In this paper, a generalized finite difference method (GFDM) is proposed and analyzed for meshless numerical solution of the time-fractional diffusion-wave equation. Two (3−α)-order accurate temporal discretization schemes are presented by using the L1 formula and the original H2N2 or fast H2N2 formulas to discretize the time-fractional derivative of order α∈(1,2). The stability of the temporal discretization schemes is analyzed. Then, the time-fractional diffusion-wave initial-boundary value problem is transformed into a series of time-independent integer-order boundary value problems, and discrete linear algebraic systems are built by the application of the GFDM. Accuracy analysis of the GFDM with both original H2N2 and fast H2N2 formulas is presented in theory, and numerical experimental results are provided to verify the theoretical results and the effectiveness of the proposed meshless method.