Soil salinity has become a major threat to land degradation worldwide. The application of organic amendments is a promising alternative to restore salt-degraded soils and alleviate the deleterious effects of soil salt ions on crop growth and productivity. The aim of present study was to explore the potential impact of biochar and vermicompost, applied individually or in combination, on soil enzyme activity and the growth, yield and quality of Hybrid Pennisetum plants suffered moderate salt stress (5.0 g kg−1 NaCl in the soil). Our results showed that biochar and/or vermicompost promoted Na+ exclusion and K+ accumulation, relieved stomatal limitation, increased leaf pigment contents, enhanced electron transport efficiency and net photosynthesis, improved root activity, and minimized the oxidative damage in Hybrid Pennisetum caused by soil salinity stress. In addition, soil enzymes were also activated by biochar and vermicompost. These amendments increased the biomass and crude protein content, and decreased the acid detergent fiber and neutral detergent fiber contents in salt-stressed Hybrid Pennisetum. Biochar and vermicompost addition increased the biomass and quality of Hybrid Pennisetum due to the direct effects related to plant growth parameters and the indirect effects via soil enzyme activity. Finally, among the different treatments, the use of vermicompost showed better results than biochar alone or the biochar–compost combination did, suggesting that the addition of vermicompost to the soil is an effective and valuable method for reclamation of salt-affected soils.