Monitoring wetland as one of the important parts of the global ecosystem is necessary for conservational programs. But, usually, collecting in situ data is restricted in these areas because of their remote locations, vast area and dynamic conditions. Remote sensing provides a cost effective tool to investigate hydrological patterns and the seasonal trend of changes in wetlands. In this paper, Land-use/land-cover change during water inundation period of Hamun wetland was investigated in order to determine change trend during this period. Hamun wetland is an unsustainable ecosystem, and monitoring this wetland is essential for conservation goals. This trend is critical for decision makers in order to plan the conservational scheme in all unsustainable ecosystems. To reach this objective, the land-use/land-cover maps during inundation period of Hamun were produced using Landsat 8 time series images. The results of accuracy assessment showed the classification of water and vegetation have the highest accuracy (94% and 93%, respectively). And the accuracy of plants in the water classes was the lowest (water–veg = 89.9%, veg–water 1 = 88.8%, veg–water 2 = 87.6%). This means the higher misclassification is in determining the vegetation in the water. Then, the changes in the land-cover classes in relation to wetland inundation were investigated. Results of land-use/land-cover change illustrate the regions that were suitable for water birds but lost their suitability when the wetland dried out. These areas are crucial for water bird’s conservation. Satellite data determined these areas with acceptable accuracy.