Accuracy Of T2-weighted Imaging Research Articles

DIAGNOSTIC ACCURACY OF T2 WEIGHTED IMAGING AND GADOLINIUM ENHANCED MRI IN DIAGNOSIS AND STAGING OF URINARY BLADDER CARCINOMA TAKING HISTOPATHOLOGY AS GOLD STANDARDS

Urinary bladder carcinoma (UBC) diagnosis and staging are critical for treatment planning and patient prognosis. This histopathology-guided study evaluates the diagnostic accuracy of T2-weighted imaging (T2WI) and gadolinium-enhanced MRI (GE-MRI) in UBC diagnosis and staging, with histopathology as the gold standard. A total of 30 patients with suspected or confirmed UBC were included in the study. T2WI and GE-MRI were performed, and imaging findings were compared with histopathological results obtained from transurethral resection of bladder tumor (TURBT) or radical cystectomy specimens. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of T2WI and GE-MRI were calculated. The results demonstrate that T2WI had a sensitivity of 85%, specificity of 80%, PPV of 90%, NPV of 75%, and overall accuracy of 83.3% in diagnosing UBC. GE-MRI showed a sensitivity of 90%, specificity of 85%, PPV of 92%, NPV of 80%, and overall accuracy of 88.3%. Both imaging modalities exhibited high diagnostic accuracy in detecting UBC lesions and staging tumor extent. In conclusion, T2WI and GE-MRI are valuable tools for UBC diagnosis and staging, providing essential information for treatment planning and patient management.

A Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and T2-Weighted Imaging in Determining the Depth of Myometrial Invasion in Endometrial Carcinoma-A Retrospective Study.

This study aims to compare dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with T2-weighted imaging (T2WI) in defining the depth of myometrial invasion in endometrial carcinoma. This retrospective study included 32 subjects with endometrial carcinoma who underwent 3.0T magnetic resonance imaging (MRI) prior to hysterectomy. DCE-MRI and T2WI were evaluated to determine the depth of myometrial invasion in endometrial carcinoma. A set of data consisting of the sensitivity, specificity, predictive values, and accuracy of DCE-MRI and T2WI were obtained and compared with the histopathological results. Out of the 32 cases included, the histopathological examination revealed that 50% myometrial invasion was found in 11 patients and ≥50% myometrial invasion was found in 21 patients. In the assessment of the tumor invasion, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of T2WI were 45.45%, 90.48 %, 71.43%, 76.0%, and 75.0%, respectively. The corresponding values for DCE-MRI were 81.82%, 76.19%, 64.29%, 88.89 %, and 78.12%, respectively. When T2WI were read together with DCE-MRI, the values were 90.91%, 90.48%, 83.33%, 95.0%, and 90.62%, respectively. Thus, the sensitivity and accuracy of DCE-MRI were greater compared to T2WI in defining the depth of myometrial invasion. However, the merging of T2WI and DCE-MRI increased the specificity and PPV value and improved the sensitivity, NPV and accuracy in detecting myometrial invasion. DCE-MRI was more sensitive but less specific than T2WI in defining the depth of myometrial invasion. In conclusion, combining DCE-MRI and T2WI further improves the diagnostic performance for myometrial invasion in endometrial carcinoma.

MP11-07 T2-WEIGHTED/DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING AS A NOVEL SCORING MODE FOR THE EARLY DETECTION OF PROSTATE CANCER

You have accessJournal of UrologyImaging/Radiology: Uroradiology II1 Apr 2015MP11-07 T2-WEIGHTED/DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING AS A NOVEL SCORING MODE FOR THE EARLY DETECTION OF PROSTATE CANCER Xuan Wang, Ming Liu, Jianye Wang, Min Chen, Ben Wan, Chunmei Li, Gang Wan, Wei Zhang, Yong Zhang, and Yuanyuan Zhang Xuan WangXuan Wang More articles by this author , Ming LiuMing Liu More articles by this author , Jianye WangJianye Wang More articles by this author , Min ChenMin Chen More articles by this author , Ben WanBen Wan More articles by this author , Chunmei LiChunmei Li More articles by this author , Gang WanGang Wan More articles by this author , Wei ZhangWei Zhang More articles by this author , Yong ZhangYong Zhang More articles by this author , and Yuanyuan ZhangYuanyuan Zhang More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.388AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To explore the clinical efficacy of Magnetic Resonance Imaging (MRI) in the early diagnosis of prostate cancer for the patients with prostate specific antigen (PSA) level < 20ng/ml, to provide quantitative evaluation of a standardized scoring system based on Prostate Imaging Reporting and Data System (PI-RADS) to correlate the chance of prostate cancer with each scale on the identified lesion at T2 weighted imaging (T2WI) and diffusion weighted imaging (DWI) in combination and to assess the accuracy of the image scoring system of T2WI combined with DWI for the early diagnosis of prostate cancer. METHODS In total, 133 patients with PSA < 20 ng/ml were prospectively recruited. The patients'PSA level ranged from 0.2-19.8 ng/mL (Median 6.9 ng/mL ¡À 4.0). Pelvic MRI was performed before 12-core transrectal prostate biopsy. The prostate peripheral zone of each patient was divided into six regions on MR images in the same fashion of biopsy: right and left at apex, mid and base level, each region corresponds to 2 out of 12 biopsy cores. T2WI and DWI image features on peripheral zone of the prostate were evaluated according to the pre-established image scoring standards. We compared the accuracy of the scoring system of T2WI in diagnosis of prostate cancer with T2WI and DMI in combination. Histopathologic evaluation of prostate biopsies was the reference standard. RESULTS 60 patients (45.1%) were diagnosed with prostate cancer by tissue biopsies. 169 foci of peripheral zone tumor were identified from the total 798 regions (21.2%). Prostate cancer detection rate of score 0∼5 on T2WI image was 2.8%, 13.4%, 20.3%, 34.6%, 52.6% and 88.9% respectively, and the rate was 11.1%, 16.1%, 48.5%, 71.0% and 86.1% respectively on score 1∼5 of T2WI+DWI image grading. With the increase of pre-established T2WI or T2WI+DWI image score, prostate cancer detection rate showed a significant increase by Cochran-Armitage trend test (P< 0.0001, P< 0.0001). The receiver operating characteristic (ROC) analysis found that the ability of T2WI+DWI was greater than that of T2WI alone in detection of prostate cancer (Area under the ROC curve (AUC)=0.743 vs. AUC=0.715, P=0.0072). CONCLUSIONS The signals of the peripheral zone on T2WI+DWI are strongly associated with the diagnosis of prostate cancer. Clinic efficiency and accuracy of T2WI plus DWI was superior to that of T2WI alone in the early detection of prostate cancer. The proposed scoring system of T2WI+DMI can predict the risk of prostate cancer for patients with PSA < 20 ng/ml. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e121 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Xuan Wang More articles by this author Ming Liu More articles by this author Jianye Wang More articles by this author Min Chen More articles by this author Ben Wan More articles by this author Chunmei Li More articles by this author Gang Wan More articles by this author Wei Zhang More articles by this author Yong Zhang More articles by this author Yuanyuan Zhang More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging.

Dynamic magnetic resonance (MR) imaging was performed on a 1.5-T superconducting unit for evaluation of 26 stage I endometrial carcinomas. To establish the appearance of the normal uterus, 27 normal uteri were also evaluated. After rapid injection of gadopentetate dimeglumine, dynamic images were obtained every 30 seconds with the spin-echo technique in the sagittal plane. On dynamic studies of endometrial carcinoma, the tumor-myometrial contrast was marked at 120 seconds after administration of gadopentetate dimeglumine (contrast-to-noise ratio [C/N], 26.0). The tumor-myometrial contrast on the dynamic study was more marked than that on postcontrast T1-weighted images (C/N, 10.0) and on T2-weighted images (C/N, 2.14). Dynamic and postcontrast MR images were superior in enabling differentiation of viable tumors from necrosis or residual secretion in the endometrial cavity. In the evaluation of presence of tumor and myometrial invasion, the accuracy of T2-weighted imaging and dynamic imaging was 67.9% and 84.9%, respectively.