The inclusion of physiographic and atmospheric influences is critical for spatial modeling of orographic precipitation in complex terrains. However, attempts to incorporate cloud cover frequency (CCF) data when interpolating precipitation are limited. CCF considers the rain shadow effect during interpolation to avoid an overly strong relationship between elevation and precipitation in areas at equivalent altitudes across rain shadows. Conventional multivariate regression or geostatistical methods assume the precipitation–explanatory variable relationship to be steady, even though this relation is often non-stationarity in complex terrains. This study proposed a novel spatial mapping approach for precipitation that combines regression-kriging (RK) to leverage its advantages over conventional multivariate regression and the spatial autocorrelation structure of residuals via kriging. The proposed hybrid model, RK (GT + CCF), utilized CCF and other physiographic factors to enhance the accuracy of precipitation interpolation. The implementation of this approach was examined in a mountainous region of southern Syria using in situ monthly precipitation data from 57 rain gauges. The RK model’s performance was compared with conventional multivariate regression models (CMRMs) that used geographical and topographical (GT) factors and CCF as predictors. The results indicated that the RK model outperformed the CMRMs with a root mean square error of <8 mm, a mean absolute percentage error range of 5–15%, and an R2 range of 0.75–0.96. The findings of this study showed that the incorporation of MODIS–CCF with physiographic variables as covariates significantly improved the interpolation accuracy by 5–20%, with the largest improvement in modeling precipitation in March.
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