Acid Chlorides In Presence Research Articles

Synthesis, in vitro cytotoxic activity and molecular docking study of androstene and estrone derivatives

The development and discovery of steroidal drugs to cure cervical cancer is of the most important. The Claisen condensation of androstene and estrone with aromatic aldehydes was catalyzed by potassium tert. butoxide in tert. butanol to give the corresponding 2-arylidene and 16-arylidene estrone. Subsequently, the 16-arylidene estrone reacted with acid chloride in presence of quaternary amine in halogenated solvent resulting in the steroidal arylidene derivatives. Synthesis, Characterization and in vitro cytotoxic activity of arylidenes are rationalized. Fifteen compounds are synthesized and six of them were evaluated for cytotoxic activity against cervical cancer cell line. HT-3 cell line examination revealed a considerable growth inhibition. Compounds 4a, 4b, 6b, 8c, and 8d, which are estrone-based arylidenes, are the most potent of the series, with IC50 value of 7.15, 10.76, 6.37, 3.56, and 1.55 µM/ml against HT-3 cell line. In addition, molecular docking studies were performed for the steroidal arylidenes to elucidate the binding interactions. Compound 4a, 4b, 6b, 8c and 8d showed excellent binding energy. Docking studies agreed well with in vitro studies. The end result offers an alternative approach to develop steroidal arylidenes that are more effective and are based on estrone, leading to the development of novel anticancer agents.

Synthesis of β,γ‐unsaturated ketones with quaternary centers through regioselective hydroacylation of allenes with acyl chlorides

AbstractThe one‐pot synthesis of β,γ‐unsaturated ketones bearing all‐carbon quaternary centers at the α‐position via a highly regioselective hydroacylation of allenes using acyl chlorides and aluminum hydride is reported. The Cu‐catalyzed hydroalumination of 1,1‐disubstituted and 1,1,3‐trisubstituted allenes with diisobutylaluminum hydride resulted in allylaluminum reagents that underwent regioselective acylation in the presence of acid chlorides. Various derivatives of allenes and acyl chlorides were compatible with this process, and α‐quaternary ketones were obtained in high yields with excellent regioselectivity.

Multicomponent Wittig Reaction As Simple and Efficient Method for Synthesis of New Tri Substituted Pyrroles Under Catalytic Phosphine Mediated

The key precursor for the synthesis of the tittle system are an active hetero chalcones (1&2) which reacted with sulfathiazole to afford α-β-unsaturated Schiff bases represented by compounds 4-( (z)-(E)-2,3,5-tri aryl allylidene amino)-N-(thiazole-2-yl) benzene sulfonamide (3&4). The lase one was under went multicomponent witting reaction in presence of acid chloride and tri phenyl phosphine in basic media from tri ethyl amine to afford the substituted pyrrole named 4-(2,3,5-tri aryl-1H-pyrrole-1-yl)-N-(thiazole-2-yl) benzene sulfonamide (5-11).The structure of prepared compounds were determined by the available physical and spectral methods M.P. ,T.L.C , U.V , FT-IR & 1H-NMR

Reactivity of gossypol Schiff bases in reactions with 2,2'-diphenyl-1-picrylhydrazyl in the presence of chloride acid

Reactivity of gossypol Schiff bases in reactions with 2,2'-diphenyl-1-picrylhydrazyl in the presence of chloride acid

Green Production of Anionic Surfactant Obtained from Pea Protein

AbstractA pea protein isolate was hydrolyzed by a double enzyme treatment method in order to obtain short peptide sequences used as raw materials to produce lipopeptides‐based surfactants. Pea protein hydrolysates were prepared using the combination of Alcalase and Flavourzyme. The influence of the process variables was studied to optimize the proteolytic degradation to high degrees of hydrolysis. The average peptide chain lengths were obtained at 3–5 amino acid units after a hydrolysis of 30 min with the mixture of enzymes. Then, N‐acylation in water, in presence of acid chloride (C12 and C16), carried out with a conversion rate of amine functions of 90%, allowed to obtain anionic surfactant mixtures (lipopeptides and sodium fatty acids). These two steps were performed in water, in continuous and did not generate any waste. This process was therefore in line with green chemistry principles. The surface activities (CMC, foaming and emulsifying properties) of these mixtures were also studied. These formulations obtained from natural renewable resources and the reactions done under environmental respect, could replace petrochemical based surfactants for some applications,.

Facile synthesis of biologically important indole based quinoxalines

Condensation of 1,2-phenylenediamine with a variety of indole based aldehydes, prepared from the corresponding acid chloride in presence of HSnBu3, furnishes (1H-indol-3-yl)quinoxalines. In addition, 1,2-phenylenediamines substituted with a strong electron-withdrawing group at the para position, provides 6-substituted (1H-indol-3-yl)quinoxalines. Several biologically important quinoxalines were prepared in the same way. The yields are good to excellent in all cases. However, 1,2-phenylenediamine substituted with the weakly electron-donating methyl group, gives an inseparable mixture of 6-methyl and 7-methyl isomers of (1H-indol-3-yl)quinoxaline. All the compounds were characterized by 1 H NMR, 13 C NMR and IR spectroscopy.

Synthesis and Characterization of Azobenzene-Functionalized Hyperbranched Polymers

Azobenzene functionalized hyperbranched polymers (HBAzPs) have been synthesized by polycondensation of 4,4′-di((2-hydroxyethoxy)azobenzene and 1,3,5-benzenetricarboxylic acid chloride in presence of triethylamine at room temperature through A2 + B3 polymerization approach. The structure and properties of HBAzPs were characterized by 1H NMR, IR, GPC, DSC and UV-Visible spectrometry. Molecular weights as well as properties of HBAzPs were found to be greatly influenced by molar ratio of monomers, amount of triethylamine and monomer concentration. HBAzP solutions in THF showed absorbances at 356 nm and 450 nm corresponding to π-π* and n-π* electronic transitions of azobenzene chromophores, respectively. A reversible trans-cis photoisomerization of HBAzPs was observed upon irradiation of UV and visible light.

Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity

2‐Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2‐aminobenzothiazole with catalyst p‐toluene sulphonic acid to form N‐[(1Z)‐1‐(benzofuran‐2‐yl)ethylidene]1,3‐benzothiazol‐2‐amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4‐[1‐benzofuran‐2‐yl]‐1‐[1, 3‐benzothiazol‐2‐yl]‐4‐methylazetidin‐2‐one (3a-3j). All the synthesized compounds were characterized on the basis of analytical data. The compounds were screened for their antimicrobial activities. Compound 3b,3cand 3d exhibited moderate activity.

HOBt·DCHA-Mediated Synthesis of Sterically Hindered Peptides employing Fmoc-Amino Acid Chlorides in Both Solution-Phase and Solid Phase Methods

The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization. The synthesis of β-casomorphin by solid-phase protocol employing Fmoc-amino acid chloride/HOBt·DCHA in DMF–CH2Cl2 has also been outlined. The final peptide was obtained in 80% yield and was fully characterized.

Reaction of ?-Aminocrotononitrile with Acid Chlorides: A Study on Regiopreference.

Chemistry of β-aminocrotononitrile is well documented in the literature. However, systematic study on its acylation reaction with acid chlorides and its immense potential in synthesis has not yet been reported as review articles. This short review describes reaction and regiopreference of β-aminocrotononitrile when reacted with acid chlorides in presence of an organic base.

Synthesis and Insecticidal Activity of Some 1,3,4‐Oxadiazole Derivatives Containing Phenoxyfluorophenyl Group.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Magnetic intercalate of pararosaniline into layered MnPS 3

A new intercalation compound, Mn 0.01 PS 3 (pararosaniline) 0.18 , is synthesized through the exchange of Mn 1-x PS 3 .K 2x with pararosaniline (HOC(C 0 H 1 NH 2 ) 3 in the presence of chloride acid in methanol. Its structure is characterized by elemental analysis, X-ray diffraction (XRD), infrared spectroscoopy. XRD results show that the lattice spacing is expanded by 10.5 A compared with pure MnPS 3 , which indicates that the molecualr ring plane of the guest is perpendicular to the layer of the host. The infrared absorption spectrum infers that the inserted guest of pararosaniline exists in the cation form to maintain the charge balance of the intercalation compound. The studies of magnetic properties with SQUID indicate that the intercalation compound exhibited bulk spontaneous magnetization below 40 K.

Reaction of β-aminocrotononitrile with acid chlorides : a study on regiopreference

Chemistry of β-aminocrotononitrile is well documented in the literature. However, systematic study on its acylation reaction with acid chlorides and its immense potential in synthesis has not yet been reported as review articles. This short review describes reaction and regiopreference of β-aminocrotononitrile when reacted with acid chlorides in presence of an organic base.

Facile Synthesis of 4-Acylamino and 4-Sulphonamido β-lactams

The cycloaddition reaction of trisubstituted amidines (7a–f) with acid chlorides in presence of triethylamine gave 4-acylamino and 4-sulphonamido-trans-β-lactams (9a–h) in very good yields. Similarly N,N′-diarylamidines (5a–d) on reaction with 2equiv. of acid chlorides (8a,b) gave 4-acylamino-trans-β-lactams (10a–e) via in situ generated acylamidines followed by cycloaddition reaction.

Étude de la susceptibilité à la corrosion d’aciers inoxydables AISI 304 ET AISI 316 soumis à des contraintes mécaniques dans l’acide nitrique dilué bouillant en présence de chlorures

A detailed study of corrosion of stressed 304 and 316 stainless steels in boiling solutions of diluted nitric acid in presence of chloride is presented. After a chemical study of the electrolyte, the different kinds of corrosion observed are represented on HNO 3 concentration - Cl − concentration diagrams. A more fundamental study based on several electrochemical techniques (forward scan and return potentiodynamic curves, potentiokinetic curves with different scan rates, sample depassivation by rapid straining under potentiostatic control) is carried out. The results allow to confirm the observations and to explain them in terms of competition between anodic dissolution, depassivation, repassivation processes with a precise analyze of the role of the solution and of the mechanical stress

Syntheses of heterocyclic compounds. Part XXXIII. Preparation and reactions of 4-(2-dialkylaminophenyl)azetidin-2-ones

2-Dialkylaminobenzylideneanilines and various acid chlorides in presence of triethylamine were used to obtain the novel title compounds. Those β-lactams with an α-chloro-substituent underwent intramolecular cyclisation involving the dialkylamino-group with expulsion of the chlorine atom to give β-lactams bearing a fused indolinium system. Thermolysis of these fused β-lactams afforded various N-alkylindoles (with elimination of phenyl iso-cyanate). Aspects of stereochemistry, substituent effect, and alkaline or acidic hydrolysis of the fused β-lactams which lead to novel indole derivatives are described.

Mechanism of the Reactions of Grignard Reagents and of Organocadmium Reagents with Acid Chlorides in Presence of Ferric Chloride

Mechanism of the Reactions of Grignard Reagents and of Organocadmium Reagents with Acid Chlorides in Presence of Ferric Chloride

Ketone Synthesis by the Grignard Reaction with Acid Chlorides in Presence of Ferric Chloride

Ketone Synthesis by the Grignard Reaction with Acid Chlorides in Presence of Ferric Chloride