-averaged Navier–Stokes equations integrating the volume-of-fluid multiphase flow model with a fifth-order Stokes-wave model to explore the attitude and displacement changes of the vehicle during the water exit process in the ocean wave environment. The results indicate that the wave phase and lifting force are the major effect factors in the DSMV's water exit process. An appropriate lifting force under a specific wave phase can effectively reduce attitude changes and positional drift of the DSMV during water exit, thereby enhancing recovery efficiency and stability.

Dispersion of solute in a packed cylindrical tube with wall reaction

Abstract The study aims to investigate the transport of solute in a packed cylindrical tube, analytically. At the wall, the solute experiences an irreversible chemical reaction of order-one.The combined action of moments method with integral transform technique has been introduced to employ the Gill’s generalized dispersion model. The main goal is to investigate a full time evaluation of various transport coefficients in different superficial flow through porous media together with wall reaction. This study provides a perspective on how porous media influences the migration of solutes in the presence of wall reactions. Exchange coefficient is shown to be solely dependent on wall absorption. In the presence of porosity, wall absorption causes an increase in the advection coefficient's magnitudes; however, the dispersion coefficient exhibits the reverse behavior. Fluid velocity is always suppressed by damping factor, and thus advection and dispersion coefficients both controlled by damping factor. Increase in porosity parameter will reduces the axial concentration distribution. This work could have applications in areas such as groundwater flow, contaminant transport, or chemical reactions within porous materials.

The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes.

Erythema, characterized by the redness of the skin, is a common skin reaction triggered by various endogenous and exogenous factors. This response is often a result of the activation of underlying inflammatory mechanisms within the skin. The objective of this study is to investigate the potential benefits of applying a combination of skincare ingredients, namely allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate (AB5D), in the modulation of inflammatory factors associated with erythema. Additionally, the study aims to elucidate the mechanisms by which these ingredients exert their combined actions to alleviate erythema-associated inflammation. Human epidermal keratinocytes were exposed to UVB and subsequently treated with AB5D. Transcriptomics profiling was performed to analyse the dose-response effect of AB5D treatment on keratinocytes. The quantitation of inflammatory mediators, including PGE2, IL-1α, IL-6, IL-8, IL-1RA and TNFα, was performed on cultured media. Additionally, the oxygen radical absorbance capacity (ORAC) assay was carried out to evaluate the total antioxidant capacity of both individual ingredients and the AB5D combination. To assess the in-vitro antioxidant effects of AB5D against UVB-induced oxidative stress in hTERT keratinocytes, real-time quantitation of mitochondrial superoxide was measured through live-cell imaging. The application of AB5D to UVB-exposed keratinocytes downregulated gene sets associated with inflammatory responses, highlighting the anti-inflammatory properties of AB5D. Specifically, AB5D effectively reduced the production of PGE2, leading to the downregulation of inflammatory cytokines. Moreover, our findings indicate that AB5D exhibits antioxidative capabilities, functioning as both an antioxidant agent and a regulator of antioxidant enzyme expression to counteract the detrimental effects of cellular oxidative stress. We demonstrated that AB5D can reduce UVB-induced PGE2, IL-1α, IL-6, IL-8, IL-1RA and TNFα as well as mitochondrial superoxide. These findings suggest that AB5D may alleviate erythema by modulating inflammation via PGE2 and through antioxidation mechanisms.

Electron scattering on small-scale electrostatic fields in the shock front

Electron heating and acceleration in collisionless shocks is a long-standing problem. Rapid isotropization of heated electrons cannot be explained solely by the cross-shock potential. In addition, the macroscopic cross-shock potential prevents efficient reflection and injection into the diffusive acceleration regime. Recent observations have shown that small-scale electric fields are present in the shock front, together with the large-scale cross-shock potential. These small-scale fields have been found also in the upstream and downstream regions. Electron heating in shocks is produced by the combined action of the large- and small-scale fields. The large-scale potential determines the energy transferred to the electrons. The small-scale electrostatic fields scatter electrons. Here we study the scattering of electrons on the typical waveforms, namely solitary bipolar spikes and wavepackets. The main effect is the generation of backstreaming electrons with large pitch angles. It is found that wavepackets are more efficient in electron reflection in the interaction of electrons both with a single spike and with multiple spikes.

Unveiling Potent Anti-Asthmatic Effect of Curcumin in Combination with Salmeterol in Swiss Albino Mice

Background: Asthma is a long-term inflammatory respiratory condition marked by alterations in the airways and an increase in inflammatory cell infiltration. It has been observed that Curcumin possesses immune-modulating, anti-inflammatory, and relaxing properties for smooth muscle in the airways. Salmeterol is believed to ease the smooth muscles of the airways. Objective: Swiss Albino mice were used in the research to examine the combination anti-asthmatic effects of Curcumin and Salmeterol in asthma produced by ova albumin and milk induced eosinophilia and leucocytosis. Methods: The mice received pre-treatment with Curcumin (10 mg/kg, 20 mg/kg intraperitoneally) as well as Salmeterol (5 mg/kg) after being stimulated with an Ovalbumin (OVA) challenge and milk. After the induction period, various hematological, biochemical, molecular (ELISA), and histological analyses were performed. Results: The findings demonstrated that the combined treatment decreased the animal’s overall leukocyte and eosinophil numbers in a manner that was dose-dependent. Additionally, the therapy reduced albumin and overall protein amount in serum, BALF and lung tissues, facilitated changes in haematological parameters, and reduced the rise of Th2 cytokines (IL-4, TNF-α, IL-13) levels that is induced by OVA in lungs and BALF, total IgE level in serum. The combined action of Curcumin and Salmeterol reduced OVA-induced inflammatory influx and ultrastructural abnormalities, according to histopathological evaluation. Conclusion: The findings of this investigation demonstrate that curcumin and salmeterol together possess anti-asthmatic effects through suppressing Th2 triggered immune response and possessing an anti-inflammatory effect and anti-allergic effect. Thus combination of treatments might be a novel technique for managing asthma.

Dynamic analysis of six-bar tensegrity-based robot

Abstract The tensegrity-based robot is a hot research topic in the research field of robotics. The dynamics of the robot, describing the specific motion patterns under the influence of forces and torques, play an important role in the application of robotics. In addition, the dynamics should be considered when revealing the internal mechanisms of robots and predicting their dynamic behaviors. In this work, a dynamic model for a rolling six-bar tensegrity-based robot is established. In terms of kinematic representation, quaternions are chosen as the tool for attitude description, simplifying the derivation process of the complex three-dimensional rotational kinematics calculations. Quaternions play a crucial role in mathematical processing for robot attitude control and path planning due to their effective representation of three-dimensional space rotations. The classic Newton-Euler dynamic framework was adopted to conduct in-depth and detailed studies on the dynamic characteristics of the robot under various force conditions and motion states, with a particular focus on rolling dynamic analysis. Special attention was paid to the dynamic response mechanisms of each component of the robot under the combined action of internal and external forces and torques.

Hydrodynamic response characteristics of curved shape trash intercepting net under wave–current combined conditions

Under the influence of waves and ocean currents, the mesh panels of trash nets at nuclear power plants exhibit a curved shape. The combined action of waves and currents creates a Doppler effect that significantly influences the hydrodynamic response of these nets. This paper used OpenFOAM to establish a porous media macroscopic computational fluid dynamics model for analyzing the forces on curved trash nets. Wave–current combined conditions were simulated by introducing a uniform current in the direction of wave propagation. Forces on the nets under wave–current combined conditions were analyzed and compared with forces under separate uniform current and wave conditions. The results indicate that wave run-up on the nets is more significant under wave–current combined conditions than under wave action alone. The dimensionless horizontal force decreases more rapidly with increasing wave steepness (kA) and wave number (kd) under combined conditions than with linear superposition. Specifically, the rate of increase in dimensionless horizontal force with current speed, at the same blockage ratio, is about twice that of linear superposition. Additionally, the tension in the main cable of the nets is 17% higher under combined conditions than with linear superposition.

Study on the time delay failure characteristics of sandstone unloading under dynamic disturbance

The rockburst caused by underground engineering excavation exhibits a significant lag effect. Studies have shown that the occurrence of lag-type rockburst is closely related to the delayed failure of rocks. This paper focuses on the delayed failure characteristics of unloading-damaged sandstone under the combined action of static load and dynamic disturbance. Numerical simulations are utilized to analyze the delayed failure evolution characteristics and failure mechanisms of sandstone. The results indicate that in triaxial unloading delay failure tests, the duration of loading decreases exponentially with the increase of initial unloading damage. Compared to static load conditions, the duration of loading under dynamic disturbance decreases by more than 43 %, and the average strain rate significantly increases. The number of cracks at the endpoint of triaxial unloading delay failure increases as initial unloading damage decreases, with a substantial increase in the number of cracks under dynamic disturbance. These findings provide a valuable reference for the timeliness and delayed rockburst analysis and interpretation of rock damage and failure under high-stress levels.