An optimized detection model based on weighted entropy for multiple input multiple output (MIMO) radar in multipath environment is presented. After defining the multipath distance difference (MDD), the multipath received signal model with four paths is built systematically. Both the variance and correlation coefficient of multipath scattering coefficient with MDD are analyzed, which indicates that the multipath variable can decrease the detection performance by reducing the echo power. By making use of the likelihood ratio test (LRT), a new method based on weighted entropy is introduced to use the positive multipath echo power and suppress the negative echo power, which results in better performance. Simulation results show that, compared with non-multipath environment or other recently developed methods, the proposed method can achieve detection performance improvement with the increase of sensors.