Acid-base Values Research Articles

Arterial Blood Gas, Electrolyte and Acid-Base Values as Diagnostic and Prognostic Indicators in Equine Colic.

The study aimed to investigate if arterial blood analysis in conscious horses presenting with signs of colic and breathing ambient air had diagnostic or prognostic value. Arterial blood samples from 352 horses presenting with colic at a university equine referral hospital were analysed for pH, partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2), concentrations of sodium (Na+), potassium (K+), ionised calcium (Ca2+) and chloride (Cl-), actual and standardised plasma bicarbonate concentration (HCO3- (P) and HCO3- (P, st)), blood and extracellular fluid base excess (Base (B) and Base (ecf)) and anion gap (AG). Results were compared to previously reported values for healthy horses, and comparisons were made between final diagnosis, treatment and survival to hospital discharge. Significant differences were found between colic cases and healthy reference values between some primary aetiologies. Overall, surgical and non-surgical colic cases differed in Ca2+ and Cl- concentrations and Ca2+ differed between cases that survived to discharge and those that did not. PaO2 differed between small intestinal surgical cases that survived and those that did not. From these results, we developed regression models that demonstrated excellent or good predictive value in identifying the likelihood of surgical versus medical management and survival to hospital discharge.

Venous Blood Gas and Acid-base Values in Captive Asian Elephants (Elephas maximus)

Background: Blood gas and acid base values are very much essential for health assessment and disease diagnosis of captive elephants especially when clinical signs were nonspecific and other diagnostic techniques may not be available for immediate applications. Region specific normal healthy animal profile is valuable in health care planning for captive elephants. The aim of this study was to assess and evolve the baseline reference values for Blood gas and acid base parameters in captive Asian elephants raised in the Tamil Nadu State of India. Methods: A total of 46 venous blood samples were analyzed for blood gas and acid base values such as partial pressure of oxygen (PvCO2), partial pressure of carbon-dioxide (PvO2), oxygen saturation (SvO2), total carbon dioxide content (TvCO2), Bicarbonate and Base excess (BEecf), bicarbonate (HCO3-) and pH by using i-STAT®1 hand held analyzer. Results: The mean±SE, lower and upper value, 95% and 99% of confidence interval of the pH, PvCo2, PvO2, TvCo2, BEecf, HCO3- , SvO2, Lactate were assessed. As the elephants in this study were apparently healthy, these range of values could well serve as a reference range for captive Asian elephants.

Single-breath diffusion capacity of the lungs for carbon monoxide in children with cystic fibrosis: methods of interpreting results

Introduction. Progression of pulmonary and heart failure often causes death in patients with cystic fibrosis (95%). Therefore, monitoring of lung condition is very important for patients with cystic fibrosis (CF). Structural changes are visualized by computed tomography of the chest (CT) and are scored using the Brody scale. For children older than 5 years, pulmonary function tests (PFTs) tests (which are evaluated in percent of predicted (%) values) are available, such as spirometry, body plethysmography (BP), diffusion capacity of the lungs (DL) test. The results of the single-breath (SB) DL for carbon monoxide test are DLCO-SB, alveolar volume (VA-SB) and their ratio (KCO-SB). In the presence of non-communicative zones for gas perfusion, VA-SB may not present true VA. For patients with CF, it is proposed to use VA determined by BP for calculating KCO-BP, or to adjust the predicted DLCO-SB and KCO-SB for VA.Aim. To assess the informativeness DLCO-SB, KCO-SB and KCO-BP in children with CF.Materials and methods. 28 children with CF (8–18 years old) were examined in the department of pulmonology of the National Research Center for Children’s Health. PFTs included DLCO-SB, spirometry and BP. Additionally, we evaluated the data of the blood gas and acid-base values, age, body mass index and CT scores.Results and discussion. We found that in most patients DLCO-SB and KCO-SB were within the normal range, and decreased in children older than 14 years with background of severe bronchiectasis.Conclusion. Thus, in children with CF the DL test is informative, and adjustment for VA is useful.

Intravenous lipid emulsion for the treatment of acute lipid-soluble anesthetic drug toxicity in pediatric patients

Clinical studies on the use of lipid emulsions for the treatment of lipid-soluble anesthetic drug intoxication in children are relatively absent. Since children are not shrinking versions of adults, the therapeutic efficacy of lipid emulsions for the treatment of lipid-soluble anesthetic drug intoxication in pediatric patients is uncertain. This paper investigates the therapeutic efficacy and therapeutic mechanism of intravenous lipid emulsion for reversing acute narcotic drug intoxication in pediatric patients based on clinical data from west China Hospital of Sichuan University. The clinical data of 106 pediatric patients with acute lipid-soluble drug intoxication admitted to an inpatient center in the past 3 years were retrospectively analyzed and randomly divided into an observation group and a control group. The cardiac function indexes and blood gas indexes of patients in both groups were compared before and after treatment. After treatment, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD) values and plasma B-type natriuretic peptide (BNP) in the observation group were lower than control group, and the left heart ejection fraction (LVEF) was higher than those in the control group, with statistically significant differences (P<0.05). The arterial oxygen saturation (), partial pressure of oxygen () and acid-base (pH) values were higher in the observation group than in the control group, and the partial pressure of carbon dioxide () values were lower than in the control group. And these differences were statistically significant (P<0.05). Therefore, intravenous lipid emulsion has a positive effect in reversing acute fat-soluble anesthetic drug intoxication in pediatric patients, and is effective in promoting recovery of cardiac function, reversing respiratory failure, and improving blood gas indexes. The results of the study demonstrated the effectiveness of intravenous lipid emulsion in reversing pediatric lipid-soluble anesthetic drug intoxication and enrich the clinical research on this issue.

Studying environment characteristics of cultivation land in Dai Thinh Area, Me Linh District, Ha Noi city to serve sustainable development of health safe vegetables

Cultivation land (Planting Soil) is a natural resource that plays an important role for organisms and humans. Soil pollution will badly affect human and animal health through food, vegetables, fruits, medicinal herbs, etc. To clarify the characteristics of the geochemical environment and estimate the quality of the soil environment in the Dai Thinh area, Me Linh district, Hanoi city, the authors combined the using of traditional and modern methods in the research process, such as: field research methods, grain-size analytical method plus X-ray fluorescence spectroscopy (XRF) method to determine the major components (oxides) of soil. The high-frequency inductive plasma source spectroscopy combined mass spectrometry (ICP-MS) method and optical AAS atomic adsorption spectroscopy have been used to determine the concentration of critical heavy metals in soil samples. Besides, the direct measurement method used to determine environmental indicators (pH, Eh, Ec). Research results show that agricultural soil in the studied area belongs to the group of heavy sandy loam, sandy loam, and sandy clay soils, with average content of sand (size of 0.05-2mm): 60.8 (%), silt (limon) (size of 0.005-0.05mm): 17.96 (%), clay (size of <0.005mm): 21.46 (%). The soil has not been yet polluted by critical heavy metals such as: As, Cd, Cu, Zn, Cr, Ba, Sb, Co, Mo, Se and Sn. The soil in the studied area shows neutral acid-base values (average pH is 6.61), has a strong oxidizing environment (Eh > 150mV) (with values of Eh ranging from 183 to 310 mV), and is not saline (values of Ec ranging from 58.7 - 317.0 (µS/cm). Therefore, in terms of the results of determining environmental physical-chemical criteria and heavy metal concentration, the soil in the studied area can be used for health safe vegetable production. The research results not only serve as a basis for assessing the quality of the soil environment for safe healthy vegetable planting, but also serve as a scientific basis for the authors to propose a number of appropriate solutions to protect and improve the quality of vegetables, land environment protection, contributing to the planning and sustainable use of agricultural lands for the studied area.

Prerace venous blood gases and acid-base values in Standardbred horses: effects of geography, season, prerace furosemide, gender, age, and trainer using big data analytics.

A retrospective study was conducted to establish the prerace venous acid-base and blood gas values of Standardbred horses at rest using big data analytics. Venous blood samples (73,382) were collected during seven racing seasons from 3 regional tracks in the Commonwealth of Pennsylvania. Horses were detained 2 hours prior to race time. A mixed-effects linear regression model was used for estimating the marginal model adjusted mean (marginal mean) for all major outcomes. The interaction between age and gender, track, and the interaction between month, treatment (furosemide), and year were the major confounders included in the model. Random effects were set on individual animal nested within trainer. Partial pressure of venous carbon dioxide (PVCO2), partial pressure of oxygen (PVO2), and pH were measured, and base excess (BE), total carbon dioxide (TCO2), and bicarbonate (HCO3-) were calculated. Significant (P < .001) geographical differences in track locations were seen. Seasonal reductions in acid-base values started in January with significant (P < .001) decreases from adjacent months seen in June, July, and August followed by a gradual return. There were significant increases (P < .001) in BE and TCO2 and decreases in PVO2 with age. Significant differences (P < .001) in acid-base values were seen when comparing genders. A population of trainers were significantly different (P < .001) from the marginal mean and considered outliers. In a population of horses, big data analytics was used to confirm the effects of geography, season, prerace furosemide, gender, age, and trainer influence on blood gases and the acid-base profile.

Mechanisms for Brain-Damaging Acute Birth Asphyxia Associated with Normal or Near-Normal Umbilical Acid-Base balance

It is a common misconception to believe that brain-damaging birth asphyxia is consistently associated with an umbilical cord arterial pH of less than 7.00 at the time of birth. Approximately 40% of infants with brain damage attributable to birth asphyxia have an umbilical artery (UA) pH of 7.00 or greater. This paper describes the various explanations for observing brain-damaging acute birth asphyxia associated with normal or near-normal UA pH values. What is known: Approximately 40% of infants with brain damage attributable to birth asphyxia have a UA pH of 7.00 or greater. What this study adds: Various explanations are presented to explain the occurrence of brain-damaging asphyxia with normal or near-normal acid-base values. This phenomenon has not been previously described. Key messages: -Approximately 40% of infants with brain-damaging birth asphyxia have an umbilical artery cord pH of 7.00 or greater, with most having of these having a pH greater than 7.20. -Technical explanations for this phenomenon include sampling only the umbilical vein and sampling blood with air bubbles. -The two most common pathophysiologic mechanisms to explain the lack of acidemia are complete occlusion of the umbilical cord and circulatory collapse. -Other brain-damaging processes without fetal acidemia include birth trauma, synergism, intra-uterine resuscitation, and post-asphyxial hypoxia.

Mathematically arterialised venous blood is a stable representation of patient acid-base status at steady state following acute transient changes in ventilation.

Hyper- or hypoventilation are commonly occurring stress responses to arterial puncture around the time of blood sampling and have been shown to rapidly alter arterial blood acid–base parameters. This study aimed to evaluate a physiology-based mathematical method to transform peripheral venous blood acid–base values into mathematically arterialised equivalents following acute, transient changes in ventilation. Data from thirty patients scheduled for elective surgery were analysed using the physiology-based method. These data described ventilator changes simulating ‘hyper-’ or ‘hypoventilation’ at arterial puncture and included acid–base status from simultaneously drawn blood samples from arterial and peripheral venous catheters at baseline and following ventilatory change. Venous blood was used to calculate mathematically arterialised equivalents using the physiology-based method; baseline values were analysed using Bland–Altman plots. When compared to baseline, measured arterial and calculated arterialised values at each time point within limits of pH: ± 0.03 and PCO2: ± 0.5 kPa, were considered ‘not different from baseline’. Percentage of values considered not different from baseline were calculated at each sampling timepoint following hyper- and hypoventilation. For the physiological method, bias and limits of agreement for pH and PCO2 were -0.001 (-0.022 to 0.020) and -0.02 (-0.37 to 0.33) kPa at baseline, respectively. 60 s following a change in ventilation, 100% of the mathematically arterialised values of pH and PCO2 were not different from baseline, compared to less than 40% of the measured arterial values at the same timepoint. In clinical situations where transient breath-holding or hyperventilation may compromise the accuracy of arterial blood samples, arterialised venous blood is a stable representative of steady state arterial blood.

Экспериментальное обоснование предельно допустимой концентрации дихлоргексафторбутена в воздухе рабочей зоны

To date, there have been no exposure standards for air concentrations of 1,4-dichlorohexafluorobutene (DCHF) in the work areas. The study was aimed to assess the toxicity of DCHF and to evaluate health hazard in acute, subacute, and chronic experiments. It was found that the substance was highly hazardous, DL50 in mice after intragastric injection was 79.0 mg/kg, СL50 was 229.0 mg/m3, and in rats these values were 86,0 mg/kg and 670,0 mg/m3. In animals, DCHF had a moderate local irritative effect on animal skin and ocular mucous membranes, as well as the skin resorptive effect. The 18.2 mg/m3 threshold limit concentration for a single inhalation exposure to DCHF was defined based on the changes in behavior responses and blood parameters. The 30-day subacute inhalation experiment revealed the pronounced cumulative effect of the substance. The 4-months chronic inhalation study showed that the exposure of experimental rats to 16.8 mg/m3 concentration of DCHF resulted in impaired function of central nervous system and cardiac activity, altered hematologic, biochemical, acid-base, and blood gas values, as well as in morphological alterations in lungs, which persisted after the 30-day recovery period. The chronic exposure threshold defined for DCHF was 2.2 mg/m3, and the defined no observable effect level was 0.24 mg/m3. Based on the study results, the maximum permissible concentration of DCHF in the air of the working area of 0.2 mg/m3 was confirmed and approved, the substance was assigned hazard class 2, vapor + aerosol + (specific protection of skin and eyes required). Gas chromatographic method using electron-capture detection for determination of DCHF mass air concentration in the work areas has been developed and approved.

Application of Carbon-Based Nanomaterials in Acid-Base Sensors

At present, long-term flight of carrier-based aircraft and other naval aviation equipment in high-salt, high-humidity environments will be subject to various environmental corrosion. The traditional means of monitoring aircraft corrosion is to seal water and prevent periodic inspections. The two monitoring methods are inefficient, and it is not easy to find the corrosion condition in the early stage of corrosion. When the corrosion really occurs, it will seriously threaten the safe flight of the aircraft and the safety of the pilot. Therefore, there is a need to develop an on-line monitoring sensor device for aircraft corrosion conditions to carry out real-time monitoring of aircraft acid-base corrosion (pH) conditions in high-salt, high-humidity marine environments. This paper mainly studies the application of carbon-based nanomaterials in acid-base sensors. In this paper, the acid-base sensor potential values at the same pH value are changed back and forth. In the initial state, the acid-base sensor potential values corresponding to pH = 3 are 385, 386, 379, and 392 mV, respectively. After 1500 s, the potential values of the acid-base sensor were 384, 383, 377, and 390 mV, and the three-phase hysteresis potential of the acid-base sensor was 1, 3, 2, and 2 mV, indicating that the acid-base sensor produced a small hysteresis potential. However, the amount of sensor drift is within a controllable range, and the response time of the acid-base sensor is relatively short regardless of the solution with different pH values added dropwise from acid to alkali or from alkali to acid. Therefore, the acid-base sensor has good hysteresis and recyclability.

Changes in acid-base balance in neonatal goats before and two hours after colostrum intake.

The purpose of the study was to obtain values of acid-base balance and basic biochemical parameters in neonatal kids of the White Shorthaired goat depending on colostrum intake. The research was focused on changes in acid-base balance parameters and basic biochemical parameters in neonatal kids before and two hours after colostrum intake. Total of 66 blood samples were taken from 33 neonatal kids. Blood pH, partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), bicarbonate concentration (cHCO3 -), base excess (BE), oxygen saturation (cSO2), total carbon dioxide (TCO2), sodium (Na+), potassium (K+), calcium (Ca2+), chloride (Cl-), glucose (Glu), lactate (Lac), creatinine (Crea), hematocrit (Hct) and haemoglobin (Hgb) were measured. There were no statistically significant differences in acid-base balance parameters such as pO2, pCO2, TCO2, cSO2 and biochemical parameters such as Na+, K+, Ca2+, lactate between the two groups - before colostrum intake (group BF) and after colostrum intake (group AF). There were statistically significant differences in acid-base balance parameters such as pH, BE, cHCO3 - between these groups. Differences in acid-base values of pH, BE and cHCO3 - were statistically significant (p˂0.05). Differences in biochemical values of creatinine and glucose were statistically significant (p˂0.05). Differences in values of hematocrit and haemoglobin were statistically significant (p˂0.05). The present results are important for veterinary practice and can improve the neonatal care especially for impaired kids.

Os efeitos do remifentanil sobre os marcadores do estresse oxidativo durante a cesariana, em correlação com a hemodinâmica materna e o desfecho neonatal: um estudo randômico controlado

Background and objectiveRemifentanil is used to attenuate maternal hemodynamic response to intubation and surgical stress during Induction–Delivery period of cesarean section. The goal was to compare the effects of two remifentanil dosing regimens on oxidative stress level, in correlation with its hemodynamic and neonatal effects. MethodsFifty‐one patients, 17 per group, enrolled for elective cesarean section were randomly divided by computer‐generated codes into three parallel groups: (A) patients received a 1μg.kg−1 remifentanil bolus immediately before induction, followed by 0.15μg.kg−1.min−1 infusion, that was stopped after skin incision; (B) patients received a 1μg.kg−1 remifentanil bolus immediately before induction; (C) (control), patients did not receive remifentanil until delivery. Maternal venous blood samples were taken at basal time, at extraction and 30minutes after the end of operation for spectrophotometrical determination of malondialdehyde and advanced oxidation protein products concentration. The same was conducted for umbilical venous sample. ResultsSystolic blood pressure and heart rate remained significantly lower in group A compared to B and C during entire Induction–Delivery period (p<0.001, p=0.02 after intubation; p=0.006, p=0.03 after skin incision; p=0.029, p=0.04 after extraction; respectively). Malondialdehyde concentration was lower at time of extraction in maternal blood in group A compared to B and C (p=0.026). All neonatal Apgar scores were ≥ 8 and umbilical acid–base values within normal range. ConclusionsThe remifentanil dosing regimen applied in group A significantly attenuated lipid peroxidation and maternal hemodynamic response during entire I–D period, without compromising neonatal outcome.

The effects of remifentanil used during cesarean section on oxidative stress markers in correlation with maternal hemodynamics and neonatal outcome: a randomized controlled trial

Background and objectiveRemifentanil is used to attenuate maternal hemodynamic response to intubation and surgical stress during Induction–Delivery period of cesarean section. The goal was to compare the effects of two remifentanil dosing regimens on oxidative stress level, in correlation with its hemodynamic and neonatal effects. MethodsFifty-one patients, 17 per group, enrolled for elective cesarean section were randomly divided by computer-generated codes into three parallel groups: (A) patients received a 1μg.kg−1 remifentanil bolus immediately before induction, followed by 0.15μg.kg−1.min−1 infusion, that was stopped after skin incision; (B) patients received a 1μg.kg−1 remifentanil bolus immediately before induction; (C) (control), patients did not receive remifentanil until delivery. Maternal venous blood samples were taken at basal time, at extraction and 30minutes after the end of operation for spectrophotometrical determination of malondialdehyde and advanced oxidation protein products concentration. The same was conducted for umbilical venous sample. ResultsSystolic blood pressure and heart rate remained significantly lower in group A compared to B and C during entire Induction–Delivery period (p<0.001, p=0.02 after intubation; p=0.006, p=0.03 after skin incision; p=0.029, p=0.04 after extraction; respectively). Malondialdehyde concentration was lower at time of extraction in maternal blood in group A compared to B and C (p=0.026). All neonatal Apgar scores were ≥ 8 and umbilical acid–base values within normal range. ConclusionsThe remifentanil dosing regimen applied in group A significantly attenuated lipid peroxidation and maternal hemodynamic response during entire I–D period, without compromising neonatal outcome.

The indicators of basal metabolism in inflammatory syndrome bacterial origin: predictors of prognosis or the need for timely correction?

The aim of the study was to determine the comparative significance of basal metabolism indicators and inflammatory process markers for the closest prognosis of patients in ICUs with systemic inflammation syndrome caused with infectious genesis. The paper presents the results of a retrospective analysis of the plan of treatment of 198 patients with confirmed clinical and laboratory signs of bacterial infection. The number of leukocytes, platelets, the percentage of lymphocytes, the concentration of procalcitonin, creatinine, bilirubin, C-reactive protein, acid-base balance values were determined in patients. Patients were assessed on a SOFA scale. The type of biomaterial for microbiological research was determined depending on the intended source of infectious inflammation. Identification of the isolated microorganisms was carried out using the MALDI ToF mass spectrometry method, followed by determination of antibiotic resistance. Empirical antibiotic therapy was prescribed upon admission of the patient to the ICU. Patients were switched to etiotropic antibacterial therapy after 48 hours, taking into account the results of a microbiological study. Determination of basal metabolic rate was carried out using the method of indirect calorimetry (CCM Express, Medical Graphics) with the calculation of basal metabolism, respiratory coefficient, absolute and relative amount of macronutrients. The calculation of the protein was made on the basis of the nitrogen level of the daily urine urea. Logistic analysis (ROC analysis) revealed that the antibacterial therapy strategy used, age, gender of patients, tinctorial properties of microorganisms isolated from patients, do not affect the nearest prognosis of the disease. On the contrary, SOFA score, the concentration of procalcitonin in the blood, and such parameters of the metabolic status as the need for kilocalories per kilogram of actual body weight and the percentage of protein calories significantly affect the nearest prognosis of the disease. The percentage of calories derived from protein metabolism, in the main exchange has a high reliable predictive value. The results of the study confirm the importance of adequate nutritional therapy in the treatment of patients with infectious inflammatory syndrome, including the calculation and correction of protein loss and total daily calorie.

Aiming for the optimal bicarbonate prescription for maintenance hemodialysis therapy in end-stage renal disease.

Acidemia and alkalemia, as a result of gradual depletion of the body's buffers followed by rapid repletion during hemodialysis (HD), are linked to adverse consequences. We examined the acid-base status with dialysis bath of higher bicarbonate (HC03- ) concentration or standard HC03- bath plus oral HC03- supplementation. A total of 60 stable HD patients (pts) were evaluated according to their pre-dialysis acid-base status both before the first and the second session of the week dialyzed against standard base dialysate of 35 mmol/L. Those who presented predialysis HC03- <22 mmol/L (25 pts) were assigned to dialysis against bath of increased HC03- levels (37 mmol/L) for 2 weeks (period A) and subsequently to dialysis with the standard dialysate bath plus daily oral sodium bicarbonate at a dose of 5 g/day for 2 weeks (period B). Pre and post-dialysis acid-base status at each study period and relevant laboratory tests were recorded. Pre-dialysis acid-base values were similar between the first and the second dialysis session. Twenty-five points had pre-dialysis pH <7.35, while 42 (the younger ones) presented pre-dialysis HC03- <22 mmol/L. After dialysis session 18 pts had pH >7.45. Comparing the two study periods, interdialytic weight was similar, pre-dialysis HC03- levels were improved with oral bicarbonate, while post-dialysis HC03- were higher during period A. Three pts could not tolerate the symptoms of alkalemia during period A. The impact of conventional HC03- concentrations of 35 mmol/L results in a considerable degree of pre-dialysis acidemia. Increasing the HC03- in bath results in more prominent post-dialysis alkalemia, however, it is not sufficient to maintain acid-base status during the interdialytic period. Oral bicarbonate supplement at a dose of 5 g/day (divided in three daily doses) results in a more balanced acid-base status, avoiding post-dialysis alkalemia.

Agreement between arterial and non-arterialised fingertip capillary blood gas and acid-base values

ABSTRACTBackground: Arterial puncture is considered the gold standard for obtaining blood gas and acid-base values and facilitates the assessment of acutely and critically ill patients, as well as control of patients in long-term oxygen therapy (LTOT). Substitutional capillary sampling has been proposed, as researchers cite lower complication rates, physician independence, lower degree of invasiveness and higher degree of patient comfort. An arterialised earlobe is considered the method of choice to obtain capillary blood sampling, but in an acute setting, the need for vasodilating pastes may be time-consuming and impractical.The aim of this study is to examine whether accurate blood gas and acid-base measurements can be obtained using non-arterialised fingertip blood.Materials and methods: Consecutive arterial punctures and non-arterialised capillary blood samples were drawn from 62 patients with stable-phase chronic obstructive pulmonary disease (COPD), and subsequently analysed. Agreement between arterial and capillary blood gas values was compared using the method recommended by Bland and Altman.Results: Results show that limits of agreement (LoA) regarding PO2 (LoA: −1.27–4.45 kPa); Base Excess (LoA: −1.35–0.55); lactate (LoA: −0.77–0.20 mmol/l) and SO2 (LoA: −0.02–0.06) are wider than what would be applicable for clinical use. However, clinically acceptable LoA were obtained regarding PCO2 (LoA: −0.64–0.38 kPa); pH (LoA: −0.02–0.03), and HCO3− (LoA: −1.06–0.55 mmol/l).Conclusion: LoA for PCO2, pH and HCO3− indicate that measurement of these parameters in non-arterialised capillary blood may be useful in clinical practice/an acute setting.What this paper adds:Capillary blood sampling provides a fast, non-invasive means of obtaining blood gas-values;Traditionally, capillary blood sampling for blood gas analysis is obtained from the earlobe using arterialisation;The present study presents accurate measurements of PCO2, HCO3− and pH using non-arterialised fingertip capillary blood;The present study is the first to show this in a population of stable-phase COPD patients.

The Course of Parturition Affects Piglet Condition at Birth and Survival and Growth through the Nursery Phase.

Simple SummaryIn this study, data were collected on the condition in which piglets were born, and this was related to their position in the birth order, and to the progress of parturition. The objective of the study was to find out if these observations were related to performance in early life, up to 10 weeks. It appeared that the later the piglets were born in a litter, the higher the risk of being stillborn, and this was aggravated in sows that took a relatively long time to give birth to their litter. In the first few piglets in a litter, risk of stillbirth was only 2%, whereas this increased to 17% in piglets born 13th in the litter or later. Similarly, birth order affected the condition of the liveborn piglets, with blood values such as pH being evident of suboptimal oxygenation in piglets born later. These blood values were predictive of neonatal behaviour such as colostrum intake, but also for neonatal survival and growth during suckling and even to 10 weeks of life. These data are the first in piglets to emphasise the impact of condition at birth on survival and growth until the end of the nursery phase.The aim of this study was to relate the course of parturition to the condition of piglets at birth, based on umbilical cord blood acid-base values, and relate the condition at birth to neonatal survival and performance up to 10 weeks of life. Data were collected from 37 spontaneous unassisted parturitions, and neonatal performance was based on observations of 516 piglets. Stillbirth rate increased from 2% in the first piglets, to 17% in piglets born 13th in the litter or later. This was aggravated in sows with longer than average stage II of parturition. Umbilical cord blood values also reflected the effect of birth order, with pH decreasing and lactate increasing in the course of parturition. Interestingly, sows that had a long expulsion stage of parturition also took longer to give birth to the first four piglets (r = 0.74), suggesting that sows with complicated parturition were already experiencing problems at the start of expulsion of piglets. Piglets with signs of asphyxia, based on umbilical blood lactate higher than 4.46 mmol/L, were slower to start suckling, had a higher risk of neonatal mortality, and had a slower growth rate over the first 10 weeks of life.

KAJIAN POTENSI PEMBENTUKAN AIR ASAM TAMBANG DARI TANAH LAPISAN PENUTUP BATUBARA ASAL KABUPATEN TELUK BINTUNI

Acid mine drainage is formed when certain sulfide minerals in rocks are exposed to oxidizing. Upon exposure to oxidizing conditions, these sulfide minerals are oxidized in the presence of water and oxygen to form highly acidic, sulfate-rich drainage. Acidity levels, and metal composition and concentration depend on the type and amount of sulfide mineral and the presence or absence of alkaline materials. If acid mine drainage has formed, it will be very difficult to stop the process as it is a continuous process until one of the reactions runs out. Acidic water containing heavy metals when flowing into rivers, loker or swamps will damage the condition of the ecosystem in the river. This will certainly cause a decrease in water quality. The purpose of this study is to examine the potential for the formation of acid mine drainage based on the acid base balance method.&#x0D; The results obtained in samples A, B1, B2, and C for the pasta pH test were 5.25, 4.20, 4.71, and 3.14, respectively. The results of the other parameters for the four samples were total sulfur contents (0.005%, 0.021%, 0.008%, 0.47%), acid neutralization ability (3.1, 2.82, 2.45, 13.07 kg H2SO4/ton), maximum acidic potential (0.153, 0.643, 0.245, 14.394 kg H2SO4/ton) and acid-base balance expressed as potential acid production (-12.917, -2.177, -3.065, 11,944). Evaluation of sample C data based on acid-base balance values (11.944 kg H2SO4/ton) and KPA/PKM ratio (&lt;2, 0.17) indicating that sample C has the potential to form acid mine drainage if the coal mining process is carried out.

Relationship of at Admission Lactate, Unmeasured Anions, and Chloride to the Outcome of Critically Ill Patients.

To investigate the association between the concentration of the causative anions responsible for the main types of metabolic acidosis and the outcome. Prospective observational study. Teaching ICU. All patients admitted from January 2006 to December 2014. None. Four thousand nine hundred one patients were admitted throughout the study period; 1,609 met criteria for metabolic acidosis and 145 had normal acid-base values. The association between at admission lactate, unmeasured anions, and chloride concentration with outcome was assessed by multivariate analysis in the whole cohort and in patients with metabolic acidosis. We also compared the mortality of patients with lactic, unmeasured anions, and hyperchloremic metabolic acidosis with that of patients without acid-base disorders. In the whole population, increased lactate and unmeasured anions were independently associated with increased mortality, even after adjusting for potential confounders (odds ratio [95% CI], 1.14 (1.08-1.20); p < 0.0001 and 1.04 (1.02-1.06); p < 0.0001, respectively). In patients with metabolic acidosis, the results were similar. Patients with lactic and unmeasured anions acidosis, but not those with hyperchloremic acidosis, had an increased mortality compared to patients without alterations (17.7%, 12.7%, 4.9%, and 5.8%, respectively; p < 0.05). In this large cohort of critically ill patients, increased concentrations of lactate and unmeasured anions, but not chloride, were associated with increased mortality. In addition, increased unmeasured anions were the leading cause of metabolic acidosis.

Haematological and serum electrolyte responses in goats undergoing tibial fracture reduction

Haematologic, biochemical, electrolyte and acid base values were determined in twelve goats prior to (baseline) tibia surgery, during surgery (at 45 min) and subsequently at 24 h and 72 h post operatively. The haematocrit, haemoglobin, blood urea nitrogen, blood glucose, sodium, potassium, chlorine, total carbon diaoxide (TCO 2 ), anion gap, base excess, pH, partial carbon diaoxide (PaCO 2 ) concentration and bicarbonate concentrations in the samples were obtained using the i-STAT EC8+ handheld biosensor analyzer. The osmolarity of the blood was also estimated. To investigate changes in the variables during and after fracture fixation, the control (baseline) values of the data were compared with the mean variables obtained per time point during and after surgery using ANOVA. The haematocrit, haemoglobin, blood glucose, osmolarity, anion gap, chlorine, sodium and potassium concentrations were significantly lower (p<0.05) than control values during surgery and at 24 and 72 h post-surgery. Blood urea nitrogen, base excess, pH, PaCO 2 TCO 2 and bicarbonate concentration (HCO 3 -) increased significantly (p<0.05) above control values at 24 and 72 h post-surgery. The results obtained from this study showed that tibia surgery led to alteration in fluid, electrolyte and acid base status of goats. Most importantly, metabolic alkalosis ensued post tibia fracture creation and fixation. Keywords: Haematolgy, Electrolytes, Acid-base, Tibia, Fracture, Surgery