ACTH In Human Plasma Research Articles

The use of immunoradiometric assay for the measurement of ACTH in human plasma

Bioassay and immunoassay techniques for the measurement of ACTH in human plasma have provided sensitive and specific results but have also met with some skepticism as to their reliability in some clinical circumstances. The recent development of a supersensitive two-site immunoradiometric assay for ACTH may resolve sole of the limitations of previous assays and greatly facilitate the evaluation of pituitary-adrenal disorders.

50. The changes of human plasma ACTH, immunoreative (IR)-β-endorphin(end) and cortisol (F) during gestation, labor and delivery

50. The changes of human plasma ACTH, immunoreative (IR)-β-endorphin(end) and cortisol (F) during gestation, labor and delivery

Infrequent Elevation of Plasma ACTH in Patients with Bronchogenic Carcinoma

Older methods for radioimmunoassay of ACTH in human plasma have detected a high frequency of plasma ACTH elevation in patients with lung cancer, even in the absence of Cushing’s syndrome. It now appears evident that these assay systems measure biologically inactive forms and fragments of ACTH. Since ectopic Cushing’s syndrome may be clinically atypical, a radioimmunoassay for ACTH that correlates with the clinical state would be of value. Accordingly, circulating plasma corticotropin (ACTH) levels were measured in 39 consecutive patients with biopsy-proven, untreated lung cancer, all without evidence of Cushing’s syndrome. In only one instance was ACTH found to be elevated by the method of assay used. Two interpretations are justified: (1) elevated plasma ACTH levels are infrequent in patients with lung cancer, or (2) ACTH measurements vary according to the assay system used.

A Simple and Sensitive Radioreceptor Assay for ACTH in Human Plasma

Journal Article A Simple and Sensitive Radioreceptor Assay for ACTH in Human Plasma Get access Kingsley Labrosse, M.S., Kingsley Labrosse, M.S. Department of Pathology St. Paul-Ramsey Hospital and Medical Center 640 Jackson Street St. Paul, Minnesota 55101 Address reprint requests to Dr. Lakatua. Search for other works by this author on: Oxford Academic Google Scholar David Lakatua, M.D. David Lakatua, M.D. Department of Pathology St. Paul-Ramsey Hospital and Medical Center 640 Jackson Street St. Paul, Minnesota 55101 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 63, Issue 2, 2 February 1975, Pages 285–286, https://doi.org/10.1093/ajcp/63.2.285 Published: 02 February 1975 Article history Received: 27 June 1974 Accepted: 24 July 1974 Published: 02 February 1975

Radioimmunoassay of ACTH

Radioimmunoassay of ACTH