Acid-based Hydrogel Research Articles

Experimental and theoretical investigation of allylated chitosan and acrylic acid-based smart polymer hydrogel for the removal of brilliant green from aqueous media.

Smart polymer hydrogels with superior dye adsorption (brilliant green) characteristics were synthesized via free-radical polymerization by grafting acrylic acid segments onto allylated chitosan and inducing crosslinking with a trimethylolpropane triacrylate crosslinker. The synthesized adsorbents were characterized for their chemical structure (FT-IR and 1H NMR), thermal stability (TG/DTG), and morphological features (SEM). The adsorption capacity for brilliant green (934mg/g) and water uptake (712g/g) were determined using spectrophotometric and gravimetric methods, respectively. The interaction between the synthesized adsorbent and brilliant green, including potential dye orientation on the adsorbent and hydrogen bond formation was analyzed using Density Functional Theory. The maximum adsorption of brilliant green (934mg/g) and water uptake was achieved by optimizing the monomer feed compositions. Adsorption studies revealed that dye uptake followed Fickian diffusion and the Langmuir isotherm model, with pseudo-second-order kinetics. Thermodynamic analysis demonstrated that the adsorption process was spontaneous and exothermic, as evidenced by changes in free energy, enthalpy, and entropy under varying temperatures. Theoretical investigations confirmed the excellent affinity of the synthesized adsorbent toward brilliant green. Furthermore, reusability studies showed that the adsorbent retained its dye-holding capability over 20 adsorption-desorption cycles, highlighting its potential for sustainable and efficient dye removal applications.

Integrating Metal-Organic Framework Hybrid into Nucleic Acid-Based Hydrogel for Highly Selective Recognition and Sensitive Detection of Sarafloxacin.

Metal-organic framework-based hybrids (MOFzyme) have promising applications in colorimetric aptasensors due to their highly efficient and stable catalytic activity. However, their efficient application in biosensors remains a challenging issue due to the limited reaction site and amorphous structure. Herein, we encapsulated catalase inside MOF cavities to prepare an MOFzyme with many functional groups on its surface, and the functional groups were utilized for the subsequent integration of MOFzyme into the hyaluronic acid-DNA hydrogel. Moreover, the accurate and flexible synthesis unit of the hydrogel enabled the prepared DNA hydrogel to adjust the shape to suit and encapsulate MOFzyme. Subsequently, a novel colorimetric sensing strategy for detecting Sarafloxacin (Sar) was developed based on the excellent catalytic ability mediated by MOFzyme and the stimulus responsiveness of the DNA hydrogel. In addition, an evolved aptamer with a higher affinity for Sar was obtained via a semirational design strategy and elaborately designed into a synthetic unit of DNA hydrogel, significantly improving the response sensitivity and specificity of the aptasensor. The constructed aptasensor exhibited a wide linear detection range of 0.003 and 200 ng/mL with a low detection limit of 2.06 pg/mL. Above all, this work provides a novel and sensitive way to determine hazardous substances in food and environments.

Enzyme-crosslinked hyaluronic acid-based multifunctional hydrogel promotes diabetic wound healing

Enzyme-crosslinked hyaluronic acid-based multifunctional hydrogel promotes diabetic wound healing

Functionalized amino acid-based injectable hydrogels for sustained drug delivery.

Drug delivery vehicles optimize therapeutic outcomes by enhancing drug efficacy, minimizing side effects, and providing controlled release. Injectable hydrogels supersede conventional ones in the field of drug delivery owing to their less invasive administration and improved targeting. However, they face challenges such as low biodegradability and biocompatibility, potentially compromising their effectiveness. To address these limitations, a modified amino acid-based pH-responsive injectable shear-thinning hydrogel cl-β-CD-g-p(Gly-MA) has been developed as an efficient drug carrier. In the two-step synthetic approaches, first, the well-known amino acid glycine (Gly) is modified to form glycine methacrylate (Gly-MA). Afterward, Gly-MA is chemically crosslinked with β-cyclodextrin (β-CD), an oligosaccharide, using an ethylene glycol dimethacrylate (EGDMA) crosslinker. The presence of these biomaterials as building blocks enhances the biocompatibility, hemocompatibility, and biodegradability of the hydrogel. They also reduce the risk of immunogenicity. The unique property of easy injectability enables minimally invasive administration. This feature also helps prolong drug retention at the target site, further optimizing drug delivery efficiency. Moreover, the pH-responsive feature of the developed cl-β-CD-g-p(Gly-MA) hydrogel ensures controlled drug release in response to the physiological conditions of the target site, enhancing therapeutic efficacy. The study focuses on investigating the in vitro loading and release of diclofenac sodium (DS), a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat arthritic pain and inflammation.

Anti-inflammatory MXene- and tannic acid-based synthetic-natural hybrid hydrogel for diabetic wound treatment by electrostimulation

Anti-inflammatory MXene- and tannic acid-based synthetic-natural hybrid hydrogel for diabetic wound treatment by electrostimulation

Photocrosslinking of hyaluronic acid-based hydrogels through biotissue barriers.

Photocrosslinkable hydrogels based on hyaluronic acid are promising biomaterials high in demand in tissue engineering. Typically, hydrogels are photocured under the action of UV or blue light strongly absorbed by biotissues, which limits prototyping under living organism conditions. To overcome this limitation, we propose the derivatives of well-known photosensitizers, namely chlorin p6, chlorin e6 and phthalocyanine, as those for radical polymerization in the transparency window of biotissues. Taking into account the efficiency of radical generation and dark and light cell toxicity, we evaluated water miscible pyridine phthalocyanine as a promising initiator for the intravital hydrogel photoprinting of hyaluronic acid glycidyl methacrylate (HAGM) under irradiation near 670 nm. Coinitiators (dithiothreitol or 2-mercaptoethanol) reduce the irradiation dose required for HAGM crosslinking from ∼405 J cm-2 to 80 J cm-2. Patterning by direct laser writing using a scanning 675 nm laser beam was performed to demonstrate the formation of complex shape structures. Young's moduli typical of soft tissue (∼270-460 kPa) were achieved for crosslinked hydrogels. The viability of human keratinocytes HaCaT cells within the photocrosslinking process was shown. To demonstrate scaffolding across the biotissue barrier, the subcutaneously injected photocomposition was crosslinked in BALB/c mice. The safety of the irradiation dose of 660-675 nm light (100 mW cm-2, 15 min) and the non-toxicity of the hydrogel components were confirmed by histomorphologic analysis. The intravitally photocrosslinked scaffolds maintained their shape and size for at least one month, accompanied by slow biodegradation. We conclude that the proposed technology provides a lucrative opportunity for minimally invasive scaffold formation through biotissue barriers.

A lubcan cross-linked polyethylene glycol dimethyl ether hydrogel for hyaluronic acid replacement as soft tissue engineering fillers.

The structure of soft tissues is often destroyed by injury and aging. Injectable fillers eliminate the need for surgery and enhance repair. Hyaluronic acid-based hydrogels are commonly employed for their effectiveness and biocompatibility. However, hyaluronidase breaks them down quickly. Lubcan, a naturally sourced microbial extracellular polysaccharide, has demonstrated significant water absorption and retention capabilities, as well as lubricating properties comparable to those of hyaluronic acid. In this study, a novel injectable and implantable hydrogel was created from lubcan by adding polyethylene glycol diglycidyl ether as a cross-linking agent. Lubcan hydrogels exhibit exceptional thermal stability, favorable swelling behavior, in vitro degradation, compressive strength, injectability, and rheological properties, all while preserving the integrity of their three-dimensional porous structure. In vitro tests indicated that the lubcan hydrogel was non-cytotoxic, did not adhere to blood cells, and exhibited good hemocompatibility. Compared to the subcutaneous injection of commercially available hyaluronic acid hydrogels, lubcan hydrogels demonstrated superior integrity, persistence, and a softer texture in Balb/c mice after 16weeks. At the same time, lubcan hydrogel is non-toxic to organs, does not affect blood biochemical test values, and is non-immunogenic in mice. These findings suggest that lubcan hydrogel may be a promising new superficial soft tissue filler.

Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery

Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery

Hyaluronic Acid-Based Self-Healing Hydrogels for Diabetic Wound Healing.

Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due to their impaired healing from poor circulation and high blood sugar, increased risk of infection and potential for severe complications like amputation, all compounded by peripheral neuropathy and chronic inflammation. Most therapies and dressings for DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional diabetic wounds. Motional wounds are easy-to-split wounds that experience tension, compression, and movement caused by stress now and then. Hyaluronic acid (HA) based self-healing hydrogels stand out among other biomaterials due to their ability to cover irregular wound surfaces, maintain a moist environment, repair themselves when ruptured, and exhibit excellent biocompatibility. These self-healing hydrogels can repair damages caused by movement and recover the functional properties during healing. These hydrogels can also act as therapeutic delivery vehicles and tissue regeneration systems. This review demonstrates the potential of HA-based self-healing hydrogels for diabetic wound healing. Due to its self-healing capabilities, these hydrogels offer a customized therapeutic approach for motional diabetic wounds. The review also critically examines the challenges and future directions for HA-based self-healing hydrogels in diabetic wound healing.

Molecular mechanisms of the geroprotective action of magnesium hyaluronan in inflamaging human skin fibroblasts

Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins involved in the processes of aging and skin regeneration. Hyaluronic acid preparations containing metals have shown their geroprotective effect in the conditions of inflamaging. The aim of the studyto identify key biomarkers of cell aging (the development of inflamaging), as well as to study the effect of a hyaluronic acid-based drug with the presence of magnesium in chelated form (Magniderm-09) on human skin fibroblasts in an inflamaging model to assess its possible geroprotective effect. Material and methods. The study was performed on a culture of skin fibroblasts in a model of inflamaging induced by genotoxic stress. To assess the expression of molecular markers, immunohistochemical analysis of levels of Ki-67, collagen I, III and IV, LOX, ubiquitin, CCN1, IL-8, MMP-3, NF-kB, SIRT1, CD44 was performed. Results. The modeling of inflamaging revealed a decrease in the expression of Ki-67, all types of collagen, LOX, CCN1, SIRT1, CD44, as well as an increase in proinflammatory cytokines – IL-8, NF-kB, MMP-3 and ubiquitin. Administration of the drug "Magniderm-09" returned expression levels to normal values, which indicates its geroprotective effect. Conclusion. A correlation has been revealed between the chemical composition of a hyaluronic acid-based hydrogel preparation with the presence of magnesium in chelated form and the molecular biological changes accompanying the process of cellular aging.

Upgrading skin barrier Protection: Addition of active ingredients to a Gelatin/Tannic Acid-Based hydrogel patch for treating skin lesions related to Personal protective Equipment.

Prolonged use of Personal Protective Equipment, like surgical masks, can cause skin issues such as acne ("maskne") and rosacea flare-ups due to pressure and moisture. While dressings can protect the skin, they often reduce mask effectiveness and lack pharmaceuticals to treat common skin lesions. This study introduces an innovative dual-function gelatin/tannic acid-based hydrogel patch incorporating metronidazole (1% w/w) or salicylic acid (2% w/w) to offer both skin protection and treatment. The hydrogels were characterized for gelation temperature, burst strength, extensibility, adhesivity, and tribological properties to assess the effects of the active ingredients on their mechanical performance. In vitro release studies using Franz diffusion cells under occlusive conditions evaluated the drug release profile from the patches. Results showed that gelatin/tannic acid and gelatin/tannic acid-metronidazole hydrogels had similar gelation temperatures (41.65 ± 1.95 °C), while the salicylic acid formulation exhibited a lower gelation temperature (33.24 ± 0.40 °C). Adhesivity improved with the addition of active ingredients, increasing by about 0.5 N, and burst strength significantly increased with metronidazole (about 6 N). Both formulations demonstrated enhanced extensibility and were suitable for all skin types in tribological studies. The in vitro release studies showed an initial burst release followed by controlled release, unaffected by mask placement. These findings suggest that dual-function hydrogel patches could provide effective skin protection and improve skin health during prolonged mask use, offering a promising solution for conditions like "maskne" and rosacea.

Injectable Nanocomposite Hydrogel with Synergistic Biofilm Eradication and Enhanced Re-epithelialization for Accelerated Diabetic Wound Healing.

Diabetic wounds remain a critical clinical challenge due to their harsh microenvironment, which impairs cellular function, hinders re-epithelialization and tissue remodeling, and slows healing. Injectable nanocomposite hydrogel dressings offer a promising strategy for diabetic wound repair. In this study, we developed an injectable nanocomposite hydrogel dressing (HDL@W379) using LAP@W379 nanoparticles and an injectable hyaluronic acid-based hydrogel (HA-ADH-ODEX). This dressing provided a sustained, pH-responsive release of W379 antimicrobial peptides, effectively regulating the wound microenvironment to enhance healing. The HDL@W379 hydrogel featured multifunctional properties, including mechanical stability, injectability, self-healing, biocompatibility, and tissue adhesion. In vitro, the HDL@W379 hydrogel achieved synergistic biofilm elimination and subsequent activation of basal cell migration and endothelial cell tube formation. Pathway analysis indicated that the HDL@W379 hydrogel enhances basal cell migration through MEK/ERK pathway activation. In methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wounds, the HDL@W379 hydrogel accelerated wound healing by inhibiting bacterial proliferation and promoting re-epithelialization, regenerating the granulation tissue, enhancing collagen deposition, and facilitating angiogenesis. Overall, this strategy of biofilm elimination and basal cell activation to continuously regulate the diabetic wound microenvironment offers an innovative approach to treating chronic wounds.

Immediately injectable modified gelatin and hyaluronic acid-based hydrogel encapsulating nano-hydroxyapatite and human adipose-derived MSCs for use as a bone filler in situ therapy

The use of hydrogels for tissue engineering and regenerative medicine has gained significant attention due to their biocompatibility, versatility, and ability to mimic the extracellular matrix of tissues. In this study, we investigated the potential of nano-hydroxyapatite (nHAp)-based hydrogels by using simply modified gelatin and hyaluronic acid for bone tissue engineering as means to use a 3D bioink with in situ manner. First, we confirmed the biocompatibility and cell proliferation rate of the hydrogels by encapsulating human adipose-derived stem cells (hASCs) within the hydrogel matrix. We observed that the addition of nHAp to the hydrogel matrix promoted cell proliferation and enhanced 3D cell organization. Next, we evaluated the osteogenic differentiation potential of hASCs-laden hydrogel through alkaline phosphatase (ALP) activity and alizarin red s staining. The results showed that the hydrogel-containing nHAp group had the highest ALP activity and mineralization, indicating its potential for inducing bone formation. In vivo studies using a rat subcutaneous implantation model and a rat calvarial defect model further confirmed the ability of nHAp-based hydrogels to promote bone formation. Overall, results demonstrate the potential of nHAp-based in situ hydrogels for bone tissue engineering, highlighting their potential as a promising 3D bioink material with enhanced bone regeneration.

Preparation and Rheological Evaluation of Thiol-Maleimide/Thiol-Thiol Double Self-Crosslinking Hyaluronic Acid-Based Hydrogels as Dermal Fillers for Aesthetic Medicine.

This study presents the development of thiol-maleimide/thiol-thiol double self-crosslinking hyaluronic acid-based (dscHA) hydrogels for use as dermal fillers. Hyaluronic acid with varying degrees of maleimide substitution (10%, 20%, and 30%) was synthesized and characterized, and dscHA hydrogels were fabricated using two molecular weights of four-arm polyethylene glycol (PEG10K/20K)-thiol as crosslinkers. The six resulting dscHA hydrogels demonstrated solid-like behavior with distinct physical and rheological properties. SEM analysis revealed a decrease in porosity with higher crosslinker MW and maleimide substitution. The swelling ratios of the six hydrogels reached equilibrium at approximately 1 h and ranged from 20% to 35%, indicating relatively low swelling. Degradation rates decreased with increasing maleimide substitution, while crosslinker MW had little effect. Higher maleimide substitution also required greater injection force. Elastic modulus (G') in the linear viscoelastic region increased with maleimide substitution and crosslinker MW, indicating enhanced firmness. All hydrogels displayed similar creep-recovery behavior, showing instantaneous deformation under constant stress. Alternate-step strain tests indicated that all six dscHA hydrogels could maintain elasticity, allowing them to integrate with the surrounding tissue via viscous deformation caused by the stress exerted by changes in facial expression. Ultimately, the connection between the clinical performance of the obtained dscHA hydrogels used as dermal filler and their physicochemical and rheological properties was discussed to aid clinicians in the selection of the most appropriate hydrogel for facial rejuvenation. While these findings are promising, further studies are required to assess irritation, toxicity, and in vivo degradation before clinical use. Overall, it was concluded that all six dscHA hydrogels show promise as dermal fillers for various facial regions.

A hyaluronic acid-based dual-functional hydrogel microneedle system for sequential melanoma ablation and skin regeneration

Melanoma treatment remains a challenge due to the inadequacy of existing clinical approaches and the difficulty of tissue regeneration. Recently, microneedles have been widely studied in tumor therapy and skin repair. Hence, a hyaluronic acid (HA)-based dual-functional hydrogel microneedle (MN) system was constructed to sequentially achieve tumor ablation and skin regeneration. Carbon nanotubes@calcium peroxide@tannic acid-Fe/chlorin e6 (CCa@TF/Ce6) nanomaterial was encapsulated in dissolvable polyvinyl alcohol/polyvinylpyrrolidone tips and accurately released to the tumor site to suppress melanoma via the photothermal and photodynamic therapies under the dual laser irradiation due to the generation of reactive oxygen species (ROS) and heat. Particularly, ROS and heat triggered immunogenic cell death, promoted dendritic cells maturation and reshaped the tumor-associated macrophage phenotype from the protumor M2 phenotype to the anti-tumor M1 phenotype, ultimately activating autoimmunity to eliminate the tumor. Following tumor ablation, the MN base accelerated skin regeneration owing to HB-PVA hydrogel through reducing oxidative stress, promoting cell proliferation and facilitating cell migration. Overall, the dual-functional hydrogel MN designed in this study, offers a new avenue for sequential melanoma combination treatment and skin regeneration.

Patent Overview of Innovative Hyaluronic Acid-Based Hydrogel Biosensors.

Hyaluronic acid-based hydrogels are emerging as highly versatile materials for cost-effective biosensors, capable of sensitive chemical and biological detection. These hydrogels, functionalized with specific groups, exhibit sensitivity modulated by factors such as temperature, pH, and analyte concentration, allowing for a broad spectrum of applications. This study presents a patent-centered overview of recent advancements in hyaluronic acid hydrogel biosensors from 2003 to 2023. A total of 50 patent documents-including 41 patent applications and 9 granted patents-reveal a growing interest, primarily driven by United States-based institutions, which account for approximately 54% of all filings. This trend reflects the strong collaboration between universities, industry, and foundations in pushing this technology forward. Most patented technologies focus on biosensors for in vivo blood analysis, measuring critical parameters such as gas concentration and pH, with particular emphasis on glucose monitoring via tissue impedance using enzyme-immobilized oxidase electrodes. Additionally, the 9 granted patents collectively showcase key innovations, highlighting applications from continuous glucose monitors to implantable vascular devices and sweat analyte detection systems. These patents underscore the adaptability and biocompatibility of hyaluronic acid hydrogels, reinforcing their role in enhancing biosensor performance for real-time health monitoring. In summary, this overview highlights the importance of patent analysis in tracking and directing research and development, helping to clarify the field's evolution and identify innovation gaps for hyaluronic acid-based hydrogel biosensors.

Extracellular matrix stiffness facilitates neurite outgrowth by reprogramming the fatty acid oxidation-dependent macrophage polarization

The extracellular matrix (ECM) is involved in various of pathophysiology processes, such as wound healing and neurogenesis. During tissue injury, the recruited bone marrow-derived monocytes in the impaired site undergo functional and phenotypic changes and participate in the initiation, maintenance, and resolution phases of tissue repair. However, the effects of ECM stiffness on monocyte differentiation and function remain largely unknown. Herein, we developed a gelatin-hydroxyphenylpropionic acid-based hydrogel with different substrate stiffnesses by varying hydrogen peroxide concentrations, which demonstrated good biocompatibility. Furthermore, the high substrate stiffness hydrogel could polarize macrophage into immunosuppressive phenotype with increased expression of interleukin 10, transforming growth factor β, CD206, and CD163. Twenty three differentially expressed metabolites were identified in stiff hydrogel-cultured macrophages in comparison with soft hydrogel cultured macrophages via metabolite analysis. In addition, 4-hydroxybenzoic acid was the most upregulated metabolite, which could confer protection against neuronal and acute inflammation. Mechanistically, the high substrate stiffness induced macrophage immunosuppressive differentiation by upregulating the expression of the fatty acid oxidation (FAO)-related proteins peroxisome proliferator-activated receptor (PPAR)-γ and PPAR-δ. Consistently, the FAO inhibitor etomoxir reversed the high substrate stiffness mediated macrophage immunosuppressive polarization and neurite outgrowth. Therefore, the alteration in macrophage phenotype induced by increased substrate stiffness can promote tissue repair in clinical applications.

Injectable Hyaluronic Acid-Based Hydrogels for Rapid Endoscopic Submucosal Dissection.

Endoscopic submucosal dissection (ESD) is a widely used procedure for the treatment of early and precancerous gastrointestinal lesions and has become the standard treatment. In this procedure, the commonly used materials have a short retention time and a limited lifting capacity, which will prolong the duration of the ESD procedure. Furthermore, these liquids tend to diffuse after ESD surgery, failing to adequately protect the wound. Therefore, we designed and developed injectable hydrogels based on hyaluronic acid. A series of oxidized hyaluronic acid (OHA) and hydrazide hyaluronic acid (AHA) were synthesized, and 16 kinds of injectable hydrogels were fabricated to investigate the effects of molecular structures on the properties of the hydrogels. Among these, the O1A3 hydrogel exhibited a suitable injection performance, gelation time, and mechanical properties, along with good blood and cell compatibility in vitro. Subsequently, in a porcine model of the ESD procedure, the results demonstrated that the O1A3 hydrogel exhibited a good retention time and lifting performance while also significantly reducing the operation time from 1-2 h to ∼10 min. Furthermore, the adhesive property of the O1A3 hydrogel on small bleeding spots and wounds could be observed, which was beneficial in protecting the wound from the complex environment of the gastrointestinal tract. The present work of injectable hyaluronic acid-based hydrogels could be promising to improve the efficiency of ESD surgery.

Hyaluronic acid-based hydrogels as codelivery systems: The effect of intermolecular interactions investigated by HR-MAS and solid-state NMR Spectroscopy

Hydrogels based on hyaluronic acid and agarose-carbomer, due to their peculiar 3D architecture and biocompatibility, are promising candidates for pharmaceutical strategies based on the codelivery of drugs targeting different diseases. The successful development of these applications requires a precise understanding of drug-drug interactions and their effects on transport and release mechanisms. In this study, such an investigation is carried out on hydrogels loaded with ethosuximide and sodium salicylate at different concentrations. Intermolecular interactions and transport properties are characterized by means of High Resolution Magic Angle Spinning and solid-state Magic Angle Spinning NMR Spectroscopy.At variance with our previous findings on single-drug formulations, the two drugs exhibit closely similar diffusion patterns when co-loaded in the HA-based hydrogels, plausibly due to drug-drug intermolecular interactions. At the highest drug concentrations, where superdiffusion comes into play, we find a fraction of molecules with time-varying diffusion coefficients. A trapping-release mechanism is proposed to explain this observation, which also accounts for the role of drug-hydrogel interactions in drug diffusion motion. The effects of drug-drug interactions on release profiles are finally assessed by means of in vitro release experiments.

Recyclable, high strength and electrical-mechanical self-healing wearable ionic hydrogel sensor

Ionic hydrogels are ideal materials for wearable sensors on the human body, typically requiring excellent mechanical properties, adhesion, self-healing, and sensing capabilities. However, traditional methods to enhance the mechanical properties of ionic hydrogels often compromise their self-healing and sensing performance. Considering this, in this study, we developed a high-strength, recyclable hydrogel with a wide monitoring range, formulated from acrylic acid, hexahydrate aluminum chloride, and polyquaternium-10. By employing a simple freeze-thaw process, the tensile strength of the hydrogel was significantly increased from 0.3 MPa to 1.89 MPa, and the elongation at break was enhanced from 900 % to 1400 %. Additionally, the hydrogel demonstrates exceptional adhesion to various substrates and possesses mechanical-electrical dual self-healing properties. The hydrogel's broad strain detection range (1%–400 %) further underscores its potential for high-performance sensing applications. Furthermore, the reconfigurable, high-density supramolecular network of hydrogels enables the reprocessing of discarded material into value-added products through a straightforward water swelling treatment. We believe that our approach offers a straightforward and efficient strategy for enhancing the mechanical properties of acrylic acid-based hydrogel sensors and, more significantly, contributes to the sustainable utilization of hydrogel materials.