In order to study the damage properties of red sandstone under combined action of temperature, water and stress, the uniaxial compression test was carried out for red sandstone after immersing in water for 0.5 h, 1 h and 3 h at 25 ℃, 55 ℃, 85 ℃ and 95 ℃, the mechanical properties, characteristic stress points, acoustic emission RA-AF parameters and failure forms of red sandstone were analyzed, the damage constitutive equation was established, and the damage properties of red sandstone were studied. The results showed: (1) temperature could significantly improve the saturated water content percentage of red sandstone. With the increase of temperature, the saturated water content percentage showed a trend of increase first and then decrease, and was the largest at 55 ℃; with the increase of temperature, the mechanical parameters (peak intensity, elasticity modulus, and stress at start point of expansion) decreased first and then increased, and was the smallest at 55 ℃; (2) the ratio of crack initiation stress to peak stress (σci/σf) initially increases and then decreases with rising temperatures for the same soaking duration. Conversely, it initially decreases and then increases with extended soaking time at the same temperature. The RA-AF acoustic emission signals predominantly occur in the tensile region at each stage account for a relatively large proportion, with the proportion of signals in the shear region significantly increasing as soaking time extends, corresponding well with the observed damage patterns. (3) By considering the damage due to temperature and water as Initial damage to red sandstone and the damage due to stress as load-induced damage, a damage variable based on the Weibull distribution function was established. The comprehensive damage constitutive equation derived from this can be applied to water-saturated red sandstone below 100 ℃. The findings provide theoretical reference for practical engineering applications.