Acquisition Phase Research Articles

Ayahuasca drinking using a two-bottle choice procedure in male mice

Ayahuasca has been proposed as a treatment for substance use disorders. However, because of its hallucinogenic properties, studies investigating its abuse potential are needed. The aim of the present study was to investigate voluntary ayahuasca drinking in male mice using a two-bottle choice procedure. Male mice were exposed to two bottles, one of water and one of ayahuasca (0.01, 0.03 or 0.1 mg/ml), for 15 h/day, under 3 protocols (acquisition): (1) every other day access; (2) access every 3 days; (3) access every 5 days. Animals were then submitted to a 14-day drug-free period, followed by 3 re-exposure phases (same conditions as during acquisition), with 7 drug-free days between each. Regardless of the ayahuasca concentration, animals showed a preference for ayahuasca over water when exposed to ayahuasca every other day during the acquisition and re-exposure phases. Extending the period between ayahuasca exposures changed the expression of ayahuasca preference, with the longest break (every 5 days) being associated with preference for water over ayahuasca (i.e., ayahuasca aversion), an effect that was more predominantly observed at higher ayahuasca concentrations. A significant interaction was observed between frequency of exposure to ayahuasca and ayahuasca concentration for total ayahuasca intake during the later re-exposure phase. Our findings show that both the frequency of exposure and the ayahuasca concentration are critical when determining ayahuasca preference in a two-bottle choice model in mice, which can help guide therapeutic/ritualistic ayahuasca use.

Functional MRI of imprinting memory in awake newborn domestic chicks

Filial imprinting, a crucial ethological paradigm, provides insights into the neurobiology of early learning and its long-term impact on behaviour. To date, invasive techniques like autoradiography or lesions have been used to study it, limiting the exploration of whole brain networks. Recent advances in fMRI for avian brains now open new windows to explore bird’s brain functions at the network level. We developed an fMRI technique for awake, newly hatched chicks, capturing BOLD signal changes during imprinting experiments. While early memory acquisition phases are understood, long-term storage and retrieval remain unclear. Our findings identified potential long-term storage of imprinting memories across a neural network, including the hippocampal formation, the medial striatum, the arcopallium, and the prefrontal-like nidopallium caudolaterale. This paradigm opens up new avenues for exploring the broader landscape of learning and memory in neonatal vertebrates, enhancing our understanding of behaviour and brain networks.

Astrocytes contribute to the functional differentiation of the hippocampal longitudinal axis during reward and aversion processing in the adult male rat

This study aims to investigate whether glial cells, in particular putative astrocytes, contribute to functional distinctions between the dorsal (DH), intermediate (IH), and ventral (VH) hippocampus. To evaluate this, we performed three different behavioral tasks (i.e., Morris water maze; MWM, Passive avoidance; PA, T-maze place preference; TPP) to determine whether the DH, IH, and VH are necessary for each task. Sensitivity of behavioral tasks was confirmed using lidocaine (2 %, 1 μl) reversible inactivation. Subsequently, we examined the effects of silencing astrocytes, using fluorocitrate (FC, 1 mM/1 μl), into the DH, IH, and VH on these tasks. The effects of drugs were examined separately. We observed that injection of FC into the DH resulted in a significant impairment in MWM performance. In contrast, while FC injections into the IH or VH did not prevent platform localization during the acquisition phase, rats showed difficulty recalling the target zone during the retrieval phase. In the PA test, FC injection into the VH impaired task learning and memory. During the acquisition phase, FC injection into the DH or IH did not differ from the control in the number of shocks; however, during retrieval, there was a significant decrease in the latency before entering the dark chamber. The TPP test performance was impaired by FC injection in the IH. In sum, we show that glial cells, especially astrocytes in specific functional regions of the hippocampus, play distinct roles in processing aversive and rewarding experiences and contribute to the functional organization of the hippocampal longitudinal axis.

Determining the optimal challenge point for learning motor skills in children with attention deficit/hyperactivity disorder

The purpose of this study was to investigate the optimal challenge point for learning motor skills in children with and without attention deficit/hyperactivity disorder (ADHD). Ninety-six 9- to 10-year-old children, including 48 children with ADHD and 48 neurotypical children, were randomly assigned to one of four practice groups with varying levels of nominal and functional task difficulty. They performed 63 trials of a dart throwing task in the acquisition phase and 18 trials in the retention and transfer tests a day later. The results showed that neurotypical children outperformed children with ADHD in all phases of the study. Both groups improved in the acquisition phase and performed better in the retention and transfer tests. Interestingly, low nominal task difficulty was associated with better learning for both groups, despite lower average performance for children with ADHD. Thus, despite their performance differences, we did not find a difference in the effective challenge point between children with ADHD and their neurotypical peers.

A conceptual framework proposal for the implementation of Prognostic and Health Management in production systems

AbstractPrognostic and Health Management (PHM) is an emerging maintenance concept that is highly regarded by the scientific community and practitioners, as its adoption can bring economic, technical and environmental benefits to a company. PHM fully reflects the smart maintenance paradigm encompassing data collection, data manipulation, state detection, health assessment, prognostic assessment and advisory generation. Despite the undeniable benefits, there is still a large gap between the scientific and the real world. Several authors have investigated on the barriers to PHM implementation for companies, highlighting among them the lack of systematic approaches to its design and implementation. As a first contribution to this topic, the authors conducted a systematic literature review (SLR) to investigate the use of Decision Support Systems (DSSs) to support the PHM implementation. The SLR highlighted that few DSS had been developed and were limited to critical unit identification, maintenance strategy selection and data acquisition phase of PHM. Therefore, a conceptual framework for PHM implementation was provided as a second contribution. This framework summarises the decisions that should be addressed by a practitioner wishing to implement PHM services; moreover, it could lay the foundations for the development/improvement of the missing/existing DSSs for PHM implementation.

P2X7 receptors modulate acquisition of cue fear extinction and contextual background memory generalization in male mice

The purinergic P2X7 receptors (P2X7R) are activated by adenosine triphosphate (ATP) in several brain regions, particularly those involved with emotional control and the regulation of fear-related memories. Here, we investigate the role of P2X7R in fear learning memory, specifically in the acquisition and consolidation phases of the cued fear conditioning paradigm. C57Bl/6 wildtype (WT) male mice that received a single i.p. injection of the selective P2X7R antagonist A438079 prior the conditioning session showed generalization of cued fear memory and impaired fear extinction recall in the test session, while those treated prior the extinction session exhibited a similar behavior profile accompanied by resistance in the extinction learning. However, no effects were observed when this drug was administered immediately after the conditioning, extinction, or before the test session. Our results with P2X7R knockout (P2X7 KO) mice showed a behavioral profile that mirrored the collective effects observed across all pharmacological treatment conditions. This suggests that the P2X7R KO model effectively replicates the behavioral changes induced by the pharmacological interventions, demonstrating that we have successfully isolated the role of P2X7R in the fear and extinction phases of memory. These findings highlight the role of P2X7R in the acquisition and recall of extinction memory and supports P2X7R as a promising candidate for controlling abnormal fear processing, with potential applications for stress exposure-related disorders such as post-traumatic stress disorder (PTSD).

Development of AI-assisted microscopy frameworks through realistic simulation with pySTED

The integration of artificial intelligence into microscopy systems significantly enhances performance, optimizing both image acquisition and analysis phases. Development of artificial intelligence-assisted super-resolution microscopy is often limited by access to large biological datasets, as well as by difficulties to benchmark and compare approaches on heterogeneous samples. We demonstrate the benefits of a realistic stimulated emission depletion microscopy simulation platform, pySTED, for the development and deployment of artificial intelligence strategies for super-resolution microscopy. pySTED integrates theoretically and empirically validated models for photobleaching and point spread function generation in stimulated emission depletion microscopy, as well as simulating realistic point-scanning dynamics and using a deep learning model to replicate the underlying structures of real images. This simulation environment can be used for data augmentation to train deep neural networks, for the development of online optimization strategies and to train reinforcement learning models. Using pySTED as a training environment allows the reinforcement learning models to bridge the gap between simulation and reality, as showcased by its successful deployment on a real microscope system without fine tuning.

Genotyping of oral Candida albicans and Candida tropicalis strains in patients with orofacial clefts undergoing surgical rehabilitation by MALDI-TOF MS: Case-series study

Patients with orofacial clefts are more likely to develop oral fungal diseases due to anatomo-physiological changes and surgical rehabilitation treatment. This case-series study evaluated the genetic diversity and dynamics of oral colonization and spread of C. albicans and C. tropicalis in four patients with orofacial clefts, from the time of hospital admission, perioperative and outpatient follow-up, with specialized physician. Candida biotypes previously identified by CHROMagar Candida and PCR methods were studied by MALDI-TOF MS assays and clustering analyses. Possible correlations with pathogenicity characteristics were observed, including production of hydrolytic exoenzymes and the antifungal sensitivity profiles. Amphotericin B-sensitive and fluconazole-resistant (low frequency) C. tropicalis and C. albicans, including clinically compatible MIC of nystatin, were found in the oral cavity of these patients. Clusters of isolates revealed phenomena of (i) elimination in the operative phase, (ii) maintenance or (iii) acquisition of oral C. tropicalis in the perioperative period and specialized outpatient and medical follow-up. For C. albicans, these phenomena included (i) elimination in the operative phase, (ii) acquisition in the operative phase and propagation from the hospital environment, and (iii) maintenance during hospitalization and operative phase. Amphotericin B and nystatin were shown to be effective in cases of clinical treatment and/or prophylaxis, especially considering the pre-existence of fluconazole-resistant strains. This study confirmed the phenomena of septic maintenance, septic neocolonization and septic elimination involving the opportunistic pathogens. MALDI-TOF MS associated with clustering analysis may assist the monitoring of clinical isolates or groups of epidemiologically important microbial strains in the hospital setting.

ChatGPT-based meta-analysis for evaluating the temporal and spatial characteristics of deoxynivalenol contamination in Chinese wheat

Deoxynivalenol (DON) is a major source of mycotoxins in wheat. However, there is a lack of systematic reporting of the overall contamination status in China, hindering comprehensive assessments. In this study, we utilized a meta-analysis approach based on ChatGPT to systematically analyze DON contamination in wheat-growing regions in China, as reported in the literature from 2010 to 2021. By optimizing the query processes and refining the methodology keywords using ChatGPT, efficient screening, data identification, and literature extraction were achieved for the first time during the meta-analysis data acquisition phase. The matching rates for the screening and extraction of 1091 articles were 100 % and 95.4 %, respectively, resulting in a 20.5-fold work efficiency increase compared to that by manual operations. Meta-subgroup analysis by province and year revealed significant spatiotemporal heterogeneity in DON contamination in the wheat-growing regions of China. Furthermore, the relationship between climate factors and DON levels in wheat was investigated to illustrate the spatial and temporal heterogeneity of DON in Chinese wheat. The results showed that DON concentrations were mainly influenced by relative humidity and precipitation during the wheat-growing season. This novel ChatGPT-assisted meta-analysis approach provides valuable insights and offers a promising method for efficient meta-analyses in other fields.

Effects of hyperbaric oxygen pre-exposure on the motor learning acquisition phase

Hyperbaric oxygen (HBO) exposure has recently been reported to be effective in spatial learning and memory. Additionally, HBO exposure considerably improves performance on motor tasks. These findings suggest that HBO exposure may facilitate motor learning. However, the specific effects of HBO exposure on motor learning remain largely unexplored. The present study aimed to investigate the effects of HBO exposure on motor learning tasks. In the experimental animal models (control n = 8, HBO n = 8), the HBO environment was exposed to 100 % oxygen with the chamber at 2.0 atmosphere absolute (ATA) for 90 min/day for 20 days. The motor learning task was an accelerated rotating bar task (bar width, 3 and 6 cm; rotation speed, 4–40 rpm; acceleration, 0.4, 0.6, and 0.8 rpm/s). The learning task was performed for 3 consecutive days. The HBO group showed a main effect of the day factor on the bar with a width of 6 cm, and significant differences were observed for each day comparison. However, no main effect of the day factor was observed in the control group. Additionally, significant differences were found in the bar with a width of 3 cm for both groups between days 1 and 2 and between days 1 and 3. In conclusion, these findings suggest that HBO exposure has a positive effect on more challenging motor learning tasks.

Comparison between Motor Performance of People with Multiple Sclerosis during a Virtual Reality Task Practiced on Concrete and Abstract Devices: A Cross-Sectional Randomized Study.

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with unknown etiology, resulting in various impairments that necessitate continuous rehabilitation to enhance functionality, quality of life, and motor function, including through Virtual Reality (VR) therapy. Comparing tasks in virtual environments and their potential skill transfer to real-world settings could aid in optimizing treatment programs to improve motor performance in individuals with MS. This study aimed to determine whether practicing acquisition and retention phases using two distinct interfaces (concrete-Touch Screen or abstract-Kinect system) affects performance in a subsequent task using a different interface (transfer phase). A randomized clinical trial was conducted with 56 volunteers with MS and 41 controls. Participants engaged in a computer game where they burst as many bubbles as possible within 10 s per attempt. After the acquisition and retention phases, all participants switched interfaces (e.g., those using Kinect switched to Touchscreen and vice versa). Significant performance improvements were observed in both groups during the acquisition phase, which were maintained in the retention phase. Although the abstract interface was more challenging for both groups, only the MS group that practiced with the abstract interface successfully transferred their improvements to the concrete interface. Thus, despite the increased difficulty of the abstract task during practice, it led to better performance transfer when required to complete a subsequent concrete task, suggesting that abstract devices may be beneficial in clinical practice for improving motor function in people with MS.

Phonological development of children with cochlear implants

ABSTRACT Phonological processes are examples of normal simplified articulation seen in all children during the language and speech sound acquisition phase, and their frequency decreases and disappears with age. They are of concern when they are used beyond the expected time frames or when the simplification processes do not follow the typical substitutions. The aim of this study was to examine the phonological development and consonant acquisition of Turkish-speaking children with CI and compare the results with normative data. Comparisons were made according to the duration of CI use and also according to the age of CI. Therefore, 52 participants were analysed, first divided into 4 groups according to duration of CI use and then into 2 groups according to age of CI. Phonology skills were evaluated with the Bankson-Bernthal Phonology Test. In children with CI, 1373 consonant production errors were detected. There were 28 phonological processes corresponding to these errors. The most common phonological processes were Initial Consonant Deletion, Cluster Reduction, Final Consonant Deletion, Vowel Lengthening, Devoicing, Assimilation, Nasalization and Dentalization. The most errors occurred in fricative and voiced sounds, and the fewest errors occurred in bilabial consonants (/b,/p,/m/). This study demonstrated that CI performed before the age of three years and continued use of CI over an extended period of time have beneficial impacts on the development of phonological skills. This study is thought to enhance the existing research on the acquisition of consonants and phonological development in Turkish-speaking children with CI, a topic that currently lacks sufficient information.

Life cycle assessment of limestone calcined clay concrete: Potential for low-carbon 3D printing

Limestone calcined clay cement is being promoted throughout the construction industry as a way to considerably reduce the cement proportion in concrete mixtures. At the same time, concrete 3D printing could save resources by placing concrete material only where its functionalities are maximized. This study addresses the need for a quantification of the environmental impacts related to the material acquisition phase regarding a low-clinker 3D printing material.Compared to a 30 MPa 3D printing material from the literature, a 3D printable LC3-based concrete with low clinker content in the Quebec context displays a 36 % climate change score reduction with the same compressive strength (46 % reduction in the French context). A small impact shift is noticed in 6 out of 16 midpoint indicators (5 in the French case), mainly due to the calcined clay production. However, it is offset by the significant reduction in other indicators when considering an endpoint assessment. When considering different sourcing scenarios, a global warming potential variability of up to 15 % is observed.LC3 remains a viable solution for the mitigation of greenhouse gas emissions in the context of concrete 3D printing as it provides mechanical strength and enhanced structuration rate for low-clinker materials. However, a specific attention should be accorded to the calcined clay plant locations, especially when the calcined clay content is higher than the value used in this study. As a perspective, a mix design tool could allow the optimization of environmental impacts depending on expected fresh and hardened properties.

Mathematics Worked Examples with Tracing Gesture Makes Learning Last

The immediate measurement of tracing effect in the previous studies have shown that the use of tracing gesture in the visuospatial-based worked examples instruction may enhance the learning of mathematical concepts, specifically the geometrical principles. The present study further explored whether the use of tracing gesture in the visuospatial-based worked examples during the acquisition phase results in better memory retention on the learning over time. To investigate the robustness of tracing effect, a 4-weeks interval delayed post-test was conducted after the participants (mean age = 12.37, SD = 0.27) were asked to study worked examples on angles relationships involving parallel lines either without tracing instruction or with tracing instruction. The results showed that the tracing group (N = 30) outperformed the non-tracing group (N = 30) in the delayed post-test and reported lower levels of test difficulty, suggesting that tracing gesture may help to retain the knowledge gained during instruction and consolidated the learning during the intervening period.

Poly (I:C)-induced maternal immune activation generates impairment of reversal learning performance in offspring.

Maternal immune activation (MIA) induces a variety of behavioral and brain abnormalities in offspring of rodent models, compatible with neurodevelopmental disorders, such as schizophrenia or autism. However, it remains controversial whether MIA impairs reversal learning, a basic expression of cognitive flexibility that seems to be altered in schizophrenia. In the present study, MIA was induced by administration of a single dose of polyriboinosinic-polyribocytidylic acid (Poly (I:C) (5 mg/kg i.p.)) or saline to mouse pregnant dams in gestational day (GD) 9.5. Immune activation was monitored through changes in weight and temperature. The offspring were evaluated when they reached adulthood (8 weeks) using a touchscreen-based system to investigate the effects of Poly (I:C) on discrimination and reversal learning performance. After an initial pre-training, mice were trained to discriminate between two different stimuli, of which only one was rewarded (acquisition phase). When the correct response reached above 80% values for two consecutive days, the images were reversed (reversal phase) to assess the adaptation capacity to a changing environment. Maternal Poly (I:C) treatment did not interfere with the learning process but induced deficits in reversal learning compared to control saline animals. Thus, the accuracy in the reversal phase was lower, and Poly (I:C) animals required more sessions to complete it, suggesting impairments in cognitive flexibility. This study advances the knowledge of how MIA affects behavior, especially cognitive domains that are impaired in schizophrenia. The findings support the validity of the Poly (I:C)-based MIA model as a tool to develop pharmacological treatments targeting cognitive deficits associated with neurodevelopmental disorders.

Effects of high-intensity chronic noise on spatial memory in male versus female rats.

The detrimental effects of high-intensity noise on the auditory system and emotional status, including the induction of anxiety, are well documented. Preclinical as well as epidemiological and clinical studies have solidly established differential responses between males and females to various stressful stimuli, including high-intensity white noise (HIWN). However, whether chronic exposure to noise affects cognitive functions and whether this effect is sex dependent has not been adequately addressed. In this study, we used two cognitive test paradigms, such as the Morris water maze (MWM) and the multi-branch maze (MBM), to test the effect of chronic HIWN on indices of spatial learning and memory in both male and female Wistar rats. Our findings indicate that daily (1 h) exposure to 100 dB of noise for 30 consecutive days induces different task-dependent responses in male versus female rats. For example, in the acquisition phase of MWM, female rats exposed to noise outperformed their male counterparts at twice the speed. Similarly, in the MBM test, noise-exposed female rats outperformed the male rats in reaching the nest box. It is clear from these studies that noise impairs cognitive functions twice as negatively in male rats as in female rats. Thus, sex-related differences in spatial learning and memory in response to HIWN must be taken into consideration when investigating the neurobiological components and/or treatment modalities.

Consonant Cluster Acquisition in Toddlers: An Explorative Study

The acquisition of consonant clusters is considered as one of the final stages of speech development in typically developing children. Nonetheless, the phonological development in children is now more advanced compared to the previously established norms. The current study aimed to determine how consonantal clusters, in particular non-geminate clusters, emerged throughout the early phases of phonological acquisition and to understand the positional variations in the cluster acquisition. The study involved 40 Malayalam speaking children aged between two to three years, divided into four groups with an age interval of 3 months. These children were administered 30 non-geminate consonant clusters from the Malayalam Articulation Test – Revised. Positional effect of the cluster acquisition was examined. In addition, the type of articulatory errors on consonant production were also determined. Findings from the present study revealed that children achieve the mastery of many consonant clusters by two to three years of age. Positional effect of cluster acquisition revealed medial clusters were acquired earlier than initial clusters. Cluster reduction was the dominant cluster error type, decreasing with age. Thus, compared with the previous established norms, the current findings demonstrate a much earlier acquisition of nongeminate clusters in Malayalam. The revised norms for cluster acquisition proposed from the findings of this study could benefit Speech-Language Pathologists to conduct age-appropriate assessment and treatment of speech sound disorders.

Hyperspectral image restoration using noise gradient and dual priors under mixed noise conditions

AbstractImages obtained from hyperspectral sensors provide information about the target area that extends beyond the visible portions of the electromagnetic spectrum. However, due to sensor limitations and imperfections during the image acquisition and transmission phases, noise is introduced into the acquired image, which can have a negative impact on downstream analyses such as classification, target tracking, and spectral unmixing. Noise in hyperspectral images (HSI) is modelled as a combination from several sources, including Gaussian/impulse noise, stripes, and deadlines. An HSI restoration method for such a mixed noise model is proposed. First, a joint optimisation framework is proposed for recovering hyperspectral data corrupted by mixed Gaussian‐impulse noise by estimating both the clean data as well as the sparse/impulse noise levels. Second, a hyper‐Laplacian prior is used along both the spatial and spectral dimensions to express sparsity in clean image gradients. Third, to model the sparse nature of impulse noise, an ℓ1 − norm over the impulse noise gradient is used. Because the proposed methodology employs two distinct priors, the authors refer to it as the hyperspectral dual prior (HySpDualP) denoiser. To the best of authors' knowledge, this joint optimisation framework is the first attempt in this direction. To handle the non‐smooth and non‐convex nature of the general ℓp − norm‐based regularisation term, a generalised shrinkage/thresholding (GST) solver is employed. Finally, an efficient split‐Bregman approach is used to solve the resulting optimisation problem. Experimental results on synthetic data and real HSI datacube obtained from hyperspectral sensors demonstrate that the authors’ proposed model outperforms state‐of‐the‐art methods, both visually and in terms of various image quality assessment metrics.

Primary sclerosing cholangitis: Is qualitative and quantitative 3 T MR imaging useful for the evaluation of disease severity?

PurposeTo analyze the role of qualitative and quantitative 3 T MR imaging assessment as a non-invasive method for the evaluation of disease severity in patients with primary sclerosing cholangitis (PSC). MethodsA series of 26 patients, with histological diagnosis of PSC undergoing 3 T MRI and hepatological evaluation, was retrospectively enrolled. All MR examinations included diffusion-weighted imaging (DWI), T2-weighted (T2w) and T1-weighted (T1w) sequences, before and after administration of Gd-EOB-DTPA with the acquisition of both dynamic and hepato-biliary phase (HBP). Qualitative analysis was performed by assessment of liver parenchyma and biliary tract changes, also including biliary excretion of gadoxetic acid on HBP. Quantitative evaluation was conducted on liver parenchyma by measurement of apparent diffusion coefficient (ADC) and relative enhancement (RE) on 3-minute delayed phase and on HBP. Results of blood tests (ALT, ALP, GGT, total and direct bilirubin, albumin, and platelets) and transient elastography-derived liver stiffness measurements (TE-LSM) were collected and correlated with qualitative and quantitative MRI findings. ResultsAmong qualitative and quantitative findings, fibrosis visual assessment and RE had the best performance in estimating disease severity, showing a statistically significant correlation with both biomarkers of cholestasis and TE-LSM. Statistical analysis also revealed a significant correlation of gadoxetic acid biliary excretion with ALT and direct bilirubin, as well as of ADC with total bilirubin. ConclusionQualitative and quantitative 3 T MR evaluation is a promising non-invasive method for the assessment of disease severity in patients with PSC.

Space optical communication system for space optical networks and deep space exploration

The acquisition time of tens to hundreds of seconds in the optical link between satellites makes it difficult to meet the needs of constructing spatial optical networks. In addition, as a basic requirement for deep space explorers, autonomous attitude determination and autonomous navigation demand the installation of separate, expensive, and complex inertial devices, and the communication data rate is too low to meet the timely transmission of large amounts of data. In this paper, we proposed and developed a multifunctional fusion space optical communication system for space optical networks and deep space exploration, which has the functions of autonomous attitude determination, autonomous navigation, and high-speed optical communication. The sub-second acquisition time can meet the requirements of space optical network construction, and the ability of autonomous attitude determination and autonomous navigation significantly reduce the amount of R&D expenses of the explorer; decrease the volume, weight, and power consumption of the explorer; and improve the reliability and autonomous survival ability of the explorer. The paper provides the structure, working principle, and main algorithm models and conducts a feasibility analysis and field experiments. The experimental results showed that the average open-loop pointing accuracy of the optical terminal is 95.8 µrad (attitude determination accuracy), which can be improved to 39.1 µrad after filtering, and the acquisition time is less than 1 s. For deep space exploration, the navigation accuracy is less than 67.6 km in the cruise phase and 10 km in the acquisition phase, and field experiments have also proven its feasibility. The significance of our research work lies in proposing what we believe to be a new system operation scheme and design method for optical communication systems, and its results can be widely applied in all fields of space optical communication.