HepatologyVolume 23, Issue 6 p. 1700-1703 Hepatology ElsewhereFree Access Alcohol and iron: A radical combination? K Houglum, K HouglumSearch for more papers by this author K Houglum, K HouglumSearch for more papers by this author First published: June 1996 https://doi.org/10.1002/hep.510230656Citations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Houglum K, Filip M, Witztum JL, Chojkier M. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J Clin Invest 1990; 86: 1991– 1998. 2 Pierce RA, Glaug MR, Greco RS, Mackenzie JW, Boyd CD, Deak SB. Increased procollagen mRNA levels in CCl4-induced liver fibrosis in rats. J Biol Chem 1987; 262: 1652– 1658. 3 Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J Biol Chem 1989; 264: 16957– 16962. 4 Parola M, Pinzani M, Casini A, Albano E, Poll G, Gentilini A, Gentilini P, et al. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells. Biochem Biophys Res Com-mun 1993; 194: 1044– 1050. 5 Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGFα and collagen type I is mediated by oxida-tive stress through c-myb expression. J Clin Invest 1995; 96: 2461– 2468. 6 Casini A, Ceni E, Salzano R, Schuppan D, Milani S, Pellegrini G, Surrenti C. Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-β 1: comparison with fibronectin. Biochem Biophys Res Commun 1994; 199: 1019– 1026. 7 Tuma DJ, Thiele GM, Xu DS, Klassen LW, Sorrell MF. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during chronic ethanol administration [Abstract]. Hepatology 1995; 22: 226A. 8 Irving MG, Halliday JW, Powell LW. Association between alcoholism and increased hepatic iron stores. Alcohol Clin Exp Res 1988; 12: 7– 13. 9 Houglum K, Bedossa P, Chojkier M. TGF β and collagen α(I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload. Am J Physiol 1994; 267: G908– G913. 10 Pietrangelo A, Gualdi R, Giovanna C, Montosi G, Ventura E. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. J Clin Invest 1995; 95: 1824– 1831. 11 Nakatsukasa H, Evarts RP, Hsia C, Thorgeirsson SS. Transforming growth factor-β1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab Invest 1990; 63: 171– 180. 12 Sadrzadeh SM, Nanji AA, Price PL. The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats. J Pharmacol Exp Ther 1994; 269: 232– 236. 13 Kadiiska MB, MJ Burkitt, Q-H Ziang, Mason RP. Iron supplementation generates hydroxy radicals in vivo, and ESR spin-trapping investigation. J Clin Invest 1995; 96: 1824– 1831. Citing Literature Volume23, Issue6June 1996Pages 1700-1703 ReferencesRelatedInformation