Chinese international students have emerged as the important segment in Korea while their acculturation and medical service has been relatively overlooked in literatures. The purpose of this study is to verify how different acculturation groups have different use and preference of medical service, which secure the health related quality of life during in overseas studies. A survey was administered to the 186 Chinese international students in H university campus in Seoul, Korea. Results revealed that Berry’s four acculturation groups (Integration, Assimilation, Separation and Marginalization) have significantly different preference and use over respective medical services (Western, Oriental, Korean and alternative). Also founded that acculturation groups have significantly different demographic characteristics such as age, length of stay, Korean language fluency and etc. The managerial significance and limitation of research were included.