Deformities of the maxillofacial region following trauma and ablative surgery are devastating and not uncommon. Reconstruction of such defects is a surgically challenging procedure. Conventionally, reconstruction of the jaw defects lacks pre-operative customized planning and relies heavily on surgeons' experiences to ensure optimum surgical outcomes. The restoration of jaw shape and function has taken precedence after an extensive tumor resection surgery, especially in the current age of technological advancement. Thus, personalized and accurate reconstruction of jaw defects has become a new goal. Computer-assisted surgery especially navigation-assisted surgery has gained popularity of late, in reconstructing deformities and restoring facial symmetry, appearance and function in the maxillofacial region. This technology provides a clearer three-dimensional visualization of the area of interest and its relationship with the adjacent vital structures. With pre-operative virtual surgical planning, it allows more specific and accurate osteotomies, thus reducing the ischemia and total operating times substantially. The risk of complications is also minimized whilst improving the final surgical outcomes. The use of intra-operative navigation system and other computer-assisted surgical techniques in the surgery can significantly improve the precision of the reconstruction of jaw deformities and achieve personalized and functional reconstructive goals while enhancing the patients' quality of life post-operatively. The Society of Oral and Maxillofacial Surgery, Chinese Stomatological Association provides this professional perspective and present treatment protocol for navigation-guided reconstruction of jaw defect to allow standardization of the techniques while promoting its application among the oral and maxillofacial surgeons.