AcrySof SN60WF Intraocular Lenses Research Articles

Ophthalmic viscosurgical device interaction with two hydrophobic acrylic intraocular lenses of different equilibrium water content

Ophthalmic viscosurgical device (OVD) is used during intraocular surgery to protect ocular tissue. It requires complete removal from the eye by the end of surgery to avoid postoperative complications. This study compares the interaction of a cohesive OVD with two different intraocular lenses (IOLs) of different equilibrium water content. In this laboratory study on porcine cadaver eyes, the capsular bags and anterior chambers of each eye were filled with fluorescein-stained OVD. Following implantation of 10 IOLs each of Clareon CNA0T0 and AcrySof SN60WF (Alcon Laboratory, Fort Worth, USA) IOLs, the OVD was removed using the irrigation/aspiration mode. The OVD removal was timed and differences between the both IOL groups were compared. OVD removal time ranged from 18 to 40 s (mean ± SD, 26.4 ± 6.8 s) and from 16 to 39 s (mean ± SD, 23.6 ± 6.6 s) for eyes implanted with a CNA0T0 and a SN60WF IOL, respectively, without a statistically significant difference between the groups, P > 0.05. Cohesive OVD removal times were similar between the CNA0T0 and SN60WF groups. Surgeons should experience no differences regarding the interaction between cohesive OVDs and IOLs made from the new Clareon material compared to the established AcrySof material.

Posterior Capsule Opacification With Two Hydrophobic Acrylic Intraocular Lenses: 3-Year Results of a Randomized Trial

To compare the incidence and intensity of posterior capsule opacification (PCO) and neodymium-yttrium-aluminum-garnet (Nd:YAG) capsulotomy rates between 2 similar open-loop single-piece hydrophobic acrylic intraocular lenses (IOLs) that differ in the proprietary material characteristics and design features, over a period of 3 years. Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison. Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Eighty patients (160 eyes) had bilateral cataract surgery and received a Vivinex XY1 IOL in 1 eye and an AcrySof SN60WF IOL in the other eye. Follow-up examinations were performed 3 years after surgery. Digital retroillumination images were taken of each eye. The amount of PCO (score: 0-10) was assessed subjectively at the slit lamp and objectively using automated image analysis software (AQUA). PCO score (scale, 0-10). The mean objective PCO score of the Vivinex XY1 IOLs was 0.9 ± 0.8 compared to the PCO score of 1.4 ± 1.1 for the AcrySof SN60WF IOLs (P < .001). Three years postoperatively, 11.4% of patients had an Nd:YAG capsulotomy in the Vivinex XY1 eye and 18.6% had a capsulotomy in the AcrySof SN60WF eye (P= .23). The new hydrophobic acrylic Vivinex XY1 IOL showed significantly lower PCO rates and lower YAG rates compared to the AcrySof SN60WF IOL. The interaction of various factors such as hydrophobic material, smooth optic surface, and sharp posterior optic edge plays a key role in PCO development.

Comparison of glistenings formation and their effect on forward light scatter between the Acrysof SN60WF and Eternity Natural Uni NW-60 intraocular lenses

AimsTo compare the characteristics of glistenings and forward light scatter between the Alcon Acrysof SN60WF and Santen Eternity Natural Uni NW-60 intraocular lenses (IOLs).MethodsFive Acrysof SN60WF and five Eternity Natural...

Intrasession Repeatability of Biometric Measurements Obtained with a Low-Coherence Interferometry System in Pseudophakic Eyes

ABSTRACTPurpose: To evaluate the intrasession repeatability of the biometric measurements obtained with a low-coherence reflectometry optical biometer in pseudophakic eyes implanted with two different types of intraocular lens (IOL).Methods: Prospective, single-center, comparative study including 69 eyes of 69 patients with ages ranging from 51 to 92 years. Previous uncomplicated cataract surgery had been performed in all patients 1 to 2 months before measurements, with implantation of the Acrysof SN60WF IOL in 35 eyes (35 patients, group 1) and the IOL Akreos MI60 in 34 eyes (34 patients, group 2). A complete postoperative ophthalmological examination was performed including three consecutive measurements with the “Aladdin” system from (Topcon, Japan). Intrasession repeatability of axial length (AXL), anterior chamber depth (ACD) and IOL thickness (IOLT) were assessed with the within-subject standard deviation (Sw), intraobserver precision (1.96 × Sw), coefficient of variation (CV) and intraclass correlation coefficient (ICC). Results: The Sw for AXL measurements was 0.03 and 0.05 mm in groups 1 and 2, respectively, with ICC of 1.000 and 0.999 (CV: 0.14% and 0.22%) (p ≤ 0.031). Concerning pseudophakic ACD, the Sw was 0.03 and 0.09 mm in groups 1 and 2, respectively, with ICC of 0.992 and 0.956 (CV: 0.55% and 1.75%) (p ≤ 0.021). The variability of IOLT measurements was high in both groups, with Sw of 0.12 and 0.29 mm for groups 1 and 2 (p = .008), respectively, and ICC of 0.065 and 0.770 (CV: 20.84% and 62.39%).Conclusions: The optical biometer “Aladdin” (Topcon, Japan) provides consistent measurements of AXL and ACD in pseudophakic eyes. However, there is a limitation in the consistency of IOLT measurements that should be investigated further.

Comparison of posterior capsule opacification development with 2 single-piece intraocular lens types

To evaluate the differences in the incidence of posterior capsule opacification (PCO) and visual and optical performance between2 hydrophobic acrylic single-piece sharp-edged intraocular lenses (IOLs) over 3years. Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Prospective randomized case series. Patients with bilateral cataract were prospectively randomizedto receive an Eyecee One IOL (IOL A) or an Acrysof SN60WF IOL (IOL B) and were followed for 36months. The corrected distance visual acuity (CDVA) and IOL decentration and tilt were measured. The PCO was quantified by analysis of standardized retroillumination images. The study comprised 160 eyes of 80 patients. The PCO incidence was low for both IOLs at all follow-up visits. Three years postoperatively, the median objective PCO score was 1.4 (range 0 to 5.6) for IOL A and 1.5 (range 0 to 5.0) for IOL B (P=.67). The neodymium:YAG (Nd:YAG) capsulotomy rate 3years after surgery was 16.4% and 6.0% (P=.06), respectively. Visual acuity and contrast sensitivity outcomes were also comparable at all follow-up visits. Both IOLs showed good capsular bag performance and low PCO rates 3years after surgery. Both IOLs also showed comparable results for visual acuity, contrast sensitivity, decentration and tilt, PCO score, slitlamp examination, and Nd:YAG capsulotomy rates.

Comparison of biometry and intraocular lens power calculation performed by a new optical biometry device and a reference biometer

To compare biometry measurements and intraocular lens (IOL) power calculations obtained by a new optical A-scan interferometer biometer (Galilei G6) (new biometer) and a partial coherence interferometer biometer (IOLMaster 500) (reference biometer). Private practice, Recife, Brazil. Retrospective comparative study. Cataract patients who had biometric measurements with the new biometer and the reference biometer were included in the study. Comparisons were performed for axial length (AL), keratometry (K), anterior chamber depth (ACD), and IOL power calculation to reach emmetropia with an Acrysof SN60WF IOL using the Haigis formula. The Pearson correlation coefficient and the 95% limits of agreement (LoA) were calculated. The paired Student t test and the Wilcoxon test were used to assess differences between devices. Eighty-eight eyes (88 patients) were studied. Both biometers provided statistically similar mean IOL power to reach emmetropia, AL, keratometry, and ACD measurements (P>.05). The differences in these variables did not vary as their mean values increased, and there was a strong positive correlation between the values obtained by both devices for each variable. The 95% LoA values for AL, mean keratometry, ACD, and IOL power were 0.27mm, 1.08 diopters (D), 0.66mm, and 1.56 D, respectively. The 2 devices were comparable with regard to mean IOL power, mean AL, K, and ACD measurements. However, the wide range of differences between the devices suggests they should not be used interchangeably.

Suppression of surface light scattering in intraocular lenses manufactured using an improved production process

To clinically examine the suppression of surface light scattering after implantation of an intraocular lens (IOL) manufactured using an improved production process. Miyata Eye Hospital, Miyazaki, Japan. Comparative case series. The prospective case series comprised eyes receiving hydrophobic acrylic Acrysof SN60WF IOLs that were manufactured before and after the improvement. Light scattering on the anterior IOL surface was examined up to 3years postoperatively using an EAS-1000 anterior segment analyzer. The changes during the postoperative period were evaluated and the 2 IOLs compared. The corrected distance visual acuity (CDVA) and contrast sensitivity under photopic and mesopic conditions were also examined 3years postoperatively. The case series comprised 24 eyes (received IOL before improvement) and 27 eyes (received IOL after improvement). After the improvement, the IOLs showed no increase in surface light scattering up to 2years, while there were increases after 2years in the other IOLs. The light scattering with the improved IOL was significantly reduced at all observations (P<.048, t test with Holm correction). No difference was found in the CDVA and contrast sensitivity. The improvement in the production process effectively decreased and slowed the development of surface light scattering. The slower increase in the improved IOL 3years postoperatively showed that the development of water aggregates would not be completely prevented. None of the authors has a financial or proprietary interest in any material or method mentioned.

In vitro examination of surface light scattering in hydrophobic acrylic intraocular lenses

To evaluate laboratory models using accelerated aging to assess surface light scattering in hydrophobic acrylic intraocular lenses (IOLs). Miyata Eye Hospital, Miyazaki, Japan. Experimental study. Acrysof SA60AT IOLs manufactured before optimization of the IOL production process (non-optimized IOLs) and Acrysof SN60WF IOLs that were manufactured after optimization of the production process (optimized IOLs) were examined. After the IOLs were accelerated aged corresponding to 0, 3, 5, 10, 15, and 20 years, surface light scattering was measured with a Scheimpflug camera. Formation of water aggregates below the IOL surface was observed with cryogenic focused ion-beam scanning electron microscopy. In the non-optimized IOLs, surface light scattering increased with aging (P<.001, R2=0.87). There was no significant increase in surface light scattering in the optimized IOLs. An increase in water aggregates with sizes of nanometer order was observed in the aged non-optimized IOLs. An in vitro model using accelerated aging was effective for examining the incidence of surface light scattering. The laboratory results showed suppression of surface light scattering in the IOL manufactured with the optimized process. No author has a financial or proprietary interest in any material or method mentioned.

Halo size after implantation of a multifocal intraocular lens

AbstractPurpose To determine the size of a halo in the visual field induced by bright light after cataract surgery and implantation of an aspheric apodized diffractive multifocal intraocular lens (IOL) or aspheric monofocal IOL.Methods This prospective observational study comprised 54 healthy eyes (mean age 72.6 ± 10.4) of 54 subjects having cataract surgery with bilateral implantation of an AcrySof ReSTOR SN6AD1 IOL (32 eyes, multifocal group) or AcrySof SN60WF IOL (22 eyes, monofocal group). Six months postoperatively, halo size was measured using the Vision monitor. Optotypes of low luminance (5cd/m2) were presented at a distance of 2.5 m. The visual angle subtended by the radius of the halo was calculated in minutes of arc (arc min). Best‐corrected distance logMAR visual acuity (VA) was evaluated with high‐contrast (HC‐96%) and low‐contrast (LC‐10%) logMAR Bailey‐Lovie letter charts.Results The mean radius of the halo was 219.3 ± 42.1 and 194.0 ± 55.3 arc min (p &gt; 0.05) in the multifocal and the monofocal groups respectively. The HC and LC VA means showed significant differences between the two groups, being worse in the multifocal group. Also, the HC and LC‐VA exhibited a significant correlation with halo size (r= 0.52 y r= 0.57 respectively).Conclusion Mean halo size was not significantly different between the multifocal ReSTOR SN6AD1 and the monofocal AcrySof SN60WF IOLs. Worse HC and LC‐VA values were related to higher halo size measurements in the IOLs groups.

Posterior Capsule Opacification with the iMics1 NY-60 and AcrySof SN60WF 1-Piece Hydrophobic Acrylic Intraocular Lenses: 3-Year Results of a Randomized Trial

To compare the intensity of posterior capsule opacification (PCO) 3 years after implantation of 2 different 1-piece foldable hydrophobic acrylic intraocular lenses (IOLs). Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison. One hundred patients with bilateral age-related cataract (200 eyes) had standard cataract surgery with implantation of an iMics1 NY-60 IOL (Hoya Corp) in one eye and an AcrySof SN60WF IOL (Alcon Laboratories) in the other eye. Follow-up examinations were performed at 1 week and 3 years. Digital retroillumination images were obtained of each eye. The main outcome measure was PCO score (scale, 0 to 10) assessed subjectively at the slit lamp and objectively using automated image analysis software (Automated Quantification of After-Cataract) 3 years after surgery. The objective PCO score (mean ± standard deviation) was 3.0 ± 2.0 for the iMics1 NY-60 IOL and 1.9 ± 1.4 for the AcrySof SN60WF IOL (P < .001). Three years after surgery, 35.6% of patients underwent a neodymium:yttrium-aluminum-garnet capsulotomy in the iMics1 NY-60 eye and 13.7% underwent a capsulotomy in the AcrySof SN60WF eye (P = .001). There was no statistically significant difference in best-corrected visual acuity, rhexis-IOL overlap, capsular folds, or anterior capsule opacification. Glistening formations were found in no iMics1 NY-60 IOLs, but in 97% of the AcrySof SN60WF IOLs. Comparison of 2 sharp-edged single-piece IOLs of similar design and hydrophobic acrylic material indicated a statistically significant difference in PCO and neodymium:yttrium-aluminum-garnet capsulotomy rate 3 years after surgery.

In Vivo Chromatic Aberration in Eyes Implanted With Intraocular Lenses

To measure in vivo and objectively the monochromatic aberrations at different wavelengths, and the chromatic difference of focus between green and infrared wavelengths in eyes implanted with two models of intraocular lenses (IOL). EIGHTEEN EYES PARTICIPATED IN THIS STUDY: nine implanted with Tecnis ZB99 1-Piece acrylic IOL and nine implanted with AcrySof SN60WF IOL. A custom-developed laser ray tracing (LRT) aberrometer was used to measure the optical aberrations, at 532 nm and 785 nm wavelengths. The monochromatic wave aberrations were described using a fifth-order Zernike polynomial expansion. The chromatic difference of focus was estimated as the difference between the equivalent spherical errors corresponding to each wavelength. Wave aberration measurements were highly reproducible. Except for the defocus term, no significant differences in high order aberrations (HOA) were found between wavelengths. The average chromatic difference of focus was 0.46 ± 0.15 diopters (D) in the Tecnis group, and 0.75 ± 0.12 D in the AcrySof group, and the difference was statistically significant (P < 0.05). Chromatic difference of focus in the AcrySof group was not statistically significantly different from the Longitudinal chromatic aberration (LCA) previously reported in a phakic population (0.78 ± 0.16 D). The impact of LCA on retinal image quality (measured in terms of Strehl ratio) was drastically reduced when considering HOA and astigmatism in comparison with a diffraction-limited eye, yielding the differences in retinal image quality between Tecnis and AcrySof IOLs not significant. LRT aberrometry at different wavelengths is a reproducible technique to evaluate the chromatic difference of focus objectively in eyes implanted with IOLs. Replacement of the crystalline lens by the IOL did not increase chromatic difference of focus above that of phakic eyes in any of the groups. The AcrySof group showed chromatic difference of focus values very similar to physiological values in young eyes.

Final incision size after implantation of a hydrophobic acrylic aspheric intraocular lens: New motorized injector versus standard manual injector

To assess the impact on incision size of IOL implantation using a new motorized intraocular lens (IOL) injector versus a standard manual injector. Cataract Treatment Centre, Sunderland Eye Infirmary, Sunderland, United Kingdom. Comparative case series. All patients received an Acrysof SN60WF IOL implanted using a D cartridge and an Autosert motorized injector at fast speed, an Autosert motorized injector at slow speed, or a manual Monarch injector. Each group had a range of preimplantation incision sizes (1.9 mm, 2.0 mm, 2.1 mm, 2.2 mm, 2.3 mm). Incision gauges were used to measure the incision width before and immediately after IOL implantation. The study recruited 256 patients. All incisions that were 1.8 mm at the commencement of surgery increased in size by the end of irrigation/aspiration. The motorized injector used with a fast speed (4.4 mm/sec) caused significantly less incision enlargement than the manual injector for all preimplantation incision sizes tested (P<.02). For 4 of the 5 preimplantation incision size subgroups, the motorized injector used at slow speed (1.5 mm/sec) produced less incision stretch than the manual injector, although the difference did not reach statistical significance. The motorized injector was easy to use, and its use with an injection speed of 4.4 mm/sec caused significantly less incision enlargement than the manual injector during IOL implantation.

Visual function and spectacle independence after cataract surgery: Bilateral diffractive multifocal intraocular lenses versus monovision pseudophakia

To evaluate and compare patient-reported visual function, spectacle independence, and quality of life before and after cataract surgery with bilateral diffractive multifocal or monofocal intraocular lens (IOL) implantation. Department of Ophthalmology, Henry Ford Health System, Taylor Branch, Detroit, Michigan, USA. Prospective cohort study. This study evaluated consecutive cataract patients having bilateral implantation of Acrysof Restor SN60D3 multifocal IOLs or monofocal Acrysof SN60WF IOLs, the latter as monovision, between July 2007 and June 2009. Parameters analyzed 3 months postoperatively included binocular uncorrected distance, intermediate, and near visual acuities; stereo vision; spectacle independence; subjective visual symptoms; and patient satisfaction. Preoperative and postoperative quality of life was assessed with the National Eye Institute Visual Function Questionnaire-25(NEI VFQ-25). The multifocal group comprised 21 patients and the monovision group, 22 patients. Binocular uncorrected visual acuity at distance and near at 3 months was significantly better than preoperatively in both groups. In both groups, there was an improvement in all ocular and visual-related NEI VFQ-25 responses postoperatively. Bilateral multifocal IOLs and conventional monofocal IOL pseudophakic monovision significantly improved spectacle independence and visual quality-of-life measures.

Visual function and patient satisfaction: Comparison between bilateral diffractive multifocal intraocular lenses and monovision pseudophakia

To compare visual function and patient satisfaction in patients with bilateral diffractive multifocal intraocular lenses (IOLs) and patients with monofocal IOL monovision. Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, USA. Cohort study. This study comprised consecutive bilateral cataract patients having implantation of AcrySof ReSTOR SN60D3 multifocal IOLs or AcrySof SN60WF IOLs as monovision between July 2007 and June 2009. Parameters analyzed 3 months postoperatively included binocular uncorrected distance, intermediate, and near visual acuities; stereo vision; spectacle independence; subjective visual symptoms; and patient satisfaction. Patients were administered the Visual Function Questionnaire-25 preoperatively and postoperatively. The multifocal IOL group comprised 21 patients and the monovision group, 22 patients. Although bilateral uncorrected distance vision and near vision were slightly better in the multifocal IOL group than in the monovision group, there was no statistically significant difference between the 2 groups. The monovision group had better intermediate vision than the multifocal IOL group and had less difficulty using computers without glasses; the differences between the 2 groups were statistically significant. Patients with monovision had a slightly higher overall satisfaction score, significantly fewer complaints, and less out-of-pocket cost. Pseudophakic monovision achieved distance vision and near vision that were comparable to those with bilateral multifocal IOLs without the inherent risk for disturbing visual symptoms associated with multifocal IOLs. Monovision patients also had significantly better intermediate vision and less difficulty using computers without glasses.

Prediction error after pediatric cataract surgery with intraocular lens implantation: Contact versus immersion A-scan biometry

To evaluate the accuracy of pediatric intraocular lens (IOL) calculations performed using contact and immersion A-scan biometry. Storm Eye Institute, Charleston, South Carolina, USA. Evaluation of diagnostic test or technology. Data from a prospective study of pediatric eyes that had in-the-bag implantation of an AcrySof SN60WF IOL and had refraction results available from 14 days to 3 months postoperatively were retrospectively analyzed. The contact and immersion A-scan biometry techniques were performed in each eye and compared. The mean age at surgery of the 22 patients (22 eyes) was 4.8 years ± 4.1 (SD). The mean prediction error was +0.4 ± 0.7 diopter (D) in the contact group and -0.4 ± 0.8 D in the immersion group (P < .001) and the mean absolute prediction error, 0.7 ± 0.4 D and 0.7 ± 0.6 D, respectively (P=.694). The absolute prediction error was less than 0.5 D in 5 eyes (23%) using the contact technique and 11 eyes (50%) using the immersion technique. The mean postoperative spherical equivalent was +2.9 ± 2.5 D, which was significantly different from the mean predicted refraction for contact A-scan (3.3 ± 2.8 D; P=.010) but not immersion A-scan (2.5 ± 2.5 D; P=.065). There was a significant difference in prediction error between postoperative refractive results obtained with contact biometry and immersion A-scan biometry in children. Based on the results, the immersion A-scan technique is recommended for pediatric IOL power calculation.

The Effect of Yellow Tinted Intraocular Lenses on the Result of Frequency Doubling Perimetry after Cataract Surgery

PurposeTo investigate the effect of yellow tinted intraocular lenses (IOLs), implanted in the bag after phacoemulsification, on the result of frequency doubling technique (FDT) perimetry.MethodsFor 68 eyes of 52 patients, an IOL was implanted in the bag after phacoemulsification. The patients were categorized into three groups according to the type of implanted IOLs used. IOLs were selected randomly among two types of yellow IOLs (Acrysof SN60WF IOL, Hoya YA60BBR IOL) and a clear IOL was used as a control. A FDT Humphrey matrix was performed 2 months after the surgery. The mean deviation (MD) and pattern standard deviation (PSD) among these three groups was analyzed using Mann-Whitney U-test.ResultsTwo months after the procedure, there was no significant difference between each of the three groups: the clear IOL and Hoya YA60BBR IOL (MD, p = 0.21; PSD, p = 0.27), the clear IOL and Alcon SN60WF IOL (MD, p = 0.11; PSD, p = 0.22), and the Hoya YA60BBR IOL and Alcon SN60WF IOL (MD, p = 0.33; PSD, p = 0.56).ConclusionsWhen interpreting the result of the FDT after cataract surgery, the color and type of IOLs used should not be considered.

Visual axis opacification after cataract surgery and hydrophobic acrylic intraocular lens implantation in the first year of life

To report the incidence of visual axis opacification (VAO) requiring surgery after cataract extraction with hydrophobic acrylic intraocular lens (IOL) implantation during the first year of life. Storm Eye Institute, Charleston, South Carolina, USA; Iladevi Cataract and IOL Research Center, Ahmedabad, India. Cohort study. Medical records of patients younger than 1 year who had primary posterior capsulectomy, vitrectomy, and in-the-bag hydrophobic acrylic IOL implantation were reviewed. In bilateral cases, 1 eye was randomly chosen. The need for surgery for visually significant VAO was evaluated 12 months after cataract surgery. Seventy-two eyes were included. The mean age at cataract surgery was 6.0 months. Seventeen eyes (23.6%) required surgery for VAO a mean of 6.2 ± 2.9 months postoperatively. The odds for VAO surgery were 3.5 times greater in eyes of female children than in eyes of male children. For AcrySof MA60AC, SA60AT, SN60AT, or SN60WF IOLs, surgery for VAO was required in 25%, 23%, 23%, and 23% of eyes, respectively. The earliest time between cataract and secondary VAO surgery was relatively later (9.0 months) with the SN60WF IOL than with the MA60AC, SA60AT, or SN60AT IOL (4.4, 2.2, and 2.0 months, respectively). Nearly 25% of operated eyes of infants required a secondary surgical procedure for VAO; the rate was higher in eyes of female infants but did not differ between IOL models. The data indicate that surgery for VAO is required later in eyes with an SN60WF IOL than in eyes in which other AcrySof IOLs were used. No author has a financial or proprietary interest in any material or method mentioned.

The clinical investigation of dynamic changes of corneal astigmatism and visual quality for patients after phacoemulsification surgery through different incision and implantation of different designed intraocular lens

To compare the corneal astigmatism and wavefront aberration differences of patients with cataract coexisting corneal astigmatism after phacoemulsification surgery through traditional superior clear corneal incision or phacoemulsification surgery through clear corneal incision guided by corneal topography and implantation of different spherical aberration intraocular lenses (IOL). In a prospective randomized sample controlled clinical trial, 90 patients (90 eyes) with age-related cataract and corneal astigmatism were randomly divided into 3 groups: (Group A) traditional superior corneal incision phacoemulsification surgery and AcrySof SN60AT IOL implantation, (Group B) corneal topography guiding incision phacoemulsification surgery and AcrySof SN60AT IOL implantation and (Group C) corneal topography guiding incision phacoemulsification surgery and AcrySof SN60WF IOL implantation. Corneal topography tests were performed at 1 week, 1 month, 3 months and 6 months postoperatively. The Wavefront aberration was measured using a custom built Tscherning wavefront sensor-ALLEGRETTO WAVE Analyze at 90 days postoperatively. Third-, 4th-, 5th-, total and higher-order aberration (HOA) root-mean-square (RMS), spherical aberration and coma aberration were compared at virtual pupil diameters of 6 mm postoperatively. Statistical analyses were performed using the analysis of chi square test, repeated measurement data analysis of variance, one-way analysis of variance (ANOVA), and multiple comparisons Students-Newman-Keuls test. Corneal topography tests indicated that no significant difference for corneal astigmatism was found between these three groups preoperatively (F = 0.08, P > 0.05). The corneal astigmatism was decomposed into J(0), J(45) and P with a Vector-based method, and statistically analyzed. When compared with Group B and GroupC, Group A had higher values of corneal J(0) (F = 9.54, P < 0.01) and P (F = 18.69, P < 0.01). For corneal J(0) and P, no significant difference was found between Group B and Group C (P > 0.05). However groups and times had interactions (F = 13.45, 50.22, P < 0.01, respectively). For astigmatic vectors, there were statistical significances between different times in 3 groups (F = 74.33, 92.11, P < 0.01, respectively). Wavefront aberration test results indicated that the mean values of RMSg (root mean square of general aberration), coma aberration, RMSh, RMS(3), RMS(5) and RMS(6) of Group A were obviously higher than that of Group B and C (F = 93.40, 471.94, 176.95, 216.99, 44.37, 37.19, P < 0.01, respectively). And the values of RMS(4) and spherical aberration in Group A were significantly higher than that in Group C (q = 25.30, 26.23, P < 0.01, respectively). No statistically significant was found between Group A and Group B of RMS(4) and spherical aberration (q = 0.57, 2.34, P > 0.05, respectively). The values of RMS(4), RMSh, RMSg and spherical aberration in Group B were statistically significantly higher than that in Group C (q = 24.73, 7.90, 6.41, 23.89, P < 0.01, respectively). Corneal topography guiding incision phacoemulsification surgery and the implantation of negative spherical aberration IOL is a more favorable solution for cataract patients coexisting corneal astigmatism, which can correct the corneal astigmatism, decrease the spherical aberration, high-order aberration and general aberration of pseudophakic eyes and therefore improve the visual quality of patients.

Wavefront aberrations, depth of focus, and contrast sensitivity with aspheric and spherical intraocular lenses: Fellow-eye study

To compare wavefront aberration, depth of focus, contrast sensitivity, and in vivo modulation transfer function (MTF) after fellow-eye implantation of aspheric and spherical intraocular lenses (IOLs). Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. This prospective randomized controlled study comprised patients with bilateral cataract who received an aspheric AcrySof SN60WF IOL or a spherical AcrySof SN60AT IOL in the first eye and the other IOL in the second eye. Assessments at 3 and 6 months included 100% and 9% logMAR best corrected visual acuity (BCVA) and photopic and mesopic functional acuity contrast testing. Total internal and corneal aberrations and depth of focus were computed. Distance-corrected near logMAR acuity was available at 12 months. At 3 and 6 months, there was no significant difference in 100% and 9% BCVA or photopic contrast sensitivity. Mesopic contrast sensitivity was better and total and internal spherical aberrations were significantly less with the aspheric IOL. Total and internal eye vertical coma was reduced with aspheric IOL. Total MTF was not significantly different between groups. The aspheric IOL group had 0.46 diopter less depth of focus than the spherical IOL group at 6 months (P<.05). Distance-corrected near acuity was significantly better with the spherical IOL. Aspheric IOLs significantly reduced spherical aberration, improving mesopic contrast sensitivity. Vertical coma was reduced with aspheric IOLs. Reduction of aberrations may be responsible for reduced depth of focus with aspheric IOLs. This may be disadvantageous for near vision and reading ability.

Visual performance and contrast sensitivity after phacoemulsification with implantation of aspheric foldable intraocular lenses

To compare visual performance after phacoemulsification with implantation of an aspheric intraocular lens (IOL). Tertiary eyecare center in north India. This prospective study comprised patients with visually significant age-related cataract having clear corneal phacoemulsification with implantation of 1 of 3 types of aspheric IOLs. Twelve weeks postoperatively, visual acuity and contrast sensitivity were recorded. Wavefront analysis was performed with the Optical Path Difference scanner. All patients completed a questionnaire on subjective quality of vision. Main outcome measures were best corrected visual acuity (BCVA), contrast sensitivity, visual function score, and patient satisfaction. Of the 130 eyes (130 patients), a Tecnis Z9003 IOL was implanted in 43 eyes, an AcrySof SN60WF IOL in 41 eyes, and an Akreos Adapt AO IOL in 46 eyes. Contrast sensitivity and BCVA were similar between groups. With 4.0 mm, 5.0 mm, and 6.0 mm pupil diameters, the mean spherical aberrations were significantly less with AcrySof SN60WF and Akreos Adapt AO IOLs than with the Tecnis Z9003 IOL. There were no significant differences in total higher-order root-mean-square (RMS) values between IOLs. Visual performance scores with the 3 IOLs were comparable. All 3 aspheric IOLs significantly decreased positive spherical ocular aberration after phacoemulsification and may induce negative spherical aberration. However, there was no significant difference in total higher-order RMS values between the IOLs. The 3 IOL models provided comparable contrast sensitivity and visual performance.