This article investigates the morphostructural evolution of the Labe and Jizera rivers confluence area in the Bohemian Massif of Czechia. The main stages of morphostructural evolution are identified and related landform patterns are described. The lithological and tectonic character of this contact area between the Barrandian and the Bohemian Cretaceous Basin has been gradually evolving since the Early Palaeozoic. Tectonic subsidence of the northeastern part of the Bohemian Massif and the Cretaceous transgression of the sea caused extensive marine sedimentation, which covered the pre-Cenomanian relief. The uplift of the Bohemian Massif during the Santonian initiated a widespread erosion and denudation in the Tertiary. The Labe River valley constitutes a remarkable boundary between the morphostructural plateaus in the south and the system of river accumulation terraces of the Labe and Jizera in the north. The originally extensive and currently considerably eroded III. river terrace of the Labe was formed in the Elsterian glacial period (Cromerian complex c). The conspicuous Jizera alluvial fan developed during the aggradation phase of the VII. river terrace in the Upper Pleistocene. Subsidence along the NW-SE-trending Labe Fault zone, deciphered from the vertical throw of the VII. terrace rock bases of Labe as well as related paleochannels of its local tributaries, which caused the current asymmetry of the Labe valley, reached up to 14 meters prior to the Holocene. The different rock resistance to weathering, arrangement of fault structures and neotectonic movements that took place even during the late Quaternary significantly influenced the intensity of varied climate-morphogenetic processes.